UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F53F1.2	F53F1.2	3e-173	chrV 13,407,532	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
2	K03C7.3	K03C7.3	n/a	chrX 3,828,246
3	ubh-4	C08B11.7	n/a	chrII 8,038,864	C. elegans UBH-4 protein; contains similarity to Pfam domain PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 contains similarity to Interpro domains IPR001578 (Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1), IPR017390 (Ubiquitinyl hydrolase, UCH37 type)
4	R12E2.12	R12E2.12	n/a	chrI 4,174,271	contains similarity to Interpro domain IPR000529 (Ribosomal protein S6)
5	prx-19	F54F2.8	n/a	chrIII 8,808,467	prx-19 is orthologous to the human gene PEROXISOMAL FARNESYLATED PROTEIN (PXF; OMIM:600279), which when mutated leads to peroxisome biogenesis (Zellweger) syndrome of complementation group J.
6	C34C12.8	C34C12.8	n/a	chrIII 3,460,983	contains similarity to Pfam domain PF01025 GrpE contains similarity to Interpro domains IPR009012 (GrpE nucleotide exchange factor, head), IPR013805 (GrpE nucleotide exchange factor, coiled-coil), IPR000740 (GrpE nucleotide exchange factor)
7	B0303.15	B0303.15	n/a	chrIII 8,717,978	contains similarity to Pfam domains PF00298 (Ribosomal protein L11, RNA binding domain) , PF03946 (Ribosomal protein L11, N-terminal domain) contains similarity to Interpro domain IPR000911 (Ribosomal protein L11)
8	F22E10.5	F22E10.5	n/a	chrX 12,763,749	contains similarity to Pfam domain PF03171 2OG-Fe(II) oxygenase superfamily contains similarity to Interpro domains IPR006620 (Prolyl 4-hydroxylase, alpha subunit), IPR005123 (2OG-Fe(II) oxygenase)
9	C17E4.9	C17E4.9	n/a	chrI 9,432,529	contains similarity to Pfam domain PF00287 Sodium / potassium ATPase beta chain contains similarity to Interpro domain IPR000402 (ATPase, P-type cation exchange, beta subunit)
10	F25E5.1	F25E5.1	n/a	chrV 7,468,526	contains similarity to Interpro domain IPR009091 (Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)
11	F46C5.9	F46C5.9	n/a	chrII 8,809,612	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
12	iff-2	F54C9.1	n/a	chrII 8,560,312	C. elegans IFF-2 protein; contains similarity to Pfam domains PF01287 (Eukaryotic initiation factor 5A hypusine, DNA-binding OB fold) , PF00467 (KOW motif) contains similarity to Interpro domains IPR001884 (Eukaryotic initiation factor 5A hypusine (eIF-5A)), IPR008991 (Translation protein SH3-like), IPR005824 (KOW), IPR012340 (Nucleic acid-binding, OB-fold), IPR014722 (Translation protein SH3-like, subgroup)
13	T20B12.3	T20B12.3	n/a	chrIII 7,382,935	contains similarity to Pfam domain PF03914 CBF/Mak21 family contains similarity to Interpro domain IPR005612 (CBF)
14	rap-3	C08F8.7	n/a	chrIV 11,177,654	C. elegans RAP-3 protein; contains similarity to Pfam domains PF00071 (Ras family) , PF08477 (Miro-like protein) contains similarity to Interpro domains IPR002041 (Ran GTPase), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR006688 (ADP-ribosylation factor), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily)
15	ppk-1	F55A12.3	n/a	chrI 5,361,848	ppk-1 encodes a putative phosphatidylinositol-4-phosphate 5' kinase that is essential for ovulation, intense gonad sheath contraction and dilation of the spermathecal valve during oocyte maturation, and UNC-54 filament organization; more generally, PPK-1 is required for fertility, progression through larval development, normal locomotion and defecation, and overall health; defects of ppk-1(RNAi) animals in sterility, ovulation, and UNC-54 filaments are suppressed by the gain-of-function itr-1(sy290) allele, presumably through increased IP(3) signalling; PPK-1 is expressed in gonad sheath, spermatheca, uterine and vulva muscles, distal tip cells, intestine, head mesodermal cell, and many neurons (e.g., in the ventral nerve cord, near the nerve ring, and in tail); PPK-1 may be activated by VAV-1; PPK-1 is orthologous to five human proteins (e.g., PIP5K1B, OMIM:602745), and distantly paralogous to PPK-2.
16	T23B12.2	T23B12.2	n/a	chrV 8,468,082	contains similarity to Pfam domain PF00573 Ribosomal protein L4/L1 family contains similarity to Interpro domains IPR013005 (Ribosomal protein L4/L1e, bacterial-type), IPR002136 (Ribosomal protein L4/L1e)
17	M01A10.3	M01A10.3	n/a	chrI 5,549,799	contains similarity to Pfam domain PF05817 Ribophorin II (RPN2) contains similarity to Interpro domain IPR008814 (Ribophorin II)
18	F43E2.9	F43E2.9	n/a	chrII 7,359,080
19	pfd-3	T06G6.9	n/a	chrI 12,729,010	pfd-3 encodes a putative prefoldin, orthologous to human VBP1 (OMIM:300133), that is required for normal alpha-tubulin synthesis, microtubule growth, mitotic spindle formation and positioning, early embryonic cell division, and embryonic and larval viability; PFD-3 is expressed cytoplasmically in most, if not all, tissues.
20	K12H4.3	K12H4.3	n/a	chrIII 8,046,749	contains similarity to Pfam domain PF04427 Brix domain contains similarity to Interpro domain IPR007109 (Brix)
21	C29F7.1	C29F7.1	n/a	chrX 13,413,508	contains similarity to Pfam domains PF02958 (Domain of unknown function (DUF227)) , PF07914 (Protein of unknown function (DUF1679)) contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR004119 (Protein of unknown function DUF227), IPR015897 (CHK kinase-like)
22	his-3	T10C6.12	n/a	chrV 16,040,965	his-3 encodes an H2A histone; by homology, HIS-3 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-3 is a replication-dependent histone locus that resides in the HIS1 cluster on chromosome V.
23	T20H4.5	T20H4.5	n/a	chrIII 7,233,493	T20H4.5 gene encodes a 23 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation and for resistance to volatile anesthetics; T20H4.5 is orthologous to human NDUFS8 (OMIM:602141, mutated in Leigh syndrome).
24	M88.2	M88.2	n/a	chrIII 4,541,915	contains similarity to Aedes aegypti Mitochondrial ribosomal protein, S34, putative.; TR:Q17JQ1
25	gly-13	B0416.6	n/a	chrX 9,295,081	gly-13 encodes an experimentally verified UDP-N-acetylglucosamine alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I (GnT I), that is the primary GnT I enzyme in vivo, and that can act on unusual substrates; gly-13 is expressed throughout development in many cell types; gly-13 has no obvious function in vivo, since a deletion allele of gly-13 is phenotypically normal even as a double or triple mutant with gly-12 and gly-14.
26	C30C11.1	C30C11.1	n/a	chrIII 8,450,050	contains similarity to Pfam domain PF01783 Ribosomal L32p protein family contains similarity to Interpro domain IPR002677 (Ribosomal protein L32p)
27	F36G3.2	F36G3.2	n/a	chrX 9,793,271	contains similarity to Pfam domain PF00583 Acetyltransferase (GNAT) family contains similarity to Interpro domains IPR000182 (GCN5-related N-acetyltransferase), IPR016181 (Acyl-CoA N-acyltransferase)
28	vha-2	R10E11.2	n/a	chrIII 9,782,355	vha-2 and vha-3 encode an ortholog of subunit c of the membrane-bound (V0) domain of vacuolar proton-translocating ATPase (V-ATPase); the protein encoded by vha-2 and vha-3 (VHA-2/3) is identical; VHA-2/3 is a predicted V-ATPase transmembrane rotor component, whose polypeptide sequence is identical to that of VHA-3; VHA-1 and VHA-2/3 comprise a closely related family of subunit c co-orthologs, predicted to carry protons from the cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) for transmembrane export; VHA-2/3 is dispensable for viability, since vha-2/3(RNAi) animals have mostly healthy progeny; however, VHA-2 is required for ovulation and embryogenesis, since vha-2(RNAi) animals are sterile with polyploid, unmatured oocytes; VHA-2, along with VHA-15 and probably all V-ATPase subunits, is required for systemic RNAi, probably during endocytotic RNAi uptake; VHA-2 is required for necrosis, since vha-2(RNAi) suppresses necrotic neurodegeneration; vha-2 shares an operon with vha-1 and R10E11.6; both vha-2 and vha-1 are expressed in the excretory cell, the rectum, and a pair of cells posterior to the anus.
29	B0205.6	B0205.6	n/a	chrI 10,738,293	contains similarity to Pfam domains PF01212 (Beta-eliminating lyase) , PF00266 (Aminotransferase class-V) contains similarity to Interpro domains IPR001597 (Aromatic amino acid beta-eliminating lyase/threonine aldolase), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR000192 (Aminotransferase, class V/Cysteine desulphurase), IPR016454 (Cysteine desulphurase, NifS), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
30	ars-2	F28H1.3	n/a	chrI 3,984,796	ars-2 encodes a predicted cytoplasmic alanyl-tRNA synthetase (AlaRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of alanine to its cognate tRNA and is thus required for protein biosynthesis; ARS-2 is essential for embryogenesis, and is required for fertility and a normal rate of postembryonic development; ARS-2 expression is likely ubiquitous and detected in hypodermis, intestine, neurons, and the pharynx from late embryogenesis through the adult stage of development.
31	clec-17	E03H4.10	n/a	chrI 12,430,738	C. elegans CLEC-17 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF00059 (Lectin C-type domain) (2)contains similarity to Interpro domains IPR000859 (CUB), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
32	ugt-21	C33A12.6	n/a	chrIV 9,501,385	C. elegans UGT-21 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
33	lys-10	F17E9.11	n/a	chrIV 8,333,154	C. elegans LYS-10 protein; contains similarity to Interpro domains IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site)
34	W02D3.2	W02D3.2	n/a	chrI 6,738,931	contains similarity to Pfam domain PF01180 Dihydroorotate dehydrogenase contains similarity to Interpro domains IPR001295 (Dihydroorotate dehydrogenase, core), IPR013785 (Aldolase-type TIM barrel), IPR005719 (Dihydroorotate dehydrogenase, class 2), IPR012135 (Dihydroorotate dehydrogenase, classes 1 and 2)
35	C47E12.7	C47E12.7	n/a	chrIV 9,981,472	contains similarity to Pfam domain PF05997 Nucleolar protein,Nop52 contains similarity to Interpro domain IPR010301 (Nucleolar, Nop52)
36	eif-3.K	T16G1.11	n/a	chrV 12,954,593	The protein product of this gene was predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS72 release of WormBase, i.e., in wormpep77).
37	rnf-121	C16C10.5	n/a	chrIII 4,169,952	C. elegans RNF-121 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
38	mel-46	T06A10.1	n/a	chrIV 16,859,204	C. elegans MEL-46 protein; contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
39	R04E5.2	R04E5.2	n/a	chrX 8,814,421	R04E5.2 encodes a predicted transmembrane protein orthologous to human ACDP1-ACDP4 and S. cerevisiae MAM3, and paralogous to C01H6.6, C33D12.2, C52D10.12, M02F4.3, and R13G10.4; by orthology with MAM3, R04E5.2 may participate in metal homoeostasis; R04E5.2, MAM3, and ACDP1-ACDP4 belong to a family of proteins (sharing an ACD domain) from bacteria, yeast, plants, and metazoa; murine Acdp1 is a plasma membrane protein; bacterial proteins containing the ACD domain include CorC from Salmonella typhimurium, which is involved in magnesium and cobalt efflux; R04E5.2 has no obvious function in RNAi assays.
40	gip-2	C45G3.3	n/a	chrI 9,227,490	gip-2 encodes a member of the Biotin/lipoate A/B protein ligase family.
41	ruvb-1	C27H6.2	n/a	chrV 9,979,753	C. elegans RUVB-1 protein; contains similarity to Pfam domain PF06068 TIP49 C-terminus contains similarity to Interpro domains IPR010339 (TIP49, C-terminal), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal)
42	C01A2.3	C01A2.3	n/a	chrI 13,389,622	contains similarity to Pfam domain PF02096 60Kd inner membrane protein contains similarity to Interpro domain IPR001708 (60 kDa inner membrane insertion protein)
43	nuo-1	C09H10.3	n/a	chrII 11,099,005	nuo-1 encodes a encodes a 51 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, and progression through development; nuo-1 is orthologous to human NDUFV1 (OMIM:161015, mutated in Leigh syndrome); nuo-1(ua1) induces a developmental arrest at the third larval (L3) stage that blocks reproduction, and thus is lethal to a population homozygous for nuo-1(ua1); yet arrested L3 nuo-1(ua1) animals have an individual lifespan significantly longer than normal.
44	nlt-1	ZK892.2	n/a	chrII 10,000,661	nlt-1 encodes a member of the SCP-2 sterol transfer family.
45	B0280.9	B0280.9	n/a	chrIII 7,121,829	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR001680 (WD40 repeat), IPR011046 (WD40 repeat-like), IPR015943 (WD40/YVTN repeat-like)
46	dnc-2	C28H8.12	n/a	chrIII 5,925,025	dnc-2 encodes a member of the dynamitin family that affects spindle alignment in polarized cells in early embryos, nuclear movement, spindle morphology, chromosome segregation, and pronuclear migration.
47	tsfm-1	F55C5.5	n/a	chrV 12,270,895	F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline.
48	rpb-2	C26E6.4	n/a	chrIII 4,941,947	C. elegans RPB-2 protein; contains similarity to Pfam domains PF04566 (RNA polymerase Rpb2, domain 4) , PF04561 (RNA polymerase Rpb2, domain 2) , PF04567 (RNA polymerase Rpb2, domain 5) , PF04565 (RNA polymerase Rpb2, domain 3) , PF00562 (RNA polymerase Rpb2, domain 6) , PF04560 (RNA polymerase Rpb2, domain 7) , PF04563 (RNA polymerase beta subunit) contains similarity to Interpro domains IPR007120 (DNA-directed RNA polymerase, subunit 2, domain 6), IPR007641 (RNA polymerase Rpb2, domain 7), IPR007644 (RNA polymerase, beta subunit, protrusion), IPR015712 (DNA-directed RNA polymerase, subunit 2), IPR007645 (RNA polymerase Rpb2, domain 3), IPR007642 (RNA polymerase Rpb2, domain 2), IPR014724 (RNA polymerase Rpb2, OB-fold), IPR007646 (RNA polymerase Rpb2, domain 4), IPR007647 (RNA polymerase Rpb2, domain 5), IPR007121 (RNA polymerase, beta subunit, conserved site)
49	W02B12.11	W02B12.11	n/a	chrII 11,474,835	contains similarity to Pfam domain PF02709 Galactosyltransferase contains similarity to Interpro domain IPR003859 (Metazoa galactosyltransferase)
50	F39B2.3	F39B2.3	n/a	chrI 14,788,812	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)