UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	aat-3	F52H2.2	0	chrX 2,555,967	aat-3 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-3 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-3 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-3 localizes to the cell surface of oocytes, but when expressed alone, or with ATG-1, AAT-3 localizes intracellularly.
2	H01G02.2	H01G02.2	n/a	chrIV 11,799,864	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
3	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	fox-1	T07D1.4	n/a	chrX 2,448,279	fox-1 encodes an RNA-binding protein of the RNA recognition motif (RRM) superfamily of ribonucleic acid binding proteins; during C. elegans development, FOX-1 functions redundantly with other numerator elements to effect proper dosage compensation in the early embryo; in influencing dosage compensation, FOX-1 likely acts via post-transcriptional regulation of xol-1 mRNA levels; in addition to its role in dosage compensation, fox-1 activity is also required for normal male mating behavior; Western analysis and lacZ reporter constructs indicate that FOX-1 is expressed throughout the life cycle, beginning at the 18-20-cell stage of embryogenesis and continuing on through larval stages and into adult hermaphrodites and males; while early embryonic expression of fox-1 is ubiquitous, postembryonic expression is limited to a subset of head and tail neurons.
5	Y17G7B.17	Y17G7B.17	n/a	chrII 12,096,120	contains similarity to Drosophila melanogaster Flybase gene name is Mlf-PD;; FLYBASE:CG8295
6	nhr-196	K06B4.5	n/a	chrV 15,686,814	C. elegans NHR-196 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
7	F23H11.7	F23H11.7	n/a	chrIII 918,259
8	unc-24	F57H12.2	n/a	chrIV 7,980,963	unc-24 encodes a protein that contains a stomatin-like domain and a lipid transfer domain; unc-24 activity is essential for normal locomotion and for wild-type sensitivity to lipid-soluble volatile anesthetics; unc-24 is genetically epistatic to unc-79 and to unc-1, which encodes an additional stomatin whose stability and localization to the nerve ring are dependent upon UNC-24; unc-24 is expressed in the touch receptor neurons as well as neurons in the ventral cord.
9	B0285.7	B0285.7	n/a	chrIII 4,360,726	contains similarity to Pfam domain PF01433 Peptidase family M1 contains similarity to Interpro domains IPR014782 (Peptidase M1, membrane alanine aminopeptidase, N-terminal), IPR001930 (Peptidase M1, membrane alanine aminopeptidase)
10	M151.1	M151.1	n/a	chrII 3,642,785
11	F28H7.7	F28H7.7	n/a	chrV 10,752,577	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
12	mlt-8	W08F4.6	n/a	chrII 570,690	mlt-8 encodes a novel protein; during development, mlt-8 activity is required for molting; a mlt-8::gfp reporter is expressed in hypodermal cells and in a single posterior neuron.
13	Y116A8C.33	Y116A8C.33	n/a	chrIV 17,113,736	contains similarity to Interpro domain IPR003125 (Protein of unknown function WSN)
14	T05A7.9	T05A7.9	n/a	chrII 4,684,669	contains similarity to Pfam domain PF01744 GLTT repeat (6 copies) contains similarity to Interpro domain IPR008164 (Repeat of unknown function XGLTT)
15	K05C4.9	K05C4.9	n/a	chrI 14,728,785	contains similarity to Pfam domain PF00560 Leucine Rich Repeat
16	srx-97	F19B10.7	n/a	chrII 3,667,915	C. elegans SRX-97 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
17	flp-4	C18D1.3	n/a	chrII 10,054,913	C. elegans FLP-4 protein ;
18	C41G7.7	C41G7.7	n/a	chrI 9,534,916	contains similarity to Plasmodium falciparum S-antigen (Fragment).; TR:Q9GZB4
19	ceh-37	C37E2.5	n/a	chrX 14,203,216	ceh-37 encodes one of three C. elegans proteins with an OTX-like homeodomain; however, CEH-37 lacks other domains found in OTX proteins, and the CEH-37 homeodomain is predicted to resemble the Myb domain of telomere-binding proteins; CEH-37 binds the telomeric sequence 'TTAGGC' if it is repeated at least 1.5 times, and is mainly localized to the telomere in vivo; ceh-37 mutants have a weak increase in chromosomal nondisjunction; CEH-37 is involved in specifying some aspects of the AWB olfactory neuron fate, such as expression of an AWB-specific odorant receptor and a LIM-class homeodomain protein, LIM-4; CEH-37 is expressed broadly in the early embryo, while in larvae and adults it is expressed solely in the excretory cell.
20	ZC204.14	ZC204.14	n/a	chrII 1,662,200
21	mbk-1	T04C10.1	n/a	chrX 14,822,147	mbk-1 encodes a putative dual-specificity kinase (predicted to have both serine/threonine and tyrosine substrates) that is orthologous to Drosophila MINIBRAIN and mammalian DYRK1A/MnbK and that has a glutamine/asparagine-rich domain; MBK-1 is found in most or all nuclei, is dispensable for viability, and perturbs olfaction in AWC when overexpressed.
22	C39D10.6	C39D10.6	n/a	chrX 7,896,965
23	M176.4	M176.4	n/a	chrII 9,421,150	contains similarity to Pfam domain PF07947 YhhN-like protein contains similarity to Interpro domains IPR012506 (YhhN-like), IPR003492 (Batten's disease protein Cln3)
24	F38B6.3	F38B6.3	n/a	chrX 6,693,910
25	F11D11.3	F11D11.3	n/a	chrV 18,759,090	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
26	eat-2	Y48B6A.4	n/a	chrII 14,169,168	eat-2 encodes a ligand-gated ion channel subunit most closely related to the non-alpha-subunits of nicotinic acetylcholine receptors (nAChR); EAT-2 functions postsynaptically in pharyngeal muscle to regulate the rate of pharyngeal pumping; eat-2 is also required for normal life span and defecation; a functional EAT-2::GFP fusion protein localizes to two small dots near the junction of pharyngeal muscles pm4 and pm5, which is the site of the posterior-most MC motor neuron processes and the MC synapse; eat-2 genetically interacts with eat-18, which encodes a predicted novel transmembrane protein expressed in pharyngeal muscle and required for proper function of pharyngeal nicotonic receptors.
27	C03H5.6	C03H5.6	n/a	chrII 396,394	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
28	R08C7.4	R08C7.4	n/a	chrIV 4,436,206	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
29	C29H12.6	C29H12.6	n/a	chrII 6,116,301
30	F16D3.6	F16D3.6	n/a	chrI 8,376,505	contains similarity to Pfam domain PF06681 Protein of unknown function (DUF1182) contains similarity to Interpro domains IPR002091 (Aromatic amino acid permease), IPR010601 (Protein of unknown function DUF1182)
31	ctbp-1	F49E10.5	n/a	chrX 5,867,998	tag-45 encodes a D-isomer specific 2-hydroxyacid dehydrogenase.
32	ZC190.6	ZC190.6	n/a	chrV 8,675,924
33	bbs-2	F20D12.3	n/a	chrIV 7,935,876	bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
34	C17E4.11	C17E4.11	n/a	chrI 9,420,385	contains similarity to Pfam domain PF08241 Methyltransferase domain contains similarity to Interpro domain IPR013216 (Methyltransferase type 11)
35	C46E10.5	C46E10.5	n/a	chrII 3,712,130
36	ZC518.4	ZC518.4	n/a	chrIV 12,367,373	contains similarity to Neurospora crassa Hypothetical protein B8B8.120.; TR:Q872S5
37	T12E12.6	T12E12.6	n/a	chrIV 5,570,564	contains similarity to Pfam domain PF01433 Peptidase family M1 contains similarity to Interpro domains IPR014782 (Peptidase M1, membrane alanine aminopeptidase, N-terminal), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001930 (Peptidase M1, membrane alanine aminopeptidase)
38	C33C12.8	C33C12.8	n/a	chrII 2,184,467	contains similarity to Pfam domain PF02055 O-Glycosyl hydrolase family 30 contains similarity to Interpro domains IPR017853 (Glycoside hydrolase, catalytic core), IPR001139 (Glycoside hydrolase, family 30), IPR013781 (Glycoside hydrolase, subgroup, catalytic core)
39	F28B4.1	F28B4.1	n/a	chrX 3,205,615
40	nhr-67	C08F8.8	n/a	chrIV 11,172,266	nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell.
41	ZK287.1	ZK287.1	n/a	chrV 9,668,349	contains similarity to Interpro domain IPR006560 (AWS)
42	Y39E4B.6	Y39E4B.6	n/a	chrIII 13,072,610	contains similarity to Rattus norvegicus Nucleolar protein NOP5 (Nucleolar protein 5) (Nopp140 associatedsprotein).; SW:NOP5_RAT
43	C34F6.9	C34F6.9	n/a	chrX 11,220,316	contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
44	ife-4	C05D9.5	n/a	chrX 1,105,125	The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family.
45	F44E7.7	F44E7.7	n/a	chrV 5,784,253	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
46	srj-20	Y45G12C.15	n/a	chrV 2,572,367	C. elegans SRJ-20 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
47	C16C10.9	C16C10.9	n/a	chrIII 4,156,357	contains similarity to Bacillus anthracis MutS2 family protein.; TR:Q81L40
48	nhr-84	T06C12.7	n/a	chrV 15,878,178	C. elegans NHR-84 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
49	srt-2	Y45G12C.5	n/a	chrV 2,545,033	C. elegans SRT-2 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
50	dyb-1	F47G6.1	n/a	chrI 1,486,779	The dyb-1 gene encodes a homolog of mammalian alpha-dystrobrevin (DTNA; OMIM:601239), mutation of which can lead to left ventricular noncompaction with congenital heart defects.