UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F47B8.5	F47B8.5	0	chrV 14,326,311	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domains IPR002485 (Protein of unknown function DUF13), IPR000694 (Proline-rich region), IPR000976 (Wilm's tumour protein), IPR003071 (Orphan nuclear receptor, HMR type)
2	K12D9.12	K12D9.12	n/a	chrV 3,021,212	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
3	ivd-1	C02B10.1	n/a	chrIV 5,087,748	The C02B10.1 gene encodes an isovaleryl-CoA dehydrogenase; this function has been verified by both sequence homology and direct biochemical assay.
4	R13D11.4	R13D11.4	n/a	chrV 810,558	contains similarity to Interpro domain IPR013785 (Aldolase-type TIM barrel)
5	F46G11.2	F46G11.2	n/a	chrX 5,789,196
6	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
7	F55A12.1	F55A12.1	n/a	chrI 5,370,477	contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
8	tyr-1	C02C2.1	n/a	chrIII 7,875,371	C02C2.1 encodes a tyrosinase homolog with a glutamine/asparagine-rich domain.
9	C18B2.4	C18B2.4	n/a	chrX 3,605,110	contains similarity to Pfam domain PF02893 GRAM domain contains similarity to Interpro domains IPR001419 (HMW glutenin), IPR004182 (GRAM)
10	Y52B11B.1	Y52B11B.1	n/a	chrI 11,123,920	contains similarity to Lactococcus lactis FhuD-like protein.; TR:Q8VU74
11	B0238.9	B0238.9	n/a	chrV 5,276,818	contains similarity to Aedes aegypti Putative uncharacterized protein.; TR:Q16RM2
12	C32B5.12	C32B5.12	n/a	chrII 952,421
13	R07B7.2	R07B7.2	n/a	chrV 12,058,156	contains similarity to Saccharomyces cerevisiae Protein required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; protects centromeric Spo69p; SGD:YOR073W
14	C30B5.6	C30B5.6	n/a	chrII 6,220,573
15	F44A6.5	F44A6.5	n/a	chrX 10,217,967	contains similarity to Sulfolobus tokodaii Hypothetical protein ST0534.; TR:Q974X9
16	str-232	T10C6.1	n/a	chrV 16,015,103	C. elegans STR-232 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
17	qua-1	T05C12.10	n/a	chrII 8,201,326	qua-1 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Qua domain, a 5W repeat, an extended region of low-complexity sequence, and a Hint/Hog domain; QUA-1 is conserved among nematodes from Caenorhabditis to Brugia; QUA-1 is expressed prior to molting in hyp1 to hyp11 hypodermal cells, but not in seam cells, and ceases to be expressed after each molting cycle or in gravid adults no longer molting; QUA-1 is strongly required for normal molting, with lethal molting defects in qua-1 mutants and severe defects in qua-1(RNAi) animals; similar molting defects in RNAi of ptr-4 and ptr-23 (encoding Dispatched homologs) suggest that PTR-4 and PTR-23 may export QUA-1 from hypodermal cells synthesizing it; other sites of QUA-1 expression include intestinal and rectal cells, excretory duct and pore cells, sensilla support cells, the P cell lineage in L1, body wall muscle, and the adult reproductive system; QUA-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, locomotion, and male tail development; the Hint/Hog domain is predicted to cut QUA-1 into two halves and then covalently link cholesterol to the C-terminus of the Qua domain; the Qua domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and the Qua domain has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; both Qua and Hint/Hog domains are required for transgenic rescue of a lethal qua-1 allele; defects in both qua-1 mutants and qua-1(RNAi) animals; all of QUA-1's functions may reflect common defects in cholesterol-dependent hedgehog-like signalling.
18	K03H1.10	K03H1.10	n/a	chrIII 9,923,743	contains similarity to Pfam domains PF02172 (KIX domain) , PF02135 (TAZ zinc finger) contains similarity to Interpro domains IPR003101 (Coactivator CBP, KIX), IPR000197 (Zinc finger, TAZ-type)
19	fbxa-167	C31C9.3	n/a	chrII 13,642,551	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
20	nhr-232	Y22F5A.1	n/a	chrV 10,257,478	C. elegans NHR-232 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
21	F46H5.5	F46H5.5	n/a	chrX 7,256,401
22	nhr-106	T01G6.4	n/a	chrV 490,539	nhr-106 encodes a nuclear receptor that is most highly conserved amongst nematode species.
23	F56B3.6	F56B3.6	n/a	chrIV 789,430	contains similarity to Pfam domain PF03134 TB2/DP1, HVA22 family contains similarity to Interpro domain IPR004345 (TB2/DP1 and HVA22 related protein)
24	emb-5	T04A8.14	n/a	chrIII 4,717,943	emb-5 encodes the C. elegans ortholog of the Spt6 family of RNA polymerase II transcription elongation factors; first identified in screens for temperature-sensitive embryonic lethal mutations, emb-5 is required for the correct timing of the second E (endoderm)-cell division in the early embryo and thus, for normal embryonic gastrulation; in addition, emb-5 activity is required postembryonically for proper gonad development; in yeast two-hybrid studies, EMB-5 interacts with the intracellular domains of LIN-12 and GLP-1, suggesting that EMB-5 functions as a positive downstream effector in Notch-like signaling pathways during C. elegans development; emb-5 mRNA is most abundant during embryonic stages, with lower levels apparent during the L1-L3 larval stages, and even lower levels observed during L4.
25	ZK669.4	ZK669.4	n/a	chrII 7,943,957	ZK669.4 is orthologous to the human gene DIHYDROLIPOAMIDE BRANCHED CHAIN TRANSACYLASE (E2 COMPONENT OF BRANCHED CHAIN KETO ACID DEHYDROGENASE COMPLEX; (DBT), which when mutated leads to maple syrup urine disease, type II (OMIM:248610); the ZK669.4 protein is predicted to be mitochondrial with 68% accuracy.
26	F58G1.1	F58G1.1	n/a	chrII 12,921,386	contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
27	twk-23	F19D8.1	n/a	chrX 13,819,543	twk-23 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; the precise role of TWK-23 in C. elegans development and/or behavior is not yet known, however TWK-23 may function redundantly with other TWK channels; TWK-23 is expressed in neurons, muscle, the posterior intestine, and diffusely in many other tissues.
28	C14C6.8	C14C6.8	n/a	chrV 552,129	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
29	C04F12.7	C04F12.7	n/a	chrI 9,696,226	contains similarity to Legionella pneumophila CITA.; TR:O54543
30	R13H4.6	R13H4.6	n/a	chrV 11,864,309	contains similarity to Archaeoglobus fulgidus Putative protease La homolog type (EC 3.4.21.-).; SW:O29883
31	ZC373.3	ZC373.3	n/a	chrX 10,061,060	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
32	T12B3.3	T12B3.3	n/a	chrIV 7,375,883	contains similarity to Pfam domain PF03009 Glycerophosphoryl diester phosphodiesterase family contains similarity to Interpro domain IPR004129 (Glycerophosphoryl diester phosphodiesterase)
33	C13A2.1	C13A2.1	n/a	chrV 7,290,625	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
34	F59A7.8	F59A7.8	n/a	chrV 2,010,108	contains similarity to Pfam domains PF00271 (Helicase conserved C-terminal domain) , PF00176 (SNF2 family N-terminal domain) contains similarity to Interpro domains IPR000330 (SNF2-related), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
35	ard-1	F01G4.2	n/a	chrIV 11,132,448	ard-1 encodes a homolog of mammalian 3-hydroxyacyl-CoA dehydrogenase (HADH II)/amyloid-beta binding alcohol dehydrogenase (ABAD) that is predicted to be mitochondrial.
36	T10B10.3	T10B10.3	n/a	chrX 15,179,981	contains similarity to Pfam domain PF00169 PH domain contains similarity to Interpro domains IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR004012 (RUN)
37	C06E4.6	C06E4.6	n/a	chrIV 7,257,716	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
38	C10H11.8	C10H11.8	n/a	chrI 4,736,771	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
39	F38B6.2	F38B6.2	n/a	chrX 6,699,255	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
40	ZK673.3	ZK673.3	n/a	chrII 10,451,229	ZK673.3 encodes a protein with a THAP or THAP-like domain required for embryonic development; other proteins with THAP or THAP-like domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
41	srv-30	T13A10.7	n/a	chrIV 6,268,435	C. elegans SRV-30 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
42	F36G9.12	F36G9.12	n/a	chrV 15,980,154	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domains IPR002656 (Acyltransferase 3), IPR001356 (Homeobox), IPR006621 (Nose resistant to fluoxetine-4, N-terminal)
43	tag-225	K07C11.5	n/a	chrV 8,202,146	K07C11.5 is orthologous to the human gene SIMILAR TO TISSUE INHIBITOR OF METALLOPROTEINASE 3 (SORSBY FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY) (TIMP3; OMIM:188826), which when mutated leads to disease.
44	F55A11.7	F55A11.7	n/a	chrV 11,785,988	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
45	R07A4.4	R07A4.4	n/a	chrX 10,753,200	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR003609 (Apple-like), IPR003014 (N/apple PAN), IPR008266 (Tyrosine protein kinase, active site)
46	W04A4.5	W04A4.5	n/a	chrI 13,669,210	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR000357 (HEAT), IPR016024 (Armadillo-type fold)
47	C32E12.4	C32E12.4	n/a	chrI 5,236,241	contains similarity to Trichomonas vaginalis G3 Variable membrane protein, putative.; TR:A2FNC4
48	H25K10.2	H25K10.2	n/a	chrIV 16,210,717	contains similarity to Halobacterium sp ORF H0114.; TR:O51964
49	scl-22	T05A10.5	n/a	chrX 10,790,085	C. elegans SCL-22 protein; contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR002413 (Ves allergen), IPR001283 (Allergen V5/Tpx-1 related)
50	F22D3.6	F22D3.6	n/a	chrII 6,949,185	The F22D3.6 gene encodes a paracaspase homolog that may be involved in apoptosis, and that is orthologous to the human gene MUCOSA ASSOCIATED LYMPHOID TISSUE LYMPHOMA TRANSLOCATION GENE 1 (MALT1; OMIM:604860).