UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F47B8.4	F47B8.4	6e-119	chrV 14,324,002	contains similarity to Pfam domain PF00462 Glutaredoxin contains similarity to Interpro domains IPR002109 (Glutaredoxin), IPR012336 (Thioredoxin-like fold)
2	nlp-31	B0213.6	n/a	chrV 3,980,323	nlp-31 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-31 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-31 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; nlp-31 expression is also detected in precomma-stage embryos; as loss of nlp-31 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-31-encoded peptides in development and/or behavior is not yet known.
3	ins-11	C17C3.4	n/a	chrII 5,556,897	ins-11 encodes an insulin-like peptide of the insulin superfamily of proteins (OMIM:176730, 147440); INS-11 is one of 38 insulin-like peptides in C. elegans and is expressed in the labial sensory neurons, the nerve ring, and other neurons; although the precise role of INS-11 in C. elegans development is not yet clear, loss of INS-11 function via RNA-mediated interference can result in animals that are smaller than wild type (Sma).
4	srw-120	K12D9.5	n/a	chrV 2,995,551	C. elegans SRW-120 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
5	F53F4.7	F53F4.7	n/a	chrV 13,613,185	contains similarity to Pfam domain PF03407 Protein of unknown function (DUF271) contains similarity to Interpro domain IPR005069 (Protein of unknown function DUF271)
6	tyr-3	F21C3.2	n/a	chrI 7,276,425	C. elegans TYR-3 protein; contains similarity to Pfam domains PF00264 (Common central domain of tyrosinase) , PF01549 (ShK domain-like) (4)contains similarity to Interpro domains IPR008922 (Di-copper centre-containing), IPR002227 (Tyrosinase), IPR003582 (Metridin-like ShK toxin)
7	ocr-3	T10B10.7	n/a	chrX 15,171,101	ocr-3 encodes a predicted TRPV channel (transient receptor potential cation channel, subfamily V) containing six membrane-spanning regions, cytoplasmic ankyrin repeats, and a long, unconserved cytoplasmic tail that is related to the mammalian TRPV1 cation channel (OMIM:602076) activated by capsaicin and other noxious stimuli; although the precise role of OCR-3 in C. elegans development and/or behavior is not yet known, OCR-3 expression is detected solely in the rectal gland cells and occasionally the glial socket cells of the head, suggesting that OCR-3 may function in sensory signal transduction in these cell types.
8	T07D1.3	T07D1.3	n/a	chrX 2,443,181	contains similarity to Interpro domain IPR016160 (Aldehyde dehydrogenase, conserved site)
9	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
10	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
11	skr-5	F47H4.10	n/a	chrV 17,348,283	The skr-5 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-5(RNAi) animals are at least superficially normal.
12	C32H11.3	C32H11.3	n/a	chrIV 12,919,384	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
13	dhs-26	ZK816.5	n/a	chrX 3,361,621	dhs-26 encodes a short-chain dehydrogenase predicted to be mitochondrial.
14	nlp-30	B0213.5	n/a	chrV 3,982,348	nlp-30 encodes five predicted neuropeptide-like proteins; in C. elegans, nlp-30 is part of the YGGWamide neuropeptide family that also contains nlp-24, nlp-25, and nlp-27-32; nlp-30 is expressed in the hypodermis, suggesting that the peptides it encodes may have a non-neuronal function; as loss of nlp-30 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of the nlp-30-encoded peptides in development and/or behavior is not yet known.
15	T28A11.5	T28A11.5	n/a	chrV 3,270,895	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR003559 (Cytolethal distending toxin C), IPR002542 (Protein of unknown function DUF19)
16	T19D12.3	T19D12.3	n/a	chrII 6,660,581
17	fbxa-164	C08E3.7	n/a	chrII 1,613,450	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
18	C14A6.2	C14A6.2	n/a	chrV 18,151,568	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR001991 (Sodium:dicarboxylate symporter), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
19	C17B7.4	C17B7.4	n/a	chrV 3,339,687	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR003559 (Cytolethal distending toxin C), IPR002542 (Protein of unknown function DUF19)
20	ZC443.2	ZC443.2	n/a	chrV 12,810,803	contains similarity to Listeria innocua Hypothetical protein lin2372.; TR:Q929A5
21	F46A8.7	F46A8.7	n/a	chrI 11,238,164	contains similarity to Homo sapiens hypothetical protein MGC35285; ENSEMBL:ENSP00000279688
22	grd-9	C04E6.6	n/a	chrV 5,896,978	grd-9 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central low-complexity proline-rich domain, and a C-terminal Ground domain; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-9 is weakly required for normal molting; GRD-9 is also required for normal growth to full size, locomotion, and male tail development; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
23	ttr-1	K03H1.6	n/a	chrIII 9,929,635	ttr-1 encodes a protein containing a predicted signal sequence followed by a transthyretin-like domain; although TTR-1 belongs to a family of apparently nematode-specific proteins whose function is not yet known, loss of ttr-1 function via RNAi can result in enhanced dauer formation and daf-16-dependent lifespan extension.
24	gst-41	R13D7.7	n/a	chrV 7,398,864	C. elegans GST-41 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
25	B0554.1	B0554.1	n/a	chrV 438,570
26	K01D12.10	K01D12.10	n/a	chrV 12,406,600	contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR003072 (Orphan nuclear receptor, NOR1 type), IPR003982 (Leukotriene B4 type 2 receptor)
27	K02A6.2	K02A6.2	n/a	chrX 8,224,536
28	K01A2.10	K01A2.10	n/a	chrII 322,278	contains similarity to Homo sapiens Coiled-coil domain-containing protein 92; ENSEMBL:ENSP00000238156
29	F48C1.8	F48C1.8	n/a	chrI 5,335,938	contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002395 (HMW kininogen), IPR000817 (Prion protein), IPR008119 (Dense granule Gra6 protein)
30	T10G3.1	T10G3.1	n/a	chrV 13,471,322	contains similarity to Saccharomyces cerevisiae interacts with Sin1p; SGD:YER047C
31	spp-20	K04A8.8	n/a	chrV 6,557,433	C. elegans SPP-20 protein; contains similarity to Pfam domain PF05184 Saposin-like type B, region 1 contains similarity to Interpro domains IPR011001 (Saposin-like), IPR007856 (Saposin-like type B, 1), IPR008139 (Saposin B)
32	F35F10.1	F35F10.1	n/a	chrV 3,317,203	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
33	F11C1.4	F11C1.4	n/a	chrX 12,979,059	contains similarity to Drosophila melanogaster Flybase gene name is CG9186-PA;; FLYBASE:CG9186
34	F07C4.10	F07C4.10	n/a	chrV 7,639,387	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
35	fbxa-24	F54D10.2	n/a	chrII 3,817,370	C. elegans FBXA-24 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
36	F08H9.3	F08H9.3	n/a	chrV 14,462,384	F08H9.3 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the larval pharynx and the anterior adult pharynx), and its expression is not strongly induced by heat shock; however, F08H9.3 expression is increased by heat shock (with adult expression in the full pharynx) and probably aids heat shock resistance, since F08H9.3(RNAi) animals have sensitivity to heat shock that is sporadically higher than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP.
37	C36C5.12	C36C5.12	n/a	chrV 3,158,933	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
38	C54F6.4	C54F6.4	n/a	chrV 7,530,843	contains similarity to Pfam domain PF03083 MtN3/saliva family contains similarity to Interpro domain IPR004316 (MtN3 and saliva related transmembrane protein)
39	F20D6.2	F20D6.2	n/a	chrV 8,186,659	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
40	dhs-31	T04B2.6	n/a	chrIV 10,040,250	C. elegans DHS-31 protein; contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
41	cyp-13A3	T10B9.5	n/a	chrII 9,791,013	C. elegans CYP-13A3 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
42	C17G10.7	C17G10.7	n/a	chrII 5,607,281
43	C07A9.8	C07A9.8	n/a	chrIII 9,688,522	contains similarity to Pfam domain PF01062 Bestrophin contains similarity to Interpro domain IPR000615 (Bestrophin)
44	Y20C6A.1	Y20C6A.1	n/a	chrV 17,374,108	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
45	F26D11.2	F26D11.2	n/a	chrV 7,960,124
46	srw-33	T26H5.5	n/a	chrV 15,450,551	C. elegans SRW-33 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000276 (GPCR, rhodopsin-like)
47	srbc-20	C45H4.11	n/a	chrV 2,147,858	C. elegans SRBC-20 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
48	pax-3	F27E5.2	n/a	chrII 10,149,568	pax-3 encodes a divergent paired-like homeodomain protein that does not belong to the Q50, K50, or S50 classes; PAX-3 is required for locomotion and vulval development; pax-3(RNAi) animals have consistent Pvl and Unc phenotypes (as well as less consistent Bmd, Rup, and Stp phenotypes).
49	F18G5.6	F18G5.6	n/a	chrX 9,263,128
50	F07C3.9	F07C3.9	n/a	chrV 9,254,456