UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ubl-5	F46F11.4	4.0000000000000004e-39	chrI 5,608,335	This gene encodes an ortholog of the human ubiquitin-like gene UBL5, which is a distinct cytoplasmic paralog of nuclear ubiquitin or ubiquitin-like proteins; ubl-5 shares an operon with vha-10, and thus might be a previously undescribed V-ATPase component or ancillary protein.
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	gfl-1	M04B2.3	n/a	chrIV 11,521,685	gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
5	F29A7.6	F29A7.6	n/a	chrII 2,752,187	contains similarity to Mus musculus M-phase phosphoprotein 6.; SW:Q9D1Q1
6	F59D12.5	F59D12.5	n/a	chrX 15,646,886
7	egl-26	C23H3.1	n/a	chrII 70,469	egl-26 encodes a protein that contains an H-box and an NC domain that is a member of the LRAT (lecithin retinol acyltransferase) subfamily of the NlpC/P60 superfamily of enzymes; egl-26 activity is required for fertility, egg laying, and vulval development, specifically the connection of the uterus to the vulva mediated by proper morphogenesis of vulF, the most dorsal vulval cell; EGL-26 is an apical membrane protein that is expressed in many cells, including vulF, and appears to be expressed near the vulva and uterus only during the L4 larval stage; EGL-26 membrane localization is necessary for its function.
8	rpb-8	F26F4.11	n/a	chrIII 4,917,583	C. elegans RPB-8 protein; contains similarity to Pfam domain PF03870 RNA polymerase Rpb8 contains similarity to Interpro domains IPR005570 (RNA polymerase, Rpb8), IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold)
9	R10E4.11	R10E4.11	n/a	chrIII 4,299,234	contains similarity to Pfam domain PF00096 (Zinc finger, C2H2 type)
10	C28H8.1	C28H8.1	n/a	chrIII 5,926,486	C28H8.1 is orthologous to the human gene BCL7A (OMIM:601406), which when mutated leads to high-grade B-cell non-Hodgkin lymphoma.
11	K01A2.9	K01A2.9	n/a	chrII 316,397	contains similarity to Interpro domain IPR002229 (Blood group Rhesus C/E and D polypeptide)
12	C15H11.8	C15H11.8	n/a	chrV 14,423,017	contains similarity to Pfam domain PF01096 Transcription factor S-II (TFIIS) contains similarity to Interpro domain IPR001222 (Zinc finger, TFIIS-type)
13	ceh-41	T26C11.5	n/a	chrX 1,847,671	ceh-41 encodes a a ONECUT class CUT homeobox protein with a single N-terminal OCAM domain; the OCAM domain is a nematode-specific motif conserved between CEH-21, CEH-41, and T02B5.2; ceh-41 is one of three nematode-specific ONECUT genes in a cluster with ceh-21 and ceh-39; ceh-41 has no obvious function in mass RNAi assays.
14	lsm-4	F32A5.7	n/a	chrII 7,252,636	C. elegans LSM-4 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core)
15	rpb-11	W01G7.3	n/a	chrII 14,060,256	C. elegans RPB-11 protein; contains similarity to Pfam domain PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain contains similarity to Interpro domains IPR008193 (DNA-directed RNA polymerase Rpb11, 13-16 kDa subunit, conserved site), IPR011261 (DNA-directed RNA polymerase, dimerisation), IPR009025 (DNA-directed RNA polymerase, RBP11-like)
16	fbxb-57	F55C9.4	n/a	chrV 19,289,333	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
17	F47G3.3	F47G3.3	n/a	chrX 2,377,319
18	VH15N14R.1	VH15N14R.1	n/a	chrI 7,781,895	contains similarity to Aspergillus niger Protein kinase C-like (EC 2.7.1.-).; SW:KPC1_ASPNG
19	snr-6	Y49E10.15	n/a	chrIII 12,429,334	snr-6 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein E, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-6 activity is essential for embryogenesis and is required for several aspects of germ cell specification including cell division patterns, localization and subcellular distribution of P granules, maintenance of transcriptional quiescence, and expression of the germ lineage-specific proteins PIE-1, GLD-1, and NOS-2; snr-6 is also required for wild-type levels of fertility; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins suggests that SNR-6 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors.
20	C18E3.2	C18E3.2	n/a	chrI 4,211,756	The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division.
21	ncbp-2	F26A3.2	n/a	chrI 7,642,924	ncbp-2 encodes the C. elegans ortholog of the CBP20 subunit of the nuclear cap binding complex; by homology, NCBP-2 is predicted to play a role in mRNA decay; loss of ncbp-2 activity via RNAi indicates that this gene is essential for embryonic and larval development and in addition, plays a role in reproduction and vulval morphogenesis; staining of C. elegans embryos with an antibody to human CBP20 suggests that NCBP-2 localizes predominantly to the nuclear envelope.
22	ZK1236.5	ZK1236.5	n/a	chrIII 8,431,825	ZK1236.5 encodes a protein with no obvious non-nematode homologs; either ZK1236.9, or ZK1236.5, or both proteins weakly inhibit DHC-1 in vivo; likewise, either ZK1236.5, or ZK1236.9, or both proteins are required in mass RNAi assays for normal osmoregulation and normally rapid growth.
23	T02C1.1	T02C1.1	n/a	chrIII 9,248,028	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR003613 (U box), IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
24	K08H10.9	K08H10.9	n/a	chrV 9,992,294	contains similarity to Pfam domain PF04051 Transport protein particle (TRAPP) component, Bet3 contains similarity to Interpro domain IPR007194 (Transport protein particle (TRAPP) component, Bet3)
25	nhr-151	C06B8.3	n/a	chrV 15,484,320	C. elegans NHR-151 protein ;
26	str-255	C45H4.15	n/a	chrV 2,162,667	C. elegans STR-255 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR000301 (CD9/CD37/CD63 antigen)
27	hil-6	F59A7.4	n/a	chrV 2,031,066	C. elegans HIL-6 protein; contains similarity to Pfam domain PF00538 linker histone H1 and H5 family contains similarity to Interpro domains IPR003993 (Treacher Collins syndrome, treacle), IPR011991 (Winged helix repressor DNA-binding), IPR005819 (Histone H5), IPR003882 (Pistil-specific extensin-like protein), IPR005818 (Histone H1/H5), IPR003216 (Linker histone, N-terminal)
28	R12C12.5	R12C12.5	n/a	chrII 6,044,615	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
29	F39H11.1	F39H11.1	n/a	chrI 8,697,062	contains similarity to Pfam domain PF07572 Bucentaur or craniofacial development contains similarity to Interpro domains IPR011421 (Bucentaur or craniofacial development), IPR005413 (Low calcium response V antigen)
30	Y106G6H.9	Y106G6H.9	n/a	chrI 10,455,014	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
31	F41H10.9	F41H10.9	n/a	chrIV 5,389,855
32	F38C2.7	F38C2.7	n/a	chrIV 16,277,045	F38C2.7 encodes a CCCH tandem zinc finger (TZF) protein; based upon its sequence similarity to other TZF proteins, such as MEX-5 and POS-1, the product of F38C2.7 is predicted to function as an RNA-binding protein.
33	ZK418.5	ZK418.5	n/a	chrIII 7,073,217	contains similarity to Mus musculus Transmembrane protein 147.; SW:Q9CQG6
34	atg-10	D2085.2	n/a	chrII 8,659,384	C. elegans ATG-10 protein; contains similarity to Pfam domain PF03987 Autophagocytosis associated protein, C-terminal domain contains similarity to Interpro domain IPR007135 (Autophagocytosis associated protein, C-terminal)
35	T11B7.1	T11B7.1	n/a	chrIV 8,841,747	contains similarity to Mus musculus Girdin (Girders of actin filament) (Coiled-coil domain-containingsprotein 88A) (Akt phosphorylation enhancer) (APE) (Hook-relatedsprotein 1) (HkRP1) (G alpha-interacting vesicle-associated protein)s(GIV).; SW:Q5SNZ0
36	exos-1	Y48A6B.5	n/a	chrIII 11,009,701	C. elegans EXOS-1 protein ; contains similarity to Drosophila melanogaster Flybase gene name is Csl4-PA;; FLYBASE:CG6249
37	D2030.3	D2030.3	n/a	chrI 7,579,667	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
38	ZK512.1	ZK512.1	n/a	chrIII 9,116,087	contains similarity to Interpro domain IPR007110 (Immunoglobulin-like)
39	C33H5.8	C33H5.8	n/a	chrIV 7,778,475	contains similarity to Pfam domain PF00515 Tetratricopeptide repeat contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR001440 (Tetratricopeptide TPR-1), IPR013026 (Tetratricopeptide region)
40	M04C9.3	M04C9.3	n/a	chrI 9,353,710	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like), IPR000816 (Peptidase C15, pyroglutamyl peptidase I)
41	Y76G2A.1	Y76G2A.1	n/a	chrI 5,979,820
42	B0285.3	B0285.3	n/a	chrIII 4,342,632	contains similarity to Interpro domain IPR002952 (Eggshell protein)
43	taf-11.1	F48D6.1	n/a	chrX 4,255,964	C. elegans TAF-11.1 protein; contains similarity to Pfam domain PF04719 hTAFII28-like protein conserved region contains similarity to Interpro domains IPR006809 (TAFII28-like protein), IPR000104 (Antifreeze protein, type I), IPR009072 (Histone-fold)
44	amx-1	R13G10.2	n/a	chrIII 3,824,311	C. elegans AMX-1 protein; contains similarity to Pfam domains PF01593 (Flavin containing amine oxidoreductase) , PF01266 (FAD dependent oxidoreductase) contains similarity to Interpro domains IPR006076 (FAD dependent oxidoreductase), IPR001613 (Flavin-containing amine oxidase), IPR000960 (Flavin-containing monooxygenase FMO), IPR002937 (Amine oxidase), IPR016040 (NAD(P)-binding), IPR007526 (SWIRM)
45	F32E10.2	F32E10.2	n/a	chrIV 7,576,735	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like)
46	C26E6.3	C26E6.3	n/a	chrIII 4,945,871	contains similarity to Pfam domain PF04078 Cell differentiation family, Rcd1-like contains similarity to Interpro domain IPR007216 (Cell differentiation proteins, Rcd1-like)
47	T28C6.3	T28C6.3	n/a	chrIV 8,820,742	contains similarity to Homo sapiens HIV Tat-specific factor 1; ENSEMBL:ENSP00000218364
48	sna-1	W02F12.6	n/a	chrV 6,710,071	sna-1 encodes an snRNP-binding protein (SNA-1/SL21p) orthologous to Ascaris SL30p (SL 30kd) and Brugia 13258.m00169, and paralogous to Brugia 14704.m00455; SNA-1 is found in the Sm snRNP SL1, but not in SL2; in snRNP SL1, SNA-1 associates with the SNA-2/SL75p protein, while being replaced by SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-1(RNAi) animals, like sut-1(bk79) mutants, have cold-sensitive sterility, whereas sna-1(RNAi) combined with sut-1(bk79) is synthetically lethal; double sna-1(RNAi) sut-1(RNAi) is lethal; these RNAi data indicate that SNA-1 and SUT-1 are partially redundant, and suggest that snRNP Y (like snRNP SL1) may participate in trans-splicing; SNA-1 can bind SNA-2 even in the absence of RNA.
49	R09F10.3	R09F10.3	n/a	chrX 8,295,584	contains similarity to Dictyostelium discoideum Spore coat protein sp96.; SW:P14328
50	C08B6.8	C08B6.8	n/a	chrV 10,138,746	contains similarity to Pfam domain PF00929 Exonuclease contains similarity to Interpro domains IPR013520 (Exonuclease, RNase T and DNA polymerase III), IPR006055 (Exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)