UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	dpy-7	F46C8.6	9.999999999999999e-101	chrX 7,537,167	dpy-7 encodes a cuticular collagen; DPY-7 functions as a structural constituent of the extracellular cuticle whose activity is required for normal cuticular morphology and hence, proper body form.
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	K08B12.1	K08B12.1	n/a	chrV 6,260,074	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
4	F53B1.4	F53B1.4	n/a	chrX 2,112,426	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF04321 (RmlD substrate binding domain) , PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) , PF02719 (Polysaccharide biosynthesis protein) contains similarity to Interpro domains IPR003869 (Polysaccharide biosynthesis protein CapD), IPR002225 (3-beta hydroxysteroid dehydrogenase/isomerase), IPR005913 (dTDP-4-dehydrorhamnose reductase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR002347 (Glucose/ribitol dehydrogenase), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
5	dpy-3	EGAP7.1	0.00000000003	chrX 2,145,125	dpy-3 encodes a cuticular collagen; along with dpy-2, dpy-7, dpy-8, and dpy-10, dpy-3 is required postembryonically for annular furrow formation and/or maintenance; specifically, DPY-3 activity is required for proper assembly of the DPY-7 collagen into the mature extracellular matrix; during each cuticle synthetic period, dpy-3 mRNA is expressed approximately four hours prior to the secretion of new cuticle.
6	noah-2	F52B11.3	n/a	chrIV 14,093,906	noah-2 encodes a PAN and ZP domain-containing protein that is related to the Drosophila extracellular matrix component NompA (no-mechanoreceptor-potential A); loss of noah-2 function via RNAi indicates that NOAH-2 activity is essential for molting; in addition, NOAH-2 appears to be required for embryonic and larval development, reproduction, coordinated locomotion, and the overall health of the animal.
7	Y37A1B.7	Y37A1B.7	n/a	chrIV 14,043,158
8	sym-1	C44H4.3	n/a	chrX 14,582,934	sym-1 encodes a protein containing 15 contiguous leucine-rich repeats (LRRs) that functionally overlaps with sym-5 and interacts with mec-8 with respect to embryonic viability and attachment of body muscle to the extracellular cuticle; expression begins at the time of embryonic elongation and SYM-1 is secreted from the apical hypodermal surface of the embryo
9	wrt-1	ZK1290.12	n/a	chrII 7,532,133	C. elegans WRT-1 protein; contains similarity to Pfam domain PF01079 Hint module contains similarity to Interpro domains IPR003586 (Hedgehog/intein hint domain, C-terminal), IPR001657 (Peptidase C46, hedgehog protein), IPR002034 (Alpha-isopropylmalate/homocitrate synthase, conserved site), IPR006141 (Intein splicing site), IPR003587 (Hedgehog/intein hint, N-terminal), IPR001767 (Peptidase C46, hedgehog protein, hint region)
10	W08A12.3	W08A12.3	n/a	chrV 3,683,717
11	sqt-3	F23H12.4	0.000000000009	chrV 12,353,631	sqt-3 encodes a cuticle collagen; during development, sqt-3 activity is essential for viability and normal body morphology; genetic and expression studies indicate that SQT-3 is a cuticle component at all stages of development and that SQT-3 likely forms higher order cuticular structures with the DPY-17 cuticular collagen, both of which are candidate substrates for the DPY-31 procollagen C-proteinase.
12	lpr-4	W04G3.3	n/a	chrX 11,065,896	C. elegans LPR-4 protein; contains similarity to Interpro domains IPR012674 (Calycin), IPR011038 (Calycin-like)
13	dpy-2	T14B4.6	0.0002	chrII 6,715,073	The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5.
14	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
15	lpr-3	W04G3.8	n/a	chrX 11,058,541	W04G3.8 encodes a novel protein, conserved amongst nematodes; large-scale RNAi experiments indicate that W04G3.8 activity is required for normal growth rates, early larval development, and coordinated locomotion.
16	F58H1.2	F58H1.2	n/a	chrV 11,929,524	contains similarity to Lycopersicon esculentum Abscisic acid and environmental stress inducible protein TAS14s(Dehydrin TAS14).; SW:DH14_LYCES
17	wrt-10	ZK1290.8	n/a	chrII 7,533,839	wrt-10 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of low-complexity sequence; WRT-10 is expressed in both male and hermaphrodite intestine; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-10 is required for normal growth to full size and locomotion; both of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
18	M03B6.3	M03B6.3	n/a	chrX 13,862,714	contains similarity to Interpro domain IPR000694 (Proline-rich region)
19	grl-15	Y75B8A.20	n/a	chrIII 12,234,051	grl-15 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-15 is expressed in the reproductive system, vulva, and larval hypodermis; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
20	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
21	F09F9.2	F09F9.2	n/a	chrX 4,110,914
22	F20G2.3	F20G2.3	n/a	chrV 13,767,197	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
23	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
24	D1014.5	D1014.5	n/a	chrV 8,125,176	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
25	F15B9.8	F15B9.8	n/a	chrV 12,990,344	contains similarity to Pfam domain PF00090 Thrombospondin type 1 domain contains similarity to Interpro domains IPR008085 (Thrombospondin, subtype 1), IPR000884 (Thrombospondin, type I)
26	F09C12.6	F09C12.6	n/a	chrII 5,117,137	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
27	pqn-46	F57B9.9	n/a	chrIII 6,943,249	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
28	R02F11.1	R02F11.1	n/a	chrV 4,801,848	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
29	C34F6.1	C34F6.1	n/a	chrX 11,194,603	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
30	ZC434.3	ZC434.3	n/a	chrI 10,334,634	contains similarity to Interpro domain IPR000931 (Adenovirus fibre protein)
31	clec-180	F32E10.3	n/a	chrIV 7,571,306	C. elegans CLEC-180 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
32	mlt-11	W01F3.3	n/a	chrV 20,668,250	C. elegans MLT-11 protein; contains similarity to Pfam domains PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (10), PF00086 (Thyroglobulin type-1 repeat) contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
33	H03E18.1	H03E18.1	n/a	chrX 8,510,941	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN)
34	F01D5.6	F01D5.6	n/a	chrII 14,007,416	contains similarity to Pfam domain PF04536 Domain of unknown function (DUF477) contains similarity to Interpro domain IPR007621 (Protein of unknown function DUF477)
35	D1005.5	D1005.5	n/a	chrX 1,471,940
36	cyn-6	F42G9.2	n/a	chrIII 773,770	cyn-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
37	wrt-2	F52E4.6	n/a	chrX 3,093,375	wrt-2 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of low-complexity sequence; WRT-2 is expressed in seam cells and hypodermal syncytia; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-2 is weakly required for normal molting; WRT-2 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking; in two-hybrid assays, WRT-2 binds EYA-1, which may parallel the derepression of Drosophila eyes absent by HEDGEHOG.
38	gei-13	F58A4.11	n/a	chrIII 9,634,553	gei-13 encodes a protein, with a BED finger domain (predicted to be DNA-binding) and a glutamine/asparagine-rich domain; GEI-13 physically interacts with GEX-3, and is required for normal body shape, cuticle synthesis, and locomotion.
39	grl-10	C26F1.5	n/a	chrV 7,775,086	grl-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
40	F49E11.2	F49E11.2	n/a	chrIV 13,037,470	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
41	F53F1.5	F53F1.5	n/a	chrV 13,415,573	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001859 (Ribosomal protein P2), IPR013286 (Annexin, type VII)
42	F22F4.1	F22F4.1	n/a	chrX 6,005,723
43	phg-1	F27E5.4	n/a	chrII 10,138,351	C. elegans PHG-1 protein; contains similarity to Pfam domain PF02351 GDNF/GAS1 domain contains similarity to Interpro domain IPR016017 (GDNF/GAS1)
44	nas-4	C05D11.6	n/a	chrIII 6,413,237	nas-4 encodes a predicted extracellular matrix metalloprotease of the M12A (astacin) family that contains an N-terminal signal sequence and a catalytic domain, but no recognizable regulatory domains in the C-terminus; as loss of nas-4 activity via RNAi results in no obvious abnormalities, the precise role of NAS-4 in C. elegans development and/or behavior is not yet known; however, an NAS-4 translational reporter is expressed in the pharynx and intestine in larvae and adults, suggesting a role for NAS-4 in digestion; NAS-4 is specifically detected within cells of the pharyngeal procorpus, metacorpus, isthmus, and terminal bulb, with extracellular expression detected in the lumen of the terminal bulb and in the gut.
45	ZK154.1	ZK154.1	n/a	chrX 7,780,026	contains similarity to Interpro domain IPR010916 (TonB box, conserved site)
46	sym-5	C44H4.2	n/a	chrX 14,579,420	sym-5 encodes a predicted transmembrane protein that contains 13 contiguous leucine-rich repeats (LRRs) and that is similar to SYM-1, a secreted protein involved in muscle attachment; sym-5 activity appears to be required for embryogenesis and functionally overlaps with that of sym-1 and mec-8 in affecting muscle attachment; in addition, loss of sym-5 activity via RNA-mediated interference (RNAi) in a hypersensitized strain indicates that SYM-5 may also be required for locomotion, body morphology, and normal rates of postembryonic growth.
47	T26C5.2	T26C5.2	n/a	chrII 9,234,631	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN)
48	rol-6	T01B7.7	0.00006	chrII 8,733,614	The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages.
49	F42A9.8	F42A9.8	n/a	chrIV 8,618,533
50	B0395.2	B0395.2	n/a	chrX 16,032,720	contains similarity to Pfam domain PF03062 MBOAT family contains similarity to Interpro domain IPR004299 (Membrane bound O-acyl transferase, MBOAT)