UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F45C12.2	F45C12.2	4e-139	chrII 1,732,740	contains similarity to Interpro domains IPR001356 (Homeobox), IPR009057 (Homeodomain-like)
2	Y48E1B.4	Y48E1B.4	n/a	chrII 13,562,596	contains similarity to Buchnera aphidicola Flagellar hook-length control protein.; SW:FLIK_BUCAP
3	efl-1	Y102A5C.18	n/a	chrV 16,962,099	efl-1 encodes a homolog of mammalian E2F that is required for embryonic asymmetry and that functions as a transcriptional repressor; during vulval development, efl-1, a class B synMuv gene, acts with class B synMuv genes dpl-1 and lin-35/Rb to antagonize receptor tyrosine kinase and Ras-mediated signaling; EFL-1 also negatively regulates the G1 to S phase cell cycle transition.
4	C28A5.2	C28A5.2	n/a	chrIII 4,437,117	contains similarity to Interpro domain IPR001564 (Nucleoside diphosphate kinase)
5	ced-12	Y106G6E.5	n/a	chrI 10,224,961	ced-12 is required both for phagocytotic engulfment of dying (apoptotic) cells, and for normal migrations of healthy cells during development.
6	F56A6.4	F56A6.4	n/a	chrI 622,086
7	hcf-1	C46A5.9	n/a	chrIV 7,772,495	C. elegans HCF-1 protein; contains similarity to Pfam domains PF01344 (Kelch motif) (3), PF00041 (Fibronectin type III domain) , PF07646 (Kelch motif) (4)contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR008957 (Fibronectin, type III-like fold), IPR003961 (Fibronectin, type III), IPR006652 (Kelch repeat type 1), IPR011498 (Kelch repeat type 2), IPR015915 (Kelch-type beta propeller)
8	nac-1	F31F6.6	n/a	chrX 14,896,719	nac-1 encodes a low-affinity sodium-coupled dicarboxylate transporter homologous to INDY in D. melanogaster and to mammalian NaDC1 and NaDC3; nac-1 has no obvious function in either mass or individual RNAi assays; nac-1 is expressed in the intestine, in larvae and adults.
9	C17E4.6	C17E4.6	n/a	chrI 9,426,826	contains similarity to Pfam domains PF05764 (YL1 nuclear protein) , PF08265 (YL1 nuclear protein C-terminal domain) contains similarity to Interpro domains IPR013272 (YL1 nuclear, C-terminal), IPR008895 (YL1 nuclear)
10	Y4C6B.1	Y4C6B.1	n/a	chrIV 5,355,504	contains similarity to Interpro domain IPR000694 (Proline-rich region)
11	F59A2.5	F59A2.5	n/a	chrIII 3,405,129	F59A2.5 encodes a moderately small (123-residue) protein; F59A2.5 is orthologous to Brugia 14979.m04575, and more distantly similar to budding yeast Pcc1p, to human CTAG1B (OMIM:300156, cancer antigen), CTAG2 (OMIM:300396, melanoma antigen), and LAGE3 (OMIM:300060), and to many other uncharacterized proteins, ~80-200 residues long, in animals, fungi, and plants; F59A2.5 is required for fertility and embryonic development in mass RNAi assays and is bound by CKU-80 in two-hybrid assays; F59A2.5 is transcriptionally activated by HLH-2 and HLH-8, but has no known expression pattern; while F59A2.5 is putatively secreted and its human homologs are antigens, its yeast homolog Pcc1p is thought to be a transcription factor.
12	Y48A6C.3	Y48A6C.3	n/a	chrIII 11,118,099	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR015880 (Zinc finger, C2H2-like), IPR013026 (Tetratricopeptide region), IPR007087 (Zinc finger, C2H2-type)
13	srh-128	Y47G7B.1	n/a	chrII 2,704,344	C. elegans SRH-128 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	C07A4.1	C07A4.1	n/a	chrX 10,169,900	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
15	his-59	F55G1.2	n/a	chrIV 7,488,436	his-59 encodes an H3 histone; by homology, HIS-59 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-59 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV.
16	ubc-18	R01H2.6	n/a	chrIII 7,068,071	ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known.
17	fem-2	T19C3.8	n/a	chrIII 633,323	A CB5161 ortholog of fem-2, Cbn-fem-2, has been isolated from the sibling Caenorhabditis species CB5161.
18	taf-6.1	W09B6.2	n/a	chrII 1,130,167	C. elegans TAF-6.1 protein; contains similarity to Pfam domains PF07571 (Protein of unknown function (DUF1546)) , PF02969 (TATA box binding protein associated factor (TAF)) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR004823 (TATA box binding protein associated factor (TAF)), IPR011442 (Protein of unknown function DUF1546)
19	bub-3	Y54G9A.6	n/a	chrII 13,727,744	C. elegans BUB-3 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
20	C37C3.1	C37C3.1	n/a	chrV 7,858,917	contains similarity to Pfam domain PF08719 Domain of unknown function (DUF1768) contains similarity to Interpro domains IPR012816 (Conserved hypothetical protein CHP02464), IPR005448 (Voltage-dependent calcium channel, P/Q-type, alpha-1 subunit)
21	cdk-8	F39H11.3	n/a	chrI 8,704,132	cdk-8 encodes a member of the cyclin-dependent serine/threonine protein kinase family orthologous to human CDK8 (OMIM:603184) which functions in transcriptional regulation with the positive regulatory factor cyclin C, is associated with the RNA polymerase II holoenzyme, and may regulate gene-specific activators; CDK-8 also contains a glutamine/asparagine-rich domain; loss of cdk-8 function via RNA-mediated interference (RNAi) results in sterility in the injected hermaphrodite, suggesting that in C. elegans, CDK-8 may play a role in germ-line development.
22	his-63	F22B3.2	n/a	chrIV 11,406,611	his-63 encodes an H3 histone; by homology, HIS-63 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-63 is a replication-dependent histone locus.
23	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
24	ath-1	K04G2.5	n/a	chrI 8,037,923	C. elegans ATH-1 protein; contains similarity to Pfam domain PF02230 Phospholipase/Carboxylesterase contains similarity to Interpro domains IPR003140 (Phospholipase/carboxylesterase), IPR003089 (Alpha/beta hydrolase)
25	F59A3.4	F59A3.4	n/a	chrI 5,508,149	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
26	F55A3.3	F55A3.3	n/a	chrI 10,791,127	contains similarity to Pfam domains PF08512 (Histone chaperone Rttp106-like) , PF08644 (FACT complex subunit (SPT16/CDC68)) , PF00557 (metallopeptidase family M24) contains similarity to Interpro domains IPR013719 (Region of unknown function DUF1747, eukaryote), IPR000994 (Peptidase M24, catalytic core), IPR013953 (FACT complex subunit Spt16p/Cdc68p)
27	ekl-6	T16G12.5	n/a	chrIII 10,066,125	C. elegans EKL-6 protein; contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
28	his-62	F55G1.3	n/a	chrIV 7,486,714	his-62 encodes an H2B histone.
29	B0511.2	B0511.2	n/a	chrI 10,651,985	contains similarity to Interpro domain IPR015804 (Cysteinyl-tRNA synthetase, class Ia, C-terminal)
30	F41C3.4	F41C3.4	n/a	chrII 4,740,995	contains similarity to Pfam domain PF04178 Got1-like family contains similarity to Interpro domain IPR007305 (Got1-like protein)
31	R11.1	R11.1	n/a	chrX 16,192,348	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
32	F52C9.7	F52C9.7	n/a	chrIII 5,309,798	contains similarity to Interpro domain IPR002226 (Catalase)
33	ceh-49	F17A9.6	n/a	chrV 6,119,282	ceh-49 encodes a divergent ONECUT class CUT homeobox protein with a single N-terminal cut domain; CEH-49 has an atypical tyrosine residue at position 48 of its homeodomain rather than a phenylalanine or tryptophan residue; the cut domain may be a compact DNA-binding domain composed of alpha helices; phylogenetically, CEH-49 is (somewhat distantly) affiliated with CEH-48, Drosophila ONECUT, and mammalian HNF6 proteins; CEH-49 has no obvious function in mass RNAi assays.
34	srx-53	T27C5.2	n/a	chrV 17,400,916	C. elegans SRX-53 protein; contains similarity to Interpro domain IPR010989 (t-SNARE)
35	C50D2.5	C50D2.5	n/a	chrII 98,671	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1), IPR002343 (Paraneoplastic encephalomyelitis antigen)
36	F08F1.9	F08F1.9	n/a	chrX 8,410,171	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal)
37	hda-2	C08B11.2	n/a	chrII 8,021,602	hda-2 encodes a Class I histone deacetylase; by homology, HDA-2 is predicted to function in deacetylation of histone residues and transcriptional regulation; loss of hda-2 activity via RNAi results in an increased spontaneous mutation rate, suggesting that hda-2 also plays a role in regulating genome stability.
38	wve-1	R06C1.3	n/a	chrI 11,927,136	wve-1 encodes a homolog of the mammalian WAVE protein; based on homology WVE-1 might be involved in actin cytoskeletal dynamics; wve-1 is required for early cell migrations in the epidermis during embryonic morphogenesis and may require gex-2 and gex-3 for its function.
39	M03F4.4	M03F4.4	n/a	chrX 4,957,667
40	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
41	ZK1098.2	ZK1098.2	n/a	chrIII 9,530,428	contains similarity to Klebsiella aerogenes Siroheme synthetase.; TR:Q9EYX8
42	pph-6	C34C12.3	n/a	chrIII 3,464,667	C. elegans PPH-6 protein; contains similarity to Pfam domain PF00149 Calcineurin-like phosphoesterase contains similarity to Interpro domains IPR004843 (Metallophosphoesterase), IPR006186 (Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase)
43	C25A11.2	C25A11.2	n/a	chrX 9,115,559	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
44	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
45	Y54E5A.7	Y54E5A.7	n/a	chrI 14,713,042	contains similarity to Pfam domain PF00622 SPRY domain contains similarity to Interpro domains IPR001870 (B302, (SPRY)-like), IPR006594 (LisH dimerisation motif), IPR006595 (CTLH, C-terminal to LisH motif), IPR003877 (SPla/RYanodine receptor SPRY)
46	K05C4.7	K05C4.7	n/a	chrI 14,738,206	contains similarity to Interpro domains IPR016617 (Uncharacterised conserved protein UCP013899, metal binding), IPR016024 (Armadillo-type fold)
47	Y38C9A.1	Y38C9A.1	n/a	chrV 112,782	contains similarity to Leishmania major strain Friedlin Proteophosphoglycan ppg4.; TR:Q4FX63
48	C43H8.2	C43H8.2	n/a	chrI 10,623,645	contains similarity to Pfam domain PF09174 Maf1 regulator contains similarity to Interpro domains IPR017152 (RNA polymerase III transcriptional repressor, MAF1), IPR015257 (Maf1 regulator)
49	K11E4.2	K11E4.2	n/a	chrX 13,718,299	contains similarity to Pfam domain PF00017 SH2 domain contains similarity to Interpro domains IPR006020 (Phosphotyrosine interaction region), IPR000980 (SH2 motif)
50	his-47	B0035.7	n/a	chrIV 11,324,148	his-47 encodes an H2A histone; by homology, HIS-47 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-47 is a replication-dependent histone locus that resides in a histone gene-rich region on chromosome IV.