UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cpn-1	F43G9.9	8e-107	chrI 8,636,741	cpn-1 encodes a calponin homolog, more closely related to calponin per se than to its paralogs transgelin (SM22 alpha) or neuronal protein NP25, that is is dispensable for viability and gross morphology in mass RNAi screens, and that has no obvious mutant phenotype in a rearrangement that probably disrupts cpn-1.
2	prx-6	F39G3.7	n/a	chrV 4,717,742	C. elegans PRX-6 protein; contains similarity to Pfam domain PF00004 ATPase family associated with various cellular activities (AAA) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal)
3	F22B7.1	F22B7.1	n/a	chrIII 8,666,020
4	K08B5.1	K08B5.1	n/a	chrX 16,560,293
5	C03F11.2	C03F11.2	n/a	chrX 5,395,712	contains similarity to Pfam domain PF00753 Metallo-beta-lactamase superfamily contains similarity to Interpro domain IPR001279 (Beta-lactamase-like)
6	F08B4.3	F08B4.3	n/a	chrIV 8,666,337	contains similarity to Interpro domain IPR000719 (Protein kinase, core)
7	chn-1	T09B4.10	n/a	chrI 6,182,743	chn-1 encodes an ortholog of mammalian carboxyl-terminus of Hsc70 interacting protein (CHIP), an E4 ubiquitin-chain elongation factor; chn-1 is ubiquitously expressed; chn-1(by155) mutants are viable and superficially normal, but have reduced fertility and arrest as larvae if subjected to heat shock; chn-1 overexpression causes either embryonic lethality (if strong) or defective egg-laying and locomotion, along with constitutive dauer formation (if weak); chn-1(by155) mutations suppress viable unc-45(e286ts) and unc-45(m94ts) mutations, but not lethal unc-45(st604) ones; chn-1(by155) mutants, unlike wild-type, show defective sarcomeres if overexpressing unc-45 from a extrachromosomal array; CHN-1 binds the ubiquitin conjugating enzyme UFD-2, which in turn binds the Hsp90 cochaperone UNC-45; UNC-45 is a substrate for CHN-1- and UFD-2-dependent multiubiquitination; the parkin ortholog PDR-1 binds CHN-1, and requires CHN-1 for self-ubiquitination; chn-1(RNAi) animals accumulate abnormally phosphorylated tau proteins.
8	srh-10	Y38A10A.3	n/a	chrV 6,066,281	C. elegans SRH-10 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
9	nas-12	C24F3.3	n/a	chrIV 10,225,155	nas-12 encodes an astacin-like metalloprotease; large-scale expression studies reveal that a nas-12::GFP promoter fusion is expressed in the intestine and in the pharyngeal and rectal gland cells.
10	T27F6.7	T27F6.7	n/a	chrI 12,496,077	contains similarity to Timmia bavarica NADH dehydrogenase subunit 4 (Fragment).; TR:Q94YV9
11	tag-236	R11B5.1	n/a	chrX 2,528,819	C. elegans TAG-236 protein; contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
12	fbxa-45	F09C6.6	n/a	chrV 16,898,926	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
13	Y79H2A.4	Y79H2A.4	n/a	chrIII 12,041,576	contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
14	ver-4	F59F3.5	n/a	chrX 10,985,087	C. elegans VER-4 protein; contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) , PF00047 (Immunoglobulin domain) (2), PF07714 (Protein tyrosine kinase) , PF00069 (Protein kinase domain) , PF07679 (Immunoglobulin I-set domain) contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR013098 (Immunoglobulin I-set), IPR011009 (Protein kinase-like), IPR003596 (Immunoglobulin V-set, subgroup), IPR013783 (Immunoglobulin-like fold), IPR000719 (Protein kinase, core), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site), IPR013151 (Immunoglobulin)
15	F13H8.5	F13H8.5	n/a	chrII 6,254,376	F13H8.5 encodes a protein with a domain of unknown function (DB; IPR002602) that is found in several worm proteins, and a glutamine/asparagine-rich domain.
16	soc-1	F41F3.2	n/a	chrV 4,644,923	C. elegans SOC-1 protein; contains similarity to Pfam domain PF00169 PH domain contains similarity to Interpro domains IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type)
17	nhr-181	F38H12.3	n/a	chrV 4,097,665	nhr-181 encodes a putative nuclear hormone receptor (NHR), belonging to a large nematode-specific expanded family of NHRs, that inhibits CEP-1- and HUS-1-dependent germline apoptosis as do BMK-1, RAD-50, and RAD-51.
18	unc-50	T07A5.2	n/a	chrIII 10,316,260	unc-50 encodes an integral membrane protein orthologous to the Saccharomyces cerevisiae Golgi component Gmh1p; UNC-50 is required for regulating subtype-specific nicotinic receptor trafficking to the cell surface and thus, for normal synaptic transmission at the neuromuscular junction; UNC-50 is ubiquitously expressed from early embryogenesis to adulthood and localizes to the Golgi.
19	nlp-13	E03D2.1	n/a	chrV 4,237,211	nlp-13 encodes a predicted neuropeptide of the MSFamide family; expressed primarily in neurons or in the endocrine/secretory cells, and expression includes pharyngeal neurons that modulate pharyngeal pumping of food.
20	immp-1	C24H11.6	n/a	chrIII 11,775,731	C. elegans IMMP-1 protein; contains similarity to Pfam domain PF00717 Peptidase S24-like contains similarity to Interpro domains IPR001733 (Peptidase S26B, eukaryotic signal peptidase), IPR015927 (Peptidase S24, S26A, S26B and S26C), IPR014037 (Peptidase S26A), IPR011056 (Peptidase S24, S26A and S26B, C-terminal), IPR000223 (Peptidase S26A, signal peptidase I)
21	lrp-2	T21E3.3	n/a	chrI 3,939,445	C. elegans LRP-2 protein; contains similarity to Pfam domains PF00008 (EGF-like domain) (6), PF07974 (EGF-like domain) , PF00057 (Low-density lipoprotein receptor domain class A) (14), PF00058 (Low-density lipoprotein receptor repeat class B) (7)contains similarity to Interpro domains IPR000033 (), IPR000742 (EGF-like, type 3), IPR006209 (EGF-like), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR001881 (EGF-like calcium-binding), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR015943 (WD40/YVTN repeat-like)
22	C07D8.2	C07D8.2	n/a	chrX 7,362,559	contains similarity to Interpro domain IPR000104 (Antifreeze protein, type I)
23	K08F11.1	K08F11.1	n/a	chrIV 4,725,078
24	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
25	tor-2	Y37A1B.13	n/a	chrIV 13,983,393	tor-2 encodes a AAA ATPase that, along with TOR-1 and OOC-5, comprise the three C. elegans orthologs of human torsinA, mutations in which are associated with torsion dystonia (OMIM:605204); overexpression of TOR-2 in nematodes with polyglutamine repeat-induced protein aggregates indicates that TOR-2 can suppress protein aggregation, suggesting TOR-2 may play a role in regulation of protein folding; in wild-type animals, TOR-2 localizes to the endoplasmic reticulum; in animals containing polyglutamine protein aggregates, TOR-2 localizes to these sites of protein aggregation.
26	F55F8.3	F55F8.3	n/a	chrI 5,651,700	contains similarity to Pfam domains PF04047 (Periodic tryptophan protein 2 WD repeat associated presumed domain) , PF00400 (WD domain, G-beta repeat) (5)contains similarity to Interpro domains IPR000009 (Protein phosphatase 2A, regulatory subunit PR55), IPR017441 (Protein kinase ATP binding, conserved site), IPR011046 (WD40 repeat-like), IPR007190 (Periodic tryptophan protein-associated region), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
27	R06B9.4	R06B9.4	n/a	chrII 13,754,197	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR011021 (Arrestin-like, N-terminal)
28	C33E10.10	C33E10.10	n/a	chrX 17,301,563	contains similarity to Interpro domains IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
29	T02H6.3	T02H6.3	n/a	chrII 692,115
30	Y39A1C.1	Y39A1C.1	n/a	chrIII 10,857,346	contains similarity to Xylella fastidiosa Hypothetical protein Xf0776.; TR:Q9PFA2
31	F46C8.1	F46C8.1	n/a	chrX 7,550,722
32	ZK430.5	ZK430.5	n/a	chrII 4,411,199	contains similarity to Pfam domain PF03568 Peptidase family C50 contains similarity to Interpro domain IPR005314 (Peptidase C50, separase)
33	C30A5.6	C30A5.6	n/a	chrIII 8,206,270
34	nas-1	F45G2.1	n/a	chrIII 13,407,525	nas-1 encodes an astacin-like metalloprotease.
35	W04C9.6	W04C9.6	n/a	chrI 485,237	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
36	dpm-3	F28D1.11	n/a	chrIV 12,391,825	dpm-3 encodes a putative regulatory subunit of dolichol phosphate mannosyltransferase, orthologous to human DPM3 (OMIM:605951); in mass RNAi assays, DPM-3 is required for normal body size, fertility, and health.
37	F48B9.5	F48B9.5	n/a	chrX 2,148,428	contains similarity to Pfam domain PF00292 'Paired box' domain contains similarity to Interpro domains IPR001523 (Paired box protein, N-terminal), IPR011991 (Winged helix repressor DNA-binding), IPR009057 (Homeodomain-like)
38	F11A5.6	F11A5.6	n/a	chrV 16,203,986	contains similarity to Bradyrhizobium japonicum Bll7368 protein.; TR:Q89DS1
39	AC8.7	AC8.7	n/a	chrX 230,898
40	Y116A8C.15	Y116A8C.15	n/a	chrIV 16,996,337	contains similarity to Homo sapiens similar to KIAA1357 protein; ENSEMBL:ENSP00000258005
41	F55G1.12	F55G1.12	n/a	chrIV 7,494,554	contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
42	rog-1	F54D12.6	n/a	chrII 1,374,343	rog-1 encodes a protein with an insulin receptor substrate-1 (IRS-type) phosphotyrosine-binding (PTB) domain that is required for the progression from pachytene to diakinesis in meiosis; rog-1 is primarily transcribed in germ cells, and this expression is required for oocyte development; ROG-1 is orthologous to human FRS2 (OMIM:607743) and FRS3 (OMIM:607744); rog-1(tm1031) mutant oocytes fail to progress from pachytene to diakinesis, a phenotype reminiscent of let-60 or mpk-1 mutant oocytes, and rog-1(tm1031) gonads lack phosphorylated MPK-1; rog-1(tm1031) and rog-1(RNAi) hermaphrodites show reduced brood sizes and increased embryonic lethality, with rog-1(tm1031) being more phenotypically severe than rog-1(RNAi); rog-1(tm1031) germ cell, brood size, and MPK-1 phosphorylation phenotypes are suppressed by the gain-of-function mutations let-60(n1046) or let-60(ga89ts); during meiosis, ROG-1 may function as an adaptor downstream of LET-23 and upstream of LET-60.
43	C09G9.3	C09G9.3	n/a	chrIV 8,871,534	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
44	ptd-2	F07C3.1	n/a	chrV 9,252,223	C. elegans PTD-2 protein; contains similarity to Interpro domains IPR000731 (Sterol-sensing 5TM box), IPR006069 (ATPase, P-type cation exchange, alpha subunit)
45	Y45F3A.5	Y45F3A.5	n/a	chrIII 10,585,998	contains similarity to Saccharomyces cerevisiae Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA; SGD:YOR310C
46	F56A8.1	F56A8.1	n/a	chrIII 13,252,041	contains similarity to Pfam domain PF04547 Protein of unknown function, DUF590 contains similarity to Interpro domain IPR007632 (Protein of unknown function DUF590)
47	F08D12.7	F08D12.7	n/a	chrII 2,768,193	F08D12.7 encodes a novel protein conserved amongst Caenorhaditis species; although loss of F08D12.7 activity via RNAi results in no obvious defects, F08D12.7 transcripts are enriched in L1-stage muscle and upregulated in L2 larvae in response to overexpression of hlh-2 and hlh-8; in addition, in analyses of the early embryonic transcriptome, F08D12.7 transcripts are classified as strictly maternal; an F08D12.7::gfp reporter fusion is expressed in the vm1 and vm2 vulval muscles, the intestinal and anal depressor muscles, the hypodermis, distal tip cell, ventral nerve cord, head and tail neurons, and body wall muscle.
48	sri-28	B0454.3	n/a	chrII 3,049,551	C. elegans SRI-28 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	cyp-33D3	Y17D7A.4	n/a	chrV 18,834,726	C. elegans CYP-33D3 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR008071 (Cytochrome P450, E-class, group I, CYP2J-like), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
50	trxr-2	ZK637.10	n/a	chrIII 8,915,015	C. elegans TRXR-2 protein; contains similarity to Pfam domains PF02852 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain) , PF07992 (Pyridine nucleotide-disulphide oxidoreductase) , PF00070 (Pyridine nucleotide-disulphide oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR000447 (FAD-dependent glycerol-3-phosphate dehydrogenase), IPR000103 (Pyridine nucleotide-disulphide oxidoreductase, class-II), IPR012999 (Pyridine nucleotide-disulphide oxidoreductase, class I, active site), IPR004099 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation), IPR006338 (Thioredoxin and glutathione reductase selenoprotein), IPR016156 (FAD/NAD-linked reductase, dimerisation), IPR001327 (Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region), IPR000815 (Mercuric reductase), IPR016040 (NAD(P)-binding), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)