UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F43G9.3	F43G9.3	3e-156	chrI 8,613,923	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR002167 (Graves disease carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
2	glo-4	F07C3.4	n/a	chrV 9,238,868	glo-4 encodes a guanine nucleotide exchange factor (GEF) that is similar to Drosophila Claret and human RP3; throughout development, glo-4 activity is required for biogenesis of the lysosome-related gut granules; based upon phenotypic similarity, glo-4 is likely to encode a GEF for the GLO-1 Rab-like GTPase; in regulating gut granule formation, glo-4 acts downstream of apb-3, which encodes the AP-3 complex beta subunit.
3	ncr-1	F02E8.6	n/a	chrX 4,476,155	ncr-1 encodes a large transmembrane glycoprotein with a patched-like domain that is orthologous to human NPC1 (OMIM:257220, mutated in Niemann-Pick type C disease); NCR-1 and NPC1 are eukaryotic members of the resistance-nodulation-division (RND) family of membrane permeases, and have a putative sterol-sensing domain; by homology, NCR-1 is predicted to function in intracellular cholesterol and glycolipid trafficking; in C. elegans, NCR-1 is required for growth and survival in the absence of cholesterol, newly hatched ncr-1 mutant larvae grow poorly on cholesterol-free medium and die at the L1 or L2 stage; NCR-1 is also involved in negative regulation of dauer formation, being required redundantly with NCR-2, a second C. elegans NPC1-like protein, for preventing constitutive dauer formation; dauer formation in ncr-1; ncr-2 double mutants is suppressed by mutations in daf-12, which encodes a steroid hormone receptor, and by overexpression of daf-9, which encodes a cytochrome P450, suggesting that NCR-1 and NCR-2 may function to transport a sterol precursor that is metabolized by DAF-9 to then serve as the DAF-12 ligand.
4	B0454.6	B0454.6	n/a	chrII 3,034,446	contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domains IPR004841 (Amino acid permease-associated region), IPR002293 (Amino acid/polyamine transporter I)
5	C18E9.9	C18E9.9	n/a	chrII 8,988,878	contains similarity to Thermoplasma volcanium Hypothetical protein TV1312.; TR:Q978V3
6	W03G11.3	W03G11.3	n/a	chrX 12,101,925	contains similarity to Pfam domain PF01120 Alpha-L-fucosidase contains similarity to Interpro domains IPR016286 (Alpha-L-fucosidase), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR000933 (Glycoside hydrolase, family 29 (alpha-L-fucosidase))
7	ZK1037.6	ZK1037.6	n/a	chrV 15,326,789	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
8	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
9	C30F12.7	C30F12.7	n/a	chrI 6,975,813	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004434 (Isocitrate dehydrogenase NAD-dependent, mitochondrial), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
10	cyp-35B1	K07C6.4	n/a	chrV 3,940,140	C. elegans CYP-35B1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
11	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
12	gsnl-1	K06A4.3	n/a	chrV 9,498,184	C. elegans GSNL-1 protein; contains similarity to Pfam domain PF00626 Gelsolin repeat contains similarity to Interpro domains IPR007122 (Gelsolin), IPR007123 (Gelsolin region)
13	ctl-1	Y54G11A.6	n/a	chrII 14,304,828	ctl-1 encodes one of three C. elegans catalases; CTL-1 exhibits catalase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-1 activity contributes to the extended lifespan seen in daf-2 mutant animals; in addition, ctl-1 expression is negatively regulated by DAF-2-mediated insulin signaling; as CTL-1 does not possess a C-terminal peroxisomal targeting signal (PTS), it is predicted to be a cytosolic catalase.
14	ZK1058.9	ZK1058.9	n/a	chrIII 3,924,612	contains similarity to Borrelia burgdorferi Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57)s(Glycoprotease).; SW:GCP_BORBU
15	far-8	K02F3.3	n/a	chrIII 843,359	C. elegans FAR-8 protein ;
16	plc-2	Y75B12B.6	n/a	chrV 15,195,140	C. elegans PLC-2 protein; contains similarity to Pfam domains PF00387 (Phosphatidylinositol-specific phospholipase C, Y domain) , PF00388 (Phosphatidylinositol-specific phospholipase C, X domain) contains similarity to Interpro domains IPR001192 (Phospholipase C, phosphoinositol-specific, C-terminal (PLC)), IPR000909 (Phospholipase C, phosphatidylinositol-specific , X region), IPR001711 (Phospholipase C, phosphatidylinositol-specific, Y domain), IPR013841 (Phospholipase C, phosphatidylinositol-specific , X and Y boxes)
17	Y17G7B.8	Y17G7B.8	n/a	chrII 12,026,748	contains similarity to Pfam domain PF00646 F-box domain contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
18	C49G7.7	C49G7.7	n/a	chrV 4,036,291
19	ubc-17	B0403.2	n/a	chrX 7,052,951	C. elegans UBC-17 protein; contains similarity to Pfam domain PF00179 Ubiquitin-conjugating enzyme contains similarity to Interpro domains IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR000608 (Ubiquitin-conjugating enzyme, E2)
20	F28F5.4	F28F5.4	n/a	chrIII 6,816,698
21	F26A3.5	F26A3.5	n/a	chrI 7,669,167	contains similarity to Clostridium tetani Conserved protein.; TR:Q890T1
22	F09B9.1	F09B9.1	n/a	chrX 10,140,628	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domains IPR002656 (Acyltransferase 3), IPR006621 (Nose resistant to fluoxetine-4, N-terminal)
23	fbxa-218	Y49E10.17	n/a	chrIII 12,438,684	C. elegans FBXA-218 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
24	M02D8.1	M02D8.1	n/a	chrX 8,765,033	contains similarity to Pfam domain PF07679 Immunoglobulin I-set domain contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR013098 (Immunoglobulin I-set), IPR013783 (Immunoglobulin-like fold), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype)
25	tli-1	F25H2.1	n/a	chrI 10,536,634	C. elegans TLI-1 protein; contains similarity to Pfam domains PF00168 (C2 domain) , PF02845 (CUE domain) contains similarity to Interpro domains IPR003892 (Ubiquitin system component Cue), IPR009060 (UBA-like), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
26	bre-3	B0464.4	n/a	chrIII 9,471,846	bre-3 encodes a protein similar to beta-glycosyltransferases from bacteria that is required for the toxicity of Bacillus thuringiensis Cry5B; BRE-3 may act in a pathway with bre-5 and is expressed and functions in the gut epithelium.
27	Y37D8A.2	Y37D8A.2	n/a	chrIII 12,822,776	contains similarity to Pfam domain PF04916 Phospholipase B contains similarity to Interpro domains IPR007000 (Laminin A), IPR013032 (EGF-like region, conserved site)
28	Y41E3.6	Y41E3.6	n/a	chrIV 15,006,683	contains similarity to Bacillus halodurans Stress-and starvation-induced gene controlled by sigma-B.; TR:Q9KE40
29	C50C3.2	C50C3.2	n/a	chrIII 8,185,577	contains similarity to Pfam domains PF00435 (Spectrin repeat) (4), PF00036 (EF hand) contains similarity to Interpro domains IPR002017 (Spectrin repeat), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
30	R02D5.3	R02D5.3	n/a	chrV 14,483,717	contains similarity to Arabidopsis thaliana Putative RNA-binding protein.; TR:Q9SHZ5
31	T26E4.4	T26E4.4	n/a	chrV 15,791,503	contains similarity to Oryctolagus cuniculus Galactoside 2-alpha-L-fucosyltransferase 2 (EC 2.4.1.69) (Secretorsblood group alpha-2-fucosyltransferase) (GDP-L-fucose:beta-D-sgalactoside 2-alpha-L-fucosyltransferase 2) (Alpha(1,2)FT 2)s(Fucosyltransferase 2).; SW:FUT2_RABIT
32	C44C8.4	C44C8.4	n/a	chrIV 891,926	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
33	str-30	T27C4.3	n/a	chrV 3,725,910	C. elegans STR-30 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
34	Y37D8A.8	Y37D8A.8	n/a	chrIII 12,867,161	contains similarity to Interpro domain IPR006629 (LPS-induced tumor necrosis factor alpha factor)
35	lec-4	C44F1.3	n/a	chrIII 3,772,356	lec-4 encodes a predicted galectin that exhibits sugar binding properties in vitro.
36	W07B8.3	W07B8.3	n/a	chrV 1,125,705
37	pqn-24	D1007.14	n/a	chrI 4,564,993	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
38	ttr-46	T07C12.7	n/a	chrV 9,951,666	C. elegans TTR-46 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
39	Y57G11C.4	Y57G11C.4	n/a	chrIV 14,766,103	contains similarity to Pfam domain PF05008 Vesicle transport v-SNARE protein contains similarity to Interpro domains IPR000727 (Target SNARE coiled-coil region), IPR007705 (Vesicle transport v-SNARE)
40	R05D3.6	R05D3.6	n/a	chrIII 8,350,531	R05D3.6 encodes the epsilon subunit of the soluble, catalytic F1 portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); RNAi experiments indicate that loss of R05D3.6 activity has minor effects on growth rate.
41	ZK849.4	ZK849.4	n/a	chrI 14,207,136	contains similarity to Pfam domain PF01062 Bestrophin contains similarity to Interpro domains IPR000615 (Bestrophin), IPR000694 (Proline-rich region)
42	lgc-12	R13A5.4	n/a	chrIII 7,563,273	C. elegans LGC-12 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR002394 (Nicotinic acetylcholine receptor, N-terminal), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
43	C44C8.3	C44C8.3	n/a	chrIV 896,078	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
44	T08B2.11	T08B2.11	n/a	chrI 6,222,182	contains similarity to Homo sapiens Transcription initiation factor TFIID subunit 3; ENSEMBL:ENSP00000340271
45	gcy-1	AH6.1	n/a	chrII 9,514,635	gcy-1 is predicted to encode a guanylate cyclase; however, transcriptional fusions of the putative upstream regulatory region with a GFP reporter did not confirm its expression.
46	T19D12.6	T19D12.6	n/a	chrII 6,640,052	contains similarity to Pfam domains PF00008 (EGF-like domain) , PF02210 (Laminin G domain) (3), PF00054 (Laminin G domain) (2)contains similarity to Interpro domains IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR001791 (Laminin G), IPR006209 (EGF-like), IPR006210 (EGF), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR012680 (Laminin G, subdomain 2), IPR008985 (Concanavalin A-like lectin/glucanase), IPR012679 (Laminin G, subdomain 1)
47	C28H8.3	C28H8.3	n/a	chrIII 5,911,573	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) , PF04851 (Type III restriction enzyme, res subunit) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR006935 (Restriction endonuclease, type I, R subunit/Type III, Res subunit), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR008162 (Inorganic pyrophosphatase), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
48	apm-1	F55A12.7	n/a	chrI 5,343,455	The apm-1 gene encodes an adaptin: specifically, it encodes an ortholog of the mu1-II subunit of adaptor protein complex 1 (AP-1).
49	F55A12.6	F55A12.6	n/a	chrI 5,340,452	contains similarity to Interpro domain IPR002952 (Eggshell protein)
50	M04F3.3	M04F3.3	n/a	chrI 4,764,191	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)