UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F42A9.8	F42A9.8	8.999999999999999e-63	chrIV 8,618,533
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	ZK154.1	ZK154.1	n/a	chrX 7,780,026	contains similarity to Interpro domain IPR010916 (TonB box, conserved site)
4	nmgp-1	F13H8.4	n/a	chrII 6,261,707	F13H8.4 encodes a homolog of the human neuronal membrane glycoproteins PLP1 (OMIM:300401, mutated in Pelizaeus-Merzbacher disease and spastic paraplegia), M6A (OMIM:601275), and M6B (300051); the presence of a myelin-related protein in C. elegans is currently unexplained, but suggests that some evolutionary precursor of myelin may exist in invertebrates, perhaps involving septate junctions between cells.
5	F13B9.2	F13B9.2	n/a	chrX 8,286,170
6	F26A10.2	F26A10.2	n/a	chrX 7,634,533	F26A10.2 encodes a protein with four zinc-finger domains and a glutamine/asparagine-rich domain, that is required for maintenance of the germline and for locomotion; F26A10.2(RNAi) animals are uncoordinated and have sterile progeny.
7	C46H11.7	C46H11.7	n/a	chrI 5,042,625	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR003582 (Metridin-like ShK toxin)
8	F49E11.2	F49E11.2	n/a	chrIV 13,037,470	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
9	C52D10.1	C52D10.1	n/a	chrIV 17,188,302	contains similarity to Interpro domain IPR011935 (Conserved hypothetical protein CHP02231)
10	F25D1.3	F25D1.3	n/a	chrV 10,529,632	contains similarity to Pfam domain PF06083 Interleukin-17 contains similarity to Interpro domain IPR010345 (Interleukin-17)
11	pqn-55	R09E10.7	n/a	chrIV 10,289,947	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
12	hog-1	W06B11.4	n/a	chrX 5,852,661	hog-1 encodes a hedgehog-like protein, with a solitary Hint/Hog domain; the function of HOG-1's isolated Hint/Hog domain is unknown; in proteins where they coexist with other, N-terminal, domains, the Hint/Hog domain is predicted to cut its host protein into two halves and then covalently link cholesterol to the C-terminus of the N-terminal domain; HOG-1 is weakly required for normal molting; HOG-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
13	arf-3	F57H12.1	n/a	chrIV 7,983,211	arf-3 encodes a member of the ADP-ribosylation factor related protein family; likely expressed in touch receptors and regulated by MEC-3.
14	gna-1	B0024.12	n/a	chrV 10,319,821	gna-1 encodes one of two C. elegans glucosamine 6-phosphate N-acetyltransferases (GNAs); by homology, GNA-1 is predicted to be required for the formation of UDP-N-acetylglucosamine, a substrate in chitin synthesis, Golgi and cytoplasmic glycosylation, and GPI anchoring; gna-1, like chs-2, is expressed pharyngeally rather than in germline, and (unlike its paralog gna-2) does not have an osmotically-sensitive embryonic lethal RNAi phenotype; as loss of gna-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of GNA-1 in C. elegans development and/or behavior is not yet known.
15	T19A5.1	T19A5.1	n/a	chrV 8,959,477	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) , PF00515 (Tetratricopeptide repeat) (2)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
16	Y38H6C.16	Y38H6C.16	n/a	chrV 20,532,568	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
17	C38C6.3	C38C6.3	n/a	chrII 14,633,822	contains similarity to Schizosaccharomyces pombe Hypothetical transmembrane protein.; TR:O74525
18	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
19	pqn-26	DY3.5	n/a	chrI 8,774,608	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
20	sym-5	C44H4.2	n/a	chrX 14,579,420	sym-5 encodes a predicted transmembrane protein that contains 13 contiguous leucine-rich repeats (LRRs) and that is similar to SYM-1, a secreted protein involved in muscle attachment; sym-5 activity appears to be required for embryogenesis and functionally overlaps with that of sym-1 and mec-8 in affecting muscle attachment; in addition, loss of sym-5 activity via RNA-mediated interference (RNAi) in a hypersensitized strain indicates that SYM-5 may also be required for locomotion, body morphology, and normal rates of postembryonic growth.
21	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
22	rab-6.2	T25G12.4	n/a	chrX 17,223,409	rab-6.2 encodes a small, monomeric Rab GTPase that is most closely related to the Drosophila and mammalian Rab6 GTPases; by homology, RAB-6.2 is predicted to function in the regulation of intracellular membrane trafficking; RNAi experiments indicate that rab-6.2 is required redundantly with rab-6.1 for normal embryonic development and reproduction.
23	C36A4.10	C36A4.10	n/a	chrIII 3,830,011
24	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
25	B0507.1	B0507.1	n/a	chrV 8,777,950	contains similarity to Interpro domains IPR006150 (Cysteine-rich repeat), IPR013032 (EGF-like region, conserved site)
26	F44E2.4	F44E2.4	n/a	chrIII 8,835,361	contains similarity to Pfam domain PF00057 Low-density lipoprotein receptor domain class A contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich)
27	chs-2	F48A11.1	n/a	chrII 207,689	chs-2 encodes a putative chitin synthase, paralogous to CHS-1; CHS-2 is required for synthesis of chitin lining the inner pharyngeal surface (primarily in the buccal cavity and grinder), while CHS-1 is dispensable for pharyngeal chitin; CHS-2 is also required for normal pharyngeal shape and function, and for larval viability; chs-2(RNAi) animals have abnormally large, misshapen grinders, and arrest as early larvae; chs-2 is expressed by the glandular pharyngeal g1 and g2 cells, and by m3 and m4 myoepithelial cells; chs-2 is transcribed in short periods before each larval molt; the pharyngeal expression of chs-2 parallels gna-1; CHS-2 is predicted to be in the plasma membrane rather than the Golgi apparatus.
28	C14F11.6	C14F11.6	n/a	chrX 6,238,566	contains similarity to Pfam domain PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase contains similarity to Interpro domains IPR000888 (dTDP-4-dehydrorhamnose 3,5-epimerase related), IPR011051 (Cupin, RmlC-type), IPR014710 (RmlC-like jelly roll fold)
29	gana-1	R07B7.11	n/a	chrV 12,088,053	gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes; the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency.
30	phat-2	C46H11.9	n/a	chrI 5,047,210	C. elegans PHAT-2 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
31	W08G11.1	W08G11.1	n/a	chrV 16,348,431	contains similarity to Pfam domains PF00788 (Ras association (RalGDS/AF-6) domain) , PF02204 (Vacuolar sorting protein 9 (VPS9) domain) contains similarity to Interpro domains IPR013995 (Vacuolar sorting protein 9, subgroup), IPR003123 (Vacuolar sorting protein 9), IPR000159 (Ras-association)
32	C27C7.2	C27C7.2	n/a	chrI 11,433,261	contains similarity to Pfam domain PF01697 (Domain of unknown function)
33	exc-7	F35H8.5	n/a	chrII 9,578,446	exc-7 encodes an ELAV, an mRNA-binding protein homologous to Drosophila ELAV and human HuC/D (OMIM:603458, 168360, autoimmune antigens associated with paraneoplastic neurologic disorders); EXC-7 is required for formation of the tailspike and the excretory cell canals; exc-7 mutations enhance defects produced by mutations in exc-3, predicted to encode a peptidase, and sma-1, which encodes beta H-spectrin, a key component of the apical cytokeleton of polarized epithelial cells such as the excretory cell; in vitro, EXC-7 can bind the sma-1 mRNA 3' UTR, and thus is predicted to regulate SMA-1 expression in vivo; EXC-7 is expressed transiently in the excretory cell nucleus during mid-embryogenesis and during larval stages is detected in the pharynx, nerve ring, and nerve cord nuclei.
34	M153.1	M153.1	n/a	chrX 12,147,684	contains similarity to Pfam domains PF03807 (NADP oxidoreductase coenzyme F420-dependent) , PF01210 (NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus) contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR011128 (NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal), IPR016040 (NAD(P)-binding)
35	R07B1.5	R07B1.5	n/a	chrX 9,865,660	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
36	ZC123.3	ZC123.3	n/a	chrI 819,328	contains similarity to Pfam domains PF00046 (Homeobox domain) (3), PF00096 (Zinc finger, C2H2 type) (5)contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR012287 (Homeodomain-related), IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR001356 (Homeobox), IPR009057 (Homeodomain-like), IPR006572 (Zinc finger, DBF-type), IPR007087 (Zinc finger, C2H2-type)
37	C07E3.10	C07E3.10	n/a	chrII 10,346,620	contains similarity to Saccharomyces cerevisiae Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p; SGD:YDL013W
38	dpy-2	T14B4.6	n/a	chrII 6,715,073	The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5.
39	F37A4.3	F37A4.3	n/a	chrIII 6,719,158
40	F46C8.8	F46C8.8	n/a	chrX 7,552,792
41	ptr-6	C54A12.1	n/a	chrII 5,244,628	ptr-6 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-6 is weakly required for normal molting from L4 to adult stages; however, PTR-6 in conjunction with PTR-1 and PTR-10 is strongly required for both molting and viability, with triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-6 is also required for normal growth to full size and locomotion.
42	C56C10.4	C56C10.4	n/a	chrII 6,583,720	contains similarity to Pfam domain PF01682 DB module contains similarity to Interpro domain IPR002602 (Protein of unknown function DB)
43	ccb-1	T28F2.5	n/a	chrI 3,644,343	ccb-1 encodes a homolog of the beta subunits of dihydropyridine sensitive L-type calcium channels that, in RNAi screens, is dispensable for viability or grossly normal morphology; a mutant allele of ccb-1 exists, but its phenotype has not yet been described.
44	C07B5.2	C07B5.2	n/a	chrX 9,516,733	contains similarity to Listeria monocytogenes Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferases(EC 2.1.1.61).; SW:TRMU_LISMO
45	C34C12.6	C34C12.6	n/a	chrIII 3,483,701	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR009038 (GOLD), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
46	R90.1	R90.1	n/a	chrV 12,893,678	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
47	T13H5.3	T13H5.3	n/a	chrII 8,522,122	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001579 (Glycoside hydrolase, chitinase active site), IPR001002 (Chitin-binding, type 1)
48	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
49	C28H8.4	C28H8.4	n/a	chrIII 5,907,687	contains similarity to Pfam domain PF00810 ER lumen protein retaining receptor contains similarity to Interpro domain IPR000133 (ER lumen protein retaining receptor)
50	F53H4.5	F53H4.5	n/a	chrX 15,883,542	contains similarity to Pfam domain PF01342 SAND domain contains similarity to Interpro domains IPR010919 (SAND-like), IPR000770 (SAND)