UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F41G3.6	F41G3.6	2e-170	chrII 6,743,499
2	R160.3	R160.3	n/a	chrX 4,365,909
3	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
4	F29G9.7	F29G9.7	n/a	chrV 6,036,359	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
5	R13A5.7	R13A5.7	n/a	chrIII 7,568,723
6	K04G2.2	K04G2.2	n/a	chrI 8,031,912	contains similarity to Aedes aegypti Putative uncharacterized protein.; TR:Q17GK3
7	R11H6.5	R11H6.5	n/a	chrV 14,611,457	contains similarity to Pfam domain PF07528 DZF contains similarity to Interpro domains IPR006561 (DZF), IPR006116 (2-5-oligoadenylate synthetase, ubiquitin-like region)
8	F11A10.5	F11A10.5	n/a	chrIV 12,095,498	contains similarity to Pfam domain PF04184 ST7 protein contains similarity to Interpro domain IPR007311 (ST7)
9	C06G3.8	C06G3.8	n/a	chrIV 7,032,043	contains similarity to Pfam domain PF01336 OB-fold nucleic acid binding domain contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold)
10	spe-42	B0240.2	n/a	chrV 11,735,328	C. elegans SPE-42 protein; contains similarity to Pfam domain PF07782 DC-STAMP-like protein contains similarity to Interpro domain IPR012858 (DC-STAMP-like)
11	C35D10.10	C35D10.10	n/a	chrIII 4,861,200	contains similarity to Pfam domain PF00085 Thioredoxin contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR013766 (Thioredoxin domain)
12	F26A3.7	F26A3.7	n/a	chrI 7,675,432	contains similarity to Gallus gallus Putative uncharacterized protein.; TR:Q5ZIQ9
13	fsn-1	C26E6.5	n/a	chrIII 4,938,358	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins
14	srbc-67	T24A6.10	n/a	chrV 3,539,627	C. elegans SRBC-67 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
15	F22B5.6	F22B5.6	n/a	chrII 8,455,504
16	K04G7.1	K04G7.1	n/a	chrIII 7,163,752
17	R02D3.7	R02D3.7	n/a	chrIV 254,500	contains similarity to Interpro domains IPR009060 (UBA-like), IPR015880 (Zinc finger, C2H2-like)
18	efn-3	F15A2.5	n/a	chrX 13,476,463	efn-3 encodes a potential GPI-modified ephrin that is, with EFN-2, is required for normal epidermal organization in the male tail; EFN-3, along with EFN-1 and EFN-2, activates the VAB-1 tyrosine kinase in vivo and binds it in vitro, and has a minor role in embryonic epiboly.
19	F19F10.10	F19F10.10	n/a	chrV 7,579,007	F19F10.10 encodes a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
20	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
21	T02C12.2	T02C12.2	n/a	chrIII 4,020,894	contains similarity to Danio rerio Zgc:56295.; TR:Q7ZU76
22	brc-1	C36A4.8	n/a	chrIII 3,858,030	brc-1 encodes an ortholog of human BRCA1 (OMIM:113705, mutated in early onset breast and ovarian cancer) required for double-strand break repair via inter-sister recombination during meiosis; BRC-1 forms a heterodimer with BRD-1, which constitutes an E3 ubiquitin ligase; after irradiation, the DNA checkpoint proteins ATL-1 and MRE-11 are required for BRC-1/BRD-1 heterodimers to associate with RAD-51 and LET-70/Ubc5, and to ubiquitylate damaged chromatin; brc-1(RNAi) animals have excess chromosomal nondisjunction, abnormally high levels of CEP-1-dependent germ cell apoptosis (both with and without gamma-irradiation) and hypersensitivity to gamma-irradiation (e.g., abnormal sterility after irradiation); BRC-1 and BRD-1 bind one another, probably through their N-terminal RING domains, in yeast two-hybrid experiments and pull-down assays; BRC-1/BRD-1 heterodimers may interact with RAD-51 and other proteins via mutual binding to UBC-9; brc-1 is genetically dispensable for the induction of nuclear ATL-1 foci by gamma-irradiation or hydroxyurea.
23	C50B6.3	C50B6.3	n/a	chrV 13,314,685	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
24	Y76G2A.1	Y76G2A.1	n/a	chrI 5,979,820
25	dsh-2	C27A2.6	n/a	chrII 5,079,682	dsh-2 encodes a protein containing a DIX domain, a DEP domain, and a PDZ domain that is required for embryonic viability and functions in Wnt pathway signaling between the embryonic blastomeres P2 and EMS with respect to endoderm specification and to orient the division axis of the EMS cell; expressed from the four-cell embryo stage, and is primarily associated with membranes.
26	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
27	pri-1	F58A4.4	n/a	chrIII 9,613,184	pri-1 encodes a homolog of the DNA polymerase alpha-primase subunit D that is required in embryos for the normal timing of embryonic cell divisions, much as DIV-1 is.
28	F32E10.5	F32E10.5	n/a	chrIV 7,576,352	contains similarity to Pfam domain PF00567 Tudor domain contains similarity to Interpro domains IPR008191 (Maternal tudor protein), IPR002011 (Receptor tyrosine kinase, class II, conserved site), IPR002999 (Tudor)
29	F56D1.1	F56D1.1	n/a	chrII 5,479,410	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
30	F56D2.2	F56D2.2	n/a	chrIII 5,588,134	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
31	bath-7	F52C6.10	n/a	chrII 1,920,562	C. elegans BATH-7 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
32	tbg-1	F58A4.8	n/a	chrIII 9,627,816	tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.
33	apc-2	K06H7.6	n/a	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
34	T24C4.5	T24C4.5	n/a	chrIII 878,584	contains similarity to Pfam domain PF01896 Eukaryotic and archaeal DNA primase small subunit contains similarity to Interpro domains IPR014052 (DNA primase, small subunit, eukaryotic and archaeal), IPR002755 (DNA primase, small subunit)
35	cutc-1	ZK353.7	n/a	chrIII 8,402,774	C. elegans CUTC-1 protein; contains similarity to Pfam domain PF03932 CutC family contains similarity to Interpro domain IPR005627 (CutC)
36	R119.1	R119.1	n/a	chrI 360,571	contains similarity to Interpro domain IPR009080 (Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)
37	K02B12.5	K02B12.5	n/a	chrI 8,522,044	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domains IPR002110 (Ankyrin), IPR013026 (Tetratricopeptide region)
38	polh-1	F53A3.2	n/a	chrIII 1,947,677	polh-1 encodes a putative DNA polymerase eta orthologous to human POLH (OMIM:603968, mutated in xeroderma pigmentosum); POLH-1 promotes lagging-strand synthesis through G/C rich sequences, is required for normal resistance to UV-induced mutagenesis in early embryos, and suppresses the damage-induced DNA replication checkpoint in embryos; polh-1(RNAi) enhances the mutator phenotype of dog-1(gk10) 2.3-fold.
39	C27C12.1	C27C12.1	n/a	chrX 14,853,081	contains similarity to Homo sapiens 10 kDa protein; VG:OTTHUMP00000170593
40	set-17	T21B10.5	n/a	chrII 8,939,689	set-17 encodes a SET domain-containing protein orthologous to human PRDM11 and PRDM7 (Q9NQW5-2; OMIM:609759); SET-17 is expressed in many or all cells of embryo, and several postembryonic tissues (hypodermis, muscle, and excretory cell); neither set-17(n5017) nor set-17(RNAi) have any obvious phenotypes.
41	cir-1	F55F8.4	n/a	chrI 5,654,871	C. elegans CIR-1 protein ; contains similarity to Homo sapiens Isoform 1 of CBF1-interacting corepressor; ENSEMBL:ENSP00000339723
42	B0464.6	B0464.6	n/a	chrIII 9,464,196	contains similarity to Xenopus laevis MGC83764 protein.; TR:Q6DFD0
43	trm-1	ZC376.5	n/a	chrV 14,184,351	C. elegans TRM-1 protein; contains similarity to Pfam domain PF02005 N2,N2-dimethylguanosine tRNA methyltransferase contains similarity to Interpro domain IPR002905 (N2,N2-dimethylguanosine tRNA methyltransferase)
44	sup-17	DY3.7	n/a	chrI 8,795,117	sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so.
45	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
46	ZK1067.3	ZK1067.3	n/a	chrII 9,224,144	contains similarity to Mus musculus Serine/threonine-protein kinase Nek9 (EC 2.7.1.37) (NimA-relatedsprotein kinase 9).; SW:NEK9_MOUSE
47	F59A6.5	F59A6.5	n/a	chrII 5,001,644	contains similarity to Pfam domains PF00169 (PH domain) , PF00780 (CNH domain) , PF00130 (Phorbol esters/diacylglycerol binding domain (C1 domain)) contains similarity to Interpro domains IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR000533 (Tropomyosin), IPR001180 (Citron-like), IPR002219 (Protein kinase C, phorbol ester/diacylglycerol binding)
48	T07F10.3	T07F10.3	n/a	chrV 12,869,009	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
49	edc-3	R05D11.8	n/a	chrI 8,603,637	C. elegans EDC-3 protein; contains similarity to Interpro domain IPR010920 (Like-Sm ribonucleoprotein-related, core)
50	F31C3.4	F31C3.4	n/a	chrI 15,051,595	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)