UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F40E10.5	F40E10.5	9.999999999999999e-135	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
2	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
3	T03G6.1	T03G6.1	n/a	chrX 2,609,102
4	pfn-3	K03E6.6	n/a	chrX 1,080,056	C. elegans PFN-3 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
5	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
6	erv-46	K09E9.2	n/a	chrX 15,615,388	C. elegans ERV-46 protein; contains similarity to Pfam domain PF07970 Protein of unknown function (DUF1692) contains similarity to Interpro domain IPR012936 (Protein of unknown function DUF1692)
7	set-15	R11E3.4	n/a	chrIV 4,777,653	set-15 encodes a SET domain-containing protein required for normally short lifespan; SET-15 has no non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-19, SET-20, SET-21, and SET-32); other than extending lifespan, set-15(RNAi) has no obvious phenotype.
8	F42A10.3	F42A10.3	n/a	chrIII 6,156,244	contains similarity to Pfam domain PF01234 NNMT/PNMT/TEMT family contains similarity to Interpro domain IPR000940 (Methyltransferase, NNMT/PNMT/TEMT)
9	gana-1	R07B7.11	n/a	chrV 12,088,053	gana-1 encodes a protein with homology to both human alpha-galactosidase (alpha-GAL) and alpha-N-acetylgalactosaminidase (alpha-NAGA) enzymes; these dual enzymatic activities were detected in mixed culture homogenates; immunofluorescence studies show cytoplasmic expression of GANA-1 in body wall muscle and intestinal cells and in coelomocytes; the human gene alpha-galactosidase B (GALB; OMIM:104170), when mutated leads to Schindler disease, Kanzaki disease, or NAGA deficiency.
10	Y47D3B.6	Y47D3B.6	n/a	chrIII 11,427,622	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR000480 (Glutelin), IPR006149 (Nematode-specific EB region)
11	pat-6	T21D12.4	n/a	chrIV 263,062	pat-6 encodes the worm ortholog of alpha-parvin; it is required for muscle assembly and function, with mutations leading to embryonic lethality.
12	F53F1.5	F53F1.5	n/a	chrV 13,415,573	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001859 (Ribosomal protein P2), IPR013286 (Annexin, type VII)
13	cyn-6	F42G9.2	n/a	chrIII 773,770	cyn-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
14	K01A2.5	K01A2.5	n/a	chrII 303,020	contains similarity to Pfam domain PF00561 alpha/beta hydrolase fold contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR003089 (Alpha/beta hydrolase)
15	erd-2	F09B9.3	n/a	chrX 10,158,581	erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1.
16	pyr-1	D2085.1	n/a	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
17	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
18	mlt-11	W01F3.3	n/a	chrV 20,668,250	C. elegans MLT-11 protein; contains similarity to Pfam domains PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (10), PF00086 (Thyroglobulin type-1 repeat) contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
19	dre-1	K04A8.6	n/a	chrV 6,535,821	dre-1 encodes an ortholog of human FBXO11/PRMT9 (OMIM:607871, associated with vitiligo and otitis media) that is required, in conjunction with DAF-12 and its partners, for global developmental timing of the transistion from larval to adult cell fates; DRE-1 has an N-terminal F-box domain, three central tandem C-terminal CASH domains, and a C-terminal zinc finger; hypomorphic dre-1 mutations are synthetically heterochronic with loss-of-function daf-12 alleles, inducing defective distal tip cell migration and precocious fusion of seam cells; five different hypomorphic dre-1 alleles alter conserved glycine residues in the CASH domain region, whereas the null dre-1(hd60) allele is lethal at the three-fold embryo stage; DRE-1 is expressed in many tissues, including epidermal and distal tip cells, and localizes to both nucleus and cytoplasm; strong loss-of-function of dre-1 (the dh99 mutant fed RNAi) induces defects at all four molts; dre-1 also has synthetic phenotypes with daf-9(k182), daf-36(k114), and lin-29(n546); dre-1-like enhancement of daf-12 is also seen in skr-1(RNAi), cul-1(RNAi), or rbx-1/2(RNAi) animals; DRE-1 and SKR-1 bind one another, as do their human orthologs; DRE-1 affects lin-29 expression, and is suppressed by lin-42(RNAi); DRE-1 is paralogous to C. elegans BE0003N10.3.
20	C46H11.7	C46H11.7	n/a	chrI 5,042,625	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR003582 (Metridin-like ShK toxin)
21	C26B9.3	C26B9.3	n/a	chrX 5,339,194
22	nhr-45	F16H11.5	n/a	chrX 4,658,348	C. elegans NHR-45 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
23	C29F5.1	C29F5.1	n/a	chrII 6,304,849
24	ZC13.3	ZC13.3	n/a	chrX 885,679	contains similarity to Interpro domain IPR000998 (MAM)
25	C15C6.1	C15C6.1	n/a	chrI 12,202,933	contains similarity to Caulobacter crescentus Hypothetical protein CC0499.; TR:Q9AAU5
26	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
27	F22F4.1	F22F4.1	n/a	chrX 6,005,723
28	ZK682.5	ZK682.5	n/a	chrV 9,285,827	contains similarity to Pfam domain PF00560 Leucine Rich Repeat contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype), IPR000480 (Glutelin)
29	ZK154.1	ZK154.1	n/a	chrX 7,780,026	contains similarity to Interpro domain IPR010916 (TonB box, conserved site)
30	F21C10.7	F21C10.7	n/a	chrV 9,117,429	contains similarity to Pfam domains PF07686 (Immunoglobulin V-set domain) (2), PF00047 (Immunoglobulin domain) (3), PF07679 (Immunoglobulin I-set domain) (6)contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR002017 (Spectrin repeat), IPR013098 (Immunoglobulin I-set), IPR013783 (Immunoglobulin-like fold), IPR013106 (Immunoglobulin V-set), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype), IPR013151 (Immunoglobulin)
31	ost-1	C44B12.2	n/a	chrIV 1,109,128	ost-1 encodes the C. elegans ortholog of the conserved basement membrane glycoprotein component osteonectin/SPARC/BM-40; loss of ost-1 function via RNAi indicates that ost-1 activity is required for embryonic and larval development, as well as for normal gut development, body size, and fecundity; an OST-1::GFP reporter fusion protein localizes to the basement membranes along body wall and sex muscles, as well as around the pharynx and gonad, with particular concentration at the spermatheca and distal tip cells.
32	nrs-2	F25G6.6	n/a	chrV 8,547,557	nrs-2 encodes a predicted asparaginyl-tRNA synthetase (AsnRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of asparagine to its cognate tRNA and is thus required for protein biosynthesis; loss of nrs-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
33	C52D10.1	C52D10.1	n/a	chrIV 17,188,302	contains similarity to Interpro domain IPR011935 (Conserved hypothetical protein CHP02231)
34	ZK662.2	ZK662.2	n/a	chrX 15,697,316	contains similarity to Homo sapiens Metallothionein-IL; ENSEMBL:ENSP00000290704
35	T20D4.3	T20D4.3	n/a	chrV 3,420,496	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
36	myo-3	K12F2.1	n/a	chrV 12,230,556	myo-3 encodes MHC A, the minor isoform of MHC (myosin heavy chain) that is essential for thick filament formation, and for viability, movement, and embryonic elongation; expressed in body muscle, the somatic sheath cell covering the hermaphrodite gonad, and also expressed in enteric muscle, vulval muscles of the hermaphrodite and the diagonal muscles of the male tail.
37	Y75B8A.4	Y75B8A.4	n/a	chrIII 12,110,492	contains similarity to Pfam domains PF07726 (ATPase family associated with various cellular activities (AAA)) , PF00004 (ATPase family associated with various cellular activities (AAA)) , PF05362 (Lon protease (S16) C-terminal proteolytic domain) , PF07728 (ATPase family associated with various cellular activities (AAA)) contains similarity to Interpro domains IPR003959 (AAA ATPase, core), IPR000767 (Disease resistance protein), IPR011704 (ATPase associated with various cellular activities, AAA-5), IPR011703 (ATPase associated with various cellular activities, AAA-3), IPR004815 (Peptidase S16, ATP-dependent protease La), IPR008269 (Peptidase S16, lon C-terminal), IPR003111 (Peptidase S16, lon N-terminal), IPR003593 (AAA+ ATPase, core), IPR001984 (Peptidase S16, Lon protease)
38	cyp-33A1	C12D5.7	n/a	chrV 7,680,386	C. elegans CYP-33A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV)
39	Y113G7B.16	Y113G7B.16	n/a	chrV 20,268,307	contains similarity to Pfam domain PF05600 Protein of unknown function (DUF773) contains similarity to Interpro domain IPR008491 (Protein of unknown function DUF773)
40	Y32F6B.1	Y32F6B.1	n/a	chrV 10,482,818	contains similarity to Pfam domain PF03137 Organic Anion Transporter Polypeptide (OATP) family contains similarity to Interpro domains IPR004156 (Organic anion transporter polypeptide OATP), IPR016196 (MFS general substrate transporter)
41	sft-4	C54H2.5	n/a	chrX 5,779,970	sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein.
42	C06G1.2	C06G1.2	n/a	chrX 16,622,192	contains similarity to Drosophila melanogaster Flybase gene name is CG31439-PA;; FLYBASE:CG31439
43	gbf-1	C24H11.7	n/a	chrIII 11,762,525	C. elegans GBF-1 protein; contains similarity to Pfam domain PF01369 Sec7 domain contains similarity to Interpro domains IPR008979 (Galactose-binding like), IPR000904 (SEC7-like)
44	T19A5.1	T19A5.1	n/a	chrV 8,959,477	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) , PF00515 (Tetratricopeptide repeat) (2)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
45	fkb-4	ZC455.10	n/a	chrV 12,786,120	fkb-4 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-4 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and in part, through the activity of the DAF-16 fork-head transcription factor suggesting that FKB-4 could play a role in metabolism and longevity; as loss of FKB-4 function via RNA-mediated interference does not result in any abnormalities, the precise role of FKB-4 in C. elegans development and/or behavior is not yet known; FKB-4 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER.
46	K05B2.4	K05B2.4	n/a	chrX 4,919,986	contains similarity to Pfam domains PF08840 (BAAT / Acyl-CoA thioester hydrolase C terminal) , PF04775 (Acyl-CoA thioester hydrolase / Bile acid-CoA amino acid N-acetyltransferase) contains similarity to Interpro domains IPR006862 (Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase), IPR014940 (BAAT/Acyl-CoA thioester hydrolase C-terminal), IPR016662 (Acyl-CoA thioesterase, long chain)
47	R02F11.1	R02F11.1	n/a	chrV 4,801,848	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
48	inx-5	R09F10.4	n/a	chrX 8,301,164	inx-5 encodes a predicted member of the innexin family; expressed in the embryonic hypodermis, developing vulva, seam cells, and spermatheca.
49	T19B10.2	T19B10.2	n/a	chrV 11,222,045
50	T20B3.1	T20B3.1	n/a	chrV 16,818,064	contains similarity to Pfam domain PF00755 Choline/Carnitine o-acyltransferase contains similarity to Interpro domain IPR000542 (Acyltransferase ChoActase/COT/CPT)