UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	uev-1	F39B2.2	2e-74	chrI 14,790,521	uev-1 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the characteristic UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-1 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-1 in C. elegans development and/or behavior is not yet known; UEV-1 does, however, interact with a number of proteins, such as UBC-13, that are likely involved in the response to DNA damage; thus, UEV-1 may play a role in ubiquitination and protein turnover in conjunction with DNA repair or the DNA damage checkpoint pathway.
2	secs-1	D1054.13	n/a	chrV 10,803,314	C. elegans SECS-1 protein; contains similarity to Pfam domain PF05889 Soluble liver antigen/liver pancreas antigen (SLA/LP autoantigen) contains similarity to Interpro domains IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR008829 (Soluble liver antigen/liver pancreas antigen)
3	H14A12.3	H14A12.3	n/a	chrIII 7,464,450	H14A12.3 encodes an ortholog of S. cerevisiae RAV2; like RAV2, H14A12.3 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
4	R05D3.8	R05D3.8	n/a	chrIII 8,357,800	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
5	rrt-2	C29H12.1	n/a	chrII 6,126,706	C. elegans RRT-2 protein; contains similarity to Pfam domains PF05746 (DALR anticodon binding domain) , PF00750 (tRNA synthetases class I (R)) contains similarity to Interpro domains IPR015945 (Arginyl-tRNA synthetase, class Ic, core), IPR008909 (DALR anticodon binding), IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site), IPR009080 (Aminoacyl-tRNA synthetase, class 1a, anticodon-binding), IPR001278 (Arginyl-tRNA synthetase, class Ic), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
6	ZK1236.7	ZK1236.7	n/a	chrIII 8,441,581	contains similarity to Drosophila melanogaster Flybase gene name is CG5862-PA;; FLYBASE:CG5862
7	T27E9.6	T27E9.6	n/a	chrIII 13,475,636	contains similarity to Bradyrhizobium japonicum Bsl1006 protein.; TR:Q89VN9
8	C06A5.4	C06A5.4	n/a	chrI 5,981,191	contains similarity to Interpro domain IPR006578 (MADF)
9	ZK829.7	ZK829.7	n/a	chrIV 11,960,692	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
10	spd-3	H34C03.1	n/a	chrIV 6,763,933	C. elegans SPD-3 protein ;
11	K08C7.7	K08C7.7	n/a	chrIV 10,665,006	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
12	C10A4.2	C10A4.2	n/a	chrX 7,412,571
13	C44C10.3	C44C10.3	n/a	chrX 11,703,337	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
14	M01G5.1	M01G5.1	n/a	chrIII 1,503,267	contains similarity to Homo sapiens hypothetical protein; VG:OTTHUMP00000024537
15	K03B4.1	K03B4.1	n/a	chrV 4,690,455
16	his-63	F22B3.2	n/a	chrIV 11,406,611	his-63 encodes an H3 histone; by homology, HIS-63 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-63 is a replication-dependent histone locus.
17	cka-1	C28D4.2	n/a	chrIV 9,734,654	cka-1 encodes an isoform of choline kinase whose activity has been verified in vitro, and that has a strong preference for choline over ethanolamine; CKA-1 and CKA-2 comprise a related group ('A') of choline kinases.
18	K02B7.2	K02B7.2	n/a	chrII 14,692,031	contains similarity to Pfam domains PF07735 (F-box associated) , PF00646 (F-box domain) contains similarity to Interpro domains IPR001810 (Cyclin-like F-box), IPR012885 (F-box associated type 2)
19	osm-11	F11C7.5	n/a	chrX 17,420,817	C. elegans OSM-11 protein ;
20	F57C9.7	F57C9.7	n/a	chrI 4,825,902
21	F26E4.5	F26E4.5	n/a	chrI 9,769,984	F26E4.5 encodes an SH2 domain-containing tyrosine kinase related to the vertebrate FER non-receptor protein tyrosine kinase; loss of F26E4.5 activity in an RNAi-hypersensitive strain results in axon guidance defects indicating that F26E4.5 likely plays a role in regulation of axon navigation.
22	F25B5.5	F25B5.5	n/a	chrIII 5,944,924	contains similarity to Pfam domains PF00919 (Uncharacterized protein family UPF0004) , PF04055 (Radical SAM superfamily) , PF01938 (TRAM domain) contains similarity to Interpro domains IPR005839 (Protein of unknown function UPF0004), IPR013848 (Protein of unknown function UPF0004, N-terminal), IPR007197 (Radical SAM), IPR006638 (Elongator protein 3/MiaB/NifB), IPR002792 (Deoxyribonuclease/rho motif-related TRAM)
23	C08F11.1	C08F11.1	n/a	chrIV 13,624,656	contains similarity to Coxiella burnetii Hypothetical protein.; TR:Q83D43
24	kin-4	C10C6.1	n/a	chrIV 11,441,819	C. elegans KIN-4 protein; contains similarity to Pfam domains PF08926 (Domain of unknown function (DUF1908)) , PF00595 (PDZ domain (Also known as DHR or GLGF)) , PF00069 (Protein kinase domain) contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR015022 (Region of unknown function DUF1908), IPR000719 (Protein kinase, core), IPR001478 (PDZ/DHR/GLGF), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR000961 (Protein kinase, C-terminal)
25	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
26	F02E9.7	F02E9.7	n/a	chrI 8,414,687	contains similarity to Pfam domain PF00149 Calcineurin-like phosphoesterase contains similarity to Interpro domain IPR004843 (Metallophosphoesterase)
27	F13G3.6	F13G3.6	n/a	chrI 7,304,082	contains similarity to Pfam domain PF00535 Glycosyl transferase family 2 contains similarity to Interpro domains IPR001173 (Glycosyl transferase, family 2), IPR016040 (NAD(P)-binding)
28	C09G5.2	C09G5.2	n/a	chrII 10,708,359	C09G5.2 encodes an ortholog of S. cerevisiae DPH2/YKL191W and human DPH2L2 (OMIM:603456); C09G5.2 is a putative protein component of diphtamide synthesis; C09G5.2 has no obvious function in mass RNAi assays.
29	T12E12.3	T12E12.3	n/a	chrIV 5,543,170
30	pme-2	E02H1.4	n/a	chrII 9,594,003	pme-2 encodes a poly(ADP-ribose) polymerase (PARP) orthologous to human PARP2 (OMIM:607725); PME-2 has a predicted C-terminal catalytic domain; PME-2 has PARP activity in vitro, which is blocked by mammalian PARP inhibitors; since these inhibitors also cause embryonic lethality in worms exposed to ionizing radiation, PME-1 is likely to be required in vivo for repairing broken DNA.
31	C53D6.7	C53D6.7	n/a	chrIV 9,035,988	contains similarity to Pfam domain PF00337 Galactoside-binding lectin contains similarity to Interpro domains IPR001079 (Galectin, galactose-binding lectin), IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR008985 (Concanavalin A-like lectin/glucanase)
32	K07A12.1	K07A12.1	n/a	chrI 8,668,182	contains similarity to Pfam domain PF04910 Protein of unknown function, DUF654 contains similarity to Interpro domains IPR006994 (Basic helix-loop-helix, Nulp1-type), IPR000294 (Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)
33	srh-181	ZK228.6	n/a	chrV 18,475,360	C. elegans SRH-181 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
34	M03F4.4	M03F4.4	n/a	chrX 4,957,667
35	ulp-4	C41C4.6	n/a	chrII 8,132,271	C. elegans ULP-4 protein; contains similarity to Pfam domain PF02902 Ulp1 protease family, C-terminal catalytic domain contains similarity to Interpro domain IPR003653 (Peptidase C48, SUMO/Sentrin/Ubl1)
36	his-62	F55G1.3	n/a	chrIV 7,486,714	his-62 encodes an H2B histone.
37	srw-121	K12D9.3	n/a	chrV 2,990,948	C. elegans SRW-121 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
38	ani-3	Y43F8C.14	n/a	chrV 19,696,771	ani-3 encodes one of three C. elegans anillins.
39	nhr-257	C17A2.1	n/a	chrII 3,853,795	C. elegans NHR-257 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
40	fcd-2	Y41E3.9	n/a	chrIV 15,031,338	fcd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconi anemia, OMIM:227646) that is strongly required for resistance to DNA interstrand crosslinking (ICL) agents, but not to ionizing radiation (IR); fcd-2 mutants are viable and dispensable for resistance to IR, meiotic recombination, and S-phase checkpoint activation, but are hypersensitive to ICL agents; like its human ortholog, FCD-2 is monoubiquitylated and recruited to chromosomal foci after ICL but not IR; transgenic expresssion of the FANCD2 gene in mutant FA-D2 cells rescues their abnormal sensitivity to mitomycin C, an agent that cross-links strands of DNA.
41	lips-17	R07G3.2	n/a	chrII 7,609,466	C. elegans LIPS-17 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domains IPR002918 (Lipase, class 2), IPR008262 (Lipase, active site)
42	nlp-16	T13A10.5	n/a	chrIV 6,257,461	nlp-16 encodes a predicted neuropeptide that does not belong to a multigene family in C. elegans and is not clearly related to well-characterized neuropeptides; the peptide encoded by nlp-16 has been isolated from Ascaris suum.
43	R11.1	R11.1	n/a	chrX 16,192,348	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
44	W09D6.5	W09D6.5	n/a	chrIII 11,089,923	contains similarity to Saccharomyces cerevisiae cell wall integrity and stress response component 1; SGD:YOR008C
45	F13H8.3	F13H8.3	n/a	chrII 6,264,731	contains similarity to Pfam domain PF01156 Inosine-uridine preferring nucleoside hydrolase contains similarity to Interpro domain IPR001910 (Inosine/uridine-preferring nucleoside hydrolase)
46	lim-6	K03E6.1	n/a	chrX 1,076,785	lim-6 encodes a LIM class homeodomain protein that contains two Zinc-finger-like LIM domains N-terminal to a predicted DNA-binding homeodomain; LIM-6 is predicted to function as a transcription factor whose activity is required for regulating uterine morphogenesis and specific aspects of terminal neuronal differentiation, including normal axonal morphology, full expression of UNC-25/glutamic acid decarboxylase in select GABAergic neurons, and repression of sensory receptor gene expression in the ASEL chemosensory neuron; LIM-6 is expressed in a group of nine chemosensory-, inter-, and motorneurons, uterine toroid cells, spermathecal junction cells, and the binucleate excretory gland cell.
47	B0205.9	B0205.9	n/a	chrI 10,722,143	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
48	W08D2.5	W08D2.5	n/a	chrIV 9,821,001	contains similarity to Pfam domains PF00122 (E1-E2 ATPase) , PF00702 (haloacid dehalogenase-like hydrolase) contains similarity to Interpro domains IPR008250 (E1-E2 ATPase-associated region), IPR006544 (P-type ATPase of unknown pump specificity (type V)), IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter), IPR000150 (Cof protein), IPR005834 (Haloacid dehalogenase-like hydrolase)
49	taf-6.1	W09B6.2	n/a	chrII 1,130,167	C. elegans TAF-6.1 protein; contains similarity to Pfam domains PF07571 (Protein of unknown function (DUF1546)) , PF02969 (TATA box binding protein associated factor (TAF)) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR004823 (TATA box binding protein associated factor (TAF)), IPR011442 (Protein of unknown function DUF1546)
50	R10E8.2	R10E8.2	n/a	chrV 18,254,063	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)