UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F35E8.4	F35E8.4	3e-140	chrV 15,910,554	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
2	M117.3	M117.3	n/a	chrIV 11,823,697	M117.3 can encode a protein with similarity to the C-terminal half of the 14-3-3 proteins PAR-5 and FTT-2, beginning in predicted alpha helix five and continuing through the ends of the proteins; loss of M117.3 activity via large-scale RNAi results in no obvious abnormalities.
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	T26C11.2	T26C11.2	n/a	chrX 1,836,847	contains similarity to Interpro domains IPR000893 (Luteovirus ORF6 protein), IPR000694 (Proline-rich region), IPR000480 (Glutelin)
5	sru-9	Y45F10B.11	n/a	chrIV 13,589,633	C. elegans SRU-9 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
6	Y44F5A.1	Y44F5A.1	n/a	chrIII 4,246,236	contains similarity to Interpro domains IPR017422 (WD repeat protein 55), IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
7	gpa-6	F48C11.1	n/a	chrX 13,192,522	gpa-6 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects response to water-soluble odorants; it is expressed in AWA amphid neurons, the PHB sensory cell, and (at low levels) in ASI amphid neurons.
8	F07G6.5	F07G6.5	n/a	chrX 1,706,500
9	str-68	Y73C8C.6	n/a	chrV 3,106,888	C. elegans STR-68 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
10	C47D12.8	C47D12.8	n/a	chrII 11,700,677	C47D12.8 encodes an ortholog of the DNA repair protein XPF/ERCC4, which when mutated in humans leads to xeroderma pigmentosum (complementation group F; OMIM:133520); C47D12.8(RNAi) animals are hypersensitive to ultraviolet radiation, with increased germ cell apoptosis and embryonic lethality; C47D12.8 protein interacts with F10G8.7 (an ERCC1 ortholog) in yeast two-hybrid assays; C47D12.8 is expressed broadly in both embryonic and postembryonic animals, and is required for embryonic development; C47D12.8 is upregulated in dauers, and shares an operon with kel-1 and VF13D12L.3.
11	bbs-2	F20D12.3	n/a	chrIV 7,935,876	bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
12	lagr-1	Y6B3B.10	n/a	chrI 13,728,317	C. elegans LAGR-1 protein; contains similarity to Pfam domain PF03798 Longevity-assurance protein (LAG1) contains similarity to Interpro domains IPR016439 (Longevity assurance proteins LAG1/LAC1), IPR005547 (Longevity-assurance protein (LAG1)), IPR006634 (TRAM, LAG1 and CLN8 homology)
13	nhr-15	F33E11.1	n/a	chrV 321,993	nhr-15 is predicted to encode a member of the nuclear hormone receptor family.
14	F39F10.2	F39F10.2	n/a	chrX 16,895,317	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
15	sri-11	T22H2.3	n/a	chrI 11,696,802	C. elegans SRI-11 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR015964 (Cytochrome C oxidase subunit II-like, transmembrane region)
16	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
17	kel-1	C47D12.7	n/a	chrII 11,692,402	kel-1 encodes a BTB/POZ- and Kelch motif-containing protein orthologous to Drosophila Kelch, which is essential for actin organization in ovarian ring canals; in C. elegans, kel-1 is required for regulating feeding during larval development and more specifically, for pharyngeal isthmus peristalsis and efficient trapping of food in the pharynx; KEL-1 is first expressed at the 1.5-fold stage of embryogenesis in the pharyngeal lumen and the nerve ring; later adult and larval expression is confined to the pharyngeal gland cells in which KEL-1 may be required for maintenance of gland cell-specific structures.
18	nhr-83	F48G7.3	n/a	chrV 632,120	C. elegans NHR-83 protein; contains similarity to Pfam domains PF07914 (Protein of unknown function (DUF1679)) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core), IPR015897 (CHK kinase-like)
19	fbxa-156	C06H5.1	n/a	chrV 17,896,012	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
20	srg-45	C51F7.2	n/a	chrV 12,308,051	C. elegans SRG-45 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
21	F36F12.7	F36F12.7	n/a	chrV 2,099,700
22	R09A1.3	R09A1.3	n/a	chrV 1,025,455
23	K07G5.4	K07G5.4	n/a	chrI 7,167,846	contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
24	del-1	E02H4.1	n/a	chrX 14,274,420	del-1 encodes an ion channel protein of the DEG/ENaC (degenerin/epithelial Na+ channel) family; like other members of the degenerin family, DEL-1 is predicted to function as a sensory mechanotransduction channel, however detailed analysis of the DEL-1 mutant phenotype has not yet been reported; DEL-1 is expressed postembryonically in the VA and VB motor neurons and in the FLP sensory neurons; the DEL-1 expression pattern overlaps that of UNC-8, an additional C. elegans degenerin involved in movement control, with which DEL-1 may coassemble to form mechanically activated cation channels.
25	str-144	C09H5.5	n/a	chrV 8,071,381	C. elegans STR-144 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
26	str-101	Y6E2A.2	n/a	chrV 15,711,366	C. elegans STR-101 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
27	Y69H2.1	Y69H2.1	n/a	chrV 18,621,264	contains similarity to Myxine glutinosa NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3).; SW:NU4M_MYXGL
28	C06A1.2	C06A1.2	n/a	chrII 10,570,302	contains similarity to Mus musculus Olfactory receptor MOR111-5 (Olfactory receptorsGA_x6K02T2PULF-11116958-11117896).; TR:Q8VFH8
29	T05B4.4	T05B4.4	5e-21	chrV 4,128,560
30	F56D2.5	F56D2.5	n/a	chrIII 5,579,782	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) (2)contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
31	srh-112	T19C9.2	n/a	chrV 17,225,620	C. elegans SRH-112 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
32	ZK262.3	ZK262.3	n/a	chrV 18,415,571	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
33	gst-18	F37B1.7	n/a	chrII 13,630,251	C. elegans GST-18 protein; contains similarity to Pfam domains PF00043 (Glutathione S-transferase, C-terminal domain) , PF02798 (Glutathione S-transferase, N-terminal domain) contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR004046 (Glutathione S-transferase, C-terminal), IPR004045 (Glutathione S-transferase, N-terminal), IPR010987 (Glutathione S-transferase, C-terminal-like)
34	C06E4.3	C06E4.3	n/a	chrIV 7,261,440	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF00106 (short chain dehydrogenase) contains similarity to Interpro domains IPR002424 (Insect alcohol dehydrogenase family), IPR001509 (NAD-dependent epimerase/dehydratase), IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
35	srbc-19	C45H4.16	n/a	chrV 2,165,802	C. elegans SRBC-19 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR002208 (SecY protein)
36	twk-20	C40C9.1	n/a	chrX 13,640,987	C. elegans TWK-20 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR013521 (Potassium channel, inwardly rectifying, Kir, conserved region 2), IPR003280 (Potassium channel, two pore-domain), IPR003938 (Potassium channel, voltage-dependent, EAG/ELK/ERG), IPR013099 (Ion transport 2), IPR003092 (Potassium channel, two pore-domain, TASK)
37	F28H6.6	F28H6.6	n/a	chrX 14,121,403	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
38	tag-336	Y69H2.12	n/a	chrV 18,653,219	C. elegans TAG-336 protein; contains similarity to Pfam domains PF00008 (EGF-like domain) (7), PF00858 (Amiloride-sensitive sodium channel) , PF07974 (EGF-like domain) contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR006209 (EGF-like), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR001873 (Na+ channel, amiloride-sensitive)
39	cwn-2	W01B6.1	n/a	chrIV 10,069,006	cwn-2 encodes a member of the WNT family; expressed at highest levels in embryos and expression declines and is almost absent by the third larval stage.
40	lgc-23	C15A7.1	n/a	chrX 12,066,273	C. elegans LGC-23 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
41	str-149	Y32B12B.5	n/a	chrV 16,574,182	C. elegans STR-149 protein ;
42	C23H5.7	C23H5.7	n/a	chrIV 2,107,829	contains similarity to Pfam domains PF00027 (Cyclic nucleotide-binding domain) , PF00520 (Ion transport protein) contains similarity to Interpro domains IPR005821 (Ion transport), IPR000595 (Cyclic nucleotide-binding), IPR014710 (RmlC-like jelly roll fold)
43	glc-4	C27H5.8	n/a	chrII 7,173,524	glc-4 encodes a predicted glutamate-gated chloride channel that affects ivermectin sensitivity and reversal behavior and genetically interacts with avr-14; expressed in neurons.
44	nhr-54	F36D3.2	n/a	chrV 16,504,904	C. elegans NHR-54 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
45	C16D9.4	C16D9.4	n/a	chrV 8,241,945	contains similarity to Pfam domain PF07801 Protein of unknown function (DUF1647) contains similarity to Interpro domains IPR008068 (Cytochrome P450, E-class, group I, CYP2B-like), IPR012444 (Protein of unknown function DUF1647)
46	tsr-1	F53G2.6	n/a	chrII 2,466,865	tsr-1 encodes a homolog of human transportin-SR, a nuclear transport receptor, and affects embryonic viability.
47	Y56A3A.16	Y56A3A.16	n/a	chrIII 11,912,267	contains similarity to Homo sapiens Isoform 1 of Pleckstrin homology domain-containing family M member 3; ENSEMBL:ENSP00000373899
48	C01G6.9	C01G6.9	n/a	chrII 9,294,851	contains similarity to Plasmodium falciparum SET-domain protein, putative.; TR:Q8IC77
49	T07D10.3	T07D10.3	n/a	chrI 12,627,858	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
50	ZC482.3	ZC482.3	n/a	chrIII 12,762,606	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)