UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F33E2.6	F33E2.6	8e-179	chrI 12,589,287	contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region)
2	mif-3	F13G3.9	n/a	chrI 7,313,193	C. elegans MIF-3 protein; contains similarity to Pfam domain PF01187 Macrophage migration inhibitory factor (MIF) contains similarity to Interpro domains IPR014347 (Tautomerase), IPR001398 (Macrophage migration inhibitory factor)
3	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
4	CD4.5	CD4.5	n/a	chrV 5,590,729
5	gab-1	ZC482.1	n/a	chrIII 12,775,682	gab-1 encodes a gamma-aminobutyric acid (GABA) receptor beta-like subunit with both the neurotransmitter-gated ion-channel ligand binding and transmembrane domains; gab-1 can form a GABA-responsive channel when co-expressed with alpha/gamma type subunits in a heterologous expression system; experiments with gab-1 indicate that GABA receptors are involved in the mechanism of resistance to the widely used broad-spectrum anthelmintic drug Ivermectin.
6	F31F4.11	F31F4.11	n/a	chrV 663,441	contains similarity to Pfam domains PF00788 (Ras association (RalGDS/AF-6) domain) , PF02204 (Vacuolar sorting protein 9 (VPS9) domain) contains similarity to Interpro domains IPR013995 (Vacuolar sorting protein 9, subgroup), IPR003123 (Vacuolar sorting protein 9), IPR000159 (Ras-association)
7	F36D4.4	F36D4.4	n/a	chrV 9,404,118	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000832 (GPCR, family 2, secretin-like), IPR000276 (GPCR, rhodopsin-like)
8	sup-9	F34D6.3	n/a	chrII 2,685,863	sup-9 encodes one of 44 C. elegans TWK (two-P domain K+) potassium channel subunits that contain two pore-forming domains and four transmembrane domains; sup-9 was originally defined by gain-of-function mutations that result in defects in pharyngeal, body-wall, egg-laying, and enteric muscle activation; loss of sup-9 function via reversion or RNA-mediated interference (RNAi) does not result in any abnormalities suggesting that SUP-9 may function redundantly with other TWK channels; SUP-9 is expressed in neurons and muscle.
9	F07C3.2	F07C3.2	n/a	chrV 9,226,731
10	ZC239.3	ZC239.3	n/a	chrII 3,216,335	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
11	ssu-1	Y113G7A.11	n/a	chrV 20,126,167	ssu-1 encodes, by alternative splicing, two isoforms of a cytosolic alcohol sulfotransferase that interacts in the ASJ amphid neurons with the stomatins UNC-1 and UNC-24; the longer SSU-1 isoform is required for normal anesthetic sensitivity and unc-1 phenotypes; ssu-1(fc73) suppresses the anesthetic sensitivity and uncoordinated phenotypes of unc-1 and unc-24 mutants; ssu-1(fc73), along with daf-12, suppresses the synthetic constitutive dauer-formation phenotype of fc83;unc-24(e138) mutants; ssu-1 suppression is rescued by transgenic expression of SSU-1 in the ASJ neurons alone, implying that sulfation is required for an endocrine function; SSU-1 protein sulfates 4-nitrophenol and 2-naphthol substrates, and bisphenol A, but not monoamines or hydroxysteroids; SSU-1 is cytosolic, but its activity is not detectable in cytosolic extracts; ssu-1 is strongly expressed in embryos, growing larvae, and dauer larvae; ssu-1 expression is increased in daf-2; by homology with other sulfotransferases, SSU-1 may link sulfates to the alcohol group of small molecules as part of detoxification or signal transduction.
12	fbxa-129	F59A1.8	n/a	chrV 17,656,084	C. elegans FBXA-129 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
13	K04F1.11	K04F1.11	n/a	chrV 1,660,979	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
14	str-252	C06B3.9	n/a	chrV 13,917,252	C. elegans STR-252 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR008365 (Prostanoid receptor), IPR003002 (7TM chemoreceptor, subfamily 1)
15	srg-14	F26B1.6	n/a	chrI 6,313,673	C. elegans SRG-14 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
16	C16D6.1	C16D6.1	n/a	chrX 12,525,704	contains similarity to Interpro domain IPR000694 (Proline-rich region)
17	F02E11.2	F02E11.2	n/a	chrII 3,267,119
18	T05B4.9	T05B4.9	n/a	chrV 4,117,993	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
19	tkr-1	C38C10.1	n/a	chrIII 9,386,535	tkr-1 encodes a G protein-coupled receptor that is the C. elegans tachykinin-like neuropeptide receptor homolog; by homology, TKR-1 is predicted to function in modulation of excitatory neurotransmission; as loss of tkr-1 activity via RNAi results in moderate reduction of fat content, TKR-1 may play a specific role in regulating lipid metabolism; a tkr-1 reporter gene fusion is reportedly expressed in the socket cells of the deirid and post-deirid sensilla from the L2 larval stage through adulthood.
20	C16D9.6	C16D9.6	n/a	chrV 8,249,274	contains similarity to Drosophila melanogaster Flybase gene name is CG9520-PA;; FLYBASE:CG9520
21	str-250	C06B3.10	n/a	chrV 13,919,315	C. elegans STR-250 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
22	F42A6.2	F42A6.2	n/a	chrIV 3,341,612
23	C18H7.6	C18H7.6	n/a	chrIV 590,772	contains similarity to Interpro domain IPR000817 (Prion protein)
24	C18D1.2	C18D1.2	n/a	chrII 10,057,912	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR008075 (Lipocalin-1 receptor), IPR016196 (MFS general substrate transporter)
25	F30B5.7	F30B5.7	n/a	chrIV 4,230,520	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
26	Y113G7B.24	Y113G7B.24	n/a	chrV 20,231,897	contains similarity to Pfam domain PF05916 Synthetic lethal mutants of dpb11-1 five contains similarity to Interpro domain IPR008591 (GINS complex, Sld5 component)
27	str-66	Y73C8C.5	n/a	chrV 3,103,680	C. elegans STR-66 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
28	C26F1.6	C26F1.6	n/a	chrV 7,772,218	C26F1.6 encodes a homolog of the functionally active Fmrf Receptor (FR; CG2114) of D. melanogaster; it is thus possible that C26F1.6 is a receptor for one of the FMRF-like neurotransmitters in C. elegans (e.g., FLP-1 through FLP-12).
29	R04A9.1	R04A9.1	n/a	chrX 405,128
30	nhr-39	F44A2.4	n/a	chrV 9,303,947	C. elegans NHR-39 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
31	nhr-167	C49F5.4	n/a	chrX 11,981,020	C. elegans NHR-167 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
32	sng-1	T08A9.3	n/a	chrX 7,328,590	sng-1 encodes the C. elegans synaptogyrin ortholog, a vertebrate integral membrane synaptic vesicle protein; loss-of-function mutations in sng-1 result in no obvious defects in synaptogenesis or neuronal activity, suggesting that SNG-1 is likely required for more subtle neuronal functions; SNG-1::GFP reporters are expressed throughout the nervous system in neurons in the dorsal and ventral nerve cords, as well as the anterior nerve ring; SNG-1 colocalizes with the synaptic vesicle component SNT-1.
33	dyf-5	M04C9.5	n/a	chrI 9,360,991	dyf-5 encodes a putative MAP kinase orthologous to human MAK/ICK (OMIM:154235), Chlamydomonas reinhardtii LF4, and Leishmania mexicana MPK9; DYF-5 negatively regulates cilial length, restricts KAP-1 to middle ciliary segments, is required for normal localization of six IFT components, and is required for OSM-3 to comigrate normally with IFT particles; DYF-5 is also required for dye-filling of amphid and phasmid neurons and for normal chemotaxis, dauer formation, and male mating; DYF-5 is expressed in head neurons (including amphid neurons), tail neurons (including phasmid neurons), CAN cells, excretory canal neurons, posterior lateral ganglion neurons and in many male tail cells; dyf-5 mutant cilia are abnormally elongated, either failing to enter the amphid channel or accumulating IFT proteins at their distal ends, whereas DYF-5 overexpression results in truncated cilia; the dyf-5 promoter region contains an X-box, predicted to be bound and transcriptionally activated by DAF-19, and dyf-5 is regulated by DAF-19 in vivo; dyf-5 animals are slightly shorter than normal.
34	R05G6.1	R05G6.1	n/a	chrIV 7,539,920
35	asic-2	T28F4.2	n/a	chrI 7,481,759	C. elegans ASIC-2 protein; contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domains IPR001873 (Na+ channel, amiloride-sensitive), IPR004726 (Degenerin)
36	T07D10.1	T07D10.1	n/a	chrI 12,604,999	contains similarity to Strongylocentrotus purpuratus Katanin p80 subunit.; TR:O61585
37	rab-14	K09A9.2	n/a	chrX 15,605,871	rab-14 encodes a member of the Rab GTPase family.
38	set-11	F34D6.4	n/a	chrII 2,692,391	set-11 encodes a putative histone H3 lysine-9 methyltransferase orthologous to human EHMT1 (OMIM:607001, mutated in 9q subtelomeric deletion syndrome) and EHMT2 (OMIM:604599); neither set-11(n4488) nor set-11(RNAi) have any obvious phenotypes.
39	C03H5.7	C03H5.7	n/a	chrII 381,414	contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR001958 (Tetracycline resistance protein, TetA)
40	srd-36	R04D3.6	n/a	chrX 13,294,014	C. elegans SRD-36 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
41	sir-2.3	F46G10.3	n/a	chrX 13,332,774	C. elegans SIR-2.3 protein; contains similarity to Pfam domain PF02146 Sir2 family contains similarity to Interpro domain IPR003000 (NAD-dependent histone deacetylase, silent information regulator Sir2)
42	nkat-1	F28H6.3	n/a	chrX 14,139,007	nkat-1 encodes kynurenine aminotransferase III, an ortholog of mammalian KAT3; nkat-1(RNAi) animals have no obvious phenotype.
43	C35E7.4	C35E7.4	n/a	chrI 10,833,345
44	C15B12.3	C15B12.3	n/a	chrX 6,467,380
45	ZC155.2	ZC155.2	n/a	chrIII 5,219,635	contains similarity to Interpro domains IPR000164 (Histone H3), IPR009072 (Histone-fold)
46	ZC84.4	ZC84.4	n/a	chrIII 9,211,781	ZC84.4 encodes a G protein-coupled receptor with acidic amino acids in the -3 position of its PDZ binding motif; ZC84.4 protein binds PDZ domain 10 of the multi-PDZ domain protein, MPZ-1, in GST pulldown experiments; by analogy with SER-1, the PDZ binding motif of ZC84.4 may enhance its signalling.
47	srh-79	C04F2.1	n/a	chrV 7,498,378	C. elegans SRH-79 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR003002 (7TM chemoreceptor, subfamily 1)
48	F29A7.3	F29A7.3	n/a	chrII 2,753,579	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domain IPR006583 (CW)
49	M163.1	M163.1	n/a	chrX 14,503,087	contains similarity to Mus musculus Adapter-related protein complex 3 beta 1 subunit (Beta-adaptin 3A)s(AP-3 complex beta-3A subunit) (Beta-3A-adaptin).; SW:A3B1_MOUSE
50	srx-45	K01B6.2	n/a	chrIII 9,305,269	C. elegans SRX-45 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)