UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F32E10.2	F32E10.2	7e-113	chrIV 7,576,735	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like)
2	H25K10.5	H25K10.5	n/a	chrIV 16,231,750	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domains IPR001940 (Peptidase S1C, HrtA/DegP2/Q/S), IPR000494 (EGF receptor, L domain)
3	hil-6	F59A7.4	n/a	chrV 2,031,066	C. elegans HIL-6 protein; contains similarity to Pfam domain PF00538 linker histone H1 and H5 family contains similarity to Interpro domains IPR003993 (Treacher Collins syndrome, treacle), IPR011991 (Winged helix repressor DNA-binding), IPR005819 (Histone H5), IPR003882 (Pistil-specific extensin-like protein), IPR005818 (Histone H1/H5), IPR003216 (Linker histone, N-terminal)
4	B0285.4	B0285.4	n/a	chrIII 4,344,312	contains similarity to Pfam domain PF04072 Leucine carboxyl methyltransferase contains similarity to Interpro domains IPR016651 (Leucine carboxyl methyltransferase, LCTM1 1), IPR007213 (Leucine carboxyl methyltransferase)
5	F47G3.3	F47G3.3	n/a	chrX 2,377,319
6	C18E3.2	C18E3.2	n/a	chrI 4,211,756	The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division.
7	his-38	K03A1.6	n/a	chrX 7,309,668	his-38 encodes an H4 histone; by homology, HIS-38 is predicted to function as a nucleosome component required for packaging of DNA into chromatin; his-38 is a replication-dependent histone locus that does not reside in a cluster, but exists as a single histone locus on the X chromosome.
8	gut-2	T10G3.6	n/a	chrV 13,498,242	gut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability.
9	F31F6.1	F31F6.1	n/a	chrX 14,867,621	F31F6.1 encodes a novel protein that is conserved in C. elegans; three other genes related to F31F6.1 are present in tandem on the X chromosome.
10	sup-17	DY3.7	n/a	chrI 8,795,117	sup-17 encodes an ADAM protein, an integral membrane disintegrin and zinc-activated metalloproteinase, orthologous to Drosophila and mouse KUZBANIAN and the vertebrate ADAM10 proteins; SUP-17 is required maternally for embryonic development and plays a role in LIN-12/Notch-mediated cell signaling required for several cell fate decisions during vulval development; SUP-17 is also required for normal body morphology and male tail development; SUP-17 functions cell autonomously to facilitate LIN-12 signaling and requires the LIN-12 extracellular domain to do so.
11	snr-6	Y49E10.15	n/a	chrIII 12,429,334	snr-6 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein E, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-6 activity is essential for embryogenesis and is required for several aspects of germ cell specification including cell division patterns, localization and subcellular distribution of P granules, maintenance of transcriptional quiescence, and expression of the germ lineage-specific proteins PIE-1, GLD-1, and NOS-2; snr-6 is also required for wild-type levels of fertility; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins suggests that SNR-6 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors.
12	T13H5.5	T13H5.5	n/a	chrII 8,526,169	contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
13	dhs-21	R11D1.11	n/a	chrV 12,732,679	dhs-21 encodes a member of the short-chain dehydrogenases/reductases family (SDR) expressed in the intestine, hypodermis, uterus, and spermatheca.
14	F09E5.11	F09E5.11	n/a	chrII 5,357,780	F09E5.11 encodes a divergent ortholog of S. cerevisiae VPH2/VMA12; like VPH2, F09E5.11 may be required for vacuolar proton-translocating ATPase (V-ATPase) assembly in the endoplasmic reticulum.
15	ZK632.12	ZK632.12	n/a	chrIII 9,831,513	ZK632.12 encodes one of 12 C. elegans FYVE-domain containing proteins and is orthologous to mammalian Phafin2; as loss of ZK632.12 activity via RNAi screens results in no obvious defects, the precise role of ZK632.12 in C. elegans development and/or behavior is not yet known.
16	F08B4.5	F08B4.5	n/a	chrIV 8,684,532	contains similarity to Pfam domain PF04042 DNA polymerase alpha/epsilon subunit B contains similarity to Interpro domains IPR016266 (DNA polymerase epsilon, subunit B), IPR007185 (DNA polymerase alpha/epsilon, subunit B)
17	ergo-1	R09A1.1	n/a	chrV 1,013,580	C. elegans ERGO-1 protein; contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
18	C47G2.4	C47G2.4	n/a	chrII 11,292,129	contains similarity to Pfam domain PF04791 LMBR1-like membrane protein contains similarity to Interpro domain IPR006876 (LMBR1-like conserved region)
19	mcm-5	R10E4.4	n/a	chrIII 4,289,788	C. elegans MCM-5 protein; contains similarity to Pfam domain PF00493 MCM2/3/5 family contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold), IPR008048 (MCM protein 5), IPR003593 (AAA+ ATPase, core), IPR001208 (MCM)
20	sdz-30	T04D3.2	n/a	chrI 13,307,433	C. elegans SDZ-30 protein; contains similarity to Interpro domain IPR002048 (Calcium-binding EF-hand)
21	cup-4	C02C2.3	n/a	chrIII 7,867,528	The primary phenotype of cup-4 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes.
22	F59E12.11	F59E12.11	n/a	chrII 5,648,707	contains similarity to Homo sapiens Isoform 1 of Loss of heterozygosity 12 chromosomal region 1 protein; ENSEMBL:ENSP00000321546
23	R05G6.4	R05G6.4	n/a	chrIV 7,513,829	contains similarity to Interpro domains IPR003613 (U box), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR016818 (Nitric oxide synthase-interacting)
24	cpf-2	F56A8.6	n/a	chrIII 13,267,824	C. elegans CPF-2 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR012677 (Nucleotide-binding, alpha-beta plait), IPR003954 (RNA recognition, region 1), IPR000504 (RNA recognition motif, RNP-1)
25	F33D11.10	F33D11.10	n/a	chrI 5,867,449	contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR000629 (RNA helicase, ATP-dependent, DEAD-box, conserved site), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR014014 (RNA helicase, DEAD-box type, Q motif), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
26	ZK1010.3	ZK1010.3	n/a	chrIII 12,979,542	contains similarity to Pfam domain PF06229 FRG1-like family contains similarity to Interpro domains IPR010414 (FRG1-like), IPR008999 (Actin-crosslinking proteins)
27	R13A5.7	R13A5.7	n/a	chrIII 7,568,723
28	T13F2.2	T13F2.2	n/a	chrIV 9,797,072	contains similarity to Pfam domain PF02229 Transcriptional Coactivator p15 (PC4) contains similarity to Interpro domains IPR003173 (Transcriptional coactivator p15), IPR009044 (ssDNA-binding transcriptional regulator)
29	R160.3	R160.3	n/a	chrX 4,365,909
30	smo-1	K12C11.2	n/a	chrI 1,340,894	C. elegans SMO-1 protein; contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
31	F22B5.6	F22B5.6	n/a	chrII 8,455,504
32	gop-2	C34E10.2	n/a	chrIII 5,259,723	gop-2 encodes a member of the conserved hypothetical ATP binding protein family that affects embryonic viability, growth, and fertility.
33	fzr-1	ZK1307.6	n/a	chrII 9,642,652	fzr-1 encodes a WD repeat-containing protein homologous to Cdh1/Hct1/FZR (OMIM:603619), a regulatory subunit of the anaphase-promoting complex/cyclosome (APC/C) required for anaphase initiation and exit from mitosis; FZR-1 is required for fertility, and also functions redundantly with lin-35/Rb to for normal embryogensis and control of postembryonic cell proliferation; FZR-1 probably regulates the levels of G1 cyclins, degradation of which is critical for G1 arrest.
34	ubc-18	R01H2.6	n/a	chrIII 7,068,071	ubc-18 encodes an E2 ubiquitin-conjugating enzyme related to human UBCH7 (OMIM:603731); UBC-18 activity is required for normal growth and reproduction, and UBC-18 functions redundantly with LIN-35/Rb and other class B synthetic multivulval (SynMuv) gene products to regulate pharyngeal morphogenesis during embryonic development; ubc-18 transcripts are detected in the germline, embryos, late larval stages, and adults, suggesting that UBC-18 may function maternally to regulate several aspects of C. elegans development; the substrates of UBC-18 are not yet known.
35	dpl-1	T23G7.1	n/a	chrII 9,171,156	dpl-1 encodes the C. elegans ortholog of mammalian DP, the E2F-heterodimerization partner; dpl-1 is a class B synMuv gene whose activity is required for oogenesis as well as embryonic asymmetry and vulval development; in addition, dpl-1 acts with a subset of class B synMuv genes and the MCD-1 zinc-finger protein to promote the killing process during programmed cell death; DPL-1 is a nuclear protein that is widely expressed throughout development in both somatic and germ cell lineages.
36	srh-128	Y47G7B.1	n/a	chrII 2,704,344	C. elegans SRH-128 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
37	sna-1	W02F12.6	n/a	chrV 6,710,071	sna-1 encodes an snRNP-binding protein (SNA-1/SL21p) orthologous to Ascaris SL30p (SL 30kd) and Brugia 13258.m00169, and paralogous to Brugia 14704.m00455; SNA-1 is found in the Sm snRNP SL1, but not in SL2; in snRNP SL1, SNA-1 associates with the SNA-2/SL75p protein, while being replaced by SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-1(RNAi) animals, like sut-1(bk79) mutants, have cold-sensitive sterility, whereas sna-1(RNAi) combined with sut-1(bk79) is synthetically lethal; double sna-1(RNAi) sut-1(RNAi) is lethal; these RNAi data indicate that SNA-1 and SUT-1 are partially redundant, and suggest that snRNP Y (like snRNP SL1) may participate in trans-splicing; SNA-1 can bind SNA-2 even in the absence of RNA.
38	atg-10	D2085.2	n/a	chrII 8,659,384	C. elegans ATG-10 protein; contains similarity to Pfam domain PF03987 Autophagocytosis associated protein, C-terminal domain contains similarity to Interpro domain IPR007135 (Autophagocytosis associated protein, C-terminal)
39	R07E5.3	R07E5.3	n/a	chrIII 4,405,506	The R07E5.3 gene encodes a homolog of SNF5/Ini1, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; R07E5.3 may be involved in asymmetric cell division of the T cells.
40	ncbp-2	F26A3.2	n/a	chrI 7,642,924	ncbp-2 encodes the C. elegans ortholog of the CBP20 subunit of the nuclear cap binding complex; by homology, NCBP-2 is predicted to play a role in mRNA decay; loss of ncbp-2 activity via RNAi indicates that this gene is essential for embryonic and larval development and in addition, plays a role in reproduction and vulval morphogenesis; staining of C. elegans embryos with an antibody to human CBP20 suggests that NCBP-2 localizes predominantly to the nuclear envelope.
41	F31C3.3	F31C3.3	n/a	chrI 15,045,790	contains similarity to Interpro domain IPR001000 (Glycoside hydrolase, family 10)
42	bub-3	Y54G9A.6	n/a	chrII 13,727,744	C. elegans BUB-3 protein; contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
43	lsm-4	F32A5.7	n/a	chrII 7,252,636	C. elegans LSM-4 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core)
44	pfd-4	B0035.4	n/a	chrIV 11,315,430	pfd-4 encodes a putative prefoldin subunit 4, orthologous to human PFDN4 (OMIM:604898), that is dispensable for viability; PFD-4 is redundant for prefoldin function in C. elegans; pfd-4(gk403) mutants and pfd-4(RNAi) animals, unlike animals undergoing RNAi against most prefoldin subunits, have no obvious phenotypes.
45	tag-203	K02F2.3	n/a	chrI 6,824,603	C. elegans TAG-203 protein; contains similarity to Pfam domain PF03178 CPSF A subunit region contains similarity to Interpro domains IPR004871 (Cleavage and polyadenylation specificity factor, A subunit, C-terminal), IPR011046 (WD40 repeat-like), IPR015943 (WD40/YVTN repeat-like)
46	ZK512.1	ZK512.1	n/a	chrIII 9,116,087	contains similarity to Interpro domain IPR007110 (Immunoglobulin-like)
47	aos-1	C08B6.9	n/a	chrV 10,128,881	aos-1 encodes the C. elegans ortholog of Saccharomyces cerevisiae Aos1p and human SUMO-1 activating enzyme E1 N subunit; by homology, AOS-1 is predicted to form, with a catalytic subunit, UBA-2, a heterodimeric enzyme that activates the ubiquitin-like protein SMO-1/SUMO in preparation for its covalent attachment to target proteins to regulate their subcellular localization and/or stability; in C. elegans, AOS-1 is required for embryonic and larval development, as well as for proper Hox gene regulation; uba-2/aos-1(RNAi) animals that survive embryogenesis show ectopic expression of EGL-5 and ectopic anterior sensory ray formation.
48	unc-71	Y37D8A.13	n/a	chrIII 12,886,268	unc-71 encodes an ADAM, a disintegrin and metalloprotease-containing transmembrane protein that is a member of the metzincin superfamily of proteases; UNC-71 is required non-cell autonomously for motor axon guidance and sex myoblast migration; UNC-71 does not appear to have an active metalloprotease domain, but functions with UNC-6/netrin and integrins INA-1/PAT-3 to provide guidance cues during axonal migration; UNC-71 is expressed in a restricted pattern in the excretory and excretory gland cells, some head neurons, the sphincter muscles, and hypodermal cells surrounding the vulva.
49	fzy-1	ZK177.6	n/a	chrII 5,502,742	fzy-1 encodes an ortholog of S. cerevisiae Cdc20p that is required for the metaphase-to-anaphase transition, the deposition of extra meiotic chromosomes to polar bodies, and postembryonic vulval development; on the basis of orthology, FZY-1 is predicted to regulate anaphase-promoting complex (APC); FZY-1 protein is found in early embryonic cells at prometaphase and metaphase of mitosis and meiosis I, being localized to condensed chromosomes in prometaphase, and chromosomes on the metaphase plate during metaphase; FZY-1 binds IFY-1 and MDF-2 in yeast two-hybrid experiments; the missense fzy-1(h1983) mutation suppresses the lethal phenotype of mdf-1; fzy-1(RNAi) animals have vulval defects reflecting those seen in homozygotes for mat-3(ku233), whereas mat-3(ku233) is partly suppressed by RNAi of the fzy-1 paralog fzr-1.
50	gfl-1	M04B2.3	n/a	chrIV 11,521,685	gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.