UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F32A11.1	F32A11.1	5e-168	chrII 13,158,777	contains similarity to Interpro domains IPR016071 (Staphylococcal nuclease (SNase-like), OB-fold), IPR006021 (Staphylococcal nuclease (SNase-like))
2	dhp-2	C47E12.8	n/a	chrIV 9,979,451	The dhp-2 gene encodes an ortholog of the human gene DIHYDROPYRIMIDINASE (DPYS), which when mutated leads to dihydropyrimidinuria (OMIM:222748).
3	T20D4.6	T20D4.6	n/a	chrV 3,411,676	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR014752 (Arrestin, C-terminal), IPR011021 (Arrestin-like, N-terminal)
4	glr-4	C06A8.9	n/a	chrII 7,789,680	glr-4 encodes a putative non-NMDA ionotropic glutamate receptor subunit, most closely related to GLR-3 and less so to GLR-7, possibly of the kainate subfamily; glr-4 is expressed in various sensory neurons and interneurons from embyrogenesis onward; glr-4 expression requires UNC-42, as well as CFI-1 in URA cells.
5	H10E21.1	H10E21.1	n/a	chrIII 16,729
6	F58E2.4	F58E2.4	n/a	chrIV 3,465,102	contains similarity to Pfam domains PF01827 (FTH domain) (2), PF00646 (F-box domain) contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
7	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
8	tag-51	K02F3.1	n/a	chrIII 855,363	C. elegans TAG-51 protein ;
9	F35G12.12	F35G12.12	n/a	chrIII 4,582,734	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
10	srv-31	T13A10.9	n/a	chrIV 6,270,882	C. elegans SRV-31 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR001209 (Ribosomal protein S14), IPR002651 (Protein of unknown function DUF32)
11	T28F3.9	T28F3.9	n/a	chrIV 17,310,065	contains similarity to Pfam domain PF02485 Core-2/I-Branching enzyme contains similarity to Interpro domain IPR003406 (Glycosyl transferase, family 14)
12	F38A1.8	F38A1.8	n/a	chrIV 1,236,362	contains similarity to Pfam domains PF00448 (SRP54-type protein, GTPase domain) , PF02881 (SRP54-type protein, helical bundle domain) , PF04086 (Signal recognition particle, alpha subunit, N-terminal) contains similarity to Interpro domains IPR007222 (Signal recognition particle receptor, alpha subunit, N-terminal), IPR000897 (Signal recognition particle, SRP54 subunit, GTPase), IPR011012 (Longin-like), IPR013822 (Signal recognition particle, SRP54 subunit, helical bundle), IPR003593 (AAA+ ATPase, core)
13	F20D6.11	F20D6.11	n/a	chrV 8,197,919	F20D6.11 encodes a putative flavin-adenine dinucleotide (FAD)-binding oxidoreductase orthologous to human AIFM3 (AIFL), and paralogous to WAH-1 and mammalian PDCD8 (AIF; OMIM:300169, mutated in Harlequin mice); F20D6.11 is expressed in pharynx, anal depressor and body wall muscles, the reproductive system (including spermatheca), and unidentified tail cells; given its orthology to AIFM3, F20D6.11 may promote apoptosis; however, F20D6.11 has no obvious function in mass RNAi assays.
14	cif-1	K08F11.3	n/a	chrIV 4,708,690	C. elegans CIF-1 protein; contains similarity to Pfam domain PF01399 PCI domain contains similarity to Interpro domain IPR000717 (Proteasome component region PCI)
15	sre-12	T07H8.7	n/a	chrV 6,978,417	C. elegans SRE-12 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domains IPR004151 (C. elegans Sre G protein-coupled chemoreceptor), IPR001680 (WD40 repeat)
16	F53F1.3	F53F1.3	n/a	chrV 13,409,019	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
17	C42C1.7	C42C1.7	n/a	chrIV 12,297,231	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
18	gpr-2	C38C10.4	n/a	chrIII 9,392,118	gpr-2 encodes a protein containing a GPR (G Protein Regulator)/GoLoco motif characteristic of guanine nucleotide exchange factors specific for G-alpha GTPases; GPR-2 appears to function redundantly during early embryogenesis and germ-line development to regulate chromosome and spindle movements during cell division; GPR-2 likely acts as a positive regulator of G protein signaling and specifically, may regulate GOA-1 signaling in the embryo; GPR-2 forms a protein complex with the nearly identical GPR-1 and with LIN-5, a coiled-coil protein that is required for proper localization of GPR-2 to the cell cortex and spindle asters of the early embryo; in addition, proper GPR-2/GPR-1/LIN-5 localization between the P2 and EMS blastomeres at the four-cell stage, which may contribute to spindle positioning in EMS, requires the MES-1/SRC-1 tyrosine kinase signaling pathway; GPR-2 is believed to act downstream of, or in parallel to, PAR-3, a PDZ domain-containing protein, in mitotic spindle positioning in the early embryo.
19	T19H12.3	T19H12.3	n/a	chrV 4,886,241	contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
20	M02D8.1	M02D8.1	n/a	chrX 8,765,033	contains similarity to Pfam domain PF07679 Immunoglobulin I-set domain contains similarity to Interpro domains IPR003598 (Immunoglobulin subtype 2), IPR013098 (Immunoglobulin I-set), IPR013783 (Immunoglobulin-like fold), IPR007110 (Immunoglobulin-like), IPR003599 (Immunoglobulin subtype)
21	R09D1.7	R09D1.7	n/a	chrII 9,455,937	contains similarity to Pfam domain PF00704 Glycosyl hydrolases family 18 contains similarity to Interpro domains IPR011583 (Chitinase II), IPR017853 (Glycoside hydrolase, catalytic core), IPR001223 (Glycoside hydrolase, family 18, catalytic domain), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001574 (Ribosome-inactivating protein)
22	srw-58	H24D24.2	n/a	chrV 15,947,853	C. elegans SRW-58 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
23	figl-1	F32D1.1	n/a	chrV 4,343,730	F32D1.1 encodes an homolog of human SPASTIN (OMIM:604277, mutated in spastic paraplegia), FIDGETIN (OMIM:605295, mutated in fidget mice), and FIDGETIN-LIKE-1, and of Drosophila SPASTIN; recombinant F32D1.1 protein has N-ethylmaleimide-sensitive ATPase activity in vitro, which is strongly dependent on the C368 residue immediately C-terminal to its Walker A motif; F32D1.1 is required for persistence of the germline in RNAi assays.
24	lig-4	C07H6.1	n/a	chrIII 7,523,062	lig-4 encodes an ortholog of DNA ligase IV in budding yeast (DNL4) and human (LIG4; OMIM:601837, mutated in LIG4 syndrome); LIG-4 is required for resistance to ionizing radiation (IR) in somatic tissues (such as motor neurons, vulva, or uterus) and in endoreduplicating intestinal cells, but not in the germline (e.g., in dog-1-induced lesions); LIG-4 is required for non-homologous end-joining of double-stranded breaks (DSB) in somatic genomic DNA; although LIG-4 is not strongly required in the germline, it is active on DSB of DNA injected into syncytial gonads, and its absence enhances the hypersensitivity of rad-51(RNAi) germlines to ionizing radiation; in meiotic cells deprived of homologous DNA repair by a rad-51(Ig08701) mutation, both LIG-4 and BRC-2 can promote chromosomal aggregation (presumably by repairing meiotic double-stranded breaks in DNA), but they do so independently; mutant lig-4 late-stage embryos or dauer larvae are hypersensitive to radiation-induced DNA damage in somatic cells; after irradiation, lig-4 mutants tend to display various postembryonic phenotypes (such as slow growth, uncoordinated locomotion, impaired egg-laying, or vulval defects) that are thought to reflect missegregation of fragmented chromosomes; LIG-4 is N-terminally acetylated on a serine residue.
25	C34H4.1	C34H4.1	n/a	chrIV 1,556,565	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
26	F48F5.2	F48F5.2	n/a	chrV 20,441,470	contains similarity to Homo sapiens Intestinal mucin; TR:O43420
27	C09B8.3	C09B8.3	n/a	chrX 6,009,216
28	E01G6.1	E01G6.1	n/a	chrX 12,263,633	contains similarity to Pfam domains PF00027 (Cyclic nucleotide-binding domain) (2), PF01734 (Patatin-like phospholipase) contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR002641 (Patatin), IPR000595 (Cyclic nucleotide-binding), IPR001423 (Lysophospholipase patatin, conserved site), IPR014710 (RmlC-like jelly roll fold)
29	T25F10.1	T25F10.1	n/a	chrV 6,768,591
30	K01A11.3	K01A11.3	n/a	chrIII 3,450,547	contains similarity to Pfam domain PF00443 (Ubiquitin carboxyl-terminal hydrolases family 2)
31	ubc-20	F40G9.3	n/a	chrIII 189,890	C. elegans UBC-20 protein; contains similarity to Pfam domain PF00179 Ubiquitin-conjugating enzyme contains similarity to Interpro domains IPR000608 (Ubiquitin-conjugating enzyme, E2), IPR009060 (UBA-like), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR015940 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)
32	gst-6	F11G11.3	n/a	chrII 4,880,483	gst-6 encodes a predicted glutathione S-transferase.
33	C49C3.10	C49C3.10	n/a	chrIV 17,337,847	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR000215 (Protease inhibitor I4, serpin), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
34	F22G12.3	F22G12.3	n/a	chrI 13,153,129	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
35	H34I24.1	H34I24.1	n/a	chrIII 2,847,797
36	B0238.1	B0238.1	n/a	chrV 5,241,934	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
37	gcy-1	AH6.1	n/a	chrII 9,514,635	gcy-1 is predicted to encode a guanylate cyclase; however, transcriptional fusions of the putative upstream regulatory region with a GFP reporter did not confirm its expression.
38	F16H6.10	F16H6.10	n/a	chrV 18,223,587	contains similarity to Haemophilus influenzae Putative protease HI0419 (EC 3.4.-.-).; SW:YEGQ_HAEIN
39	ZK593.1	ZK593.1	n/a	chrIV 10,911,466	contains similarity to Pfam domains PF02887 (Pyruvate kinase, alpha/beta domain) , PF00224 (Pyruvate kinase, barrel domain) contains similarity to Interpro domains IPR015806 (Pyruvate kinase, beta-barrel), IPR015794 (Pyruvate kinase, alpha/beta), IPR015795 (Pyruvate kinase, C-terminal-like), IPR015813 (Pyruvate/Phosphoenolpyruvate kinase, catalytic core), IPR001697 (Pyruvate kinase), IPR015793 (Pyruvate kinase, barrel)
40	VT23B5.2	VT23B5.2	n/a	chrIV 12,671,338	VT23B5.2 encodes a BEACH-WD40 domain-containing protein that is orthologous to human WDFY3 (WD repeat and FYVE domain containing 3); loss of VT23B5.2 activity via mutation or large-scale RNAi screens in a wild-type background results in no obvious abnormalities.
41	C44B9.1	C44B9.1	n/a	chrIII 10,871,842	contains similarity to Interpro domains IPR008162 (Inorganic pyrophosphatase), IPR001220 (Legume lectin, beta domain)
42	gop-1	C34E10.3	n/a	chrIII 5,256,655	C. elegans GOP-1 protein; contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
43	F21H12.6	F21H12.6	n/a	chrII 6,095,139	F21H12.6 encodes the C. elegans tripeptidyl peptidase II ortholog; loss of F21H12.6 activity via RNAi indicates that the product of F21H12.6 promotes fat formation; an F21H12.6::GFP reporter fusion is expressed in the intestine, the site of fat storage, and in a subset of nerve ring neurons.
44	C12D12.5	C12D12.5	n/a	chrX 3,505,953	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
45	C18G1.6	C18G1.6	n/a	chrV 4,752,187	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
46	cyp-25A2	C36A4.2	n/a	chrIII 3,836,163	C. elegans CYP-25A2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
47	C04C3.3	C04C3.3	n/a	chrIV 3,401,683	contains similarity to Pfam domains PF02780 (Transketolase, C-terminal domain) , PF02779 (Transketolase, pyrimidine binding domain) contains similarity to Interpro domains IPR005476 (Transketolase, C-terminal), IPR005475 (Transketolase, central region), IPR015941 (Transketolase C-terminal-like)
48	mab-10	R166.1	n/a	chrII 10,532,058	C. elegans MAB-10 protein; contains similarity to Pfam domains PF04905 (NAB conserved region 2 (NCD2)) , PF04904 (NAB conserved region 1 (NCD1)) contains similarity to Interpro domains IPR010993 (Sterile alpha motif homology), IPR006988 (Nab, N-terminal), IPR006989 (Nab, central region)
49	T10E10.4	T10E10.4	n/a	chrX 6,318,637	T10E10.4 encodes a large (966-residue) protein, predicted to be secreted, with two N-terminal chitin-binding peritrophin-A domains followed by 14 cysteine-rich domains and one C-terminal EB module; the general organization of T10E10.4 protein resembles that of K04H4.2; T10E10.4 has no obvious function in mass RNAi assays but, like CEJ-1 and CPG-2, might participate in chitin synthesis.
50	pqn-53	R07B7.3	n/a	chrV 12,064,393	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).