UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rps-23	F28D1.7	1e-80	chrIV 12,390,663	rps-23 encodes a small ribosomal subunit S23 protein; by homology, RPS-23 is predicted to function in protein biosynthesis; in C. elegans, RPS-23 activity is required for germline development, vulval morphogenesis, and the overall health of the animal.
2	rpl-20	E04A4.8	n/a	chrIV 4,749,465	rpl-20 encodes a large ribosomal subunit L18a protein.
3	sfxn-1.5	T04F8.1	n/a	chrX 11,660,570	C. elegans SFXN-1.5 protein; contains similarity to Pfam domain PF03820 Tricarboxylate carrier contains similarity to Interpro domain IPR004686 (Tricarboxylate/iron carrier)
4	Y54G11A.7	Y54G11A.7	n/a	chrII 14,298,367	contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site), IPR000023 (Phosphofructokinase)
5	tsfm-1	F55C5.5	n/a	chrV 12,270,895	F55C5.5 encodes a translational elongation factor Ts (EF-Ts) that binds two different EF-Tu proteins (EF-TU1/Y71H2AM.23 and EF-TU2/C43E11.4) in vitro, stimulating guanine-nucleotide exchange and mRNA translation; F55C5.5 is predicted to be mitochondrial and has a putative N-terminal transit peptide sequence; F55C5.5 is required in mass RNAi assays for normally rapid growth and for maintenance of the germline.
6	rps-25	K02B2.5	n/a	chrIV 5,947,351	rps-25 encodes a small ribosomal subunit S25 protein.
7	abcf-1	F18E2.2	n/a	chrV 12,762,189	C. elegans ABCF-1 protein; contains similarity to Pfam domain PF00005 ABC transporter contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR003593 (AAA+ ATPase, core)
8	rpl-37	C54C6.1	n/a	chrIII 3,528,763	rpl-37 encodes a large ribosomal subunit L37 protein.
9	rpl-6	R151.3	n/a	chrIII 7,209,034	rpl-6 encodes a large ribosomal subunit L6 protein.
10	tag-314	F15H10.4	n/a	chrV 10,427,635	C. elegans TAG-314 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR002867 (Zinc finger, C6HC-type)
11	rpl-36	F37C12.4	n/a	chrIII 7,180,363	rpl-36 encodes a large ribosomal subunit L36 protein; by homology, RPL-36 is predicted to function in protein biosynthesis; in C. elegans, RPL-36 activity is required for embryonic and germline development and normal postembryonic growth rates.
12	hlh-15	C43H6.8	n/a	chrX 2,413,123	C. elegans HLH-15 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
13	pas-2	D1054.2	n/a	chrV 10,770,774	pas-2 encodes a proteasome subunit with highest similarity to vertebrate proteasome alpha 2 subunits.
14	rpl-30	Y106G6H.3	n/a	chrI 10,436,561	rpl-30 encodes a large ribosomal subunit L30 protein; by homology, RPL-30 is predicted to function in protein biosynthesis; in C. elegans, loss of rpl-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
15	fshr-1	C50H2.1	n/a	chrV 9,892,316	fshr-1 encodes a putative neuropeptide receptor required for normal acetylcholine secretion by synapses; FSHR-1 is orthologous to human follicle-stimulating hormone receptor (OMIM:136435; mutated in ovarian dysgenesis), thyrotropin receptor (OMIM:603372; mutated in hyperthyroidism), and luteinizing hormone receptor (OMIM:152790, mutated in precocious puberty); fshr-1 mutants have abnormally many GFP::SNB-1 puncta at synapses, suggesting exocytotic defects; the requirement for FSHR-1 and ten other predicted neuropeptide signalling proteins in cholinergic neurotransmission indicates that such signalling is important for regulating acetylcholine release at neuromuscular junctions; possible ligands of FSHR-1 are FLP-1 and NLP-12.
16	F44D12.9	F44D12.9	n/a	chrIV 10,020,215	contains similarity to Pfam domain PF01733 Nucleoside transporter contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR002259 (Delayed-early response protein/equilibrative nucleoside transporter), IPR016196 (MFS general substrate transporter)
17	nst-1	K01C8.9	n/a	chrII 8,281,963	nst-1 encodes a homolog of human GNL3 (OMIM:608011, nucleostemin) and GNL3L, and of S. cerevisiae NUG1; NST-1 may suppress tumorous growth in the germline; like PRO-1, -2, and -3, NST-1 is probably required for ribosome biogenesis, suggesting a link between biogenesis in the distal sheath and control of cell division in the germline; nucleostemin is a nucleolar protein found in stem cells that is required in quantitatively correct amounts (neither too little nor too much) for continued cell division and survival by stem cells or transformed cells; NST-1 is required in mass RNAi assays for normally rapid growth, larval viability, and normal body morphology and pigmentation.
18	R11D1.9	R11D1.9	n/a	chrV 12,729,002	contains similarity to Pfam domain PF05046 Mitochondrial large subunit ribosomal protein (Img2) contains similarity to Interpro domain IPR007740 (Ribosomal protein L49/IMG2)
19	F54H12.6	F54H12.6	n/a	chrIII 7,972,813	contains similarity to Pfam domain PF00736 EF-1 guanine nucleotide exchange domain contains similarity to Interpro domains IPR014038 (Translation elongation factor EF1B, beta and delta chains, guanine nucleotide exchange), IPR001326 (Translation elongation factor EF1B, beta/delta chains, conserved site), IPR014717 (Translation elongation factor EF1B/ribosomal protein S6), IPR010987 (Glutathione S-transferase, C-terminal-like)
20	B0281.3	B0281.3	n/a	chrII 2,307,697	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR003058 (Cloacin), IPR001841 (Zinc finger, RING-type), IPR000315 (Zinc finger, B-box), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
21	rps-1	F56F3.5	n/a	chrIII 4,476,370	rps-1 encodes a small ribosomal subunit S3A protein.
22	pcp-1	ZK112.1	n/a	chrIII 7,759,923	C. elegans PCP-1 protein; contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domain IPR008758 (Peptidase S28)
23	K08C7.1	K08C7.1	n/a	chrIV 10,658,786	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
24	K10D11.6	K10D11.6	n/a	chrIV 12,988,061	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
25	D2096.8	D2096.8	n/a	chrIV 8,378,494	D2096.8 encodes a protein related in sequence to the conserved NAP (Nucleosome Assembly Protein) family of proteins involved in chromatin remodeling; loss of D2096.8 activity in wild-type and various mutant backgrounds suggests that in C. elegans the product of D2096.8 is required for proper transcriptional regulation that affects a number of biological processes including embryonic and larval development, body morphology, locomotion, and vulval formation.
26	B0280.9	B0280.9	n/a	chrIII 7,121,829	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR001680 (WD40 repeat), IPR011046 (WD40 repeat-like), IPR015943 (WD40/YVTN repeat-like)
27	B0205.6	B0205.6	n/a	chrI 10,738,293	contains similarity to Pfam domains PF01212 (Beta-eliminating lyase) , PF00266 (Aminotransferase class-V) contains similarity to Interpro domains IPR001597 (Aromatic amino acid beta-eliminating lyase/threonine aldolase), IPR015424 (Pyridoxal phosphate-dependent transferase, major region), IPR000192 (Aminotransferase, class V/Cysteine desulphurase), IPR016454 (Cysteine desulphurase, NifS), IPR015422 (Pyridoxal phosphate-dependent transferase, major region, subdomain 2), IPR015421 (Pyridoxal phosphate-dependent transferase, major region, subdomain 1)
28	skr-3	F44G3.6	n/a	chrV 16,122,209	The skr-3 gene encodes a homolog of Skp1 in S. cerevisiae that has no known function in vivo, since skr-3(RNAi) animals are at least superficially normal.
29	Y48A6B.7	Y48A6B.7	n/a	chrIII 11,025,784	contains similarity to Pfam domain PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region contains similarity to Interpro domains IPR002125 (CMP/dCMP deaminase, zinc-binding), IPR016193 (Cytidine deaminase-like)
30	F25E5.1	F25E5.1	n/a	chrV 7,468,526	contains similarity to Interpro domain IPR009091 (Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)
31	K05F1.10	K05F1.10	n/a	chrII 5,805,057	K05F1.10 encodes a putative secreted TIL-domain protease inhibitor paralogous to SWM-1, ISL-1, and the products of 11 other C. elegans genes; K05F1.10 and its relatives are collectively similar to other TIL-domain protease inhibitors from nematodes, insects, and vertebrates; although it has no obvious function in mass RNAi assays, K05F1.10 transcription is reproducibly induced by infection, suggesting that it may participate in innate immunity.
32	F43E2.9	F43E2.9	n/a	chrII 7,359,080
33	C44C8.4	C44C8.4	n/a	chrIV 891,926	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
34	E02A10.1	E02A10.1	n/a	chrV 12,564,567	contains similarity to Pfam domains PF00333 (Ribosomal protein S5, N-terminal domain) , PF03719 (Ribosomal protein S5, C-terminal domain) contains similarity to Interpro domains IPR014720 (Double-stranded RNA-binding-like), IPR013810 (Ribosomal protein S5, N-terminal), IPR005324 (Ribosomal protein S5, C-terminal), IPR000851 (Ribosomal protein S5), IPR014721 (Ribosomal protein S5 domain 2-type fold)
35	scpl-4	T21C9.12	n/a	chrV 10,600,600	scpl-4 encodes an ortholog of budding yeast TIM50 and human TIMM50 (OMIM:607381); by orthology, SCPL-4 is expected to be part of the mitochondrial inner membrane protein translocase; SCPL-4 is required for embryonic development and fertility in mass RNAi assays; SCPL-4 is distantly similar to FCP-1 and SCPL-1, -2, and -3.
36	drs-2	F10C2.6	n/a	chrV 12,050,440	drs-2 encodes a putative aspartyl-tRNA synthetase.
37	C44C8.3	C44C8.3	n/a	chrIV 896,078	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
38	asg-2	C53B7.4	n/a	chrX 6,841,624	asg-2 encodes a homolog of subunit G of the membrane-bound F0 proton channel portion of ATP synthase (mitochondrial respiratory chain [MRC] complex V); asg-2 activity is required for growth at a normally high rate and for normal osmoregulation; in addition, asg-2 activity is required for response to hermaphrodite contact, the first step in a series of stereotypical male mating behaviors; an ASG-2::GFP fusion localizes to mitochondria and to cilia of the male-specific CEM neurons.
39	pcp-2	F23B2.12	n/a	chrIV 9,162,862	C. elegans PCP-2 protein; contains similarity to Pfam domain PF05577 Serine carboxypeptidase S28 contains similarity to Interpro domains IPR008758 (Peptidase S28), IPR000258 (Bacterial ice-nucleation proteins octamer repeat)
40	F42A10.5	F42A10.5	n/a	chrIII 6,172,231	contains similarity to Interpro domain IPR003072 (Orphan nuclear receptor, NOR1 type)
41	lys-10	F17E9.11	n/a	chrIV 8,333,154	C. elegans LYS-10 protein; contains similarity to Interpro domains IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site)
42	R12E2.12	R12E2.12	n/a	chrI 4,174,271	contains similarity to Interpro domain IPR000529 (Ribosomal protein S6)
43	ZK328.6	ZK328.6	n/a	chrIII 6,029,645	contains similarity to Pfam domains PF02818 (PPAK motif) , PF00646 (F-box domain) contains similarity to Interpro domain IPR001810 (Cyclin-like F-box)
44	ubh-4	C08B11.7	n/a	chrII 8,038,864	C. elegans UBH-4 protein; contains similarity to Pfam domain PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 contains similarity to Interpro domains IPR001578 (Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1), IPR017390 (Ubiquitinyl hydrolase, UCH37 type)
45	C36E8.1	C36E8.1	n/a	chrIII 4,001,753	contains similarity to Pfam domain PF05327 RNA polymerase I specific transcription initiation factor RRN3 contains similarity to Interpro domain IPR007991 (RNA polymerase I specific transcription initiation factor RRN3)
46	R02F2.7	R02F2.7	n/a	chrIII 5,482,043
47	rps-30	C26F1.4	n/a	chrV 7,776,842	rps-30 encodes two proteins, a small ribosomal subunit S30 protein and ubiquitin, which is cleaved from the ribosomal protein posttranslationally; by homology, S30 is predicted to function in protein biosynthesis and ubiquitin in protein degradation; in C. elegans, loss of rps-30 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
48	ddb-1	M18.5	n/a	chrIV 12,117,957	M18.5 is orthologous to the human gene DAMAGE-SPECIFIC DNA BINDING PROTEIN 1 (127KD) (DDB1; OMIM:600045), which when mutated leads to disease.
49	cyp-35B1	K07C6.4	n/a	chrV 3,940,140	C. elegans CYP-35B1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
50	H34I24.1	H34I24.1	n/a	chrIII 2,847,797