UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tam-1	F26G5.9	0	chrV 4,960,832	tam-1 encodes a broadly expressed nuclear protein with RING finger, B-box, and glutamine/asparagine-rich domains that promotes signalling in the class B synthetic-multivulva gene pathway (which includes the lin-35/RB gene), and also promotes the activity of genes in multicopy transgenic arrays; the normal role of TAM-1's class B activity is presumably to inhibit RAS pathway activity in vulval development, while TAM-1's effect on transgenes may be through changes in the acetylation state of histones in chromatin.
2	fhod-2	F56E10.2	n/a	chrV 67,785	fhod-2 encodes an ortholog of Drosophila DAAM and human DAAM1 (OMIM:606626); FHOD-2 enables Wnt-directed planar cell polarity; FHOD-2 is required for the fully asymmetrical division of B.a versus B.p cells, though this requirement is quantitatively weak.
3	T21D12.7	T21D12.7	n/a	chrIV 290,077	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR013090 (Phospholipase A2, active site), IPR006150 (Cysteine-rich repeat)
4	ace-4	Y48B6A.7	n/a	chrII 14,201,652	ace-4 encodes an divergent acetylcholinesterase homolog with biochemically undetectable activity.
5	T22C8.3	T22C8.3	n/a	chrII 8,621,191	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
6	lact-7	C40H5.4	n/a	chrX 11,762,779	lact-7 encodes a beta-lactamase domain-containing protein.
7	T05A10.4	T05A10.4	n/a	chrX 10,791,361	contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR001343 (Haemolysin-type calcium-binding region), IPR002413 (Ves allergen), IPR001283 (Allergen V5/Tpx-1 related)
8	hum-6	T10H10.1	n/a	chrX 2,309,009	hum-6 is orthologous to the human gene MYOSIN VIIA (MYO7A; OMIM:276903), which when mutated leads to Usher syndrome type IB.
9	Y106G6H.4	Y106G6H.4	n/a	chrI 10,437,301	contains similarity to Interpro domain IPR006578 (MADF)
10	F40E3.2	F40E3.2	n/a	chrI 2,643,222
11	E04F6.2	E04F6.2	n/a	chrII 7,200,583	contains similarity to Drosophila pseudoobscura GA13509-PA (Fragment).; TR:Q28YG6
12	nhr-182	F41B5.9	n/a	chrV 2,258,611	C. elegans NHR-182 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
13	T21B4.3	T21B4.3	n/a	chrII 12,495,897	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
14	unc-50	T07A5.2	n/a	chrIII 10,316,260	unc-50 encodes an integral membrane protein orthologous to the Saccharomyces cerevisiae Golgi component Gmh1p; UNC-50 is required for regulating subtype-specific nicotinic receptor trafficking to the cell surface and thus, for normal synaptic transmission at the neuromuscular junction; UNC-50 is ubiquitously expressed from early embryogenesis to adulthood and localizes to the Golgi.
15	F18A11.3	F18A11.3	n/a	chrII 13,036,522	contains similarity to Candida albicans Multidrug resistance protein CDR2.; SW:CDR2_CANAL
16	F31F7.2	F31F7.2	n/a	chrV 6,272,906	contains similarity to Pfam domain PF00092 von Willebrand factor type A domain contains similarity to Interpro domain IPR002035 (von Willebrand factor, type A)
17	F39C12.1	F39C12.1	n/a	chrX 4,843,950	contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000694 (Proline-rich region), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
18	W02C12.1	W02C12.1	n/a	chrIV 4,011,101	contains similarity to Pfam domains PF00008 (EGF-like domain) (10), PF07699 (GCC2 and GCC3) (4), PF07974 (EGF-like domain) (5), PF02494 (HYR domain) contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR013320 (Concanavalin A-like lectin/glucanase, subgroup), IPR003410 (Hyalin), IPR001791 (Laminin G), IPR001759 (Pentaxin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR011641 (GCC2 and GCC3), IPR006150 (Cysteine-rich repeat), IPR001881 (EGF-like calcium-binding), IPR013032 (EGF-like region, conserved site), IPR013111 (EGF, extracellular), IPR008985 (Concanavalin A-like lectin/glucanase), IPR003645 (Follistatin-like, N-terminal)
19	fbxb-114	C30E1.5	n/a	chrX 16,922,274	C. elegans FBXB-114 protein; contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
20	osm-10	T20H4.1	n/a	chrIII 7,244,451	osm-10 encodes a novel protein conserved amongst several Caenorhabditis species; osm-10 activity is required for normal osmosensory signaling in the ASH sensory neuron; in regulating ASH-mediated osmosensation, osm-10 interacts genetically with eos-1 and eos-2; OSM-10 is expressed in the ASH, ASI, PHA, and PHB sensory neurons beginning just prior to hatching and continuing through larval and adult stages; OSM-10 localizes to cell bodies, sensory processes, and axons.
21	C08G9.2	C08G9.2	n/a	chrIV 7,668,512	contains similarity to Pfam domains PF02822 (Antistasin family) (6), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) , PF00095 (WAP-type (Whey Acidic Protein) 'four-disulfide core') (8), PF00086 (Thyroglobulin type-1 repeat) (6)contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR008197 (Whey acidic protein, 4-disulphide core), IPR008198 (Proteinase inhibitor I17), IPR006150 (Cysteine-rich repeat), IPR013032 (EGF-like region, conserved site), IPR004094 (Proteinase inhibitor I15, antistasin), IPR015874 (4-disulphide core), IPR007087 (Zinc finger, C2H2-type), IPR003645 (Follistatin-like, N-terminal), IPR000737 (Proteinase inhibitor I7, squash)
22	fbxa-220	Y66A7A.1	n/a	chrIII 11,483,373	C. elegans FBXA-220 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
23	F54C4.3	F54C4.3	n/a	chrIII 78,455	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domains IPR000637 (HMG-I and HMG-Y, DNA-binding), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
24	F46F11.7	F46F11.7	n/a	chrI 5,621,853	contains similarity to Interpro domain IPR011061 (Proteinase inhibitor I14/I15, hirudin/antistatin)
25	ZK1086.2	ZK1086.2	n/a	chrX 13,792,979	contains similarity to Shewanella oneidensis Hypothetical protein.; TR:Q8EJA6
26	F54F3.3	F54F3.3	n/a	chrV 12,920,812	contains similarity to Pfam domains PF04083 (ab-hydrolase associated lipase region) , PF00561 (alpha/beta hydrolase fold) contains similarity to Interpro domains IPR006693 (AB-hydrolase associated lipase region), IPR000073 (Alpha/beta hydrolase fold-1), IPR008262 (Lipase, active site)
27	unc-130	C47G2.2	n/a	chrII 11,282,880	A member of the forkhead domain family of transcription factors that affects the generation of the AWA and ASG chemosensory neurons and is partially required for male tail morphogenesis and embryogenesis; it is expressed in the AWA and ASG precursors; it is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor.
28	tza-2	K03E6.4	n/a	chrX 1,067,909	C. elegans TZA-2 protein; contains similarity to Pfam domain PF07162 B9 protein contains similarity to Interpro domain IPR010796 (B9)
29	C01A2.2	C01A2.2	n/a	chrI 13,397,863	contains similarity to Streptomyces coelicolor Putative sugar transporter integral membrane protein.; TR:Q9K489
30	ZC15.3	ZC15.3	n/a	chrV 20,299,636	contains similarity to Homo sapiens Myosin heavy chain, smooth muscle isoform; ENSEMBL:ENSP00000300036
31	ceh-34	C10G8.6	n/a	chrV 5,317,530	ceh-34 encodes a homeodomain protein, homologous to human SIX2 (OMIM:604994), that is expressed very weakly in the pharynxes of late embryos and early larvae; it has no known function.
32	F23A7.5	F23A7.5	n/a	chrX 16,233,076	contains similarity to Homo sapiens Isoform 3 of Cyclin-L1; VG:OTTHUMP00000173336
33	crb-1	F11C7.4	n/a	chrX 17,408,117	crb-1 encodes a homolog of Drosophila CRUMBS that affects dauer formation and feeding behavior; CRB-1 can bind cyclic AMP-response element (CRE) sites and be phosphorylated by PKA in vitro, and is expressed immediately apical to the zonula adherens in embryos and then ubiquitously later during development and in adults; CRB-1 is homologous to human CRB1 (OMIM:604210, mutated in retinitis pigmentosa 12 or Leber congenital amaurosis).
34	F25H9.2	F25H9.2	n/a	chrV 13,458,772	contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
35	unc-122	F11C3.2	n/a	chrI 14,873,757	unc-122 encodes a predicted type II transmembrane protein with extracellular collagen-like domains and a highly conserved olfactomedin (OLF) domain that is found in a family of secreted proteins involved in formation and function of nervous systems; UNC-122 is required for proper locomotion and for normal morphology of the DVB motorneuron, and may regulate neuromuscular function by acting in an aminergic/peptidergic pathway parallel to cholinergic neurotransmission; although mosaic analysis indicates that UNC-122 activity is required in muscle cells, the precise expression and localization patterns of UNC-122 are not yet known.
36	K11E4.3	K11E4.3	n/a	chrX 13,721,488	The K11E4.3 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease.
37	F58F6.5	F58F6.5	n/a	chrIV 1,343,974	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domain IPR006874 (Protein of unknown function DUF621)
38	Y56A3A.5	Y56A3A.5	n/a	chrIII 11,889,625	contains similarity to Pfam domain PF01425 Amidase contains similarity to Interpro domains IPR000120 (Amidase signature enzyme), IPR000504 (RNA recognition motif, RNP-1)
39	cyld-1	F40F12.5	n/a	chrIII 9,904,526	F40F12.5 encodes an ortholog of human CYLD1 (OMIM:605018, mutated in cylindromatosis); CYLD1 binds several members of the NF-kappaB signalling pathway, and can deubiquitinate target proteins.
40	F57G12.2	F57G12.2	n/a	chrX 12,158,178	contains similarity to Mus musculus Nuclear protein ZAP3.; SW:ZAP3_MOUSE
41	tag-224	B0496.8	n/a	chrIV 7,450,248	tag-224 encodes an ortholog of Drosophila CG6522-PA and of human LMCD1 and TESTIN; TAG-224 is dispensable for Wnt-directed planar cell polarity and the fully asymmetrical division of B.a versus B.p cells.
42	unc-97	F14D12.2	n/a	chrX 5,593,799	The unc-97 gene encodes a LIM domain-containing protein of the PINCH family that is highly similar to human LIMS1 (OMIM:602567) and LIMS2; UNC-97 functions as an adaptor protein important for assembly of muscle adherens junctions and the mechanosensory functions of the touch neurons; UNC-97 interacts with PAT-4/integrin-linked kinase and with UNC-98; UNC-97 colocalizes with PAT-3/beta integrin at dense bodies, focal adhesion-like muscle attachment structures.
43	C30A5.6	C30A5.6	n/a	chrIII 8,206,270
44	R07D5.2	R07D5.2	n/a	chrX 15,113,200	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR008979 (Galactose-binding like)
45	C29F9.1	C29F9.1	n/a	chrIII 133,396
46	K08C9.7	K08C9.7	n/a	chrI 11,495,873	contains similarity to Homo sapiens ubiquitin and ribosomal protein S27a precursor; ENSEMBL:ENSP00000272317
47	K02E10.6	K02E10.6	n/a	chrX 2,481,834	contains similarity to Pfam domain PF01705 CX module contains similarity to Interpro domain IPR002619 (Protein of unknown function CX)
48	F59C6.8	F59C6.8	n/a	chrI 10,511,155	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
49	cyp-25A5	F42A6.4	n/a	chrIV 3,328,559	C. elegans CYP-25A5 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
50	F59E10.3	F59E10.3	n/a	chrII 10,873,252	F59E10.3 encodes a zeta subunit of the coatomer (COPI) complex; in mass RNAi assays, F59E10.3 is required for embryonic, larval, and adult viability, for fertility, and for normal osmoregulation.