UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	rpb-8	F26F4.11	8e-83	chrIII 4,917,583	C. elegans RPB-8 protein; contains similarity to Pfam domain PF03870 RNA polymerase Rpb8 contains similarity to Interpro domains IPR005570 (RNA polymerase, Rpb8), IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold)
2	tag-267	W06E11.2	n/a	chrIII 641,164	C. elegans TAG-267 protein ;
3	T25E12.6	T25E12.6	n/a	chrV 16,743,622	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
4	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
5	gst-7	F11G11.2	n/a	chrII 4,882,703	gst-7 encodes a predicted glutathione S-transferase.
6	snr-6	Y49E10.15	n/a	chrIII 12,429,334	snr-6 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein E, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-6 activity is essential for embryogenesis and is required for several aspects of germ cell specification including cell division patterns, localization and subcellular distribution of P granules, maintenance of transcriptional quiescence, and expression of the germ lineage-specific proteins PIE-1, GLD-1, and NOS-2; snr-6 is also required for wild-type levels of fertility; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins suggests that SNR-6 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors.
7	C18D11.3	C18D11.3	n/a	chrIII 11,823,825	contains similarity to Homo sapiens Transcription factor MLL UPN95022; TR:Q86YN8
8	K07F5.14	K07F5.14	n/a	chrIV 9,863,121	contains similarity to Danio rerio Novel protein.; TR:Q1LV47
9	F29A7.6	F29A7.6	n/a	chrII 2,752,187	contains similarity to Mus musculus M-phase phosphoprotein 6.; SW:Q9D1Q1
10	F10E9.4	F10E9.4	n/a	chrIII 8,309,032	contains similarity to Homo sapiens 14 kDa protein; VG:OTTHUMP00000024648
11	ZK265.6	ZK265.6	n/a	chrI 8,255,792	contains similarity to Tetraodon nigroviridis UPF0384 protein CGI-117 homolog.; SW:Q4SQ06
12	gfl-1	M04B2.3	n/a	chrIV 11,521,685	gfl-1 encodes an ortholog of human GLIOMA-AMPLIFIED SEQUENCE-41 (GAS41; OMIM:602116, found in increased copy number in low-grade glioma); loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism; GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
13	K08D10.1	K08D10.1	n/a	chrIV 4,182,875	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
14	B0035.11	B0035.11	n/a	chrIV 11,328,468	contains similarity to Pfam domain PF04004 Leo1-like protein contains similarity to Interpro domain IPR007149 (Leo1-like protein)
15	ZK1236.5	ZK1236.5	n/a	chrIII 8,431,825	ZK1236.5 encodes a protein with no obvious non-nematode homologs; either ZK1236.9, or ZK1236.5, or both proteins weakly inhibit DHC-1 in vivo; likewise, either ZK1236.5, or ZK1236.9, or both proteins are required in mass RNAi assays for normal osmoregulation and normally rapid growth.
16	div-1	R01H10.1	n/a	chrIII 10,246,876	div-1 encodes a homolog of the B subunit of the DNA polymerase alpha-primase complex; DIV-1 is required in embryos for the normal timing of interphase in cell divisions, and for the asymmetric distribution of PIE-1 and P granules.
17	F44E7.9	F44E7.9	n/a	chrV 5,791,637	contains similarity to Pfam domain PF07019 Rab5-interacting protein (Rab5ip) contains similarity to Interpro domain IPR010742 (Rab5-interacting)
18	C15H11.8	C15H11.8	n/a	chrV 14,423,017	contains similarity to Pfam domain PF01096 Transcription factor S-II (TFIIS) contains similarity to Interpro domain IPR001222 (Zinc finger, TFIIS-type)
19	ZK686.2	ZK686.2	n/a	chrIII 7,764,804	ZK686.2 encodes a DEAD-box helicase; loss of ZK686.2 activity via RNAi indicates that ZK686.2 activity is required for positive regulation of growth rate and larval development.
20	hmg-4	T20B12.8	n/a	chrIII 7,380,295	hmg-4 encodes a protein with strong similarity to the highly conserved high mobility group protein SSRP1 (structure-specific DNA recognition protein); by homology, HMG-4 is predicted to be a member of the FACT (facilitates chromatin transcription) complex that functions as a transcription elongation factor; RNAi experiments indicate that hmg-4 is required for locomotion and larval development, and required redundantly with hmg-3, its paralog, for embryonic development.
21	C46E10.4	C46E10.4	n/a	chrII 3,718,412
22	C18E3.2	C18E3.2	n/a	chrI 4,211,756	The C18E3.2 gene encodes a homolog of Swp73/BAF60, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; C18E3.2 is probably required during mitosis of the T cells for asymmetric cell division.
23	F11A10.2	F11A10.2	n/a	chrIV 12,084,859	contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR000690 (Zinc finger, C2H2-type matrin)
24	K08F11.2	K08F11.2	n/a	chrIV 4,718,190	contains similarity to Pfam domain PF06918 Protein of unknown function (DUF1280) contains similarity to Interpro domain IPR009689 (Protein of unknown function DUF1280)
25	W06A11.4	W06A11.4	n/a	chrII 4,056,790
26	H01G02.1	H01G02.1	n/a	chrIV 11,803,772
27	ubl-5	F46F11.4	n/a	chrI 5,608,335	This gene encodes an ortholog of the human ubiquitin-like gene UBL5, which is a distinct cytoplasmic paralog of nuclear ubiquitin or ubiquitin-like proteins; ubl-5 shares an operon with vha-10, and thus might be a previously undescribed V-ATPase component or ancillary protein.
28	T07A9.1	T07A9.1	n/a	chrIV 384,318	contains similarity to Homo sapiens Protein; VG:OTTHUMP00000025811
29	C45G9.5	C45G9.5	n/a	chrIII 5,049,097
30	C25A1.4	C25A1.4	n/a	chrI 10,171,209	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
31	pfd-1	C08F8.1	n/a	chrIV 11,150,492	pfd-1 encodes a putative prefoldin subunit 1, orthologous to human PFDN1 (OMIM:604897), that is required for normal microtubule nucleation and growth, embryonic viability, distal tip cell (DTC) migration, and locomotion; PFD-1 is expressed cytoplasmically in most, if not all, tissues; pfd-1(RNAi) animals have sterile progeny and are uncoordinated, and pfd-1(RNAi) embryos show a reduced microtubule growth rate; pfd-1(gk526) or escaper pfd-1(RNAi) hermaphrodites exhibit detective DTC migration.
32	F37F2.2	F37F2.2	n/a	chrI 1,442,805	contains similarity to Pfam domain PF01922 SRP19 protein contains similarity to Interpro domain IPR002778 (Signal recognition particle, SRP19 subunit)
33	ncbp-2	F26A3.2	n/a	chrI 7,642,924	ncbp-2 encodes the C. elegans ortholog of the CBP20 subunit of the nuclear cap binding complex; by homology, NCBP-2 is predicted to play a role in mRNA decay; loss of ncbp-2 activity via RNAi indicates that this gene is essential for embryonic and larval development and in addition, plays a role in reproduction and vulval morphogenesis; staining of C. elegans embryos with an antibody to human CBP20 suggests that NCBP-2 localizes predominantly to the nuclear envelope.
34	ZK795.3	ZK795.3	n/a	chrIV 12,559,996	contains similarity to Pfam domain PF04427 Brix domain contains similarity to Interpro domain IPR007109 (Brix)
35	F10G8.6	F10G8.6	n/a	chrI 10,047,224	F10G8.6 encodes an homolog of S. cerevisiae CFD1 (also known as YIL003W/DRE3), a putative P-loop ATPase conserved in eukaryotes and required in yeast for 4Fe-4S cluster assembly; F10G8.6 is also homologous to yeast NBP35/YGL091C; in C. elegans, F10G8.6 is required for normally rapid growth and maintenance of the germline; F10G8.6 protein was predicted to be mitochondrial on the basis of its phylogenetic profile.
36	T28D6.6	T28D6.6	n/a	chrIII 11,334,762	contains similarity to Pfam domains PF01926 (GTPase of unknown function) , PF02824 (TGS domain) contains similarity to Interpro domains IPR005225 (Small GTP-binding protein), IPR002917 (GTP-binding protein, HSR1-related), IPR006073 (GTP1/OBG), IPR004095 (TGS), IPR006074 (GTP1/OBG, conserved site)
37	C30B5.4	C30B5.4	n/a	chrII 6,196,350	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
38	C25G4.3	C25G4.3	n/a	chrIV 12,445,137	contains similarity to Pfam domain PF02033 Ribosome-binding factor A contains similarity to Interpro domains IPR000238 (Ribosome-binding factor A), IPR015946 (K homology-like, alpha/beta)
39	npp-2	T01G9.4	n/a	chrI 8,292,456	npp-2 encodes a protein with low similarity to rat nucleoporin Nup75 that affects embryonic viability and has a variety of other defects in RNAi screens including: nuclear morphology, growth, fertility, locomotion, and egg laying; enriched in oocytes.
40	ZK1127.5	ZK1127.5	n/a	chrII 7,051,269	contains similarity to Pfam domains PF01137 (RNA 3'-terminal phosphate cyclase) , PF05189 (RNA 3'-terminal phosphate cyclase (RTC), insert domain) contains similarity to Interpro domains IPR016443 (RNA 3'-terminal phosphate cyclase-like, eukaryotic), IPR013796 (RNA 3'-terminal phosphate cyclase, insert region), IPR000228 (RNA 3'-terminal phosphate cyclase), IPR013792 (RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)
41	C30C11.1	C30C11.1	n/a	chrIII 8,450,050	contains similarity to Pfam domain PF01783 Ribosomal L32p protein family contains similarity to Interpro domain IPR002677 (Ribosomal protein L32p)
42	T20B12.1	T20B12.1	n/a	chrIII 7,388,607	contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (3), PF00515 (Tetratricopeptide repeat) (4)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR001664 (Intermediate filament protein), IPR008940 (Protein prenyltransferase), IPR001440 (Tetratricopeptide TPR-1), IPR001356 (Homeobox), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
43	W04C9.4	W04C9.4	n/a	chrI 462,326
44	F26E4.12	F26E4.12	n/a	chrI 9,780,834	contains similarity to Pfam domain PF00255 Glutathione peroxidase contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000889 (Glutathione peroxidase)
45	C41H7.6	C41H7.6	n/a	chrII 3,001,613	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
46	F33H2.5	F33H2.5	n/a	chrI 15,009,733	contains similarity to Pfam domains PF00136 (DNA polymerase family B) , PF03104 (DNA polymerase family B, exonuclease domain) , PF08490 (Domain of unknown function (DUF1744)) contains similarity to Interpro domains IPR006055 (Exonuclease), IPR006172 (DNA-directed DNA polymerase, family B), IPR006133 (DNA-directed DNA polymerase, family B, exonuclease), IPR006134 (DNA-directed DNA polymerase, family B, conserved region), IPR013697 (Region of unknown function DUF1744), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
47	ZK1010.3	ZK1010.3	n/a	chrIII 12,979,542	contains similarity to Pfam domain PF06229 FRG1-like family contains similarity to Interpro domains IPR010414 (FRG1-like), IPR008999 (Actin-crosslinking proteins)
48	C05C8.2	C05C8.2	n/a	chrV 7,231,951	contains similarity to Interpro domain IPR004087 (K Homology)
49	tag-170	C05D11.3	n/a	chrIII 6,432,606	C05D11.3/tag-170 encodes a thioredoxin domain-containing protein orthologous to human TXNDC9 and ENSG00000145268; in one-cell embryos, C05D11.3/TAG-170 is required for normal nuclear-centrosome rotation, male pronuclear migration, cytokinesis, and mitotic spindles, and for normally long astral microtubules; in early embryos, C05D11.3/TAG-170 is also required for normally rapid microtubule elongation; C05D11.3/tag-170 is expressed in larval and adult neurons and pharynx, and in vulva, with its strongest transcription in adults; like its mammalian ortholog, C05D11.3/TAG-170 protein is both nuclear and cytoplasmic.
50	C14A4.3	C14A4.3	n/a	chrII 10,586,058	contains similarity to Pfam domain PF03901 Alg9-like mannosyltransferase family contains similarity to Interpro domain IPR005599 (Alg9-like mannosyltransferase)