UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F26F12.2	F26F12.2	3e-136	chrV 5,838,075
2	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
3	Y57G7A.8	Y57G7A.8	n/a	chrII 1,291,464
4	Y49E10.21	Y49E10.21	n/a	chrIII 12,458,332	contains similarity to Nanoarchaeum equitans DNA double-strand break repair rad50 ATPase.; SW:P62135
5	syn-4	T01B11.3	n/a	chrIV 8,458,062	syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
6	grd-10	F09D12.1	n/a	chrIV 3,441,427	grd-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-10 is expressed in seam cells; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-10 is weakly required for normal molting; GRD-10 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
7	F18E9.3	F18E9.3	n/a	chrX 8,588,029	contains similarity to Drosophila melanogaster Flybase gene name is Sgs1-PA;; FLYBASE:CG3047
8	C36F7.2	C36F7.2	n/a	chrI 9,551,413	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
9	srh-36	T03D3.4	n/a	chrV 2,820,623	C. elegans SRH-36 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
10	ZC155.4	ZC155.4	n/a	chrIII 5,213,465	contains similarity to Pfam domain PF03009 Glycerophosphoryl diester phosphodiesterase family contains similarity to Interpro domain IPR004129 (Glycerophosphoryl diester phosphodiesterase)
11	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
12	ZK632.9	ZK632.9	n/a	chrIII 9,825,065	contains similarity to Barley yellow dwarf virus Coat protein.; SW:COAT_BYDVN
13	fbxa-145	F48C1.2	n/a	chrI 5,320,402	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
14	F07G11.2	F07G11.2	n/a	chrV 7,304,229	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
15	tbx-36	ZK829.5	n/a	chrIV 11,951,305	C. elegans TBX-36 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
16	F36H12.2	F36H12.2	n/a	chrIV 5,275,375
17	C46E10.8	C46E10.8	n/a	chrII 3,726,646	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
18	T14G10.7	T14G10.7	n/a	chrIV 10,148,080	contains similarity to Bos taurus GPI transamidase component PIG-S (Phosphatidylinositol-glycansbiosynthesis class S protein).; SW:Q3SZL5
19	fbxa-197	T06C12.4	n/a	chrV 15,868,291	C. elegans FBXA-197 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
20	B0564.2	B0564.2	n/a	chrIV 13,107,893	contains similarity to Pfam domain PF03171 2OG-Fe(II) oxygenase superfamily contains similarity to Interpro domain IPR005123 (2OG-Fe(II) oxygenase)
21	djr-1.1	B0432.2	n/a	chrII 291,212	djr-1.1 encodes an ortholog of DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitors that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2).
22	Y52B11A.8	Y52B11A.8	n/a	chrI 11,033,190	contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR013090 (Phospholipase A2, active site)
23	F56H6.4	F56H6.4	n/a	chrI 12,291,320	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
24	hop-1	C18E3.8	n/a	chrI 4,209,468	hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex.
25	mxl-2	F40G9.11	n/a	chrIII 187,571	C. elegans MXL-2 protein; contains similarity to Pfam domain PF00010 Helix-loop-helix DNA-binding domain contains similarity to Interpro domains IPR001092 (Basic helix-loop-helix dimerisation region bHLH), IPR011598 (Helix-loop-helix DNA-binding)
26	dnj-4	C01G8.4	n/a	chrI 5,283,025	This gene encodes a protein containing a DnaJ ('J') domain.
27	nex-3	C28A5.3	n/a	chrIII 4,443,071	nex-3 encodes an annexin, a member of a family of calcium-dependent phospholipid binding proteins; by homology, NEX-3 could function in a number of processes, such as membrane fusion, cytoskeletal interactions, and intracellular signaling; however, as loss of nex-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of NEX-3 in C. elegans development and/or behavior is not yet known.
28	W01C8.1	W01C8.1	n/a	chrX 5,693,921
29	btb-3	B0047.2	n/a	chrII 2,043,575	C. elegans BTB-3 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ), IPR000210 (BTB/POZ-like)
30	F58E1.7	F58E1.7	n/a	chrII 1,678,353	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
31	str-12	B0391.4	n/a	chrV 15,611,921	C. elegans STR-12 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
32	T14G8.2	T14G8.2	n/a	chrX 12,858,701	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
33	F36F12.2	F36F12.2	n/a	chrV 2,093,433	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domains IPR008167 (Protein of unknown function DUF23, C-terminal), IPR008166 (Protein of unknown function DUF23)
34	C48C5.3	C48C5.3	n/a	chrX 8,959,409	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
35	sqv-3	R10E11.4	n/a	chrIII 9,779,478	sqv-3 encodes a beta(1,4)-galactosyltransferase, biochemically active in vitro, that is required for cytokinesis of one-cell embryos, vulval morphogenesis, and chondroitin synthesis; SQV-3 is orthologous to human human galactosyltransferase I (B4GALT7; OMIM:604327, mutated in the progeroid form of Ehlers-Danlos syndrome); sqv-3 transgenically rescues hamster cells lacking galactosyl transferase I; the common requirement for SQV-3 in both cytokinesis and morphogenesis may be to promote filling an extracellular space with hygroscopic proteoglycans (either in the eggshell, or underneath the L4 cuticle), which in turn may cause the space to fill with fluid.
36	srx-10	R10D12.4	n/a	chrV 13,945,845	C. elegans SRX-10 protein; contains similarity to Pfam domain PF08560 Protein of unknown function (DUF1757) contains similarity to Interpro domain IPR013869 (Protein of unknown function DUF1757)
37	T11F8.2	T11F8.2	n/a	chrIV 5,477,982
38	rab-39	D2013.1	n/a	chrII 9,322,411	rab-39 encodes a small, monomeric Rab GTPase that is most closely related to the human and Drosophila Rab39 GTPases; by homology, RAB-39 is predicted to function as a membrane-associated GTPase required for intracellular vesicular trafficking and for regulation of endo- and exocytosis; however, as loss of rab-39 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of RAB-39 in C. elegans development and/or behavior is not yet known.
39	M4.1	M4.1	n/a	chrIV 3,215,716	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR008984 (SMAD/FHA domain), IPR009053 (Prefoldin), IPR000253 (Forkhead-associated)
40	T25G12.2	T25G12.2	n/a	chrX 17,245,951	The T25G12.2 gene encodes a homolog of the human gene HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030); T25G12.2 protein is predicted to be mitochondrial with 68% accuracy.
41	str-19	T23D5.7	n/a	chrV 15,743,832	C. elegans STR-19 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
42	C44C10.3	C44C10.3	n/a	chrX 11,703,337	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
43	F14D2.8	F14D2.8	n/a	chrII 3,348,717	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
44	kup-1	F10C2.2	n/a	chrV 12,036,541	kup-1 encodes a novel protein that is conserved in C. briggsae, but contains no other known homologs; kup-1 is the upstream gene in an operon with pkc-1, which encodes two protein kinase C isoforms of the nPKC isotype; the polycistronic kup-1/pkc-1 mRNA is detected at low levels in embryos and larvae, but its expression greatly increases in adults; as loss of kup-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of kup-1 in C. elegans development and/or behavior is not yet known.
45	his-46	B0035.9	n/a	chrIV 11,326,144	his-46 encodes an H4 histone.
46	F57C9.7	F57C9.7	n/a	chrI 4,825,902
47	T09B4.2	T09B4.2	n/a	chrI 6,184,694
48	sri-77	D2062.9	n/a	chrII 2,604,314	C. elegans SRI-77 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	srw-137	H27D07.4	n/a	chrV 2,943,264	C. elegans SRW-137 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
50	T01C8.3	T01C8.3	n/a	chrX 16,781,536