UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	sqt-3	F23H12.4	1.9999999999999999e-56	chrV 12,353,631	sqt-3 encodes a cuticle collagen; during development, sqt-3 activity is essential for viability and normal body morphology; genetic and expression studies indicate that SQT-3 is a cuticle component at all stages of development and that SQT-3 likely forms higher order cuticular structures with the DPY-17 cuticular collagen, both of which are candidate substrates for the DPY-31 procollagen C-proteinase.
2	F53B1.4	F53B1.4	n/a	chrX 2,112,426	contains similarity to Pfam domains PF07993 (Male sterility protein) , PF01370 (NAD dependent epimerase/dehydratase family) , PF04321 (RmlD substrate binding domain) , PF01073 (3-beta hydroxysteroid dehydrogenase/isomerase family) , PF02719 (Polysaccharide biosynthesis protein) contains similarity to Interpro domains IPR003869 (Polysaccharide biosynthesis protein CapD), IPR002225 (3-beta hydroxysteroid dehydrogenase/isomerase), IPR005913 (dTDP-4-dehydrorhamnose reductase), IPR001509 (NAD-dependent epimerase/dehydratase), IPR002347 (Glucose/ribitol dehydrogenase), IPR016040 (NAD(P)-binding), IPR013120 (Male sterility, NAD-binding)
3	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	noah-2	F52B11.3	n/a	chrIV 14,093,906	noah-2 encodes a PAN and ZP domain-containing protein that is related to the Drosophila extracellular matrix component NompA (no-mechanoreceptor-potential A); loss of noah-2 function via RNAi indicates that NOAH-2 activity is essential for molting; in addition, NOAH-2 appears to be required for embryonic and larval development, reproduction, coordinated locomotion, and the overall health of the animal.
5	dpy-7	F46C8.6	n/a	chrX 7,537,167	dpy-7 encodes a cuticular collagen; DPY-7 functions as a structural constituent of the extracellular cuticle whose activity is required for normal cuticular morphology and hence, proper body form.
6	dpy-3	EGAP7.1	0.000000002	chrX 2,145,125	dpy-3 encodes a cuticular collagen; along with dpy-2, dpy-7, dpy-8, and dpy-10, dpy-3 is required postembryonically for annular furrow formation and/or maintenance; specifically, DPY-3 activity is required for proper assembly of the DPY-7 collagen into the mature extracellular matrix; during each cuticle synthetic period, dpy-3 mRNA is expressed approximately four hours prior to the secretion of new cuticle.
7	H03E18.1	H03E18.1	n/a	chrX 8,510,941	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN)
8	wrt-1	ZK1290.12	n/a	chrII 7,532,133	C. elegans WRT-1 protein; contains similarity to Pfam domain PF01079 Hint module contains similarity to Interpro domains IPR003586 (Hedgehog/intein hint domain, C-terminal), IPR001657 (Peptidase C46, hedgehog protein), IPR002034 (Alpha-isopropylmalate/homocitrate synthase, conserved site), IPR006141 (Intein splicing site), IPR003587 (Hedgehog/intein hint, N-terminal), IPR001767 (Peptidase C46, hedgehog protein, hint region)
9	Y37A1B.7	Y37A1B.7	n/a	chrIV 14,043,158
10	W08A12.3	W08A12.3	n/a	chrV 3,683,717
11	sym-1	C44H4.3	n/a	chrX 14,582,934	sym-1 encodes a protein containing 15 contiguous leucine-rich repeats (LRRs) that functionally overlaps with sym-5 and interacts with mec-8 with respect to embryonic viability and attachment of body muscle to the extracellular cuticle; expression begins at the time of embryonic elongation and SYM-1 is secreted from the apical hypodermal surface of the embryo
12	K08B12.1	K08B12.1	n/a	chrV 6,260,074	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR008262 (Lipase, active site)
13	pqn-46	F57B9.9	n/a	chrIII 6,943,249	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
14	F09F9.2	F09F9.2	n/a	chrX 4,110,914
15	F15B9.8	F15B9.8	n/a	chrV 12,990,344	contains similarity to Pfam domain PF00090 Thrombospondin type 1 domain contains similarity to Interpro domains IPR008085 (Thrombospondin, subtype 1), IPR000884 (Thrombospondin, type I)
16	lpr-3	W04G3.8	n/a	chrX 11,058,541	W04G3.8 encodes a novel protein, conserved amongst nematodes; large-scale RNAi experiments indicate that W04G3.8 activity is required for normal growth rates, early larval development, and coordinated locomotion.
17	R02F11.1	R02F11.1	n/a	chrV 4,801,848	contains similarity to Interpro domain IPR006150 (Cysteine-rich repeat)
18	F01D5.6	F01D5.6	n/a	chrII 14,007,416	contains similarity to Pfam domain PF04536 Domain of unknown function (DUF477) contains similarity to Interpro domain IPR007621 (Protein of unknown function DUF477)
19	dpy-2	T14B4.6	0.000009	chrII 6,715,073	The dpy-2 gene encodes an unusual cuticular collagen that is required for maintaining the normal body length of the animal in later larval stages; dpy-2 interacts with other cuticular collagens such as dpy-10 and sqt-1, and suppresses mutations in glp-1, mup-1, and emb-5.
20	F40E10.5	F40E10.5	n/a	chrX 14,702,656	contains similarity to Onchocerca volvulus OV39 antigen (Fragment).; SW:P31730
21	mlt-11	W01F3.3	n/a	chrV 20,668,250	C. elegans MLT-11 protein; contains similarity to Pfam domains PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (10), PF00086 (Thyroglobulin type-1 repeat) contains similarity to Interpro domains IPR000716 (Thyroglobulin type-1), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR000694 (Proline-rich region), IPR006150 (Cysteine-rich repeat)
22	grl-15	Y75B8A.20	n/a	chrIII 12,234,051	grl-15 encodes a hedgehog-like protein, with an N-terminal signal sequence, a central proline-rich low-complexity region, and a C-terminal Ground-like (Grl) domain; GRL-15 is expressed in the reproductive system, vulva, and larval hypodermis; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
23	M03B6.3	M03B6.3	n/a	chrX 13,862,714	contains similarity to Interpro domain IPR000694 (Proline-rich region)
24	dpy-18	Y47D3B.10	n/a	chrIII 11,375,393	An alpha subunit of prolyl-4-hydroxylase which is a procollagen modifying enzyme required for exoskeleton formation, morphogenesis and maintenance of body shape; it is expressed throughout the hypodermis and certain head and posterior neurons.
25	T19B10.2	T19B10.2	n/a	chrV 11,222,045
26	F19H8.4	F19H8.4	n/a	chrII 14,619,275	contains similarity to Pfam domain PF04870 Protein of unknown function, DUF644 contains similarity to Interpro domain IPR006954 (Protein of unknown function DUF644)
27	cyn-6	F42G9.2	n/a	chrIII 773,770	cyn-6 encodes a cyclophilin most similar to human secreted cyclophilin type B isoforms that is functional when expressed in E. coli; it is expressed in the intestine.
28	grl-10	C26F1.5	n/a	chrV 7,775,086	grl-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
29	F22F4.1	F22F4.1	n/a	chrX 6,005,723
30	F58H1.2	F58H1.2	n/a	chrV 11,929,524	contains similarity to Lycopersicon esculentum Abscisic acid and environmental stress inducible protein TAS14s(Dehydrin TAS14).; SW:DH14_LYCES
31	wrt-10	ZK1290.8	n/a	chrII 7,533,839	wrt-10 encodes a hedgehog-like protein, with an N-terminal signal sequence, a Wart domain, and a C-terminal region of low-complexity sequence; WRT-10 is expressed in both male and hermaphrodite intestine; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-10 is required for normal growth to full size and locomotion; both of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
32	tfg-1	Y63D3A.5	n/a	chrI 14,103,115	C. elegans TFG-1 protein; contains similarity to Pfam domain PF00564 PB1 domain contains similarity to Interpro domains IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region), IPR000270 (Octicosapeptide/Phox/Bem1p)
33	dpy-8	C31H2.2	n/a	chrX 5,149,633	dpy-8 encodes a collagen with a nematode-specific N-terminal domain that is required for normal body morphology and (perhaps) for a normal embryonic cell division rate; dpy-8 interacts genetically with emb-5 and glp-1.
34	clec-180	F32E10.3	n/a	chrIV 7,571,306	C. elegans CLEC-180 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
35	D1014.5	D1014.5	n/a	chrV 8,125,176	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
36	rol-6	T01B7.7	n/a	chrII 8,733,614	The rol-6 gene encodes a cuticle collagen related to human collagen alpha 1 (III) chain precursor (OMIM:120180), and is required for normal cuticular morphology; ROL-6 interacts with SQT-1, a closely related cuticle collagen, and is expressed at all stages from L2 to adult with transcripts detected at each of the molts preceding these stages.
37	ZC434.3	ZC434.3	n/a	chrI 10,334,634	contains similarity to Interpro domain IPR000931 (Adenovirus fibre protein)
38	R07E3.6	R07E3.6	n/a	chrX 10,319,714	contains similarity to Interpro domain IPR000694 (Proline-rich region)
39	Y47D3B.6	Y47D3B.6	n/a	chrIII 11,427,622	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR000480 (Glutelin), IPR006149 (Nematode-specific EB region)
40	F20G2.3	F20G2.3	n/a	chrV 13,767,197	contains similarity to Pfam domains PF01105 (emp24/gp25L/p24 family/GOLD) , PF00650 (CRAL/TRIO domain) contains similarity to Interpro domains IPR001251 (Cellular retinaldehyde-binding/triple function, C-terminal), IPR011074 (Phosphatidylinositol transfer protein-like, N-terminal), IPR000348 (emp24/gp25L/p24)
41	dpy-13	F30B5.1	2.9999999999999997e-20	chrIV 4,236,154	dpy-13 encodes a member of the collagen superfamily containing 20 copies of the collagen triple helix repeat; transcipt levels oscillate, peaking once during each larval stage.
42	F53F1.5	F53F1.5	n/a	chrV 13,415,573	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001859 (Ribosomal protein P2), IPR013286 (Annexin, type VII)
43	T03G6.1	T03G6.1	n/a	chrX 2,609,102
44	T26C5.2	T26C5.2	n/a	chrII 9,234,631	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN)
45	pfn-3	K03E6.6	n/a	chrX 1,080,056	C. elegans PFN-3 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
46	C15C6.1	C15C6.1	n/a	chrI 12,202,933	contains similarity to Caulobacter crescentus Hypothetical protein CC0499.; TR:Q9AAU5
47	K01A2.5	K01A2.5	n/a	chrII 303,020	contains similarity to Pfam domain PF00561 alpha/beta hydrolase fold contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR003089 (Alpha/beta hydrolase)
48	fasn-1	F32H2.5	n/a	chrI 8,980,067	fasn-1 encodes a putative fatty acid synthase, orthologous to human FASN (OMIM:600212); CEP-1 is required for fully normal fasn-1 expression in vivo; CEP-1 drives transcription of luciferase reporters whose promoters contains either of two putative CEP-1 binding sites (FAS-T1 and FAS-T2) found in the fasn-1 gene, and this activity is partially lost by mutation of conserved CEP-1 residues (R298 or H310); in humans, the CEP-1 ortholog isoforms TAp73alpha and deltaNp63alpha bind the human FASN gene, suggesting that FASN genes might be a conserved direct target of p53-like proteins in metazoa; fasn-1 transcription is moderately activated (2 to 4-fold) in L1 or L2 larvae starved for 12 hours, but is not so activated in later larvae or adults.
49	fkb-3	C05C8.3	n/a	chrV 7,225,808	fkb-3 encodes a peptidylprolyl cis/trans isomerase homologous to mammalian FK506 immunosuppressant-binding protein 9; FKB-3 expression is positively regulated by signaling through the DAF-2 insulin receptor-like pathway and the activity of the DAF-16 fork-head transcription factor suggesting that FKB-3 could play a role in metabolism and longevity; however, as loss of FKB-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of FKB-3 in C. elegans development and/or behavior is not yet known; FKB-3 contains a predicted endoplasmic reticulum (ER) retention sequence and is thus proposed to localize to the ER.
50	tni-1	F42E11.4	n/a	chrX 11,376,606	tni-1 encodes a member of the troponin family that affects body morphology, locomotion, egg laying, and epithelial morphogenesis in a large-scale RNAi analysis.