UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	zyg-9	F22B5.7	0	chrII 8,461,098	zyg-9 encodes a predicted microtubule-association protein (MAP) of the XMAP215 family; during early embryonic development, maternal zyg-9 activity is required for microtubule-dependent processes such as meiotic and mitotic spindle organization and pronuclear migration; further, zyg-9 is essential for formation of long astral microtubules; ZYG-9 is required for centrosomal localization of TAC-1, the sole C. elegans TACC family member, with which it interacts, and mutually stabilizes, in vivo; in early embryos, ZYG-9 localizes to the meiotic spindle and spindle poles, as well as to mitotic centrosomes; during metaphase and anaphase ZYG-9 localizes to the central spindle region, and during interphase ZYG-9 is cytoplasmic; proper localization of ZYG-9 to the meiotic spindle is dependent upon wild-type activity of MEI-1, an ATPase essential for meiotic spindle formation, while proper localization of ZYG-9 to centrosomes is dependent, at least in part, upon TAC-1.
2	sdz-13	F13E9.6	n/a	chrIV 10,878,328	C. elegans SDZ-13 protein ;
3	mtx-1	F39B2.11	n/a	chrI 14,755,776	C. elegans MTX-1 protein; contains similarity to Interpro domains IPR017410 (Metaxin), IPR010987 (Glutathione S-transferase, C-terminal-like)
4	H04M03.1	H04M03.1	n/a	chrIV 5,897,858	contains similarity to Pfam domain PF00821 Phosphoenolpyruvate carboxykinase contains similarity to Interpro domains IPR013035 (Phosphoenolpyruvate carboxykinase, C-terminal), IPR008210 (Phosphoenolpyruvate carboxykinase, N-terminal), IPR008209 (Phosphoenolpyruvate carboxykinase, GTP-utilising)
5	ZK1321.1	ZK1321.1	n/a	chrII 9,754,525	contains similarity to Sulfolobus sp NOB8H2 Hypothetical protein.; TR:O93705
6	Y18D10A.1	Y18D10A.1	n/a	chrI 12,797,263	contains similarity to Pfam domain PF02178 AT hook motif contains similarity to Interpro domains IPR000116 (High mobility group proteins HMG-I and HMG-Y), IPR000637 (HMG-I and HMG-Y, DNA-binding)
7	M18.8	M18.8	n/a	chrIV 12,125,838	contains similarity to Pfam domain PF01529 DHHC zinc finger domain contains similarity to Interpro domains IPR001594 (Zinc finger, DHHC-type), IPR011527 (ABC transporter, transmembrane region, type 1)
8	fbf-2	F21H12.5	n/a	chrII 6,090,134	fbf-2 encodes an RNA-binding protein that is one of 11 C. elegans members of the PUF family (Pumilio and FBF) of translational regulators; FBF-2 is nearly identical to FBF-1 with which it is largely redundant in regulating two aspects of germline development: 1)maintenance of stem cell proliferation, and 2)the hermaphroditic switch between spermatogenesis and oogenesis; in maintaining germline stem cells, the FBF proteins, acting through NOS-3, negatively regulate the activity of gld-1 mRNA, which encodes a translational repressor required for meiotic entry; in regulating the sperm-to-oocyte switch, the FBFs act downstream of GLD-3 to negatively regulate the activity of fem-3 mRNA, which encodes a novel protein required for germline sex determination; consistent with their role in germline development, FBF-1 and FBF-2 are expressed in the germline cytoplasm, becoming enriched in the mitotic region during the L4 larval and adult stages.
9	F59B2.8	F59B2.8	n/a	chrIII 9,008,958	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
10	F21G4.6	F21G4.6	n/a	chrX 9,913,063	F21G4.6 is orthologous to the human gene HUNTINGTIN (HD; OMIM:143100), which when mutated leads to disease.
11	M03C11.3	M03C11.3	n/a	chrIII 10,409,775	contains similarity to Saccharomyces cerevisiae Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; SGD:YKL172W
12	F36A2.13	F36A2.13	n/a	chrI 8,833,497	contains similarity to Pfam domains PF00632 (HECT-domain (ubiquitin-transferase)) , PF02207 (Putative zinc finger in N-recognin (UBR box)) contains similarity to Interpro domains IPR013993 (Zinc finger, N-recognin, metazoa), IPR009091 (Regulator of chromosome condensation/beta-lactamase-inhibitor protein II), IPR000569 (HECT), IPR003126 (Zinc finger, N-recognin), IPR016024 (Armadillo-type fold)
13	ama-1	F36A4.7	n/a	chrIV 4,253,109	ama-1 encodes the large subunit of RNA polymerase II required for mRNA transcription; AMA-1 is essential for proper embryonic development, particularly for the early division and migration of the endodermal precursor (E) cells that initiate gastrulation; AMA-1 is expressed ubiquitously in the developing embryo until the 550-cell stage.
14	F54H12.2	F54H12.2	n/a	chrIII 7,965,139	contains similarity to Interpro domain IPR000358 (Ribonucleotide reductase)
15	set-32	C41G7.4	n/a	chrI 9,520,403	set-32 encodes a divergent histone H3 lysine-9 (H3K9) methyltransferase homolog with a SET domain; SET-32 has no obvious non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-15, SET-19, SET-20, and SET-21); set-32(ok1457) has no obvious mutant phenotype, and SET-32 has no obvious function in mass RNAi assays.
16	C01G6.5	C01G6.5	n/a	chrII 9,277,455	contains similarity to Pfam domain PF00498 FHA domain contains similarity to Interpro domains IPR005819 (Histone H5), IPR008984 (SMAD/FHA domain), IPR001965 (Zinc finger, PHD-type), IPR000253 (Forkhead-associated), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011011 (Zinc finger, FYVE/PHD-type)
17	F08G12.2	F08G12.2	n/a	chrX 11,298,812	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR001632 (G-protein, beta subunit), IPR015943 (WD40/YVTN repeat-like)
18	alh-2	K04F1.15	n/a	chrV 1,646,053	C. elegans ALH-2 protein; contains similarity to Pfam domain PF00171 Aldehyde dehydrogenase family contains similarity to Interpro domains IPR016163 (Aldehyde dehydrogenase, C-terminal), IPR016162 (Aldehyde dehydrogenase, N-terminal), IPR016161 (Aldehyde/histidinol dehydrogenase), IPR015590 (Aldehyde dehydrogenase), IPR016160 (Aldehyde dehydrogenase, conserved site)
19	rle-1	M142.6	n/a	chrIII 10,941,254	C. elegans RLE-1 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
20	lin-23	K10B2.1	n/a	chrII 6,372,870	lin-23 encodes an F-box- and WD-repeat-containing protein orthologous to Saccharomyces cerevisiae MET30 and human beta TRCP (OMIM:603482), both components of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; LIN-23 negatively regulates postembryonic cell divsions in all tissue types, and specifically, has been shown to function cell autonomously in the vulva to negatively regulate cell cycle progression and allow for cell cycle exit; LIN-23 also functions cell autonomously in some neurons to regulate neurite outgrowth; LIN-23 expression is first detected broadly during gastrulation, with expression continuing postembryonically in body wall and enteric muscle, hypodermal cells, and many but not all neurons; LIN-23 localizes to the cytoplasm.
21	F17A9.3	F17A9.3	n/a	chrV 6,106,582	contains similarity to Pfam domain PF07716 Basic region leucine zipper contains similarity to Interpro domains IPR011700 (Basic leucine zipper), IPR004827 (Basic-leucine zipper (bZIP) transcription factor)
22	C07A9.5	C07A9.5	n/a	chrIII 9,682,077	contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
23	R06C7.6	R06C7.6	n/a	chrI 7,246,472	contains similarity to Mus musculus Uncharacterized protein C8orf32 homolog.; SW:Q80WB5
24	T07G12.8	T07G12.8	n/a	chrIV 10,553,796	contains similarity to Thermoplasma volcanium ABC transport system permease protein P1P2A1A2.; TR:Q978R0
25	C03B1.5	C03B1.5	n/a	chrX 6,356,595	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR008266 (Tyrosine protein kinase, active site)
26	srx-42	C06B3.11	n/a	chrV 13,921,696	C. elegans SRX-42 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
27	C06A1.2	C06A1.2	n/a	chrII 10,570,302	contains similarity to Mus musculus Olfactory receptor MOR111-5 (Olfactory receptorsGA_x6K02T2PULF-11116958-11117896).; TR:Q8VFH8
28	aspm-1	C45G3.1	n/a	chrI 9,224,107	The C45G3.1 gene encodes a protein, with one N-terminal calponin-like actin-binding domain and two IQ calmodulin-binding domains, that is likely to be required for spindle structure and function, and (indirectly) for neural function, based on its orthology to Drosophila ABNORMAL SPINDLE and on its joint sterile and uncoordinated RNAi phenotypes; C45G3.1 is also orthologous to human ASPM (OMIM:605481), which when mutated leads to primary microcephaly; C45G3.1 is required for embryonic and larval viability, germline maintenance, vulval morphogenesis, meiosis, and locomotion.
29	sre-27	Y57A10C.3	n/a	chrII 12,416,469	C. elegans SRE-27 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
30	H04D03.1	H04D03.1	n/a	chrIII 10,437,086	contains similarity to Saccharomyces cerevisiae Global transcription activator that acts in complex with Snf2p, Snf5p, Snf6p, and Swi3p to assist gene-specific activators; involved in the regulation of expression of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; SGD:YPL016W
31	ZK632.7	ZK632.7	n/a	chrIII 9,821,105	contains similarity to Interpro domain IPR011009 (Protein kinase-like)
32	pqn-20	C37A2.2	n/a	chrI 6,794,248	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
33	C04F1.1	C04F1.1	n/a	chrI 5,727,848	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
34	T05F1.9	T05F1.9	n/a	chrI 9,646,642	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8ILP3
35	srh-51	C10G11.3	n/a	chrI 6,301,375	C. elegans SRH-51 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
36	sdc-3	C25D7.3	n/a	chrV 15,043,550	sdc-3 encodes a protein that contains two mutationally separable domains: a zinc finger motif required for dosage compensation and a myosin- like putative ATP- binding region required for her-1 regulation of sex determination; SDC-3 activates dosage compensation by directing the dosage compensation protein complex to the hermaphrodite X chromosomes, and is functionally redundant with SDC-2 with respect to dosage compensation; SDC-1, SDC-2, and SDC-3 proteins form a complex.
37	H34I24.2	H34I24.2	n/a	chrIII 2,843,610	contains similarity to Homo sapiens Mucin-7 precursor; ENSEMBL:ENSP00000302021
38	ZC506.1	ZC506.1	n/a	chrX 9,961,782	contains similarity to Pfam domains PF02225 (PA domain) , PF01532 (Glycosyl hydrolase family 47) contains similarity to Interpro domains IPR001382 (Glycoside hydrolase, family 47), IPR003137 (Protease-associated PA)
39	gcy-20	F21H7.9	n/a	chrV 16,251,158	gcy-20 encodes a predicted guanylate cyclase.
40	T14B4.2	T14B4.2	n/a	chrII 6,736,402	contains similarity to Pfam domain PF01084 Ribosomal protein S18 contains similarity to Interpro domain IPR001648 (Ribosomal protein S18)
41	C05C9.3	C05C9.3	n/a	chrX 11,148,023	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
42	F43G6.4	F43G6.4	n/a	chrII 11,793,919	contains similarity to Interpro domain IPR000345 (Cytochrome c heme-binding site)
43	T01D3.5	T01D3.5	n/a	chrV 13,714,119	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
44	srg-47	C53A5.8	n/a	chrV 14,555,611	C. elegans SRG-47 protein; contains similarity to Interpro domains IPR000175 (Sodium:neurotransmitter symporter), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
45	F31A9.4	F31A9.4	n/a	chrX 1,779,978
46	F22E5.11	F22E5.11	n/a	chrII 2,644,695	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
47	mep-1	M04B2.1	n/a	chrIV 11,526,270	mep-1 is required for repression by the fem-3 3' UTR in vivo, and for maintenance of somatic (versus germline) differentiation; MEP-1 protein has zinc-finger domains and a glutamine/asparagine-rich domain.
48	tag-72	C25A1.3	n/a	chrI 10,160,921	C. elegans TAG-72 protein; contains similarity to Pfam domains PF03291 (mRNA capping enzyme) , PF08242 (Methyltransferase domain) , PF08241 (Methyltransferase domain) contains similarity to Interpro domains IPR004971 (mRNA capping enzyme, large subunit), IPR016899 (mRNA (guanine-N(7))-methyltransferase), IPR002296 (N6 adenine-specific DNA methyltransferase, N12 class), IPR013217 (Methyltransferase type 12), IPR013216 (Methyltransferase type 11)
49	C15C8.7	C15C8.7	n/a	chrV 12,744,584	contains similarity to Rhizobium loti Hypothetical protein mll2265.; TR:Q98IT0
50	mig-17	F57B7.4	n/a	chrV 11,447,925	mig-17 encodes a secreted metalloprotease that is a member of the ADAM (A Disintegrin And Metalloprotease) protein family; MIG-17 activity is required for proper migration of gonadal leader cells, namely the hermaphrodite distal tip cells (DTCs) and the male linker cell (MLC); a MIG-17::GFP translational fusion protein is first detected in late embryos with expression continuing through adulthood; expression is initially seen on the pseudocoelomic face of body wall muscles and then on the surface of the gonad, when the DTCs migrate on the lateral hypodermis towards the dorsal muscles; proper MIG-17 localization and glycosylation requires activity of MIG-23, a membrane-bound nucleoside diphosphatase, as well as activity of COGC-3 and COGC-1, two members of the conserved oligomeric Golgi complex; expression studies with MIG-17 deletion derivatives indicate that MIG-17 is expressed by the body wall muscles and then localizes to the DTCs where its activity is sufficient for guiding DTC migration.