UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	srw-67	F18E3.2	0	chrV 7,418,725	C. elegans SRW-67 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	sop-2	C50E10.4	n/a	chrII 12,342,269	sop-2 encodes a SAM domain-containing protein that is related to, but not orthologous with, Polycomb group proteins and ETS transcription factors; during development, SOP-2 activity is required for maintaining a restricted pattern of Hox gene expression, such as that of mab-5 and egl-5, to specific cells and tissues; thus, SOP-2 is required for proper cell fate specification in a variety of cell lineages, including the serotonergic and dopaminergic male tail neurons and the ventral nerve cord; in regulating neurotransmitter phenotype, sop-2 functions together with sor-3, which also encodes a Polycomb group protein, and members of the TGF-beta signaling pathway; sop-2 and sor-3 also function together to regulate progression through larval development; a SOP-2::GFP reporter fusion is expressed in the nuclei of all somatic cells beginning at the 50-cell stage of embryogenesis; SOP-2::GFP expression is initially diffuse, but by the 200-cell stage is visible in distinct nuclear bodies, the size and number of which may correlate with DNA content.
4	ife-4	C05D9.5	n/a	chrX 1,105,125	The ife-4 gene encodes a member of the Initiation Factor 4E (eIF4E) family.
5	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
6	F59D12.2	F59D12.2	n/a	chrX 15,674,207	contains similarity to Homo sapiens Calcium-dependent protease, small subunit; ENSEMBL:ENSP00000246533
7	dgn-2	F56C3.6	n/a	chrX 1,366,491	C. elegans DGN-2 protein ;
8	rhgf-2	T08H4.1	n/a	chrII 4,124,087	C. elegans RHGF-2 protein; contains similarity to Pfam domain PF00621 RhoGEF domain contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001849 (Pleckstrin-like), IPR000694 (Proline-rich region), IPR011993 (Pleckstrin homology-type), IPR015721 (Rho GTP exchange factor)
9	sgn-1	F07H5.2	n/a	chrII 8,782,783	C. elegans SGN-1 protein; contains similarity to Pfam domain PF04790 Sarcoglycan complex subunit protein contains similarity to Interpro domain IPR006875 (Sarcoglycan complex subunit protein)
10	dgn-1	T21B6.1	n/a	chrX 10,922,297	C. elegans DGN-1 protein; contains similarity to Interpro domains IPR015919 (Cadherin-like), IPR013783 (Immunoglobulin-like fold), IPR006644 (Dystroglycan-type cadherin-like), IPR003992 (Pertactin virulence factor, N-terminal)
11	phat-2	C46H11.9	n/a	chrI 5,047,210	C. elegans PHAT-2 protein; contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
12	tag-304	F53E2.1	n/a	chrV 1,469,424	C. elegans TAG-304 protein; contains similarity to Pfam domain PF08513 LisH contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR013720 (LisH dimerisation motif, subgroup), IPR006595 (CTLH, C-terminal to LisH motif)
13	F23C8.6	F23C8.6	n/a	chrI 2,421,287	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
14	D2045.9	D2045.9	n/a	chrIII 10,477,763	contains similarity to Pfam domain PF01755 Glycosyltransferase family 25 (LPS biosynthesis protein) contains similarity to Interpro domains IPR002654 (Glycosyl transferase, family 25), IPR000886 (Endoplasmic reticulum, targeting sequence)
15	ZC250.3	ZC250.3	n/a	chrV 5,796,478	contains similarity to Pfam domain PF04142 Nucleotide-sugar transporter contains similarity to Interpro domains IPR004689 (UDP-galactose transporter), IPR007271 (Nucleotide-sugar transporter)
16	rhgf-1	F13E6.6	n/a	chrX 10,704,787	rhgf-1 encodes an RGS RhoGEF (Regulator of G-protein Signaling Rho Guanine Nucleotide Exchange Factor); RHGF-1 functions within cholingergic motor neurons in one of four G-protein-mediated signaling pathways that control locomotion via regulation of acetylcholine (ACh) release at neuromuscular junctions; in regulating ACh release, RHGF-1 functions downstream of the C. elegans Galpha12 ortholog, GPA-12, and upstream of the Rho GTPase ortholog, RHO-1; additionally, rhgf-1 activity is required for normal mechanosensory behavior, egg laying, and embryonic development; an rhgf-1 reporter fusion is expressed in ventral cord motor neurons as well as several head neurons.
17	K12H4.4	K12H4.4	n/a	chrIII 8,045,336	contains similarity to Pfam domain PF04573 Signal peptidase subunit contains similarity to Interpro domain IPR007653 (Signal peptidase 22 kDa subunit)
18	glf-1	H04M03.4	n/a	chrIV 5,887,804	H04M03.4 encodes a UDP-galactopyranose mutase predicted to synthesize galactofuranose (Gal(f)) as a nucleotide sugar (UDP-Gal(f)); recombinant H04M03.4 has biochemical activity either in vivo (expressed in E. coli) or in vitro; orthologs of H04M03.4 are found in the urochordates Halocynthia and Ciona.
19	tab-1	F31E8.3	n/a	chrII 6,804,197	tab-1 encodes a homeodomain protein homologous to Drosophila bsh (brain-specific homeodomain protein) and the vertebrate BarH-like homeodomain protein 1; TAB-1 is required, during early larval development, for backward movement in response to anterior touch with a wire, while during later larval stages, TAB-1 is required for response to gentle touch with a hair; TAB-1 expression begins in the early embryo in approximately 20-30 cells and is then restricted to a subset of neurons including AIB, AVJ, and RIV; TAB-1 expression in AIB may be controlled by the UNC-42 homeodomain protein and TAB-1 may autoregulate in the AVJ and RIV neurons.
20	R06A10.1	R06A10.1	n/a	chrI 1,087,211	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
21	sem-5	C14F5.5	n/a	chrX 7,960,532	sem-5 encodes a Src homology (SH) domain 2 and 3-containing protein, orthologous to human GRB2 (OMIM:108355), that functions in multiple signaling pathways during development; these pathways include those regulating sex myoblast migration, muscle membrane extension, vulval induction, fluid balance, viability, and formation of the male tail; SEM-5 acts downstream of the LET-23 epidermal growth factor receptor to negatively regulate RAS-, MAP-, as well as IP-3-, mediated signal transduction.
22	pqn-26	DY3.5	n/a	chrI 8,774,608	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
23	chs-2	F48A11.1	n/a	chrII 207,689	chs-2 encodes a putative chitin synthase, paralogous to CHS-1; CHS-2 is required for synthesis of chitin lining the inner pharyngeal surface (primarily in the buccal cavity and grinder), while CHS-1 is dispensable for pharyngeal chitin; CHS-2 is also required for normal pharyngeal shape and function, and for larval viability; chs-2(RNAi) animals have abnormally large, misshapen grinders, and arrest as early larvae; chs-2 is expressed by the glandular pharyngeal g1 and g2 cells, and by m3 and m4 myoepithelial cells; chs-2 is transcribed in short periods before each larval molt; the pharyngeal expression of chs-2 parallels gna-1; CHS-2 is predicted to be in the plasma membrane rather than the Golgi apparatus.
24	dpy-27	R13G10.1	n/a	chrIII 3,816,595	dpy-27 encodes an ATP-binding protein that is a homolog of the SMC4 subunit of mitotic condensin; DPY-27, in combination with other proteins including MIX-1, act as a unit to repress X-linked gene expression during hermaphrodite dosage compensation; in XX oocytes and early embryos, DPY-27 exhibits diffuse nuclear localization, but by the 30-cell stage of embryogenesis, DPY-27 specifically localizes to X chromosomes; in XO animals at all stages, DPY-27 remains diffusely nuclear; the sex-specific localization of DPY-27 to X chromosomes is dependent upon wild-type activity of xol-1, as DPY-27 mislocalizes to the X chromosome of XO embryos in a xol-1 mutant background.
25	nhr-67	C08F8.8	n/a	chrIV 11,172,266	nhr-67 encodes a nuclear receptor that is orthologous to Drosophila and vertebrate tailless hormone receptors; during development, nhr-67 plays an essential role in larval development and also functions as part of a complex regulatory network that regulates vulval patterning and differentiation and thus, egg laying; specifically, nhr-67 functions to positively regulate gene expression in the vulA, vulD, and vulF cells and negatively regulate gene expression in vulE and vulF; in regulating vulval gene expression, nhr-67 functions together with other transcription factors, including egl-38, lin-11, and cog-1; nhr-67 reporter fusion constructs are expressed dynamically in multiple vulval cell types as well as in head neurons, the hyp7 syncytium, late-stage embryos, the male tail, the anchor cell, and the linker cell.
26	cdh-9	F59C12.1	n/a	chrX 16,598,558	cdh-9 encodes a member of the cadherin superfamily of transmembrane glycoproteins that mediate homophilic cell-cell adhesion; as loss of CDH-9 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of CDH-9 in C. elegans development and/or behavior is not yet known.
27	T04C9.3	T04C9.3	n/a	chrIII 5,985,695
28	srx-97	F19B10.7	n/a	chrII 3,667,915	C. elegans SRX-97 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
29	C17E4.11	C17E4.11	n/a	chrI 9,420,385	contains similarity to Pfam domain PF08241 Methyltransferase domain contains similarity to Interpro domain IPR013216 (Methyltransferase type 11)
30	tbb-4	B0272.1	n/a	chrX 9,435,612	C. elegans TBB-4 protein; contains similarity to Pfam domains PF00091 (Tubulin/FtsZ family, GTPase domain) , PF03953 (Tubulin/FtsZ family, C-terminal domain) contains similarity to Interpro domains IPR002454 (Gamma tubulin), IPR002452 (Alpha tubulin), IPR002453 (Beta tubulin), IPR000158 (Cell division protein FtsZ, N-terminal), IPR000217 (Tubulin), IPR003008 (Tubulin/FtsZ, GTPase), IPR008280 (Tubulin/FtsZ, C-terminal), IPR013838 (Beta tubulin, autoregulation binding site), IPR004057 (Epsilon tubulin), IPR002967 (Delta tubulin)
31	cwn-2	W01B6.1	n/a	chrIV 10,069,006	cwn-2 encodes a member of the WNT family; expressed at highest levels in embryos and expression declines and is almost absent by the third larval stage.
32	K06H7.2	K06H7.2	n/a	chrIII 8,094,871	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
33	C16C10.9	C16C10.9	n/a	chrIII 4,156,357	contains similarity to Bacillus anthracis MutS2 family protein.; TR:Q81L40
34	ZC328.2	ZC328.2	n/a	chrI 6,389,348	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
35	F11C1.1	F11C1.1	n/a	chrX 12,988,210	contains similarity to Pfam domain PF06747 CHCH domain contains similarity to Interpro domain IPR010625 (CHCH)
36	tsp-17	C02F12.1	n/a	chrX 3,682,658	C. elegans TSP-17 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
37	clec-151	F10F2.7	n/a	chrIII 4,629,753	C. elegans CLEC-151 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
38	R07B1.5	R07B1.5	n/a	chrX 9,865,660	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
39	M28.1	M28.1	n/a	chrII 10,624,279	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
40	nhr-207	R07B7.14	n/a	chrV 12,097,016	C. elegans NHR-207 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR001728 (Thyroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
41	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
42	C45B11.2	C45B11.2	n/a	chrV 11,043,313	contains similarity to Pfam domain PF06441 ()
43	ltd-1	K02C4.4	n/a	chrII 8,090,520	ltd-1 encodes a protein with LIM and transglutaminase domains; LTD-1 is homologous to the mouse KY protein (MGI:96709, mutated in kyphoscoliosis), and to the HILLARIN protein of Hirudo medicinalis, found at axon hillocks; ltd-1 is expressed in hypodermal cells from the twofold stage embryo to adulthood, but has no obvious function in mass RNAi assays.
44	K10C9.3	K10C9.3	n/a	chrV 1,064,729	contains similarity to Pfam domain PF00445 Ribonuclease T2 family contains similarity to Interpro domain IPR001568 (Ribonuclease T2)
45	srh-148	K08G2.5	n/a	chrV 15,857,580	C. elegans SRH-148 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
46	M04F3.4	M04F3.4	n/a	chrI 4,772,433	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR008080 (Parvalbumin), IPR003299 (Flagellar calcium-binding protein (calflagin))
47	T01B6.1	T01B6.1	n/a	chrX 2,342,147	n/a
48	M01G4.1	M01G4.1	n/a	chrIII 6,665,107
49	W05H7.1	W05H7.1	n/a	chrX 1,451,500	contains similarity to Homo sapiens hypothetical protein LOC283767; ENSEMBL:ENSP00000347269
50	F42H10.3	F42H10.3	n/a	chrIII 8,486,094	contains similarity to Pfam domains PF07653 (Variant SH3 domain) , PF00018 (SH3 domain) , PF00880 (Nebulin repeat) (2), PF00412 (LIM domain) contains similarity to Interpro domains IPR000900 (Nebulin 35 residue motif), IPR013998 (Nebulin), IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR011511 (Variant SH3), IPR001781 (Zinc finger, LIM-type)