UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	col-153	F17C11.3	1e-147	chrV 10,950,773	C. elegans COL-153 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (2)contains similarity to Interpro domains IPR002486 (Nematode cuticle collagen, N-terminal), IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	F54F2.9	F54F2.9	n/a	chrIII 8,826,142	contains similarity to Pfam domains PF00249 (Myb-like DNA-binding domain) , PF00226 (DnaJ domain) contains similarity to Interpro domains IPR015609 (Molecular chaperone, heat shock protein, Hsp40, DnaJ), IPR001005 (SANT, DNA-binding), IPR003095 (Heat shock protein DnaJ), IPR001623 (Heat shock protein DnaJ, N-terminal), IPR014778 (Myb, DNA-binding), IPR009057 (Homeodomain-like)
5	C47A4.1	C47A4.1	n/a	chrIV 13,716,255	contains similarity to Interpro domain IPR015609 (Molecular chaperone, heat shock protein, Hsp40, DnaJ)
6	C32H11.11	C32H11.11	n/a	chrIV 12,938,618	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domain IPR003677 (Protein of unknown function DUF148)
7	F39H12.3	F39H12.3	n/a	chrX 839,898	contains similarity to Pfam domains PF00612 (IQ calmodulin-binding motif) (3), PF02197 (Regulatory subunit of type II PKA R-subunit) contains similarity to Interpro domains IPR003117 (cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta), IPR000048 (IQ calmodulin-binding region)
8	F07E5.7	F07E5.7	n/a	chrII 2,071,109	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
9	ZC449.1	ZC449.1	n/a	chrX 5,026,248	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR003609 (Apple-like), IPR003014 (N/apple PAN), IPR000169 (Peptidase, cysteine peptidase active site)
10	scl-27	ZK6.3	n/a	chrV 400,930	C. elegans SCL-27 protein; contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR001283 (Allergen V5/Tpx-1 related)
11	drh-1	F15B10.2	n/a	chrIV 6,610,349	drh-1 encodes a DExH-box helicase; loss of drh-1 activity via RNAi suggests that drh-1 is required, perhaps redundantly with drh-2, for both germline and somatic RNA interference (RNAi); DRH-1 interacts in vivo with RDE-4, a double-stranded RNA-binding protein required for the initiation phase of RNAi.
12	rpn-12	ZK20.5	n/a	chrII 11,653,526	rpn-12 is predicted to encode a non-ATPase subunit of the 19S regulatory complex of the proteasome that interacts with NHR-6 in yeast two-hybrid assays.
13	nas-3	K06A4.1	n/a	chrV 9,478,855	nas-3 encodes an astacin-like metalloprotease.
14	Y38A10A.2	Y38A10A.2	n/a	chrV 6,058,787	contains similarity to Pfam domain PF02995 Protein of unknown function (DUF229) contains similarity to Interpro domain IPR004245 (Protein of unknown function DUF229)
15	clec-35	Y102A5B.2	n/a	chrV 16,853,143	C. elegans CLEC-35 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
16	ZK829.7	ZK829.7	n/a	chrIV 11,960,692	contains similarity to Pfam domains PF00107 (Zinc-binding dehydrogenase) , PF08240 (Alcohol dehydrogenase GroES-like domain) contains similarity to Interpro domains IPR013149 (Alcohol dehydrogenase, zinc-binding), IPR011032 (GroES-like), IPR013154 (Alcohol dehydrogenase GroES-like), IPR002085 (Alcohol dehydrogenase superfamily, zinc-containing), IPR016040 (NAD(P)-binding)
17	B0222.3	B0222.3	n/a	chrV 9,140,149	contains similarity to Pfam domain PF01384 Phosphate transporter family contains similarity to Interpro domains IPR001204 (Phosphate transporter), IPR001991 (Sodium:dicarboxylate symporter)
18	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
19	srh-278	T09F5.8	n/a	chrV 15,171,028	C. elegans SRH-278 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
20	fbxa-209	Y36E3A.1	n/a	chrV 15,424,620	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
21	F21G4.3	F21G4.3	n/a	chrX 9,896,105	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
22	sre-55	C50E10.7	n/a	chrII 12,330,123	C. elegans SRE-55 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
23	K07G6.1	K07G6.1	n/a	chrII 1,741,871
24	F53G2.2	F53G2.2	n/a	chrII 2,483,921
25	F47C12.1	F47C12.1	n/a	chrIV 4,001,937	contains similarity to Pfam domains PF00008 (EGF-like domain) (4), PF00754 (F5/8 type C domain) , PF07645 (Calcium binding EGF domain) (2), PF07699 (GCC2 and GCC3) (3), PF00431 (CUB domain) , PF07974 (EGF-like domain) , PF02494 (HYR domain) (2), PF00084 (Sushi domain (SCR repeat)) (6)contains similarity to Interpro domains IPR001438 (EGF-like, type 2), IPR000742 (EGF-like, type 3), IPR003410 (Hyalin), IPR000436 (Sushi/SCR/CCP), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR008979 (Galactose-binding like), IPR000859 (CUB), IPR011641 (GCC2 and GCC3), IPR001881 (EGF-like calcium-binding), IPR016060 (Complement control module), IPR009030 (Growth factor, receptor), IPR013032 (EGF-like region, conserved site), IPR000421 (Coagulation factor 5/8 type, C-terminal), IPR013111 (EGF, extracellular), IPR013091 (EGF calcium-binding)
26	C50E3.6	C50E3.6	n/a	chrV 7,589,517
27	let-70	M7.1	n/a	chrIV 11,081,640	let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system.
28	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
29	B0205.9	B0205.9	n/a	chrI 10,722,143	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
30	srh-181	ZK228.6	n/a	chrV 18,475,360	C. elegans SRH-181 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
31	lin-24	B0001.1	n/a	chrIV 12,132,269	lin-24 was identified in screens for mutations that result in altered vulval cell lineages; lin-24 is defined by two alleles, the first of which, a partially dominant mutation, generally results in vulvaless animals, while the second, a non-null amber mutation that is also partially dominant, results in wild-type animals when homozygous, but vulvaless animals when heterozygous with a wild-type allele; morphological examination of lin-24 animals indicates that some of the Pn.p cells that normally make up the vulva undergo inappropriate cell death that is dependent upon the ced-2, ced-5, and ced-10 engulfment genes, but not on the ced-3 and ced-4 killing genes; the precise molecular identity of lin-24 has not yet been reported.
32	tpst-2	F42G9.8	n/a	chrIII 772,135	C. elegans TPST-2 protein ; contains similarity to Drosophila melanogaster Flybase gene name is Tango13-PC;; FLYBASE:CG32632
33	W03G9.3	W03G9.3	n/a	chrI 4,960,459
34	ZK688.1	ZK688.1	n/a	chrIII 7,910,130
35	W06A11.1	W06A11.1	n/a	chrII 4,068,658
36	C10B5.3	C10B5.3	n/a	chrV 8,584,165
37	F25H9.3	F25H9.3	n/a	chrV 13,456,608	contains similarity to Interpro domain IPR016054 (Ly-6 antigen / uPA receptor -like)
38	ZC84.1	ZC84.1	n/a	chrIII 9,203,077	contains similarity to Pfam domains PF01683 (EB module) (3), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (5)contains similarity to Interpro domains IPR011052 (Proteinase and amylase inhibitor), IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR006150 (Cysteine-rich repeat), IPR001762 (Blood coagulation inhibitor, Disintegrin), IPR013032 (EGF-like region, conserved site), IPR006149 (Nematode-specific EB region)
39	fpn-1.2	R09B5.4	n/a	chrV 1,463,421	R09B5.4 is orthologous to the human gene HYPOTHETICAL PROTEIN (SLC11A3; OMIM:604653), which when mutated leads to disease.
40	gcy-6	B0024.6	n/a	chrV 10,311,299	gcy-6 encodes a predicted guanylate cyclase; expressed in the ASEL neurons.
41	acr-8	ZC504.2	n/a	chrX 10,414,628	acr-8 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-8 falls into the 'ACR-8' class of nAChR subunits, which includes ACR-12 and ACR-13.
42	W06D11.4	W06D11.4	n/a	chrX 12,302,364	contains similarity to Pfam domain PF08123 Histone methylation protein DOT1 contains similarity to Interpro domain IPR013110 (Histone methylation DOT1)
43	ZC412.4	ZC412.4	n/a	chrV 14,869,132	contains similarity to Brugia malayi Major allergen.; TR:Q9BJC9
44	W06E11.4	W06E11.4	n/a	chrIII 637,463	W06E11.4 encodes an ortholog of human SBDS (OMIM:607444, mutated in Shwachman-Bodian-Diamond syndrome) and S. cerevisiae SDO1; by homology, W06E11.4 is predicted to be a nucleolar protein that may be required for normal processing of rRNA; WS06E11.4 shares an operon with tag-266 and T19C3.7.
45	srv-22	H04M03.9	n/a	chrIV 5,879,196	C. elegans SRV-22 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
46	K03H6.2	K03H6.2	n/a	chrIV 1,512,894	contains similarity to Pfam domain PF01764 Lipase (class 3) contains similarity to Interpro domains IPR002921 (Lipase, class 3), IPR003659 (Plexin/semaphorin/integrin), IPR008262 (Lipase, active site), IPR016201 (Plexin-like fold)
47	grl-12	F28A12.2	n/a	chrV 8,636,381	grl-12 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground-like (Grl) domain; the Grl domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins.
48	C01B12.3	C01B12.3	n/a	chrII 14,491	C01B12.3 is orthologous to the human gene VITELLIFORM MACULAR DYSTROPHY PROTEIN (VMD2; OMIM:153700), which when mutated leads to disease.
49	ndx-9	F13H10.2	n/a	chrIV 11,010,995	The ndx-9 gene encodes a member of the NADH pyrophosphatase subfamily of the NUDIX hydrolases.
50	prx-14	R07H5.1	n/a	chrIV 11,183,588	C. elegans PRX-14 protein; contains similarity to Pfam domain PF04695 Peroxisomal membrane anchor protein (Pex14p) conserved region contains similarity to Interpro domain IPR006785 (Peroxisome membrane anchor protein Pex14p, N-terminal)