UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F15D4.3	F15D4.3	8.000000000000001e-23	chrII 13,237,564	contains similarity to Homo sapiens Protein MGR2 homolog; ENSEMBL:ENSP00000338293
2	twk-35	F31D4.7	n/a	chrV 20,859,750	C. elegans TWK-35 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
3	C33C12.7	C33C12.7	n/a	chrII 2,174,952
4	K11E4.1	K11E4.1	n/a	chrX 13,715,160	contains similarity to Pfam domain PF01764 (Lipase (class 3))
5	F12A10.6	F12A10.6	n/a	chrII 5,494,268
6	K09C4.4	K09C4.4	n/a	chrX 3,290,202	contains similarity to Pfam domain PF00083 Sugar (and other) transporter contains similarity to Interpro domains IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
7	srw-63	Y37A1B.10	n/a	chrIV 14,014,952	C. elegans SRW-63 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
8	C33H5.13	C33H5.13	n/a	chrIV 7,791,950	contains similarity to Xenopus tropicalis UPF0467 protein C5orf32 homolog.; SW:Q28H62
9	F59B10.6	F59B10.6	n/a	chrII 10,523,795	contains similarity to Prochlorococcus marinus Possible paralytic/GBP/PSP peptide precursor.; TR:Q7TUU1
10	tag-120	F40F9.2	n/a	chrV 9,708,653	tag-120 encodes a predicted transmembrane protein; as loss of tag-120 activity via RNAi does not result in any abnormalities, the precise role of TAG-120 in C. elegans development and/or behavior is not yet known; however, TAG-120 is homologous to a Drosophila NMDA receptor-associated protein and mammalian transmembrane proteins that function in Fas-mediated cell death, so TAG-120 may play a role in neuronal functions and/or apoptosis; a tag-120 reporter fusion is expressed in the nervous system, pharyngeal muscles, and to a lesser extent in the excretory system.
11	C28H8.2	C28H8.2	n/a	chrIII 5,923,760
12	ptr-8	F44F4.4	n/a	chrII 10,891,194	ptr-8 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-8 is weakly required for normal molting from L4 to adult stages; PTR-8 is also required for normal growth to full size and locomotion; PTR-8 is expressed in hypodermis.
13	K09G1.3	K09G1.3	n/a	chrV 9,597,431	contains similarity to Saccharomyces cerevisiae Product of gene unknown; SGD:YKL064W
14	Y37E11B.7	Y37E11B.7	n/a	chrIV 3,599,789
15	C28F5.4	C28F5.4	n/a	chrII 7,521,547	contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) (2)contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
16	K09F6.6	K09F6.6	n/a	chrII 2,277,012
17	srg-17	F15A4.7	n/a	chrII 12,474,385	C. elegans SRG-17 protein; contains similarity to Pfam domain PF02118 C.elegans Srg family integral membrane protein contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
18	ceeh-2	K07C5.5	n/a	chrV 10,357,064	ceeh-2 encodes a soluble epoxide hydrolase (sEH) orthologous to human ABHD7 and ABHD9; recombinant CEEH-2 is biochemically active in vitro on epoxyeicosatrienoic acids and leukotoxins (EpOMEs); conversely, CEEH-2 is inhibited by urea-based antagonists of mammalian sEH that elevate EpOME levels when fed to C. elegans; perhaps because of genetic redundancy with its paralog CEEH-1, CEEH-2 has no obvious function in mass RNAi assays.
19	srw-44	F14F8.6	n/a	chrV 16,681,440	C. elegans SRW-44 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
20	str-15	T08G3.1	n/a	chrV 16,458,013	C. elegans STR-15 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
21	F14D7.3	F14D7.3	n/a	chrV 14,296,989	contains similarity to Interpro domain IPR006621 (Nose resistant to fluoxetine-4, N-terminal)
22	B0457.2	B0457.2	n/a	chrII 8,925,501	contains similarity to Homo sapiens Isoform 8 of Elastin precursor; ENSEMBL:ENSP00000369958
23	ttr-39	C04G2.1	n/a	chrIV 10,089,158	C. elegans TTR-39 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domains IPR008969 (Carboxypeptidase-like, regulatory region), IPR001534 (Transthyretin-like)
24	C04E12.6	C04E12.6	n/a	chrV 3,355,089	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
25	F01E11.3	F01E11.3	n/a	chrX 6,975,202
26	rac-2	K03D3.10	n/a	chrIV 16,308,987	rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins; genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration; in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis; as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo; further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2; GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane.
27	T23D8.3	T23D8.3	n/a	chrI 9,974,837	T23D8.3 encodes an ortholog of yeast and human LTV1 that inhibits DHC-1 in vivo; in mass RNAi assays, T23D8.3 is required for embryonic and larval development, normally large brood sizes, and normally fast growth.
28	ser-5	F16D3.7	n/a	chrI 8,385,819	F16D3.7 encodes a homolog of mammalian alpha-adrenergic receptors that is expressed in vulval and bodywall muscle cells, intestine, and head neurons; heterologously expressed F16D3.7 has no effect on adenylate cyclase signalling; F16D3.7 has no obvious function in RNAi assays of brood size, egg laying, pharyngeal pumping, locomotion, or male mating.
29	str-67	K10C9.6	n/a	chrV 1,063,591	C. elegans STR-67 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
30	M03E7.4	M03E7.4	n/a	chrV 5,611,266	M03E7.4 encodes a protein, predicted to be secreted, with one chitin-binding peritrophin-A and three low-density lipoprotein receptor domain class A domains; M03E7.4 has no obvious function in mass RNAi assays.
31	C05D11.5	C05D11.5	n/a	chrIII 6,410,742	contains similarity to Pfam domain PF01261 Xylose isomerase-like TIM barrel contains similarity to Interpro domains IPR013279 (Apoptosis regulator, Bcl-X), IPR012307 (Xylose isomerase-type TIM barrel), IPR013022 (Xylose isomerase-like, TIM barrel)
32	F16G10.15	F16G10.15	n/a	chrII 2,406,470	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
33	pgp-10	C54D1.1	n/a	chrX 7,162,476	pgp-10 encodes an ATP-binding protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; PGP-10 is predicted to function as a transmembrane protein that couples energy to transport of various molecules across membranes, but as loss of pgp-10 activity via RNAi results in no obvious defects, the exact role of pgp-10 in C. elegans development and/or behavior is not yet known; pgp-10 promoter-gfp fusion proteins are expressed in larvae and adults in the intestine and hypodermis.
34	F53F4.1	F53F4.1	n/a	chrV 13,585,118	contains similarity to Interpro domain IPR002952 (Eggshell protein)
35	egl-36	R07A4.1	n/a	chrX 10,739,267	egl-36 encodes a Shaw-type voltage-gated potassium channel that regulates egg laying and defecation; expression of egl-36::gfp reporters is observed in several different cell types including muscle cells such as the uterine and vulval egg-laying muscles, sensory, motor and interneurons, and the distal tip cells of the gonad; when expressed in a heterologous system, EGL-36 exhibits channel activity.
36	Y48A6C.1	Y48A6C.1	n/a	chrIII 11,104,510	contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
37	F58H1.4	F58H1.4	n/a	chrV 11,937,362	contains similarity to Interpro domain IPR006207 (Cystine knot, C-terminal)
38	clec-113	F47G4.1	n/a	chrI 14,055,730	C. elegans CLEC-113 protein; contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
39	K02E10.5	K02E10.5	n/a	chrX 2,477,930
40	sri-28	B0454.3	n/a	chrII 3,049,551	C. elegans SRI-28 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
41	K10G4.5	K10G4.5	n/a	chrV 17,299,907	contains similarity to Pfam domains PF00621 (RhoGEF domain) , PF00169 (PH domain) contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR015721 (Rho GTP exchange factor)
42	T20D4.17	T20D4.17	n/a	chrV 3,395,750	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domain IPR002542 (Protein of unknown function DUF19)
43	Y39A3B.3	Y39A3B.3	n/a	chrIII 1,986,275
44	C17B7.12	C17B7.12	n/a	chrV 3,353,590
45	F45E1.2	F45E1.2	n/a	chrX 8,003,850
46	F35C11.6	F35C11.6	n/a	chrII 8,258,607	contains similarity to Homo sapiens Oxysterol binding protein-related protein 11; ENSEMBL:ENSP00000296220
47	Y32B12A.1	Y32B12A.1	n/a	chrV 16,488,780	contains similarity to Pfam domain PF00569 Zinc finger, ZZ type contains similarity to Interpro domain IPR000433 (Zinc finger, ZZ-type)
48	H32K16.1	H32K16.1	n/a	chrI 9,151,388	contains similarity to Pfam domain PF01490 Transmembrane amino acid transporter protein contains similarity to Interpro domain IPR013057 (Amino acid transporter, transmembrane)
49	ocr-2	T09A12.3	n/a	chrIV 8,216,912	ocr-2 encodes a TRPV (transient receptor potential channel, vanilloid subfamily) ion channel; OCR-2 activity is required for several types of sensory transduction including olfaction, osmosensation, mechanosensation, and chemosensation; an OCR-2 fusion protein is expressed in sensory cilia and requires the OSM-9 TRPV channel protein for proper localization; likewise, OSM-9 requires OCR-2 for its cilial localization.
50	srw-36	F14F8.7	n/a	chrV 16,684,004	C. elegans SRW-36 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300)