UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F14F9.4	F14F9.4	0	chrV 5,134,905	contains similarity to Interpro domain IPR002867 (Zinc finger, C6HC-type)
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	utx-1	D2021.1	n/a	chrX 8,560,128	utx-1 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase, required for embryonic viability and vulval development, and for high brood sizes, locomotion, and growth sizes; UTX-1 contains a JmjC domain, is orthologous to human UTX and UTY, and is paralogous to human JMJD3; by orthology, UTX-1 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes.
4	F15A4.10	F15A4.10	n/a	chrII 12,484,765	contains similarity to Saccharomyces cerevisiae Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate; SGD:YOR195W
5	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
6	R07C3.5	R07C3.5	n/a	chrII 931,761
7	srt-43	F18E2.4	n/a	chrV 12,770,035	C. elegans SRT-43 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
8	F14F9.2	F14F9.2	n/a	chrV 5,145,296	contains similarity to Homo sapiens Acidic repeat-containing protein; ENSEMBL:ENSP00000362799
9	F58E1.11	F58E1.11	n/a	chrII 1,692,234	contains similarity to Interpro domain IPR002034 (Alpha-isopropylmalate/homocitrate synthase, conserved site)
10	T19C4.1	T19C4.1	n/a	chrV 11,150,485	contains similarity to Lycopersicon esculentum 36.4 kDa proline-rich protein.; SW:PRF1_LYCES
11	F31D5.6	F31D5.6	n/a	chrII 4,211,553	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
12	pup-3	F59A3.9	n/a	chrI 5,532,199	pup-3 encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, distantly similar to human ZCCHC6 and ZCCHC11; PUP-3 is paralogous to the GLD-2 family of poly(A) polymerases; PUP-3 has no obvious function in mass RNAi assays.
13	C08F1.6	C08F1.6	n/a	chrII 1,787,707
14	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
15	fbxb-11	F45C12.5	n/a	chrII 1,725,771	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
16	T05D4.2	T05D4.2	n/a	chrIII 13,562,369	contains similarity to Mus musculus Similar to SPEER 2.; TR:Q80ZP2
17	egl-26	C23H3.1	n/a	chrII 70,469	egl-26 encodes a protein that contains an H-box and an NC domain that is a member of the LRAT (lecithin retinol acyltransferase) subfamily of the NlpC/P60 superfamily of enzymes; egl-26 activity is required for fertility, egg laying, and vulval development, specifically the connection of the uterus to the vulva mediated by proper morphogenesis of vulF, the most dorsal vulval cell; EGL-26 is an apical membrane protein that is expressed in many cells, including vulF, and appears to be expressed near the vulva and uterus only during the L4 larval stage; EGL-26 membrane localization is necessary for its function.
18	F14F7.5	F14F7.5	n/a	chrIII 13,033,511	contains similarity to Pfam domain PF02206 Domain of unknown function contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003125 (Protein of unknown function WSN)
19	C01A2.5	C01A2.5	n/a	chrI 13,385,906	contains similarity to Pfam domain PF04641 Protein of unknown function, DUF602 contains similarity to Interpro domain IPR006735 (Protein of unknown function DUF602)
20	C41H7.5	C41H7.5	n/a	chrII 3,003,154	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
21	cdh-9	F59C12.1	n/a	chrX 16,598,558	cdh-9 encodes a member of the cadherin superfamily of transmembrane glycoproteins that mediate homophilic cell-cell adhesion; as loss of CDH-9 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of CDH-9 in C. elegans development and/or behavior is not yet known.
22	cec-1	ZK1236.2	n/a	chrIII 8,427,378	cec-1 encodes a nuclear protein with a chromodomain that is ubiquitously expressed in somatic cells, but is dispensable for embryonic survival or gross adult morphology.
23	T28C6.3	T28C6.3	n/a	chrIV 8,820,742	contains similarity to Homo sapiens HIV Tat-specific factor 1; ENSEMBL:ENSP00000218364
24	ZK418.5	ZK418.5	n/a	chrIII 7,073,217	contains similarity to Mus musculus Transmembrane protein 147.; SW:Q9CQG6
25	hch-1	F40E10.1	n/a	chrX 14,698,114	hch-1 encodes a member of the zinc-dependent metalloprotease family that contains an epidermal growth factor-like domain, a CUB domain, and a TSP1 domain and affects hatching and QL neuroblast migration.
26	R186.1	R186.1	n/a	chrV 12,962,447	contains similarity to Pfam domain PF05742 Protein of unknown function (DUF833) contains similarity to Interpro domain IPR008551 (Protein of unknown function DUF833)
27	F52D10.2	F52D10.2	n/a	chrX 11,590,643	contains similarity to Interpro domains IPR011993 (Pleckstrin homology-type), IPR006020 (Phosphotyrosine interaction region)
28	EGAP1.1	EGAP1.1	n/a	chrIII 5,936,384	n/a
29	fbxb-25	F58E1.2	n/a	chrII 1,684,456	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
30	D1081.6	D1081.6	n/a	chrI 8,485,193	contains similarity to Mycoplasma pulmonis Hypothetical protein MYPU_0200.; TR:Q98RI9
31	F23D12.5	F23D12.5	n/a	chrX 14,450,814	F23D12.5 encodes a putative histone H3 di/trimethyllysine-27 (H3K27me2/me3) demethylase; F23D12.5 contains a C-terminal JmjC domain, and is homologous to human JMJD3, UTX (OMIM:300128), and UTY (OMIM:400009); F23D12.5 is expected to antagonize transcriptional repression by polycomb repressor complexes, which mark stem cells (and presumably germline) by H3K27me3-mediated repression of somatic genes; however, F23D12.5 has no obvious function in mass RNAi assays.
32	K01A2.9	K01A2.9	n/a	chrII 316,397	contains similarity to Interpro domain IPR002229 (Blood group Rhesus C/E and D polypeptide)
33	W05B2.4	W05B2.4	n/a	chrIII 10,975,818	contains similarity to Pfam domain PF08393 Dynein heavy chain, N-terminal region 2 contains similarity to Interpro domains IPR011010 (DNA breaking-rejoining enzyme, catalytic core), IPR013602 (Dynein heavy chain, N-terminal region 2)
34	R11.4	R11.4	n/a	chrX 16,210,394	contains similarity to Leishmania major Hypothetical protein.; TR:Q9GRL1
35	ins-34	F52B11.6	n/a	chrIV 14,107,090	ins-34 encodes an insulin-like peptide.
36	fbxb-98	C16C4.6	n/a	chrII 1,863,210	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
37	T24E12.1	T24E12.1	n/a	chrII 3,786,852	contains similarity to Interpro domain IPR009071 (High mobility group box, HMG)
38	rgef-1	F25B3.3	n/a	chrV 9,559,135	rgef-1 encodes a Ca2+-regulated Ras nucleotide exchange factor orthologous to human Ras guanyl-releasing protein (RasGRP); rgef-1 reporter fusions are expressed in post-mitotic neurons (pan-neuronally) beginning at the late comma stage of embryogenesis.
39	F08B6.3	F08B6.3	n/a	chrI 6,759,203	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR008080 (Parvalbumin), IPR000886 (Endoplasmic reticulum, targeting sequence)
40	F40G9.9	F40G9.9	n/a	chrIII 169,417	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
41	W01G7.4	W01G7.4	n/a	chrII 14,061,584	contains similarity to Danio rerio Protein SLC7A6OS (Solute carrier family 7 member 6 opposite strandstranscript homolog).; SW:Q5U3I2
42	sup-10	R09G11.1	n/a	chrX 17,529,998	C. elegans SUP-10 protein ;
43	sdz-14	F14B6.1	n/a	chrI 12,216,990	C. elegans SDZ-14 protein ;
44	psa-4	F01G4.1	n/a	chrIV 11,128,568	The psa-4 (phasmid socket absent) gene encodes an ortholog of SWI2/SNF2, a component of the SWI/SNF complex that is conserved from yeast to mammals and that is involved in chromatin remodeling; psa-4 is probably required during mitosis of the T cells for asymmetric cell division.
45	C54F6.5	C54F6.5	n/a	chrV 7,529,245
46	col-121	F56D5.1	n/a	chrIV 9,395,553	col-121 encodes a cuticle collagen required for resistance to the endocrine disrupting chemical bisphenol A (BPA); col-121(nx3) and col-121(RNAi) animals are hypersensitive to BPA, but are otherwise wild-type (e.g., they have normal body shape); BPA hypersensitivity has also been observed for dpy-2(e8), dpy-7(e88) and dpy-10(e128) mutants.
47	gpc-2	F08B6.2	n/a	chrI 6,757,967	gpc-2 encodes one of two C. elegans heterotrimeric G protein gamma subunits; gpc-2 is required, along with its partner GPB-1, a G protein beta subunit, for proper mitotic spindle positioning and orientation during early embryonic cell divisions; to date, GPC-2 expression has been reported in electrically excitable cells (all neurons and muscles).
48	C25H3.1	C25H3.1	n/a	chrII 5,700,590	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR017442 (Serine/threonine protein kinase-related)
49	Y106G6D.1	Y106G6D.1	n/a	chrI 10,108,184	contains similarity to Methanocaldococcus jannaschii DNA double-strand break repair rad50 ATPase.; SW:Q58718
50	fbxb-20	ZC204.9	n/a	chrII 1,649,687	fbxb-20 encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; FBXB-20 also contains a C-terminal type 2 F-box-associated domain of presently unknown function.