UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	crb-1	F11C7.4	0	chrX 17,408,117	crb-1 encodes a homolog of Drosophila CRUMBS that affects dauer formation and feeding behavior; CRB-1 can bind cyclic AMP-response element (CRE) sites and be phosphorylated by PKA in vitro, and is expressed immediately apical to the zonula adherens in embryos and then ubiquitously later during development and in adults; CRB-1 is homologous to human CRB1 (OMIM:604210, mutated in retinitis pigmentosa 12 or Leber congenital amaurosis).
2	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
3	F40E3.2	F40E3.2	n/a	chrI 2,643,222
4	W04G3.7	W04G3.7	n/a	chrX 11,084,822	contains similarity to Interpro domain IPR001211 (Phospholipase A2)
5	tmbi-4	B0563.4	n/a	chrX 9,155,606	C. elegans TMBI-4 protein; contains similarity to Pfam domain PF01027 Uncharacterised protein family UPF0005 contains similarity to Interpro domain IPR006214 (Protein of unknown function UPF0005)
6	F52C9.5	F52C9.5	n/a	chrIII 5,304,230	contains similarity to Pfam domain PF00024 PAN domain contains similarity to Interpro domains IPR000884 (Thrombospondin, type I), IPR003609 (Apple-like), IPR003014 (N/apple PAN)
7	glb-10	C29F5.7	n/a	chrII 6,308,800	glb-10 encodes a globin; glb-10 is expressed in pharynx, intestine, vulval muscle, and many neurons, with at least some subcellular localization to synapses; however, glb-10 has no obvious function in mass RNAi assays.
8	F18A11.3	F18A11.3	n/a	chrII 13,036,522	contains similarity to Candida albicans Multidrug resistance protein CDR2.; SW:CDR2_CANAL
9	F25G6.1	F25G6.1	n/a	chrV 8,577,457
10	unc-50	T07A5.2	n/a	chrIII 10,316,260	unc-50 encodes an integral membrane protein orthologous to the Saccharomyces cerevisiae Golgi component Gmh1p; UNC-50 is required for regulating subtype-specific nicotinic receptor trafficking to the cell surface and thus, for normal synaptic transmission at the neuromuscular junction; UNC-50 is ubiquitously expressed from early embryogenesis to adulthood and localizes to the Golgi.
11	srh-118	K03D7.6	n/a	chrV 17,495,205	C. elegans SRH-118 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	npp-7	T19B4.2	n/a	chrI 5,694,480	C. elegans NPP-7 protein; contains similarity to Interpro domain IPR001876 (Zinc finger, RanBP2-type)
13	nhr-165	C47F8.2	n/a	chrI 12,332,239	C. elegans NHR-165 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
14	srbc-58	R09E12.2	n/a	chrV 776,135	C. elegans SRBC-58 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
15	unc-120	D1081.2	n/a	chrI 8,461,612	unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles.
16	C30G4.5	C30G4.5	n/a	chrX 17,071,948
17	F20B4.2	F20B4.2	n/a	chrX 17,704,274
18	R05H10.5	R05H10.5	n/a	chrII 14,868,296	contains similarity to Pfam domain PF00255 Glutathione peroxidase contains similarity to Interpro domains IPR012336 (Thioredoxin-like fold), IPR012335 (Thioredoxin fold), IPR000889 (Glutathione peroxidase)
19	C07G1.7	C07G1.7	n/a	chrIV 8,211,372
20	K08C9.5	K08C9.5	n/a	chrI 11,483,971	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
21	osm-12	Y75B8A.12	n/a	chrIII 12,196,633	C. elegans OSM-12 protein; contains similarity to Interpro domain IPR016575 (Bardet-Biedl syndrome 7 protein)
22	R06B9.2	R06B9.2	n/a	chrII 13,767,269	contains similarity to Pfam domain PF00339 Arrestin (or S-antigen), N-terminal domain contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011021 (Arrestin-like, N-terminal)
23	ZK669.2	ZK669.2	n/a	chrII 7,937,580	contains similarity to Pfam domain PF03227 Gamma interferon inducible lysosomal thiol reductase (GILT) contains similarity to Interpro domain IPR004911 (Gamma interferon inducible lysosomal thiol reductase GILT)
24	T08G2.2	T08G2.2	n/a	chrX 17,207,313	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
25	C54D2.1	C54D2.1	n/a	chrX 7,843,978	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR006149 (Nematode-specific EB region), IPR002557 (Chitin binding protein, peritrophin-A)
26	F40G9.1	F40G9.1	n/a	chrIII 196,177	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
27	K10H10.6	K10H10.6	n/a	chrII 14,504,011	contains similarity to Pfam domain PF00106 short chain dehydrogenase contains similarity to Interpro domains IPR003560 (2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR016040 (NAD(P)-binding)
28	B0334.6	B0334.6	n/a	chrII 11,512,193	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
29	C52D10.3	C52D10.3	n/a	chrIV 17,179,526	contains similarity to Pelobacter propionicus DSM 2379 Hypothetical protein precursor.; TR:Q3FZT0
30	F52C12.4	F52C12.4	n/a	chrIV 1,934,886	contains similarity to Pfam domains PF01535 (PPR repeat) , PF02141 (DENN (AEX-3) domain) , PF03456 (uDENN domain) , PF03455 (dDENN domain) contains similarity to Interpro domains IPR005112 (dDENN), IPR012336 (Thioredoxin-like fold), IPR005113 (uDENN), IPR002885 (Pentatricopeptide repeat), IPR001194 (DENN)
31	F11A1.2	F11A1.2	n/a	chrX 10,658,016
32	E04A4.6	E04A4.6	n/a	chrIV 4,746,804	contains similarity to Homo sapiens Isoform 5 of Tectonic-1 precursor; ENSEMBL:ENSP00000380771
33	T25G3.4	T25G3.4	n/a	chrI 7,566,145	T25G3.4 encodes a putative mitochondrial glycerol-3-phosphate dehydrogenase, paralogous to Y50E8A.6 and orthologous to human GPD2 (OMIM:138430, mutated in type II diabetes mellitus); T25G3.4 transcripts are not obviously enriched during oogenesis, but T25G3.4 is predicted to be coexpressed in an operon with chs-1 and T25G3.3; such coexpression, if real, may simply reflect all three genes being required for oogenesis, rather than some more detailed functional connection; T25G3.4 has no obvious function in mass RNAi assays.
34	K07C11.4	K07C11.4	n/a	chrV 8,204,685	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
35	srd-43	R04D3.9	n/a	chrX 13,304,796	C. elegans SRD-43 protein ;
36	C18H7.5	C18H7.5	n/a	chrIV 587,001
37	srw-65	Y38H6C.2	n/a	chrV 20,497,408	C. elegans SRW-65 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
38	F02E9.1	F02E9.1	n/a	chrI 8,407,250	F02E9.1 encodes a divergent ortholog of S. cerevisiae VMA22; like VMA22, F02E9.1 may be required for vacuolar proton-translocating ATPase (V-ATPase) assembly in the endoplasmic reticulum.
39	rib-2	K01G5.6	n/a	chrIII 10,744,609	The rib-2 gene encodes an ortholog of human EXT2, which when mutated leads to hereditary multiple exostoses, type II (OMIM:133701).
40	str-122	W03D2.10	n/a	chrIV 4,067,151	C. elegans STR-122 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
41	R05D7.5	R05D7.5	n/a	chrI 12,186,205	contains similarity to Ascaris suum P40.; TR:Q7YXJ9
42	math-21	C40D2.3	n/a	chrII 1,994,852	C. elegans MATH-21 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
43	clec-92	Y52B11A.5	n/a	chrI 11,016,484	C. elegans CLEC-92 protein; contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
44	fbxa-160	C08E3.12	n/a	chrII 1,624,293	C. elegans FBXA-160 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
45	C45G7.4	C45G7.4	n/a	chrIV 2,434,709	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
46	apx-1	K08D9.3	2e-22	chrV 3,216,670	apx-1 encodes one of ten C. elegans DSL (Delta, Serrate, LAG-2) proteins, integral transmembrane and secreted proteins that function as signaling ligands for the Notch family receptors GLP-1 and LIN-12; in the 4-cell embryo, maternally supplied APX-1 functions as a GLP-1 ligand for an inductive interaction that specifies the fate of the ABp blastomere; later in embryogenesis, APX-1 is required for formation of the LIN-12-dependent, invariant asymmetrical twist that occurs as part of normal gut morphogenesis; during larval development, APX-1 is required redundantly with DSL-1 and LAG-2 for the LIN-12-mediated lateral signal that spatially patterns the primary and secondary vulval cell lineages; in the early embryo, APX-1 is first detected at the anterior edge of the P1 blastomere, with later expression visible in P2 at sites of contact with ABp, and in the cytoplasm of the EMS and P3 blastomeres; expression in the vulval precursor cells (VPCs) is detected in the primary VPC, P6.p, and its descendants; embryonic APX-1 expression is dependent upon PIE-1 activity, while later vulval expression is mediated by the Ras signaling pathway and the SUR-2 transcriptional cofactor.
47	F36D1.8	F36D1.8	n/a	chrI 11,257,879	contains similarity to Pfam domain PF04590 Protein of unknown function, DUF595 contains similarity to Interpro domain IPR007669 (Protein of unknown function DUF595)
48	srv-11	H25K10.3	n/a	chrIV 16,220,615	C. elegans SRV-11 protein; contains similarity to Pfam domains PF01461 (7TM chemoreceptor) , PF01748 (Caenorhabditis serpentine receptor-like protein) contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002651 (Protein of unknown function DUF32)
49	F55A4.5	F55A4.5	n/a	chrX 1,031,456	contains similarity to Pfam domain PF00035 Double-stranded RNA binding motif contains similarity to Interpro domains IPR001159 (Double-stranded RNA binding), IPR014720 (Double-stranded RNA-binding-like)
50	T25G12.1	T25G12.1	n/a	chrX 17,249,457