UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	tag-151	F10G7.1	0	chrII 4,711,891	C. elegans TAG-151 protein; contains similarity to Pfam domains PF08142 (AARP2CN (NUC121) domain) , PF04950 (Protein of unknown function (DUF663)) contains similarity to Interpro domains IPR012948 (AARP2CN), IPR007034 (Protein of unknown function DUF663)
2	F32D8.10	F32D8.10	n/a	chrV 10,907,944	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000832 (GPCR, family 2, secretin-like), IPR000276 (GPCR, rhodopsin-like)
3	math-39	T08E11.2	n/a	chrII 1,832,929	C. elegans MATH-39 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
4	end-1	F58E10.2	n/a	chrV 13,986,046	end-1 encodes a GATA-like transcription factor sufficient to initiate endoderm differentiation and binds to the canonical target DNA sequence WGATAR with specificity similar to GATA-1 and D4 transcription factors; its expression bypasses requirement for maternal SKN-1 and the maternal Wnt signaling pathway in endoderm formation and it activates endoderm differentiation in isolated Xenopus ectoderm.
5	C30E1.4	C30E1.4	n/a	chrX 16,924,785	contains similarity to Homo sapiens SID1 transmembrane family member 1 precursor; ENSEMBL:ENSP00000264852
6	ZC239.15	ZC239.15	n/a	chrII 3,224,089	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
7	fip-4	F41E6.10	n/a	chrV 8,611,069	C. elegans FIP-4 protein
8	orai-1	C09F5.2	n/a	chrIII 653,677	C. elegans ORAI-1 protein; contains similarity to Pfam domain PF07856 Protein of unknown function (DUF1650) contains similarity to Interpro domain IPR012446 (Protein of unknown function DUF1650)
9	K09B11.3	K09B11.3	n/a	chrIV 13,430,380	contains similarity to Homo sapiens DJ614O4.3; ENSEMBL:ENSP00000305301
10	C36B1.9	C36B1.9	n/a	chrI 8,745,380	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR003604 (Zinc finger, U1-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000568 (ATPase, F0 complex, subunit A)
11	T05F1.11	T05F1.11	n/a	chrI 9,654,690	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
12	let-70	M7.1	n/a	chrIV 11,081,640	let-70 encodes a class I E2 ubiquitin conjugating enzyme; let-70 was identified in screens for essential genes and phenotypic analyses indicate that loss of let-70 activity results in embryonic and larval lethality with defects in sarcomere assembly; purified LET-70 can stimulate the self-ubiquitylation activities of CHN-1 and UFD-2, E4 ubiquitin conjugation factors and, in addition, can stimulate the CHN-1- and UFD-2-dependent multiubiquitylation of UNC-45, a myosin-directed chaperone; in this manner, LET-70 may regulate UNC-45 degradation and myosin assembly; RNA blot analyses and a let-70-lacZ reporter fusion reveal that let-70 is abundantly expressed at all stages of development, including the dauer larval stage; strong staining is observed in most somatic tissues until adult stages, when expression generally becomes restricted to the nervous system.
13	atp-4	T05H4.12	n/a	chrV 6,426,736	C. elegans ATP-4 protein; contains similarity to Pfam domain PF05511 Mitochondrial ATP synthase coupling factor 6 contains similarity to Interpro domain IPR008387 (ATPase, F0 complex, subunit F6, mitochondrial)
14	kqt-3	Y54G9A.3	n/a	chrII 13,704,530	kqt-3 encodes one of three C. elegans KCNQ-like potassium channel subunits and, with respect to humans, is most similar to the KCNQ1 channel protein which when mutated leads to inherited long QT syndrome (OMIM:607542); although loss of KQT-3 activity via large-scale RNAi screens results in no obvious abnormalities, KQT-3 likely functions to regulate cellular excitability as expression of KQT-3 in Xenopus oocytes can produce K+ channel currents that functionally resemble vertebrate M-currents; activity of these KQT-3 channels can be suppressed by coexpression with the human M1 muscarinic receptor and treatment with diacylglycerol analogs, although KQT-3 is less sensitive to each of these treatments than KQT-1; a KQT-3::GFP fusion protein is expressed in the anterior- and posterior-most intestinal cells, the anterior and posterior mechanosensory neurons ALM and PLM, amphid and phasmid neurons, and in some additional head neurons.
15	fbxa-190	F56C3.2	n/a	chrX 1,373,317	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
16	srx-16	T07H8.1	n/a	chrV 6,976,849	C. elegans SRX-16 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
17	K10G4.5	K10G4.5	n/a	chrV 17,299,907	contains similarity to Pfam domains PF00621 (RhoGEF domain) , PF00169 (PH domain) contains similarity to Interpro domains IPR000219 (Dbl homology (DH) domain), IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR015721 (Rho GTP exchange factor)
18	R53.4	R53.4	n/a	chrII 9,967,683	contains similarity to Homo sapiens 10 kDa protein; ENSEMBL:ENSP00000377740
19	nhr-36	F07C3.10	n/a	chrV 9,258,968	C. elegans NHR-36 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF01461 (7TM chemoreceptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR003002 (7TM chemoreceptor, subfamily 1), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
20	tgt-1	ZK829.6	n/a	chrIV 11,958,629	tgt-1 encodes a tRNA-guanine transglycosylase predicted to be mitochondrial.
21	F02H6.7	F02H6.7	n/a	chrIV 14,227,256	contains similarity to Interpro domain IPR000884 (Thrombospondin, type I)
22	ptr-8	F44F4.4	n/a	chrII 10,891,194	ptr-8 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-8 is weakly required for normal molting from L4 to adult stages; PTR-8 is also required for normal growth to full size and locomotion; PTR-8 is expressed in hypodermis.
23	M02F4.2	M02F4.2	n/a	chrX 3,033,806
24	C06E2.1	C06E2.1	n/a	chrX 8,873,724	contains similarity to Interpro domain IPR007087 (Zinc finger, C2H2-type)
25	dgk-5	K06A1.6	n/a	chrII 6,462,041	dgk-5 encodes a putative diacylglycerol kinase, orthologous to Drosophila RDGA, and to human DGKI (OMIM:604072) and DGKZ (OMIM:601441); DGK-5 has no obvious function in mass RNAi assays.
26	Y45F10D.6	Y45F10D.6	n/a	chrIV 13,797,043
27	F19C6.5	F19C6.5	n/a	chrX 9,983,681	contains similarity to Homo sapiens Isoform 2 of Zinc transporter 8; HI:HIT000389038
28	C49C3.10	C49C3.10	n/a	chrIV 17,337,847	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR000215 (Protease inhibitor I4, serpin), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
29	T19D7.4	T19D7.4	n/a	chrX 660,149	contains similarity to Interpro domains IPR010989 (t-SNARE), IPR004012 (RUN)
30	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
31	C49A9.1	C49A9.1	n/a	chrIV 6,229,082	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
32	Y43F4B.7	Y43F4B.7	n/a	chrIII 13,310,326	contains similarity to Pfam domain PF01490 Transmembrane amino acid transporter protein contains similarity to Interpro domains IPR013057 (Amino acid transporter, transmembrane), IPR003568 (Cytochrome c-type biogenesis protein CcmF)
33	Y39A1A.22	Y39A1A.22	n/a	chrIII 10,705,056	contains similarity to Pfam domains PF03124 (EXS family) , PF03105 (SPX domain) contains similarity to Interpro domains IPR004342 (EXS, C-terminal), IPR004331 (SPX, N-terminal)
34	unc-120	D1081.2	n/a	chrI 8,461,612	unc-120 encodes a member of the MADS-box family of transcription factors that is most closely related to Drosophila blistered and the vertebrate serum response factors (SRFs); UNC-120 is required for locomotion and muscle development and for formation of the normal number of muscle A and I bands; UNC-120 is also required for maintaining wild-type expression levels of the muscle components actin and myosin; UNC-120 is first expressed in the early embryo in body wall muscle precursors and later is expressed in both body wall and vulval muscles.
35	T23D8.3	T23D8.3	n/a	chrI 9,974,837	T23D8.3 encodes an ortholog of yeast and human LTV1 that inhibits DHC-1 in vivo; in mass RNAi assays, T23D8.3 is required for embryonic and larval development, normally large brood sizes, and normally fast growth.
36	ZK856.6	ZK856.6	n/a	chrV 10,199,178	contains similarity to Ralstonia solanacearum Composite TWO-component regulatory (Sensor kinase and responsesregulator hybrid) transcription regulator protein.; TR:Q8XWL8
37	pkc-1	F57F5.5	n/a	chrV 12,019,252	pkc-1 encodes a serine/threonine protein kinase that is orthologous to mammalian protein kinase C epsilon (PRKCE), a member of the nPKC subgroup of the protein kinase C superfamily; together with UNC-13, PKC-1 may act downstream of goa-1 to modulate phorbol ester-induced stimulation of acetylcholine release at NMJs; PKC-1 positively regulates locomotion, and affects thermotaxis and chemotaxis together with kin-11; PKC-1 is required for regulating several behaviors including sensation of volatile and soluble compounds, osmolarity, and temperature (thermosensation); PKC-1 is also required for phorbolester-induced stimulation of acetylcholine release at neuromuscular junctions; PKC-1 localizes to the processes and cell bodies of approximately 75 sensory neurons and interneurons, and pkc-1 mRNA is detectable at varying levels during larval and adult stages.
38	cacn-1	W03H9.4	n/a	chrII 14,137,700	cacn-1 encodes an ortholog of Drosophila CACTIN and human C19orf29 that is required for normal distal tip cell migration, embryonic viability, fertility, locomotion, vulval morphogenesis, and normally rapid growth; like CACTIN, CACN-1 contains predicted coiled-coil domains, but otherwise lacks recognizable similarity to known proteins.
39	cul-5	ZK856.1	n/a	chrV 10,181,305	cul-5 encodes a cullin, orthologous to vasopressin-activated calcium-mobilizing receptor-1 in mammals, that is thought to regulate the cell cycle by virtue of its paralogy to cul-1 and cul-2; however, CUL-5 is dispensable for viability and gross morphology in mass RNAi screens, and does not appear to interact with any of 17 Skp1-related proteins (SKR-1 through SKR-21).
40	T10E10.4	T10E10.4	n/a	chrX 6,318,637	T10E10.4 encodes a large (966-residue) protein, predicted to be secreted, with two N-terminal chitin-binding peritrophin-A domains followed by 14 cysteine-rich domains and one C-terminal EB module; the general organization of T10E10.4 protein resembles that of K04H4.2; T10E10.4 has no obvious function in mass RNAi assays but, like CEJ-1 and CPG-2, might participate in chitin synthesis.
41	fpn-1.2	R09B5.4	n/a	chrV 1,463,421	R09B5.4 is orthologous to the human gene HYPOTHETICAL PROTEIN (SLC11A3; OMIM:604653), which when mutated leads to disease.
42	nhr-226	T27B7.3	n/a	chrV 2,295,897	C. elegans NHR-226 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR000083 (Fibronectin, type I), IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
43	srw-63	Y37A1B.10	n/a	chrIV 14,014,952	C. elegans SRW-63 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
44	Y43F4A.3	Y43F4A.3	n/a	chrIII 13,240,329	contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
45	F40G9.1	F40G9.1	n/a	chrIII 196,177	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
46	tag-324	C27C12.5	n/a	chrX 14,850,888	C. elegans TAG-324 protein; contains similarity to Pfam domain PF00858 Amiloride-sensitive sodium channel contains similarity to Interpro domain IPR001873 (Na+ channel, amiloride-sensitive)
47	F48A11.4	F48A11.4	n/a	chrII 214,905
48	F29A7.5	F29A7.5	n/a	chrII 2,747,560
49	dct-10	Y38H6C.5	n/a	chrV 20,503,211	C. elegans DCT-10 protein; contains similarity to Pfam domains PF03732 (Retrotransposon gag protein) , PF00098 (Zinc knuckle) contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR005162 (Retrotransposon gag protein), IPR001878 (Zinc finger, CCHC-type)
50	coq-6	K07B1.2	n/a	chrV 9,337,783	coq-6 encodes a putative flavin-dependent aromatic-ring monooxygenase, homologous to yeast COQ6; COQ-6 is required for ubiquinone (coenzyme Q9) biosynthesis and for normally short lifespan; coq-6(RNAi) animals have reduced levels of coenzyme Q9 and superoxide, and have abnormally long lifespans.