UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	grd-10	F09D12.1	7e-51	chrIV 3,441,427	grd-10 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; GRD-10 is expressed in seam cells; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-10 is weakly required for normal molting; GRD-10 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
2	ZK218.1	ZK218.1	n/a	chrV 17,092,954	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
3	W01C8.1	W01C8.1	n/a	chrX 5,693,921
4	B0035.16	B0035.16	n/a	chrIV 11,295,988	contains similarity to Pfam domain PF03054 tRNA methyl transferase contains similarity to Interpro domains IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold), IPR004506 (tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase)
5	W01H2.2	W01H2.2	n/a	chrX 4,218,344
6	syn-4	T01B11.3	n/a	chrIV 8,458,062	syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
7	R107.2	R107.2	n/a	chrIII 9,044,850	contains similarity to Pfam domain PF01256 Carbohydrate kinase contains similarity to Interpro domain IPR000631 (Carbohydrate kinase)
8	srd-17	Y2H9A.2	n/a	chrV 13,431,663	C. elegans SRD-17 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
9	btb-3	B0047.2	n/a	chrII 2,043,575	C. elegans BTB-3 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ), IPR000210 (BTB/POZ-like)
10	F19D8.2	F19D8.2	n/a	chrX 13,835,397	contains similarity to Homo sapiens Splice isoform 1 of Q9UMN6 Myeloid/lymphoid or mixed-lineage leukemia protein 4; ENSEMBL:ENSP00000222270
11	T25G12.2	T25G12.2	n/a	chrX 17,245,951	The T25G12.2 gene encodes a homolog of the human gene HSD, which when mutated leads to cortisol 11-beta ketoreductase deficiency (OMIM:218030); T25G12.2 protein is predicted to be mitochondrial with 68% accuracy.
12	Y49E10.21	Y49E10.21	n/a	chrIII 12,458,332	contains similarity to Nanoarchaeum equitans DNA double-strand break repair rad50 ATPase.; SW:P62135
13	srh-36	T03D3.4	n/a	chrV 2,820,623	C. elegans SRH-36 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	F56E10.3	F56E10.3	n/a	chrV 82,911	contains similarity to Pfam domain PF06371 Diaphanous GTPase-binding Domain contains similarity to Interpro domain IPR010473 (Diaphanous GTPase-binding)
15	F26F12.2	F26F12.2	n/a	chrV 5,838,075
16	C34D4.10	C34D4.10	n/a	chrIV 7,120,692
17	F10C2.5	F10C2.5	n/a	chrV 12,047,001	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domains IPR010916 (TonB box, conserved site), IPR001382 (Glycoside hydrolase, family 47)
18	spat-1	F57C2.6	n/a	chrII 14,531,337	spat-1 encodes a divergent ortholog of Drosophila melanogaster AURORA BOREALIS (BORA) and human BORA (OMIM:610510); SPAT-1 is specifically required for PAR protein-dependent cell-polarity; RNAi of spat-1 weakly suppresses the embryonic lethality of par-2(it5ts) at restrictive temperature.
19	srxa-9	ZK678.4	n/a	chrX 15,749,493	C. elegans SRXA-9 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domain IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
20	ZC412.8	ZC412.8	n/a	chrV 14,879,632	contains similarity to Plasmodium cynomolgi Circumsporozoite protein precursor (CS).; SW:P08675
21	srj-55	Y45G12A.1	n/a	chrV 2,857,011	C. elegans SRJ-55 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
22	T09B4.2	T09B4.2	n/a	chrI 6,184,694
23	W06A11.1	W06A11.1	n/a	chrII 4,068,658
24	K09C6.3	K09C6.3	n/a	chrV 852,829
25	K09A9.4	K09A9.4	n/a	chrX 15,593,283	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
26	srx-135	F09F3.11	n/a	chrV 13,860,290	C. elegans SRX-135 protein ;
27	lgc-7	Y57G11C.2	n/a	chrIV 14,712,127	C. elegans LGC-7 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
28	C09D4.2	C09D4.2	n/a	chrI 5,492,333
29	sre-29	F57G9.4	n/a	chrII 12,400,560	C. elegans SRE-29 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
30	ZK546.5	ZK546.5	n/a	chrII 4,936,745	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
31	B0207.6	B0207.6	n/a	chrI 5,936,242	contains similarity to Pfam domain PF03029 Conserved hypothetical ATP binding protein contains similarity to Interpro domain IPR004130 (Protein of unknown function, ATP binding)
32	C36F7.2	C36F7.2	n/a	chrI 9,551,413	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domain IPR002110 (Ankyrin)
33	C44C10.3	C44C10.3	n/a	chrX 11,703,337	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005828 (General substrate transporter), IPR016196 (MFS general substrate transporter)
34	C46E10.8	C46E10.8	n/a	chrII 3,726,646	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR003604 (Zinc finger, U1-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
35	nhr-60	F57A10.5	n/a	chrV 15,771,767	C. elegans NHR-60 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
36	C50B8.3	C50B8.3	n/a	chrV 13,567,762	contains similarity to Pfam domain PF08547 Complex I intermediate-associated protein 30 (CIA30) contains similarity to Interpro domain IPR013857 (NADH:ubiquinone oxidoreductase complex I intermediate-associated protein 30)
37	B0348.1	B0348.1	n/a	chrV 49,270	contains similarity to Interpro domain IPR006629 (LPS-induced tumor necrosis factor alpha factor)
38	F36H12.2	F36H12.2	n/a	chrIV 5,275,375
39	ape-1	F46F3.4	n/a	chrV 11,680,585	ape-1 encodes an ortholog of inhibitory p53-interacting protein (iASPP); APE-1 binds CEP-1 in vitro, and shares 38% amino-acid identity in its ankyrin repeats and SH3 domain to iASPP, with many iASPP residues contacting p53 being conserved; RNAi of ape-1 induces CEP-1- and HUS-1-dependent apoptosis in the germline, consistent with inhibition of the CEP-1/HUS-1 DNA damage checkpoint by APE-1 in the germline; excess ape-1(RNAi) apoptosis also requires CED-3.
40	str-12	B0391.4	n/a	chrV 15,611,921	C. elegans STR-12 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
41	grsp-3	C34D4.11	n/a	chrIV 7,131,263	C. elegans GRSP-3 protein; contains similarity to Interpro domains IPR005405 (Potassium channel, voltage dependent, Kv3.4), IPR002952 (Eggshell protein), IPR003991 (Pertactin virulence factor, C-terminal), IPR000817 (Prion protein), IPR001951 (Histone H4)
42	fbxa-145	F48C1.2	n/a	chrI 5,320,402	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
43	F31F4.1	F31F4.1	n/a	chrV 685,113	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
44	T07E3.3	T07E3.3	n/a	chrIII 6,904,401	contains similarity to Interpro domain IPR012336 (Thioredoxin-like fold)
45	F38A5.11	F38A5.11	n/a	chrIV 6,593,581	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
46	srh-245	F31F4.9	n/a	chrV 655,327	C. elegans SRH-245 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
47	K06H6.4	K06H6.4	n/a	chrV 580,280	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
48	D2092.5	D2092.5	n/a	chrI 6,603,752	contains similarity to Interpro domains IPR002713 (FF), IPR000533 (Tropomyosin)
49	ZK402.1	ZK402.1	n/a	chrX 1,405,182
50	djr-1.1	B0432.2	n/a	chrII 291,212	djr-1.1 encodes an ortholog of DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitors that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2).