UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pin-2	F07C6.1	0	chrIV 12,794,963	pin-2 encodes a LIM domain-containing protein that, along with UNC-97, comprises the two C. elegans members of the PINCH family of predicted adapter proteins; based upon its similarity to Drosophila and vertebrate members of the PINCH family, PIN-2 is predicted to play a role in regulation of cell morphology, motility, and survival, but as loss of pin-2 via large-scale RNAi results in no obvious defects, the precise role of PIN-2 in C. elegans development and/or behavior is not yet known; a PIN-2::GFP fusion protein is first expressed in embryos just prior to hatching and in early larvae is seen in several neurons, including the PVT neuron, and in intestinal cells; during postembryonic development, neuronal expression continues, whereas intestinal expression gradually declines; PIN-2 localizes to the cytoplasm and to the nucleus, and in neurons, is seen in axonal processes and varicosities.
2	F08D12.13	F08D12.13	n/a	chrII 2,795,880
3	W04G5.7	W04G5.7	n/a	chrI 11,653,511	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
4	K10G6.4	K10G6.4	n/a	chrII 3,973,888	contains similarity to Interpro domain IPR000533 (Tropomyosin)
5	W05B10.4	W05B10.4	n/a	chrV 12,668,893	contains similarity to Pfam domain PF00788 Ras association (RalGDS/AF-6) domain contains similarity to Interpro domain IPR000159 (Ras-association)
6	srg-68	ZC317.5	n/a	chrV 5,464,597	C. elegans SRG-68 protein ;
7	C55A1.4	C55A1.4	n/a	chrV 15,642,939	contains similarity to Escherichia coli TolA protein.; SW:TOLA_ECOLI
8	F40G9.6	F40G9.6	n/a	chrIII 179,840
9	C31H5.6	C31H5.6	n/a	chrI 9,045,096	contains similarity to Pfam domains PF08840 (BAAT / Acyl-CoA thioester hydrolase C terminal) , PF04775 (Acyl-CoA thioester hydrolase / Bile acid-CoA amino acid N-acetyltransferase) contains similarity to Interpro domains IPR006862 (Acyl-CoA thioester hydrolase/bile acid-CoA amino acid N-acetyltransferase), IPR014940 (BAAT/Acyl-CoA thioester hydrolase C-terminal), IPR016662 (Acyl-CoA thioesterase, long chain)
10	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
11	E03H4.3	E03H4.3	n/a	chrI 12,406,224	contains similarity to Pfam domain PF01762 Galactosyltransferase contains similarity to Interpro domain IPR002659 (Glycosyl transferase, family 31)
12	dgn-3	F07G6.1	n/a	chrX 1,730,834	C. elegans DGN-3 protein ;
13	T10C6.2	T10C6.2	n/a	chrV 16,013,354	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	F35C5.11	F35C5.11	n/a	chrII 12,909,598	contains similarity to Mus musculus Lymphocyte antigen Ly-6D precursor (Thymocyte B cell antigen) (ThB).; SW:LY6D_MOUSE
15	srg-41	T19C4.3	n/a	chrV 11,161,148	C. elegans SRG-41 protein; contains similarity to Interpro domains IPR000500 (Connexins), IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
16	F38E9.4	F38E9.4	n/a	chrX 16,452,168
17	srh-39	C06A8.7	n/a	chrII 7,764,656	C. elegans SRH-39 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
18	srz-48	F20E11.1	n/a	chrV 17,459,315	C. elegans SRZ-48 protein ;
19	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
20	F45E6.3	F45E6.3	n/a	chrX 12,488,021	contains similarity to Pfam domain PF00566 TBC domain contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
21	T17A3.10	T17A3.10	n/a	chrIII 155,573	contains similarity to Interpro domain IPR007110 (Immunoglobulin-like)
22	H14N18.2	H14N18.2	n/a	chrV 8,933,428
23	C54F6.5	C54F6.5	n/a	chrV 7,529,245
24	fbxa-103	F09C3.4	n/a	chrI 14,288,863	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
25	cfi-1	T23D8.8	n/a	chrI 9,997,318	cfi-1 encodes a DNA-binding protein containing an AT-rich interaction domain (ARID) that affects differentiation of the URA sensory neurons, AVD, and PVC interneurons; acts downstream of UNC-86 and LIN-32 in controlling URA and IL2 cell fate, and is expressed in some neurons and muscle cells.
26	ugt-15	C44H9.1	n/a	chrV 12,828,911	C. elegans UGT-15 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
27	gcy-17	W03F11.2	n/a	chrI 2,228,250	gcy-17 encodes a predicted guanylate cyclase.
28	K06A1.1	K06A1.1	n/a	chrII 6,455,658	K06A1.1 encodes an AP-2-like transcription factor.
29	fmo-2	K08C7.5	n/a	chrIV 10,683,426	fmo-2 encodes a flavin-containing monoxygenase homologous to human FMO1, FMO2, and FMO3 (OMIM:602079, mutated in trimethylaminuria).
30	nhr-148	C03G6.10	n/a	chrV 7,342,974	C. elegans NHR-148 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
31	F55A4.3	F55A4.3	n/a	chrX 1,023,626
32	F41E7.1	F41E7.1	n/a	chrX 10,281,146	contains similarity to Pfam domain PF00999 Sodium/hydrogen exchanger family contains similarity to Interpro domains IPR006153 (Sodium/hydrogen exchanger), IPR001680 (WD40 repeat)
33	ubc-1	C35B1.1	n/a	chrIV 4,104,634	ubc-1 encodes an E2 ubiquitin-conjugating enzyme that contains a novel 40 amino acid C-terminal tail, and is homologous to Saccharomyces cerevisiae RAD6/UBC2 which is involved in DNA repair; although loss of UBC-1 activity via RNA-mediated interference (RNAi) does not result in any abnormalities, UBC-1 is able to complement the DNA repair defects of a Saccharomyces cerevisiae rad6 null mutant, suggesting that UBC-1 can function in the DNA repair pathway; ubc-1 mRNA is detectable in embryos.
34	F41H8.2	F41H8.2	n/a	chrV 827,588	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
35	F08H9.4	F08H9.4	n/a	chrV 14,463,959	F08H9.4 encodes a heat shock protein (HSP) of the HSP16 class; unlike most HSP16s in C. elegans, it is specifically expressed in a particular tissue (the excretory canal and ventral nerve-cord neurons), and its expression is only mildly induced by heat shock; however, F08H9.4 expression is increased by heat shock, is induced in a new tissue type (intestine) by heat shock, and probably aids heat shock resistance, since F08H9.4(RNAi) animals die as embryos in heat shock at a higher rate than normal; in general, HSP16 proteins are thought to act as passive ligands for unfolded proteins that keep them safe from aggregation until the proteins can be refolded by a large (ATP-consuming) HSP.
36	srbc-9	C18B10.3	n/a	chrV 7,489,768	C. elegans SRBC-9 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
37	Y38H6C.9	Y38H6C.9	n/a	chrV 20,516,299	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
38	Y62H9A.14	Y62H9A.14	n/a	chrX 11,922,107	contains similarity to Interpro domain IPR009010 (Aspartate decarboxylase-like fold)
39	F53C3.4	F53C3.4	n/a	chrII 3,902,067	contains similarity to Pfam domain PF01705 CX module contains similarity to Interpro domain IPR002619 (Protein of unknown function CX)
40	T21B6.4	T21B6.4	n/a	chrX 10,934,829	contains similarity to Interpro domain IPR003006 (Immunoglobulin/major histocompatibility complex, conserved site)
41	K11E4.3	K11E4.3	n/a	chrX 13,721,488	The K11E4.3 gene encodes one of five paraoxonase-like proteins; it is homologous to the human PARAOXONASE 1 gene (PON1, OMIM:168820), which in some allelic forms is associated with susceptibility to coronary artery disease.
42	gpa-9	F56H9.4	n/a	chrV 12,648,055	gpa-9 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases; it is expressed in ASJ, PHB, PVQ, pharyngeal muscle, and the spermatheca.
43	srh-154	F20E11.12	n/a	chrV 17,441,133	C. elegans SRH-154 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR006069 (ATPase, P-type cation exchange, alpha subunit)
44	C08F11.2	C08F11.2	n/a	chrIV 13,622,516	contains similarity to Methanobacterium thermoautotrophicum Hypothetical protein MTH421.; SW:Y421_METTH
45	Y44A6B.3	Y44A6B.3	n/a	chrV 20,633,182	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domain IPR006583 (CW)
46	C24A11.5	C24A11.5	n/a	chrI 5,385,191
47	E03H4.5	E03H4.5	n/a	chrI 12,414,766	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
48	F10E9.1	F10E9.1	n/a	chrIII 8,323,702
49	F47F2.3	F47F2.3	n/a	chrX 3,894,817	contains similarity to Interpro domain IPR013032 (EGF-like region, conserved site)
50	bbs-8	T25F10.5	n/a	chrV 6,763,757	bbs-8 encodes a tetratricopeptide repeat (TPR)-containing protein that is orthologous to the human Bardet-Biedl syndrome protein, BBS8; in C. elegans, bbs-8 activity is required for cilia biogenesis and function; accordingly, bbs-8 mutant animals display odorant chemotaxis defects and exhibit both aberrant motility and abnormal localization of at least two intraflagellar transport (IFT) protein markers; a BBS-8::GFP translational fusion is expressed exclusively in ciliated head and tail neurons, where it localizes predominantly to the base of cilia, known as the ciliary transition zone; BBS-8::GFP is also observed moving bidirectionally (anterograde and retrograde) along the ciliary axoneme; DNA sequences upstream of bbs-8 contain X box DNA binding sites, suggesting that bbs-8 expression may be regulated by the DAF-19 RFX-type transcription factor.