UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F01G4.4	F01G4.4	0	chrIV 11,144,606	contains similarity to Myxococcus xanthus Pseudouridine synthase (EC 5.4.99.-).; TR:Q1D5Q2
2	T28A8.3	T28A8.3	n/a	chrIII 13,507,200	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
3	D2030.8	D2030.8	n/a	chrI 7,593,243	contains similarity to Interpro domains IPR005479 (Carbamoyl phosphate synthetase, large subunit, ATP-binding), IPR013830 (Esterase, SGNH hydrolase-type)
4	T28A8.5	T28A8.5	n/a	chrIII 13,502,424	contains similarity to Pfam domain PF04435 Domain of unknown function (DUF545) contains similarity to Interpro domain IPR006570 (SPK)
5	F13D12.5	F13D12.5	n/a	chrII 11,727,540	contains similarity to Interpro domain IPR001814 (Filamentous bacteriophage Vg4 protein)
6	R05D3.2	R05D3.2	n/a	chrIII 8,373,629	R05D3.2 is orthologous to the human gene UNKNOWN (PROTEIN FOR MGC:16889) (C7orf2; OMIM:605522), which when mutated leads to disease.
7	M02D8.2	M02D8.2	n/a	chrX 8,739,895
8	rhr-2	B0240.1	n/a	chrV 11,729,008	rhr-2 encodes a predicted transmembrane protein with similarity to human Rh blood group antigens proposed to function in inorganic ion transport and metabolism; the role of RHR-2 in C. elegans development or behavior remains unclear, as loss of RHR-2 function via RNA-mediated interference does not result in any abnormalities.
9	F59E12.1	F59E12.1	n/a	chrII 5,655,915	contains similarity to Pfam domain PF00439 Bromodomain contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR001487 (Bromodomain)
10	T10E9.2	T10E9.2	n/a	chrI 6,543,527
11	fbxa-114	Y113G7B.7	n/a	chrV 20,197,592	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
12	C55A6.9	C55A6.9	n/a	chrV 11,522,512	contains similarity to Pfam domain PF03985 Paf1 contains similarity to Interpro domain IPR007133 (RNA polymerase II-associated, Paf1)
13	K09F6.2	K09F6.2	n/a	chrII 2,268,709	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
14	F56A3.1	F56A3.1	n/a	chrI 5,192,666
15	F56D1.1	F56D1.1	n/a	chrII 5,479,410	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
16	K12D12.5	K12D12.5	n/a	chrII 11,862,086	contains similarity to Interpro domains IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
17	let-711	F57B9.2	n/a	chrIII 6,952,757	let-711 encodes the C. elegans ortholog of NOT1, the conserved core component of the multisubunit CCR4/NOT complex that plays a role in regulation of gene expression via various processes including transcriptional control, mRNA deadenylation, and protein ubiquitination; in C. elegans, let-711 activity is essential for embryonic and larval development and in particular, for proper spindle positioning, microtubule length, and centrosome morphology in early embryos; in addition, let-711 is essential for normal germline development and levels of fertility; in embryos, let-711 mutations can suppress the short microtubule phenotype produced by mutations in zyg-9, which encodes the C. elegans XMAP125 homolog, and centrosomoal ZYG-9 levels are increased in let-711 mutants, suggesting that let-711 functions, in part, by negatively regulating ZYG-9 levels or localization; in situ hybridization studies indicate that let-711 mRNA is broadly expressed in the gonad and that its gonadal expression is negatively regulated by lin-35/Rb.
18	F57B10.4	F57B10.4	n/a	chrI 6,567,540	contains similarity to Trichomonas vaginalis G3 Viral A-type inclusion protein, putative.; TR:A2E8Z5
19	T19B4.5	T19B4.5	n/a	chrI 5,675,326
20	T01C3.9	T01C3.9	n/a	chrV 15,005,731	contains similarity to Foot-and-mouth disease virus O Polyprotein.; TR:Q80B22
21	T24D1.2	T24D1.2	n/a	chrI 9,954,687	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
22	bath-1	F59H6.9	n/a	chrII 2,028,219	C. elegans BATH-1 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
23	R02D3.7	R02D3.7	n/a	chrIV 254,500	contains similarity to Interpro domains IPR009060 (UBA-like), IPR015880 (Zinc finger, C2H2-like)
24	Y54E2A.12	Y54E2A.12	n/a	chrII 14,799,590	contains similarity to Interpro domain IPR000195 (RabGAP/TBC)
25	F55A12.1	F55A12.1	n/a	chrI 5,370,477	contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR006030 (Molluscan rhodopsin C-terminal tail), IPR000694 (Proline-rich region), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
26	coh-3	F08H9.1	n/a	chrV 14,458,664	coh-3 encodes a member of the Rad21/Rec8-like family of cohesion proteins that is expressed in the germline; an effect on embryonic viability has been reported based on some RNAi screens, but has not been demonstrated in others.
27	his-66	H02I12.6	n/a	chrIV 11,400,571	his-66 encodes an H2B histone.
28	mlh-1	T28A8.7	n/a	chrIII 13,511,833	The mlh-1 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MLH1.
29	ZK1193.3	ZK1193.3	n/a	chrX 418,922	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site)
30	thoc-2	C16A3.8	n/a	chrIII 6,370,914	C. elegans THOC-2 protein ; contains similarity to Homo sapiens THO complex 2 isoform 1; ENSEMBL:ENSP00000347959
31	sas-4	F10E9.8	n/a	chrIII 8,316,386	sas-4 encodes a predicted coiled-coil protein and centriole component recruited to the centrosome once per cell cycle at the time of organelle duplication and is required for centriole duplication and spindle assembly, levels dictate centrosome size, and also affects germ cell proliferation and locomotion; colocalizes with gamma-tubulin to centrosomes both in sperm and in the syncitial part of the gonad.
32	R07B7.2	R07B7.2	n/a	chrV 12,058,156	contains similarity to Saccharomyces cerevisiae Protein required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability; protects centromeric Spo69p; SGD:YOR073W
33	F56D2.2	F56D2.2	n/a	chrIII 5,588,134	contains similarity to Pfam domains PF05773 (RWD domain) , PF01485 (IBR domain) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR006575 (RWD), IPR016135 (Ubiquitin-conjugating enzyme/RWD-like), IPR002867 (Zinc finger, C6HC-type)
34	C45B2.1	C45B2.1	n/a	chrX 6,086,305
35	rga-3	K09H11.3	n/a	chrV 5,719,976	rga-3 encodes a GTPase-activating protein (GAP); RNAi experiments predicted to target rga-3 and the related rga-4 gene result in early embryonic defects, specifically defects in cortical contractility, non-muscle myosin NMY-2 distribution, and the relative size of PAR protein domains; in vitro, RGA-3 positively regulates RHO-1 GTPase activity, consistent with genetic studies showing that the rga-3/4(RNAi) phenotype requires RHO-1 activity; in early embryos, a YFP-RGA-3 fusion protein localizes to the cellular cortex and to centrosomes, with cortical localization segregating to the anterior during polarization.
36	F55G1.5	F55G1.5	n/a	chrIV 7,475,614	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
37	C28A5.1	C28A5.1	n/a	chrIII 4,431,952	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IJR3
38	T10B11.8	T10B11.8	n/a	chrI 6,953,068
39	C27B7.5	C27B7.5	n/a	chrIV 8,902,390	contains similarity to Pfam domain PF00098 Zinc knuckle contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
40	F55G1.6	F55G1.6	n/a	chrIV 7,474,219	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR011016 (Zinc finger, variant RING-type)
41	pqn-45	F56F3.1	n/a	chrIII 4,473,243	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
42	msh-2	H26D21.2	n/a	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
43	evl-14	H38K22.1	n/a	chrIII 4,308,081	evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects.
44	pch-2	F10B5.5	n/a	chrII 8,159,065	pch-2 encodes a putative AAA+-type ATPase orthologous to budding yeast PCH2 and human TRIP13 (OMIM:604507); PCH-2 is required for the apoptosis of pachytene cells induced by unsynapsed chromosomal pairing centers, but is dispensable for meiotic apoptosis induced by DNA damage; PCH-2-mediated apoptosis is inhibited by SYP-1 and SYP-2, while it requires HIM-8 (and probably HIM-8's paralogs, ZIM-1/-3 and C02F5.12); however, PCH-2-mediated apoptosis does not require SPO-11; pch-2 transcripts are enriched during oogenesis; the excess germline apoptosis of syp-1(me17) mutants is partially suppressed by pch-2(tm1458), and fully suppressed by pch-2(tm1458);spo-11(ok79).
45	C49C3.7	C49C3.7	n/a	chrIV 17,333,023	contains similarity to Homo sapiens Isoform Short of CAP-Gly domain-containing linker protein 1; ENSEMBL:ENSP00000355314
46	M151.4	M151.4	n/a	chrII 3,625,534	contains similarity to Interpro domain IPR000533 (Tropomyosin)
47	F26E4.6	F26E4.6	n/a	chrI 9,773,519	contains similarity to Pfam domain PF02935 Cytochrome c oxidase subunit VIIc contains similarity to Interpro domain IPR004202 (Cytochrome c oxidase subunit VIIc)
48	C03B8.2	C03B8.2	n/a	chrIII 7,716,234
49	F19F10.10	F19F10.10	n/a	chrV 7,579,007	F19F10.10 encodes a protein with a THAP or THAP-like domain; other proteins with such domains include LIN-15A, LIN-15B, LIN-36, and HIM-17 (which all interact with LIN-35/Rb), as well as CDC-14B, CTB-1, GON-14, and ~100 other proteins such as Drosophila P element transposase and human nuclear proapoptotic factor THAP1.
50	cyn-11	T01B7.4	n/a	chrII 8,715,669	cyn-11 encodes a divergent cyclophilin D isoform, with alterations in the normally well-conserved cyclophilin-binding domain, and a central 7-8 residue insert not usually found in cyclophilins, except from plants; CYN-11 has sluggish but detectable peptidyl-prolyl isomerase activity in vitro, suggesting that it has a specialized substrate in vivo; CYN-11 is dispensable for viability and gross morphology in mass RNAi screens.