UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	F01G10.6	F01G10.6	9e-149	chrIV 10,226,957	contains similarity to Interpro domain IPR016054 (Ly-6 antigen / uPA receptor -like)
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
4	F09C12.6	F09C12.6	n/a	chrII 5,117,137	contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002651 (Protein of unknown function DUF32)
5	ztf-2	F13G3.1	n/a	chrI 7,292,255	C. elegans ZTF-2 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR013993 (Zinc finger, N-recognin, metazoa), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
6	T14D7.2	T14D7.2	n/a	chrII 8,850,480	T14D7.2 encodes an acyltransferase; large-scale RNAi experiments indicate that T14D7.2 activity is required for egg laying, coordination locomotion, and normal vulval morphology.
7	C50D2.1	C50D2.1	n/a	chrII 113,049
8	R07G3.6	R07G3.6	n/a	chrII 7,604,709	contains similarity to Interpro domain IPR000694 (Proline-rich region)
9	F25D1.3	F25D1.3	n/a	chrV 10,529,632	contains similarity to Pfam domain PF06083 Interleukin-17 contains similarity to Interpro domain IPR010345 (Interleukin-17)
10	pek-1	F46C3.1	n/a	chrX 11,412,423	pek-1 encodes a predicted transmembrane protein kinase orthologous to human eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3, OMIM:604032), which when mutated leads to Wolcott-Rallison syndrome; PEK-1 is strongly expressed in intestinal cells and is required for the unfolded protein response (UPR) that counteracts cellular stress induced by accumulation of unfolded proteins in the endoplasmic reticulum (ER); PEK-1 may function in the endoplasmic reticulum to phosphorylate eIF2alpha and inhibit protein synthesis in response to endogenous ER stress.
11	col-128	F12F6.9	n/a	chrIV 11,550,954	C. elegans COL-128 protein; contains similarity to Pfam domain PF01391 Collagen triple helix repeat (20 copies) contains similarity to Interpro domains IPR008161 (Collagen helix repeat), IPR008160 (Collagen triple helix repeat)
12	B0331.2	B0331.2	n/a	chrV 9,660,245	contains similarity to Pfam domain PF01384 Phosphate transporter family contains similarity to Interpro domain IPR001204 (Phosphate transporter)
13	cwp-4	K11D12.1	n/a	chrV 5,055,031	cwp-4 encodes a protein with some similarity to mucins that is predicted to be secreted, and is alleged to be coexpressed with polycystins; CWP-4 is dispensable for viability and gross morphology in mass RNAi screens.
14	R09B5.11	R09B5.11	n/a	chrV 1,440,531	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR016196 (MFS general substrate transporter)
15	T09F3.1	T09F3.1	n/a	chrII 10,386,641	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
16	scl-10	F49E11.5	n/a	chrIV 13,049,134	C. elegans SCL-10 protein; contains similarity to Pfam domain PF00188 SCP-like extracellular protein contains similarity to Interpro domains IPR014044 (SCP-like extracellular), IPR002413 (Ves allergen), IPR001283 (Allergen V5/Tpx-1 related)
17	C30F12.6	C30F12.6	n/a	chrI 6,990,585	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR008365 (Prostanoid receptor), IPR002120 (Thyrotrophin-releasing hormone receptor), IPR009144 (Thyrotropin-releasing hormone receptor), IPR000276 (GPCR, rhodopsin-like)
18	ctl-1	Y54G11A.6	n/a	chrII 14,304,828	ctl-1 encodes one of three C. elegans catalases; CTL-1 exhibits catalase activity in vitro, and thus likely functions in vivo as an antioxidant enzyme that protects cells from reactive oxygen species; ctl-1 activity contributes to the extended lifespan seen in daf-2 mutant animals; in addition, ctl-1 expression is negatively regulated by DAF-2-mediated insulin signaling; as CTL-1 does not possess a C-terminal peroxisomal targeting signal (PTS), it is predicted to be a cytosolic catalase.
19	C28C12.4	C28C12.4	n/a	chrIV 8,487,897	contains similarity to Pfam domain PF02520 Domain of unknown function DUF148 contains similarity to Interpro domain IPR003677 (Protein of unknown function DUF148)
20	R07B1.5	R07B1.5	n/a	chrX 9,865,660	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
21	cpt-6	W01A11.5	n/a	chrV 6,491,977	C. elegans CPT-6 protein; contains similarity to Pfam domain PF00755 Choline/Carnitine o-acyltransferase contains similarity to Interpro domain IPR000542 (Acyltransferase ChoActase/COT/CPT)
22	ZC581.9	ZC581.9	n/a	chrI 6,667,794	ZC581.9 encodes a serine/threonine protein kinase related to the vertebrate SCY1-like family of protein kinases; loss of ZC581.9 activity in an RNAi-hypersensitive strain results in axon guidance defects indicating that ZC581.9 likely plays a role in regulation of axon navigation.
23	F58H10.1	F58H10.1	n/a	chrI 7,756,062	contains similarity to Homo sapiens Splice isoform Long of Q8WXX7 Autism susceptibility gene 2 protein; ENSEMBL:ENSP00000329863
24	K06A1.3	K06A1.3	n/a	chrII 6,442,625	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
25	cyp-13A2	T10B9.7	n/a	chrII 9,785,530	C. elegans CYP-13A2 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
26	col-34	F36A4.10	n/a	chrIV 4,244,072	col-34 encodes a cuticle collagen protein and is a critical component of male tail cuticle organization affecting ray morphology.
27	F17H10.1	F17H10.1	n/a	chrX 13,106,728	contains similarity to Danio rerio Protein SERAC1.; SW:Q5SNQ7
28	hum-6	T10H10.1	n/a	chrX 2,309,009	hum-6 is orthologous to the human gene MYOSIN VIIA (MYO7A; OMIM:276903), which when mutated leads to Usher syndrome type IB.
29	frm-3	H05G16.1	n/a	chrX 11,578,915	frm-3 encodes a protein containing a FERM domain (Band 4.1 family); expressed in a few cells in the head.
30	vab-9	T22C8.8	n/a	chrII 8,636,902	vab-9 encodes a claudin homolog orthologous to human brain cell membrane protein 1 (BCMP1) and Drosophila CG6982; VAB-9 colocalizes with HMP-1 to an apical layer of the adherens junctions of all epithelial cells, one layer more apically than AJM-1; vab-9 mutants have disorganized F-actin at the adherens junction, implying that VAB-9 links junctions to circumferential actin filaments; VAB-9 is also expressed in the nerve ring; VAB-9 requires the cadherin HMR-1 to localize to the cell membrane, and both alpha-catenin (HMP-1) and beta-catenin (HMP-2) to remain at the cell junction after membrane localization.
31	cyp-33C9	C50H11.15	n/a	chrV 3,093,157	C. elegans CYP-33C9 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
32	W04H10.1	W04H10.1	n/a	chrII 609,207
33	Y38H6C.16	Y38H6C.16	n/a	chrV 20,532,568	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
34	mec-18	C52B9.9	n/a	chrX 4,272,688	mec-18 encodes a protein similar to firefly luciferase and plant protein 4-coumarate coA ligase; mec-18 is involved in sensory mechanotransduction; genetic interactions with other mec genes suggest that mec-18 may be involved in negative regulation of the degenerin channel in the touch receptor neurons; mec-18 is expressed exclusively in the touch cells.
35	F57G12.2	F57G12.2	n/a	chrX 12,158,178	contains similarity to Mus musculus Nuclear protein ZAP3.; SW:ZAP3_MOUSE
36	F38B6.1	F38B6.1	n/a	chrX 6,700,523
37	clec-89	C09D1.2	n/a	chrI 4,072,314	C. elegans CLEC-89 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR003990 (Pancreatitis-associated protein), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
38	F55C12.4	F55C12.4	n/a	chrII 5,857,731
39	pgp-12	F22E10.1	n/a	chrX 12,734,558	pgp-12 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of ATP-binding cassette (ABC) transporters; although loss of pgp-12 function via mutation or RNAi results in no obvious defects, pgp-12 promoter fusion constructs reveal expression in the excretory cell, consistent with a role for pgp-12 in metabolite transporter activity; pgp-12 expression is regulated by the DCP-66 transcription factor which binds the pgp-12 Ex-1 promoter element in yeast one-hybrid and EMSA experiments.
40	F14B8.6	F14B8.6	n/a	chrX 6,930,764
41	F47A4.5	F47A4.5	n/a	chrX 9,835,643	contains similarity to Pfam domains PF01734 (Patatin-like phospholipase) , PF00023 (Ankyrin repeat) (5)contains similarity to Interpro domains IPR016035 (Acyl transferase/acyl hydrolase/lysophospholipase), IPR001638 (Bacterial extracellular solute-binding protein, family 3), IPR002641 (Patatin), IPR002110 (Ankyrin), IPR001680 (WD40 repeat)
42	H10E21.5	H10E21.5	n/a	chrIII 22,248	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR011016 (Zinc finger, variant RING-type)
43	C14F11.6	C14F11.6	n/a	chrX 6,238,566	contains similarity to Pfam domain PF00908 dTDP-4-dehydrorhamnose 3,5-epimerase contains similarity to Interpro domains IPR000888 (dTDP-4-dehydrorhamnose 3,5-epimerase related), IPR011051 (Cupin, RmlC-type), IPR014710 (RmlC-like jelly roll fold)
44	ptr-4	C45B2.7	n/a	chrX 6,063,339	ptr-4 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-4 is strongly required for normal molting from L4 to adult stages male tail development (a role conserved in C. briggsae); PTR-4 is also required for normal endocytosis of yolk by oocytes, adult alae formation, growth to full size, locomotion, and viability.
45	F07E5.7	F07E5.7	n/a	chrII 2,071,109	contains similarity to Pfam domain PF02343 Domain of unknown function DUF130 contains similarity to Interpro domain IPR003326 (Protein of unknown function DUF130)
46	F21D12.5	F21D12.5	n/a	chrII 7,329,535	contains similarity to Pfam domain PF00292 'Paired box' domain contains similarity to Interpro domains IPR001523 (Paired box protein, N-terminal), IPR011991 (Winged helix repressor DNA-binding), IPR009057 (Homeodomain-like)
47	ZC416.1	ZC416.1	n/a	chrIV 3,637,332	n/a
48	K05C4.8	K05C4.8	n/a	chrI 14,732,974	contains similarity to Dictyostelium discoideum Sterol glucosyltransferase (EC 2.4.1.173).; TR:Q9XYD4
49	F44D12.1	F44D12.1	n/a	chrIV 10,012,047	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domains IPR008144 (Guanylate kinase), IPR008145 (Guanylate kinase/L-type calcium channel region), IPR001452 (Src homology-3), IPR001478 (PDZ/DHR/GLGF)
50	F54B11.11	F54B11.11	n/a	chrX 13,580,176	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)