UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pyr-1	D2085.1	0	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
2	set-15	R11E3.4	n/a	chrIV 4,777,653	set-15 encodes a SET domain-containing protein required for normally short lifespan; SET-15 has no non-nematode orthologs, but several paralogs (SET-6, SET-13, SET-19, SET-20, SET-21, and SET-32); other than extending lifespan, set-15(RNAi) has no obvious phenotype.
3	T26E4.5	T26E4.5	n/a	chrV 15,787,827	contains similarity to Interpro domain IPR008996 ()
4	ptr-1	C24B5.3	n/a	chrV 9,179,855	ptr-1 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; individually, PTR-1 is weakly required for normal molting from L4 to adult stages; however, PTR-1, in conjunction with either PTR-16 alone or with PTR-6 and PTR-10, is strongly required for both molting and viability, with double ptr-1/-16 or triple ptr-1/-6/-10 RNAi animals showing pronounced molting defects and lethality; PTR-1 is also required for normal adult alae formation, growth to full size, locomotion, and male tail development.
5	C34F6.8	C34F6.8	n/a	chrX 11,216,944	contains similarity to Pfam domain PF00180 Isocitrate/isopropylmalate dehydrogenase contains similarity to Interpro domains IPR004790 (Isocitrate dehydrogenase NADP-dependent, eukaryotic), IPR001804 (Isocitrate/isopropylmalate dehydrogenase)
6	sft-4	C54H2.5	n/a	chrX 5,779,970	sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein.
7	ZC13.3	ZC13.3	n/a	chrX 885,679	contains similarity to Interpro domain IPR000998 (MAM)
8	his-7	F45F2.4	n/a	chrV 8,533,548	his-7 encodes an H2A histone.
9	B0272.3	B0272.3	n/a	chrX 9,432,002	contains similarity to Pfam domains PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) , PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) contains similarity to Interpro domains IPR013328 (Dehydrogenase, multihelical), IPR008927 (6-phosphogluconate dehydrogenase, C-terminal-like), IPR006176 (3-hydroxyacyl-CoA dehydrogenase, NAD binding), IPR006168 (NAD-dependent glycerol-3-phosphate dehydrogenase), IPR006108 (3-hydroxyacyl-CoA dehydrogenase, C-terminal), IPR006180 (3-hydroxyacyl-CoA dehydrogenase, conserved site), IPR016040 (NAD(P)-binding), IPR006036 (Potassium uptake protein TrkA)
10	C07E3.10	C07E3.10	n/a	chrII 10,346,620	contains similarity to Saccharomyces cerevisiae Ring finger protein involved in the DNA damage response with possible recombination role; genetically identified by synthetic lethality with SGS1 (DNA helicase) and TOP3 (DNA topoisomerase); sporulation role; interacts with Slx8p and Lin1p; SGD:YDL013W
11	C03H12.1	C03H12.1	n/a	chrX 15,692,830	contains similarity to Interpro domain IPR012336 (Thioredoxin-like fold)
12	H40L08.1	H40L08.1	n/a	chrX 15,082,354	contains similarity to Pfam domain PF00627 UBA/TS-N domain contains similarity to Interpro domains IPR009060 (UBA-like), IPR000533 (Tropomyosin), IPR000449 (Ubiquitin-associated/translation elongation factor EF1B, N-terminal)
13	cogc-6	K07C11.9	n/a	chrV 8,219,777	cogc-6 encodes an ortholog of mammalian COG-6, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-6 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-6 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
14	M01A10.3	M01A10.3	n/a	chrI 5,549,799	contains similarity to Pfam domain PF05817 Ribophorin II (RPN2) contains similarity to Interpro domain IPR008814 (Ribophorin II)
15	F49E12.6	F49E12.6	n/a	chrII 8,414,691	The F49E12.6 gene encodes a protein with two E2F domains that may be involved in apoptosis.
16	T22D1.4	T22D1.4	n/a	chrIV 6,911,758	contains similarity to Pfam domain PF04597 Ribophorin I contains similarity to Interpro domain IPR007676 (Ribophorin I)
17	F46C8.8	F46C8.8	n/a	chrX 7,552,792
18	C15C6.1	C15C6.1	n/a	chrI 12,202,933	contains similarity to Caulobacter crescentus Hypothetical protein CC0499.; TR:Q9AAU5
19	lact-8	Y42A5A.2	n/a	chrV 11,092,342	lact-8 encodes a beta-lactamase domain-containing protein that contains a predicted transmembrane domain in its N terminus.
20	erd-2	F09B9.3	n/a	chrX 10,158,581	erd-2 encodes a protein with homology to human ER lumen protein retaining receptor 1.
21	C46H11.7	C46H11.7	n/a	chrI 5,042,625	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR002919 (Protease inhibitor I8, cysteine-rich trypsin inhibitor-like), IPR003582 (Metridin-like ShK toxin)
22	hog-1	W06B11.4	n/a	chrX 5,852,661	hog-1 encodes a hedgehog-like protein, with a solitary Hint/Hog domain; the function of HOG-1's isolated Hint/Hog domain is unknown; in proteins where they coexist with other, N-terminal, domains, the Hint/Hog domain is predicted to cut its host protein into two halves and then covalently link cholesterol to the C-terminus of the N-terminal domain; HOG-1 is weakly required for normal molting; HOG-1 is also required for normal adult alae formation, growth to full size, cuticle adhesion, and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
23	F52F10.2	F52F10.2	n/a	chrV 1,549,423	contains similarity to Interpro domain IPR016196 (MFS general substrate transporter)
24	his-41	C50F4.5	n/a	chrV 9,546,148	his-41 encodes an H2B histone.
25	T03G6.1	T03G6.1	n/a	chrX 2,609,102
26	M02G9.1	M02G9.1	n/a	chrII 10,330,867	contains similarity to Pfam domain PF02363 Cysteine rich repeat contains similarity to Interpro domains IPR003341 (Cysteine rich repeat, tripleX), IPR015333 (Pollen allergen ole e 6)
27	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
28	drr-1	F45H10.4	n/a	chrII 13,495,384	C. elegans DRR-1 protein; contains similarity to Interpro domain IPR008253 (Marvel)
29	K01A2.5	K01A2.5	n/a	chrII 303,020	contains similarity to Pfam domain PF00561 alpha/beta hydrolase fold contains similarity to Interpro domains IPR000073 (Alpha/beta hydrolase fold-1), IPR003089 (Alpha/beta hydrolase)
30	gosr-2.1	B0272.2	n/a	chrX 9,440,914	C. elegans GOSR-2.1 protein; contains similarity to Pfam domain PF05008 Vesicle transport v-SNARE protein contains similarity to Interpro domain IPR007705 (Vesicle transport v-SNARE)
31	nrs-2	F25G6.6	n/a	chrV 8,547,557	nrs-2 encodes a predicted asparaginyl-tRNA synthetase (AsnRS), a class II aminoacyl-tRNA synthetase that catalyzes the attachment of asparagine to its cognate tRNA and is thus required for protein biosynthesis; loss of nrs-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities.
32	F13B12.2	F13B12.2	n/a	chrIV 10,427,657	contains similarity to Pfam domains PF07690 (Major Facilitator Superfamily) , PF00083 (Sugar (and other) transporter) contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR001991 (Sodium:dicarboxylate symporter), IPR001411 (Tetracycline resistance protein, TetB), IPR011701 (Major facilitator superfamily MFS-1), IPR005829 (Sugar transporter, conserved site), IPR005828 (General substrate transporter), IPR003663 (Sugar transporter), IPR008075 (Lipocalin-1 receptor), IPR016196 (MFS general substrate transporter)
33	T16G1.2	T16G1.2	n/a	chrV 12,931,137	contains similarity to Interpro domain IPR000694 (Proline-rich region)
34	pqn-55	R09E10.7	n/a	chrIV 10,289,947	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
35	C36B7.6	C36B7.6	n/a	chrX 7,098,999	contains similarity to Pfam domain PF05602 Cleft lip and palate transmembrane protein 1 (CLPTM1) contains similarity to Interpro domain IPR008429 (Cleft lip and palate transmembrane 1)
36	atf-5	T04C10.4	n/a	chrX 14,809,925	atf-5 encodes a homolog of the mammalian bZIP transcription factors ATF4 and ATF5, analogous to GCN4 in S. cerevisiae; like like ATF4 and GCN4, atf-5 has an extensive 5' UTR with one 37-residue uORF; ATF4 is poorly translated in unstressed cells but well-translated during ER stress, amino acid starvation, or arsenite treatment; possibly atf-5 is also translationally regulated in a way similar to ATF4.
37	dnj-2	B0035.2	n/a	chrIV 11,313,197	This gene encodes a protein containing a DnaJ ('J') domain.
38	C38C6.3	C38C6.3	n/a	chrII 14,633,822	contains similarity to Schizosaccharomyces pombe Hypothetical transmembrane protein.; TR:O74525
39	ifp-1	C43C3.1	n/a	chrX 9,677,940	ifp-1 encodes a nonessential intermediate filament protein; IFP-1 is predicted to function as a structural component of the cytoskeleton; IFP-1 has no obvious function in RNAi assays.
40	T11G6.4	T11G6.4	n/a	chrIV 10,850,812	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR008075 (Lipocalin-1 receptor), IPR016196 (MFS general substrate transporter)
41	Y57G11C.15	Y57G11C.15	n/a	chrIV 14,823,817	contains similarity to Pfam domain PF00344 eubacterial secY protein contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR002208 (SecY protein)
42	B0393.5	B0393.5	n/a	chrIII 4,772,641	contains similarity to Pfam domains PF00008 (EGF-like domain) (2), PF07645 (Calcium binding EGF domain) (6), PF06119 (Nidogen-like) (2)contains similarity to Interpro domains IPR003886 (Nidogen, extracellular region), IPR001438 (EGF-like, type 2), IPR001881 (EGF-like calcium-binding), IPR000742 (EGF-like, type 3), IPR013032 (EGF-like region, conserved site), IPR006209 (EGF-like), IPR000152 (Aspartic acid and asparagine hydroxylation site), IPR013091 (EGF calcium-binding), IPR006210 (EGF)
43	T07G12.3	T07G12.3	n/a	chrIV 10,535,145	contains similarity to Pfam domain PF02995 Protein of unknown function (DUF229) contains similarity to Interpro domains IPR017849 (Alkaline phosphatase-like, alpha/beta/alpha), IPR004245 (Protein of unknown function DUF229), IPR017850 (Alkaline-phosphatase-like, core domain)
44	C26B9.3	C26B9.3	n/a	chrX 5,339,194
45	F53A2.7	F53A2.7	n/a	chrIII 13,345,704	contains similarity to Pfam domains PF02803 (Thiolase, C-terminal domain) , PF00108 (Thiolase, N-terminal domain) contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR002155 (Thiolase), IPR016039 (Thiolase-like)
46	Y54E5A.1	Y54E5A.1	n/a	chrI 14,690,180	contains similarity to Pfam domains PF00487 (Fatty acid desaturase) , PF08557 (Sphingolipid Delta4-desaturase (DES)) contains similarity to Interpro domains IPR013866 (Sphingolipid delta4-desaturase, N-terminal), IPR010257 (Fatty acid desaturase, type 1, N-terminal), IPR011388 (Sphingolipid delta4-desaturase), IPR005804 (Fatty acid desaturase, type 1)
47	gst-42	D1053.1	n/a	chrX 11,727,007	gst-42 is orthologous to the human gene GLUTATHIONE TRANSFERASE ZETA-1 (also known as MALEYLACETOACETATE ISOMERASE; GSTZ1; OMIM:603758), which when mutated is thought to lead to a variety of type I tyrosinemia.
48	B0507.1	B0507.1	n/a	chrV 8,777,950	contains similarity to Interpro domains IPR006150 (Cysteine-rich repeat), IPR013032 (EGF-like region, conserved site)
49	R04B3.3	R04B3.3	n/a	chrX 2,474,889
50	M153.1	M153.1	n/a	chrX 12,147,684	contains similarity to Pfam domains PF03807 (NADP oxidoreductase coenzyme F420-dependent) , PF01210 (NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus) contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR011128 (NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal), IPR016040 (NAD(P)-binding)