UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	wdfy-2	D2013.2	0	chrII 9,320,794	wdfy-2 encodes a WD40- and FYVE-domain containing protein that is orthologous to mammalian WDFY2; WDFY-2 is one of twelve C. elegans FYVE-domain-containing proteins; wdfy-2 activity is essential for wild-type levels of endocytosis.
2	tbg-1	F58A4.8	n/a	chrIII 9,627,816	tbg-1 encodes gamma-tubulin; in C. elegans, tbg-1 activity is essential and is required for normal bipolar spindle assembly and function, as well as the fast phase of female pronuclear migration following fertilization; while tbg-1 is required for proper organization and function of kinetochore and interpolar microtubules, it does not appear to be absolutely required for microtubule nucleation and growth; TBG-1 localizes to centrosomes in both interphase and mitotic cells, exhibiting a dynamic behavior during mitosis that differs between anterior and posterior centrosomes.
3	F11A10.5	F11A10.5	n/a	chrIV 12,095,498	contains similarity to Pfam domain PF04184 ST7 protein contains similarity to Interpro domain IPR007311 (ST7)
4	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
5	F02E9.7	F02E9.7	n/a	chrI 8,414,687	contains similarity to Pfam domain PF00149 Calcineurin-like phosphoesterase contains similarity to Interpro domain IPR004843 (Metallophosphoesterase)
6	ZK1058.3	ZK1058.3	n/a	chrIII 3,919,762	ZK1058.3 is orthologous to the human gene UNNAMED PROTEIN PRODUCT (GALT; OMIM:606999), which when mutated leads to disease.
7	M02B7.2	M02B7.2	n/a	chrIV 3,804,264	contains similarity to Pfam domain PF00929 Exonuclease contains similarity to Interpro domains IPR013520 (Exonuclease, RNase T and DNA polymerase III), IPR006055 (Exonuclease), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
8	H14A12.3	H14A12.3	n/a	chrIII 7,464,450	H14A12.3 encodes an ortholog of S. cerevisiae RAV2; like RAV2, H14A12.3 may be required for the reassociation of vacuolar proton-translocating ATPase (V-ATPase) after temporary glucose starvation.
9	C47D12.2	C47D12.2	n/a	chrII 11,677,666	C47D12.2 encodes an ortholog of human FLJ20071/FLJ90130 (dymeclin, OMIM:607461, mutated in Dyggve-Melchior-Clausen dysplasia and Smith-McCort dysplasia), which has no obvious function in mass RNAi assays
10	fbxa-22	T12B5.5	n/a	chrIII 939,140	C. elegans FBXA-22 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
11	C36B1.7	C36B1.7	n/a	chrI 8,736,564	contains similarity to Pfam domain PF00186 Dihydrofolate reductase contains similarity to Interpro domain IPR001796 (Dihydrofolate reductase region)
12	M01G5.1	M01G5.1	n/a	chrIII 1,503,267	contains similarity to Homo sapiens hypothetical protein; VG:OTTHUMP00000024537
13	C08F11.1	C08F11.1	n/a	chrIV 13,624,656	contains similarity to Coxiella burnetii Hypothetical protein.; TR:Q83D43
14	dhs-22	C15H11.4	n/a	chrV 14,420,734	dhs-22 encodes a short-chain dehydrogenase predicted to be mitochondrial.
15	dod-18	C54G4.6	n/a	chrI 8,020,275	dod-18 encodes a Maf-like protein required for normally short lifespan; dod-18 is repressed in daf-2 mutants and induced in daf-16 mutants, and dod-18(RNAi) lengthens lifespan by 30%; MAF-like proteins are ubiquitous among eukarya, bacteria, and archaea; DOD-18 is orthologous to the N-terminal ~200 residues of human ASMTL (OMIM:300162), and to Bacillus subtilis Maf (Multicopy Associated Filamentation) protein, which inhibits septum formation; while the specific biochemical function of Maf-like proteins is unknown, the tertiary structure of B. subtilis Maf is consistent with its binding nucleic acid.
16	taf-6.1	W09B6.2	n/a	chrII 1,130,167	C. elegans TAF-6.1 protein; contains similarity to Pfam domains PF07571 (Protein of unknown function (DUF1546)) , PF02969 (TATA box binding protein associated factor (TAF)) contains similarity to Interpro domains IPR009072 (Histone-fold), IPR004823 (TATA box binding protein associated factor (TAF)), IPR011442 (Protein of unknown function DUF1546)
17	F54D11.3	F54D11.3	n/a	chrV 4,636,257
18	spe-42	B0240.2	n/a	chrV 11,735,328	C. elegans SPE-42 protein; contains similarity to Pfam domain PF07782 DC-STAMP-like protein contains similarity to Interpro domain IPR012858 (DC-STAMP-like)
19	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
20	cdc-25.1	K06A5.7	n/a	chrI 6,470,859	cdc-25.1 encodes a CDC25 phosphatase homolog that affects embryonic viability, meiosis, mitosis, proliferation of the intestine (E cell lineage), and germ line proliferation; it is expressed in the developing germline, in the nuclei of oocytes, embryonic nuclei, nuclei of embryonic cortical membranes, and sperm pronuclei, and in the germline precursors Z2 and Z3.
21	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
22	C53B7.7	C53B7.7	n/a	chrX 6,862,206	C53B7.7 encodes a neprilysin; neprilysins are thermolysin-like zinc metallopeptidases, found on the outer surface of animal cells, that negatively regulate small signalling peptides (e.g., enkephalin, tachykinin, insulin, and natriuretic peptides) by cleaving them; C53B7.7 has no clear orthologs in other organisms.
23	Y116A8C.8	Y116A8C.8	n/a	chrIV 16,932,518	contains similarity to Interpro domain IPR001283 (Allergen V5/Tpx-1 related)
24	hcp-3	F58A4.3	n/a	chrIII 9,615,787	The hcp-3 gene encodes a centromere protein (CENP)-A homolog required for kinetochore function; inactivation of hcp-3 in one-cell embryos by RNAi causes a complete loss of kinetochores, with total failure of chromosomes to segregate properly during mitosis, to recruit components to the kinetochore other than HCP-3, or to assemble a stable mitotic spindle; in addition, HCP-4 fails to localize properly to the kinetochore in hcp-3(RNAi) embryos.
25	sun-1	F57B1.2	n/a	chrV 13,192,605	sun-1 encodes a paralog of UNC-84, also called matefin, whose general domain organization (one or more central transmembrane and coiled-coil domains, followed by a C-terminal SUN domain) is shared by Sad1p from Schizosaccharomyces pombe and UNC-84 from C. elegans; SUN-1 is a nuclear envelope receptor for CED-4 during apoptosis, and is bound by CED-4 in vitro; SUN-1 is partially required for apoptosis, since sun-1(RNAi) animals have a moderate defect in normal cell death; SUN-1 is strongly expressed in the nuclear envelope of all early embryonic cells, the primordial germ cells Z2 and Z3, and the germ cell lineage (but not in sperm); early (embryonic) SUN-1 protein is provided maternally, while germ line SUN-1 is zygotic; SUN-1 colocalizes with the nuclear lamin LMN-1 in vivo and binds it in vitro; SUN-1 is required for localization of the hook protein ZYG-12 to the nuclear envelope, and thus for the attachment of centrosomes to nuclei; SUN-1 and UNC-84 may define a class of proteins localized to the outer nuclear envelope but not the endoplasmic reticulum.
26	W02D9.3	W02D9.3	n/a	chrI 12,536,484	contains similarity to Pfam domain PF00505 HMG (high mobility group) box contains similarity to Interpro domains IPR000910 (High mobility group box, HMG1/HMG2), IPR009071 (High mobility group box, HMG)
27	rrt-2	C29H12.1	n/a	chrII 6,126,706	C. elegans RRT-2 protein; contains similarity to Pfam domains PF05746 (DALR anticodon binding domain) , PF00750 (tRNA synthetases class I (R)) contains similarity to Interpro domains IPR015945 (Arginyl-tRNA synthetase, class Ic, core), IPR008909 (DALR anticodon binding), IPR001412 (Aminoacyl-tRNA synthetase, class I, conserved site), IPR009080 (Aminoacyl-tRNA synthetase, class 1a, anticodon-binding), IPR001278 (Arginyl-tRNA synthetase, class Ic), IPR014729 (Rossmann-like alpha/beta/alpha sandwich fold)
28	rnf-5	C16C10.7	n/a	chrIII 4,165,557	This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein.
29	sna-2	T13F2.7	n/a	chrIV 9,776,092	sna-2 encodes an snRNP-binding protein (SNA-2/SL75p) homologous to Ascaris SL95p (SL 175kd); SNA-2 is found in at least two Sm snRNPs, SL1 and Y, but not in SL2; in snRNP SL1, SNA-2 associates with the SNA-1/SL21p protein, while associating with SUT-1/SL26p (a paralog of SNA-1) in snRNP Y; sna-2(RNAi) is lethal; SNA-2 can bind either SNA-1 or SUT-1 even in the absence of RNA.
30	R13A5.7	R13A5.7	n/a	chrIII 7,568,723
31	F32E10.5	F32E10.5	n/a	chrIV 7,576,352	contains similarity to Pfam domain PF00567 Tudor domain contains similarity to Interpro domains IPR008191 (Maternal tudor protein), IPR002011 (Receptor tyrosine kinase, class II, conserved site), IPR002999 (Tudor)
32	T07F10.3	T07F10.3	n/a	chrV 12,869,009	contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
33	cup-2	F25D7.1	n/a	chrI 10,399,657	The primary phenotype of cup-2 animals is an accumulation of secreted GFP in the pseudocoelom, suggesting a decrease in, or the absence of, endocytosis in coelomocytes.
34	Y102A5C.4	Y102A5C.4	n/a	chrV 16,923,224	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
35	T01B7.6	T01B7.6	n/a	chrII 8,723,943	contains similarity to Interpro domain IPR000694 (Proline-rich region)
36	W06B4.3	W06B4.3	n/a	chrII 4,464,653	contains similarity to Pfam domain PF05131 Pep3/Vps18/deep orange family contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR007810 (Pep3/Vps18/deep orange), IPR016024 (Armadillo-type fold)
37	K02B12.5	K02B12.5	n/a	chrI 8,522,044	contains similarity to Pfam domain PF00023 Ankyrin repeat contains similarity to Interpro domains IPR002110 (Ankyrin), IPR013026 (Tetratricopeptide region)
38	wrm-1	B0336.1	n/a	chrIII 5,724,932	wrm-1 encodes, along with bar-1 and hmp-2, one of three C. elegans beta-catenin-like proteins; during development, wrm-1 functions in noncanonical Wnt signaling pathways that specify cell fates in the early embryo, the somatic gonad, and postembryonic hypodermal lineages.
39	T02E1.2	T02E1.2	n/a	chrI 8,221,514	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IJZ2
40	F09F7.3	F09F7.3	n/a	chrIII 5,560,978	contains similarity to Pfam domains PF04566 (RNA polymerase Rpb2, domain 4) , PF04561 (RNA polymerase Rpb2, domain 2) , PF04567 (RNA polymerase Rpb2, domain 5) , PF04565 (RNA polymerase Rpb2, domain 3) , PF00562 (RNA polymerase Rpb2, domain 6) , PF04560 (RNA polymerase Rpb2, domain 7) , PF04563 (RNA polymerase beta subunit) contains similarity to Interpro domains IPR007120 (DNA-directed RNA polymerase, subunit 2, domain 6), IPR007641 (RNA polymerase Rpb2, domain 7), IPR007644 (RNA polymerase, beta subunit, protrusion), IPR015712 (DNA-directed RNA polymerase, subunit 2), IPR007645 (RNA polymerase Rpb2, domain 3), IPR007642 (RNA polymerase Rpb2, domain 2), IPR014724 (RNA polymerase Rpb2, OB-fold), IPR007646 (RNA polymerase Rpb2, domain 4), IPR007647 (RNA polymerase Rpb2, domain 5), IPR007121 (RNA polymerase, beta subunit, conserved site)
41	F46F11.8	F46F11.8	n/a	chrI 5,625,448
42	T12D8.4	T12D8.4	n/a	chrIII 13,628,781	contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF02752 (Arrestin (or S-antigen), C-terminal domain) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011022 (Arrestin-like, C-terminal), IPR011021 (Arrestin-like, N-terminal)
43	F57C9.7	F57C9.7	n/a	chrI 4,825,902
44	M03C11.2	M03C11.2	n/a	chrIII 10,402,129	contains similarity to Pfam domain PF06733 DEAD_2 contains similarity to Interpro domains IPR014013 (Helicase, superfamily 1 and 2, ATP-binding, DinG/Rad3-type), IPR010614 (DEAD2), IPR006554 (Helicase-like, DEXD box c2 type), IPR006555 (Helicase, ATP-dependent, c2 type), IPR014001 (DEAD-like helicase, N-terminal), IPR013020 (DNA helicase (DNA repair), Rad3 type)
45	K04G2.2	K04G2.2	n/a	chrI 8,031,912	contains similarity to Aedes aegypti Putative uncharacterized protein.; TR:Q17GK3
46	T04H1.5	T04H1.5	n/a	chrV 12,251,820	contains similarity to Pfam domain PF01585 G-patch domain contains similarity to Interpro domains IPR000467 (D111/G-patch), IPR007087 (Zinc finger, C2H2-type)
47	bath-3	F59H6.10	n/a	chrII 2,029,895	C. elegans BATH-3 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
48	T20G5.9	T20G5.9	n/a	chrIII 10,210,308	contains similarity to Pfam domain PF09282 Mago binding contains similarity to Interpro domain IPR015362 (Exon junction complex, Pym)
49	apc-2	K06H7.6	n/a	chrIII 8,082,080	apc-2 encodes an ortholog of subunit 2 of anaphase-promoting complex (APC, a cyclin-specific E3 RING ubiquitin ligase); APC-2 and S. cerevisiae's Apc2p have 32% identity in their cullin domains (considered crucial for function), but otherwise share no obvious similarity; inactivating apc-2 with RNAi causes embryos to arrest at the meiotic one-cell stage, implying that APC-2 is required for the metaphase-to-anaphase transition of meiosis I; this RNAi phenotype of apc-2 is shared by apc-1, apc-4, apc-11, cdc-16, cdc-23, and cdc-27; by analogy with other APC subunits with hypomorphic alleles, APC-2 is likely to be required for asymmetrical segregation of cell fate determinants in two-cell embryos.
50	M05D6.2	M05D6.2	n/a	chrII 8,469,058	contains similarity to Pfam domain PF05794 T-complex protein 11 contains similarity to Interpro domain IPR008862 (T-complex 11)