UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	D1086.6	D1086.6	4e-119	chrV 14,080,757	contains similarity to Xenopus laevis Integumentary mucin C.1 (FIM-C.1) (Fragment).; SW:Q05049
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	F31F6.3	F31F6.3	n/a	chrX 14,872,269	F31F6.3 encodes a novel protein that is conserved in C. elegans; three other genes related to F31F6.3 are present in tandem on the X chromosome.
4	B0035.3	B0035.3	n/a	chrIV 11,314,534	contains similarity to Pfam domain PF01661 Macro domain contains similarity to Interpro domain IPR002589 (Appr-1-p processing)
5	T23D8.7	T23D8.7	n/a	chrI 9,991,647	contains similarity to Pfam domains PF02170 (PAZ domain) , PF08699 (Domain of unknown function (DUF1785)) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR014811 (Region of unknown function DUF1785), IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
6	F02E8.4	F02E8.4	n/a	chrX 4,455,689
7	btb-20	F57C2.1	n/a	chrII 14,522,887	C. elegans BTB-20 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
8	C16C8.16	C16C8.16	n/a	chrII 3,447,247	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
9	tag-319	C30B5.1	n/a	chrII 6,200,135	C. elegans TAG-319 protein ;
10	fbxa-170	C36C9.3	n/a	chrX 1,677,298	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
11	W02D9.4	W02D9.4	n/a	chrI 12,538,320	contains similarity to Oryza sativa Hypothetical protein.; TR:Q8H7L3
12	C36B1.11	C36B1.11	n/a	chrI 8,756,734	contains similarity to Interpro domain IPR001576 (Phosphoglycerate kinase)
13	C40H1.2	C40H1.2	n/a	chrIII 9,318,561	contains similarity to Eikenella corrodens Cpn60 (Fragment).; TR:Q8KP64
14	Y57G11B.5	Y57G11B.5	n/a	chrIV 14,575,666
15	syp-3	F39H2.4	n/a	chrI 8,663,589	syp-3 encodes a coiled-coil protein; SYP-3 activity is required during meiosis for chromosome synapsis and chiasma formation, specifically for proper assembly of the central region of the synaptonemal complex; thus, SYP-3 is essential activity is essential for normal embryonic development; immunolocalization studies indicate that SYP-3 is likely a structural component of the central element of the synaptonemal complex.
16	F26H11.4	F26H11.4	n/a	chrII 14,410,374	contains similarity to Saccharomyces cerevisiae Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane; SGD:YMR089C
17	C17E4.4	C17E4.4	n/a	chrI 9,419,701	contains similarity to Thermoplasma acidophilum Hypothetical membrane protein.; TR:Q9HLF7
18	F57C9.3	F57C9.3	n/a	chrI 4,838,180
19	ZK1128.4	ZK1128.4	n/a	chrIII 10,119,727	contains similarity to Pfam domain PF03850 Transcription factor Tfb4 contains similarity to Interpro domain IPR004600 (Transcription factor Tfb4)
20	rmd-1	T05G5.7	n/a	chrIII 9,759,548	C. elegans RMD-1 protein; contains similarity to Interpro domain IPR011990 (Tetratricopeptide-like helical)
21	Y53C12A.6	Y53C12A.6	n/a	chrII 9,717,654	contains similarity to Bacteriophage RB69 Hypothetical protein RB69ORF024c.; TR:Q7Y5B4
22	spo-11	T05E11.4	n/a	chrIV 11,123,963	spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline.
23	EEED8.14	EEED8.14	n/a	chrII 5,413,091	contains similarity to Sulfolobus solfataricus DNA double-strand break repair rad50 ATPase.; SW:Q97WH0
24	R02F2.4	R02F2.4	n/a	chrIII 5,485,028	R02F2.4 encodes a protein with six chitin-binding peritrophin-A domains; R02F2.4 transcripts are enriched during oogenesis; like CEJ-1 and CPG-2, R02F2.4 might participate in eggshell synthesis and early embryonic development, and R02F2.4's multiple peritrophin-A domains might enable mechanical cross-linking of chitin; however, R02F2.4 has no obvious function in mass RNAi assays; while R02F2.4 is more closely similar to CPG-2 than CEJ-1, it may be less strongly expressed (since it has substantially fewer ESTs) and thus be less important in development.
25	rab-21	T01B7.3	n/a	chrII 8,714,514	rab-21 encodes a Rab GTPase most closely related to the Drosophila and vertebrate Rab21 GTPases and Saccharomyces cerevisiae VPS21; by homology, RAB-21 is predicted to be involved in membrane trafficking/vesicle transport; loss of rab-21 activity via RNAi results in 7-8% embryonic lethality.
26	C16C8.12	C16C8.12	n/a	chrII 3,453,161
27	F32D1.6	F32D1.6	n/a	chrV 4,374,245
28	C07D8.5	C07D8.5	n/a	chrX 7,344,247	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
29	C10A4.4	C10A4.4	n/a	chrX 7,402,753
30	cyp-31A2	H02I12.8	n/a	chrIV 11,404,949	cyp-31A2 encodes a class 4 cytochrome P450 predicted to hydroxylate polyunsaturated fats (PUFAs); CYP-31A2 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; cyp-31A2(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them; in mammalian eicosanoid signalling, class 4 cytochrome P450 is required for the omega hydroxylation of PUFAs, prostaglandins, and leukotrienes.
31	F52B5.2	F52B5.2	n/a	chrI 8,317,068	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
32	T23B12.6	T23B12.6	n/a	chrV 8,458,996	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR001680 (WD40 repeat), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation), IPR015943 (WD40/YVTN repeat-like)
33	hus-1	H26D21.1	n/a	chrI 3,698,705	hus-1 encodes the C. elegans ortholog of the Schizosaccharomyces pombe Hus1 DNA damage checkpoint protein; in C. elegans, hus-1 activity is required for DNA damage-induced cell cycle arrest and apoptosis, telomere maintenance, and hence, genome stability and development; specifically, hus-1 is required for the CEP-1/p53-dependent increase in germline egl-1 expression following irradiation; a HUS-1::GFP fusion protein is detected in the nuclei of mitotic and meiotic germ cells, mature oocytes, embryos, and somatic larval cells, particularly those that are proliferating; while HUS-1 localization is generally diffuse throughout these nuclei, following irradiation, HUS-1 localizes to discrete foci that overlap with chromatin; HUS-1 nuclear localization is dependent upon the Rad9 homologue HPR-9 and upon the checkpoint protein MRT-2, with which it interacts in yeast two-hybrid and in vitro assays.
34	D2030.7	D2030.7	n/a	chrI 7,589,605	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
35	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
36	rev-1	ZK675.2	n/a	chrII 7,902,571	C. elegans REV-1 protein; contains similarity to Pfam domains PF00817 (impB/mucB/samB family) , PF00533 (BRCA1 C Terminus (BRCT) domain) contains similarity to Interpro domains IPR001126 (UMUC-like DNA-repair protein), IPR012112 (DNA repair protein, Rev1), IPR001357 (BRCT)
37	C01G5.5	C01G5.5	n/a	chrIV 6,525,508	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
38	taf-11.2	K10D3.3	n/a	chrI 7,133,402	C. elegans TAF-11.2 protein; contains similarity to Pfam domain PF04719 hTAFII28-like protein conserved region contains similarity to Interpro domains IPR006809 (TAFII28-like protein), IPR009072 (Histone-fold)
39	ZC477.5	ZC477.5	n/a	chrIV 7,102,332
40	nos-1	R03D7.7	n/a	chrII 10,952,444	nos-1 encodes an putative RNA-binding protein that contains a zinc-binding motif homologous to that of Drosophila Nanos, a posterior-group protein required for embryonic patterning and primordial germ cell development; in C. elegans, NOS-1 is required redundantly with NOS-2, a second Nanos homolog, for maintenance of germ cell viability during postembryonic development and for preventing primordial germ cells from dividing in the absence of food; nos-1 mRNA is expressed dynamically in the embryo, with early expression seen throughout the embryo and later expression restricted solely to germline blastomeres; nos-1 mRNA becomes undetectable after the 200-cell stage, but reappears later at the 550-cell stage; NOS-1 protein is not detectable in germline blastomeres until the 550-cell stage, suggesting that NOS-1 might actually function zygotically in germline specification.
41	bir-2	C50B8.2	n/a	chrV 13,569,366	The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis.
42	K11H3.3	K11H3.3	n/a	chrIII 9,852,736	contains similarity to Pfam domain PF00153 Mitochondrial carrier protein contains similarity to Interpro domains IPR002067 (Mitochondrial carrier protein), IPR001993 (Mitochondrial substrate carrier), IPR002113 (Adenine nucleotide translocator 1)
43	T04A8.8	T04A8.8	n/a	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
44	zif-1	F59B2.6	n/a	chrIII 9,003,725	zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
45	bath-15	C08C3.2	n/a	chrIII 7,775,331	C. elegans BATH-15 protein; contains similarity to Pfam domains PF00917 (MATH domain) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
46	C14B1.9	C14B1.9	n/a	chrIII 3,725,339	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000307805
47	ulp-5	K02F2.4	n/a	chrI 6,813,375	C. elegans ULP-5 protein; contains similarity to Pfam domain PF02902 Ulp1 protease family, C-terminal catalytic domain contains similarity to Interpro domain IPR003653 (Peptidase C48, SUMO/Sentrin/Ubl1)
48	T01H3.2	T01H3.2	n/a	chrII 7,876,054	T01H3.2 encodes a large (980-residue) uncharacterized protein, with multiple dysferlin and beta-propeller domains, that is conserved among metazoa; T01H3.2 shares an operon with vha-4, and thus might be a previously undescribed V-ATPase component or ancillary protein.
49	C34G6.5	C34G6.5	n/a	chrI 5,873,231	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR017441 (Protein kinase ATP binding, conserved site), IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
50	Y18D10A.11	Y18D10A.11	n/a	chrI 12,862,741	contains similarity to Homo sapiens Putative uncharacterized protein DKFZp779H0156; ENSEMBL:ENSP00000344380