UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	spr-1	D1014.8	0	chrV 8,128,020	spr-1 encodes the C. elegans ortholog of the human corepressor CoREST that functions in HDAC-containing complexes to mediate transcriptional repression; in C. elegans, spr-1 was first identified in screens for genetic suppressors of the egg-laying defective phenotype of sel-12/presenilin mutants; subsequent genetic analyses showed that spr-1 likely functions as a negative regulator of LIN-12/Notch signaling in multiple cells, including those of the somatic gonad, vulva, and early embryo; spr-1 also interacts genetically with sem-5 to regulate postembryonic growth rates and lin-35Rb to regulate vulval morphogenesis and germline proliferation; in binding assays and yeast two-hybrid experiments, SPR-1 interacts with SPR-5, the C. elegans ortholog of the LSD1 histone demethylase; an SPR-1::MYC fusion protein expressed under the control of the cog-2 promoter localizes to the nucleus and shows increased staining in nuclear speckles and what appears to be the nucleolus.
2	K09F6.3	K09F6.3	n/a	chrII 2,258,704	contains similarity to Pfam domains PF02206 (Domain of unknown function) , PF00102 (Protein-tyrosine phosphatase) contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase), IPR003125 (Protein of unknown function WSN)
3	F49E8.1	F49E8.1	n/a	chrIV 7,557,976	contains similarity to Pfam domain PF06218 Nitrogen permease regulator 2 contains similarity to Interpro domain IPR009348 (Nitrogen permease regulator 2)
4	C07D8.6	C07D8.6	n/a	chrX 7,342,092	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
5	C25H3.4	C25H3.4	n/a	chrII 5,692,793	contains similarity to Pfam domains PF01472 (PUA domain) , PF01253 (Translation initiation factor SUI1) contains similarity to Interpro domains IPR004521 (Uncharacterized domain 2), IPR015947 (PUA-like), IPR001950 (Translation initiation factor SUI1), IPR002478 (PUA)
6	Y39A3A.2	Y39A3A.2	n/a	chrIII 2,057,188	contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold)
7	F55G1.9	F55G1.9	n/a	chrIV 7,476,741	contains similarity to Pfam domain PF03807 NADP oxidoreductase coenzyme F420-dependent contains similarity to Interpro domains IPR004455 (NADP oxidoreductase, coenzyme F420-dependent), IPR000304 (Delta 1-pyrroline-5-carboxylate reductase), IPR016040 (NAD(P)-binding)
8	smg-5	W02D3.8	n/a	chrI 6,735,096	smg-5 encodes a novel protein that contains two N-terminal tetratricopeptide (TPR) repeats and a C-terminal PINc domain found in nucleotide-binding proteins; SMG-5 is a component of the nonsense-mediated mRNA decay (NMD) pathway and likely functions in regulation of dephosphorylation of SMG-2, the C. elegans UPF1 ortholog, an ATPase and RNA helicase required for NMD in worms, yeast, and mammals; SMG-5 physically interacts with SMG-7, SMG-2, and the PAA-1 and LET-92 structural and catalytic subunits, respectively, of a protein phosphatase 2A (PP2A), suggesting that SMG-5 may function to direct SMG-2 to a PP2A phosphatase that regulates its activity in vivo; SMG-5 also interacts, in vivo, with components of the RNA interference (RNAi) pathway, suggesting a potential link between RNAi and NMD; SMG-5::GFP fusion proteins localize to both the nucleus and the cytoplasm.
9	C55A6.9	C55A6.9	n/a	chrV 11,522,512	contains similarity to Pfam domain PF03985 Paf1 contains similarity to Interpro domain IPR007133 (RNA polymerase II-associated, Paf1)
10	dog-1	F33H2.1	n/a	chrI 15,020,116	dog-1 encodes a predicted DEAH helicase, orthologous to the human BRCA1-binding protein BACH1 (OMIM:605882, mutated in early-onset breast cancer); DOG-1 is required for maintenance of polyguanine tracts of germline and somatic DNA, and is proposed to resolve the secondary structure that can occur in guanine-rich DNA during lagging-strand DNA synthesis.
11	T11G6.3	T11G6.3	n/a	chrIV 10,853,967	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
12	spd-5	F56A3.4	n/a	chrI 5,173,414	C. elegans SPD-5 protein; contains similarity to Interpro domains IPR002017 (Spectrin repeat), IPR000533 (Tropomyosin), IPR009053 (Prefoldin)
13	sgt-1	R05F9.10	n/a	chrII 4,903,031	C. elegans SGT-1 protein; contains similarity to Pfam domains PF07719 (Tetratricopeptide repeat) (2), PF00515 (Tetratricopeptide repeat) (3)contains similarity to Interpro domains IPR011990 (Tetratricopeptide-like helical), IPR008940 (Protein prenyltransferase), IPR001440 (Tetratricopeptide TPR-1), IPR013105 (Tetratricopeptide TPR2), IPR013026 (Tetratricopeptide region)
14	ZK632.5	ZK632.5	n/a	chrIII 9,810,489	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:O97236
15	mat-3	F10C5.1	n/a	chrIII 478,879	mat-3 encodes a tetratricopeptide repeat (TPR)-containing protein that is the C. elegans ortholog of CDC23/APC8, a conserved regulatory subunit of the anaphase-promoting complex; mat-3 activity is required for progression through metaphase of oocyte meiosis I, germline proliferation, and vulval development.
16	T13B5.3	T13B5.3	n/a	chrII 1,099,395	contains similarity to Pfam domain PF00328 Histidine acid phosphatase contains similarity to Interpro domains IPR000560 (Histidine acid phosphatase), IPR002016 (Haem peroxidase, plant/fungal/bacterial)
17	cid-1	K10D2.3	n/a	chrIII 5,177,184	cid-1 (also known as pup-1) encodes a template-independent poly(U) polymerase with 3'' end RNA substrates, orthologous to human ZCCHC6 and ZCCHC11, and paralogous to PUP-2; CID-1 prevents larvae from growing to adulthood in media containing hydroxyurea (HU, a drug that stalls replication forks) and represses HSP-4 expression; CID-1 is required for gonadogenesis, embryonic and vulval development, normally rapid growth, and normally short lifespan; CID-1, like HSP-4, is expressed in postmitotic intestinal cells; by orthology with Cid1p in fission yeast, CID-1 is predicted to act in a DNA synthesis-to-mitosis checkpoint; in cid-1(rf35::Tc4) mutants or cid-1(RNAi) animals grow from L1 larvae to adulthood despite the presence of HU, are abnormally resistant to lethal heat shock, overexpress hsp-4::GFP, have protruding vulvae, have abnormally short and thick gonads with fewer germ cells than normal, produce disorganized embryos, grow slowly, and have abnormally long lifespans; CID-1 and its eukaryotic homologs are distantly related to the GLD-2 family of poly(A) polymerases.
18	F26E4.6	F26E4.6	n/a	chrI 9,773,519	contains similarity to Pfam domain PF02935 Cytochrome c oxidase subunit VIIc contains similarity to Interpro domain IPR004202 (Cytochrome c oxidase subunit VIIc)
19	Y32B12B.2	Y32B12B.2	n/a	chrV 16,544,097	contains similarity to Vitis vinifera Putative uncharacterized protein.; TR:A5AD22
20	C56C10.11	C56C10.11	n/a	chrII 6,599,683
21	T10E9.2	T10E9.2	n/a	chrI 6,543,527
22	pqn-38	F44B9.7	n/a	chrIII 8,026,555	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
23	F17A9.2	F17A9.2	n/a	chrV 6,111,285	contains similarity to Pfam domains PF04676 (Protein similar to CwfJ C-terminus 2) , PF04677 (Protein similar to CwfJ C-terminus 1) contains similarity to Interpro domains IPR006768 (Protein similar to CwfJ, C-terminal 1), IPR006767 (Protein similar to CwfJ, C-terminal 2), IPR011146 (Histidine triad-like motif)
24	T07A9.10	T07A9.10	n/a	chrIV 391,835	contains similarity to Pfam domain PF00995 Sec1 family contains similarity to Interpro domain IPR001619 (Sec1-like protein)
25	pps-1	T14G10.1	n/a	chrIV 10,163,166	pps-1 is orthologous to human PAPSS1 (OMIM:603262) and human PAPSS2 (OMIM:603005, mutated in spondyloepimetaphyseal dysplasia).
26	evl-14	H38K22.1	n/a	chrIII 4,308,081	evl-14 encodes a homolog of the yeast sister cohesion protein Pds5p that functions during both mitosis and meiosis and is implicated in the maintenance of sister chromatid cohesion in late prophase, and affects vulval morphology, meiotic germline development, embryonic and larval viability, fertility, and cell divisions in the germ line as well as in vulval and somatic gonad lineages; some of the defects, such as somatic gonad defects, are due at least partially to cell division defects.
27	dylt-1	F13G3.4	n/a	chrI 7,300,621	dylt-1 encodes a putative dynein light chain subunit that inhibits DHC-1 in vivo, but is otherwise dispensable for viability; DYLT-1 is paralogous to DYLT-3, and orthologous to human DYNLT1 and DYNLT3 (OMIM: 300302); dylt-1(RNAi) and dylt-1(ok417) both suppress the lethality of conditional dhc-1 mutations, and dylt-1(RNAi) suppresses dhc-1(or195) spindle length and cytokinesis defects as well, indicating that DYLT-1 negatively regulates dynein; in oocytes and early embryos, DYLT-1 is associated with nuclear envelopes and centrosomes, and with meiotic and mitotic spindle poles; like DHC-1 itself, DYLT-1 is strongly mislocalized to centrosomes in dhc-1(or195) animals shifted to nonpermissive temperature.
28	sri-27	ZK697.4	n/a	chrV 1,726,643	C. elegans SRI-27 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
29	rle-1	M142.6	n/a	chrIII 10,941,254	C. elegans RLE-1 protein; contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR000694 (Proline-rich region), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
30	B0019.2	B0019.2	n/a	chrI 12,777,941	contains similarity to Pfam domains PF04435 (Domain of unknown function (DUF545)) , PF02178 (AT hook motif) contains similarity to Interpro domains IPR006570 (SPK), IPR000637 (HMG-I and HMG-Y, DNA-binding), IPR009057 (Homeodomain-like)
31	R12E2.1	R12E2.1	n/a	chrI 4,183,608	contains similarity to Pfam domains PF01344 (Kelch motif) (5), PF00651 (BTB/POZ domain) , PF07707 (BTB And C-terminal Kelch) , PF07646 (Kelch motif) (3)contains similarity to Interpro domains IPR011043 (Galactose oxidase/kelch, beta-propeller), IPR017096 (Kelch-like protein, gigaxonin), IPR000210 (BTB/POZ-like), IPR006652 (Kelch repeat type 1), IPR011333 (BTB/POZ fold), IPR011498 (Kelch repeat type 2), IPR015916 (Galactose oxidase, beta-propeller), IPR013069 (BTB/POZ), IPR011705 (BTB/Kelch-associated), IPR013089 (Kelch related), IPR006651 (Kelch), IPR015915 (Kelch-type beta propeller)
32	gbh-1	D2089.5	n/a	chrII 10,692,053	gbh-1 encodes a predicted ortholog of human hBBOX1; expressed in the intestine and in head and body muscles.
33	smc-4	F35G12.8	n/a	chrIII 4,590,281	The smc-4 gene encodes a homolog of the SMC4 subunit of mitotic condensin; SMC-4 acts with MIX-1 to enable chromosome segregation.
34	T19C9.8	T19C9.8	n/a	chrV 17,239,506	contains similarity to Amsacta moorei entomopoxvirus AMV141.; TR:Q9EMQ8
35	mog-5	EEED8.5	n/a	chrII 5,402,615	The mog-5 gene encodes a DEAH helicase orthologous to the Drosophila CG8241, the human HRH1, and the S. cerevisiae PRP22 proteins.
36	sec-10	C33H5.9	n/a	chrIV 7,780,928	C. elegans SEC-10 protein; contains similarity to Pfam domain PF07393 Exocyst complex component Sec10 contains similarity to Interpro domain IPR009976 (Exocyst complex component Sec10)
37	srh-51	C10G11.3	n/a	chrI 6,301,375	C. elegans SRH-51 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	C11D2.3	C11D2.3	n/a	chrIV 6,154,348
39	Y51B9A.5	Y51B9A.5	n/a	chrII 9,404,343	contains similarity to Mus musculus Laminin gamma-1 chain precursor (Laminin B2 chain).; SW:LMG1_MOUSE
40	F52B5.3	F52B5.3	n/a	chrI 8,321,160	The F52B5.3 gene encodes a DEAH helicase orthologous to the Drosophila SpindleE protein.
41	pqn-20	C37A2.2	n/a	chrI 6,794,248	The protein product of this gene is predicted to contain a glutamine/asparagine (Q/N)-rich ('prion') domain, by the algorithm of Michelitsch and Weissman (as of the WS77 release of WormBase, i.e., in wormpep77).
42	T12E12.2	T12E12.2	n/a	chrIV 5,546,641	contains similarity to Pfam domain PF00385 'chromo' (CHRromatin Organisation MOdifier) domain contains similarity to Interpro domains IPR000953 (Chromo domain), IPR016197 (Chromo domain-like)
43	mlh-1	T28A8.7	n/a	chrIII 13,511,833	The mlh-1 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MLH1.
44	T16G12.6	T16G12.6	n/a	chrIII 10,072,699	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
45	F08F1.9	F08F1.9	n/a	chrX 8,410,171	contains similarity to Pfam domain PF00134 Cyclin, N-terminal domain contains similarity to Interpro domains IPR006670 (Cyclin), IPR011028 (Cyclin-like), IPR013763 (Cyclin-related), IPR006671 (Cyclin, N-terminal)
46	T01D3.5	T01D3.5	n/a	chrV 13,714,119	contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domain IPR003689 (Zinc/iron permease)
47	exoc-7	C43E11.8	n/a	chrI 4,245,201	C. elegans EXOC-7 protein; contains similarity to Pfam domain PF03081 Exo70 exocyst complex subunit contains similarity to Interpro domain IPR004140 (Exo70 exocyst complex subunit)
48	bub-1	R06C7.8	n/a	chrI 7,253,581	bub-1 encodes a serine/threonine kinase orthologous to Saccharomyces cerevisiae BUB1 which is required for proper function of the mitotic spindle assembly checkpoint and human BUB1 (OMIM:602452) which is mutated in some colorectal cancers; BUB-1 activity is required at several stages of development, including embryogenesis; BUB-1 is expressed predominantly in the anterior of the embryo and in hypodermal seam cells during the L1 and L2 larval stages.
49	duo-3	Y106G6H.12	n/a	chrI 10,467,681	C. elegans DUO-3 protein; contains similarity to Pfam domains PF00443 (Ubiquitin carboxyl-terminal hydrolase) , PF02338 (OTU-like cysteine protease) contains similarity to Interpro domains IPR003323 (Ovarian tumour, otubain), IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
50	srh-177	K02E2.3	n/a	chrV 20,363,754	C. elegans SRH-177 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)