UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	bir-2	C50B8.2	3.9999999999999997e-168	chrV 13,569,366	The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis.
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	rnp-8	R119.7	n/a	chrI 366,516	C. elegans RNP-8 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
4	F26H11.4	F26H11.4	n/a	chrII 14,410,374	contains similarity to Saccharomyces cerevisiae Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane; SGD:YMR089C
5	C16C8.13	C16C8.13	n/a	chrII 3,451,870	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
6	skr-17	C06A8.4	n/a	chrII 7,784,177	skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs.
7	bath-15	C08C3.2	n/a	chrIII 7,775,331	C. elegans BATH-15 protein; contains similarity to Pfam domains PF00917 (MATH domain) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
8	Y53C12A.6	Y53C12A.6	n/a	chrII 9,717,654	contains similarity to Bacteriophage RB69 Hypothetical protein RB69ORF024c.; TR:Q7Y5B4
9	ZK418.8	ZK418.8	n/a	chrIII 7,084,302	contains similarity to Pfam domain PF00013 KH domain contains similarity to Interpro domains IPR009019 (K Homology, prokaryotic type), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
10	spo-11	T05E11.4	n/a	chrIV 11,123,963	spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline.
11	C41G7.3	C41G7.3	n/a	chrI 9,516,858	contains similarity to Pfam domains PF00013 (KH domain) , PF03073 (TspO/MBR family) contains similarity to Interpro domains IPR004307 (TspO/MBR-related protein), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
12	syp-3	F39H2.4	n/a	chrI 8,663,589	syp-3 encodes a coiled-coil protein; SYP-3 activity is required during meiosis for chromosome synapsis and chiasma formation, specifically for proper assembly of the central region of the synaptonemal complex; thus, SYP-3 is essential activity is essential for normal embryonic development; immunolocalization studies indicate that SYP-3 is likely a structural component of the central element of the synaptonemal complex.
13	btb-20	F57C2.1	n/a	chrII 14,522,887	C. elegans BTB-20 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
14	W03C9.2	W03C9.2	n/a	chrII 11,963,758	contains similarity to Schizosaccharomyces pombe Transcription elongation factor S-II (TFIIS).; SW:TFS2_SCHPO
15	C16C8.11	C16C8.11	n/a	chrII 3,454,183	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
16	C38D4.4	C38D4.4	n/a	chrIII 4,794,206	contains similarity to Saccharomyces cerevisiae Delayed Anaerobic Gene; SGD:YJR151C
17	C55B7.11	C55B7.11	n/a	chrI 6,512,726
18	T04A8.8	T04A8.8	n/a	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
19	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
20	fbxa-108	F59A1.7	n/a	chrV 17,657,524	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
21	C48B4.6	C48B4.6	n/a	chrIII 9,557,903	contains similarity to Plateumaris constricticollis toyamensis Cytochrome oxidase subunit I (Fragment).; TR:Q85QH2
22	ZC477.5	ZC477.5	n/a	chrIV 7,102,332
23	F08G5.1	F08G5.1	n/a	chrIV 12,409,650	contains similarity to Homo sapiens Putative protein TPRXL; ENSEMBL:ENSP00000322097
24	dhs-5	F56D1.5	n/a	chrII 5,454,878	dhs-5 encodes a possible steroid dehydrogenase; DHS-5 generally resembles short chain-type alcohol/other dehydrogenases, but has two predicted N-terminal transmembrane sequences, and its closest relatives in vertebrates are known or putative steroid dehydrogenases such as hydroxysteroid (17-beta) dehydrogenase 12 from mouse (also known as KIK-I or DHBK_MOUSE).
25	F52C6.3	F52C6.3	n/a	chrII 1,925,233	contains similarity to Interpro domain IPR000626 (Ubiquitin)
26	C48B4.9	C48B4.9	n/a	chrIII 9,562,829	contains similarity to Arabidopsis thaliana Hypothetical protein (At1g32400/F5D14_22) (Tobamovirus multiplications2A).; TR:Q9C5W7
27	F49E8.2	F49E8.2	n/a	chrIV 7,549,959	contains similarity to Interpro domains IPR011767 (Glutaredoxin active site), IPR007087 (Zinc finger, C2H2-type)
28	F21F3.4	F21F3.4	n/a	chrI 4,896,773	contains similarity to Homo sapiens Uncharacterized protein ENSP00000372122; ENSEMBL:ENSP00000372122
29	lsl-1	F52F12.4	n/a	chrI 9,902,069	C. elegans LSL-1 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
30	bath-2	F52C6.11	n/a	chrII 1,922,182	C. elegans BATH-2 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
31	C36B1.11	C36B1.11	n/a	chrI 8,756,734	contains similarity to Interpro domain IPR001576 (Phosphoglycerate kinase)
32	zhp-3	K02B12.8	n/a	chrI 8,530,344	zhp-3 encodes a RING finger protein orthologous to budding yeast Cst9p (meiotically expressed) and human RNF212 (associated with varying recombination rate); ZHP-3 activity is required during meiosis for crossover recombination and chiasma formation; ZHP-3 activity is thus essential for proper chromosome segregation and normal levels of fertility; a ZHP-3::GFP fusion protein localizes along synapsed chromosomes in a manner that is dependent upon the presence of mature synaptonemal complexes; ZHP-3 is paralogous to D1081.9, F55A12.10, and Y39B6A.16.
33	ulp-5	K02F2.4	n/a	chrI 6,813,375	C. elegans ULP-5 protein; contains similarity to Pfam domain PF02902 Ulp1 protease family, C-terminal catalytic domain contains similarity to Interpro domain IPR003653 (Peptidase C48, SUMO/Sentrin/Ubl1)
34	efn-3	F15A2.5	n/a	chrX 13,476,463	efn-3 encodes a potential GPI-modified ephrin that is, with EFN-2, is required for normal epidermal organization in the male tail; EFN-3, along with EFN-1 and EFN-2, activates the VAB-1 tyrosine kinase in vivo and binds it in vitro, and has a minor role in embryonic epiboly.
35	K03H4.2	K03H4.2	n/a	chrV 13,153,453	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:O96209
36	C01G5.5	C01G5.5	n/a	chrIV 6,525,508	contains similarity to Pfam domain PF00248 Aldo/keto reductase family contains similarity to Interpro domain IPR001395 (Aldo/keto reductase)
37	F33G12.2	F33G12.2	n/a	chrII 5,030,810	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR011042 (Six-bladed beta-propeller, TolB-like), IPR015943 (WD40/YVTN repeat-like)
38	D2030.7	D2030.7	n/a	chrI 7,589,605	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
39	glp-1	F02A9.6	n/a	chrIII 9,095,873	glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains
40	taf-11.2	K10D3.3	n/a	chrI 7,133,402	C. elegans TAF-11.2 protein; contains similarity to Pfam domain PF04719 hTAFII28-like protein conserved region contains similarity to Interpro domains IPR006809 (TAFII28-like protein), IPR009072 (Histone-fold)
41	F54D5.9	F54D5.9	n/a	chrII 11,543,652	F54D5.9 encodes an F-box protein orthologous to to human FBXO47 (OMIM:609498, deleted in renal cell carcinoma) and paralogous to PROM-1, that suppresses excess embryonic cell division; F54D5.9(RNAi) animals show hyperproliferating embryonic tissues, while having no obvious meiotic defects.
42	skr-2	F46A9.4	n/a	chrI 9,470,152	skr-2 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-2 is required for the restraint of cell proliferation, progression through the pachytene stage of meiosis, and the formation of bivalent chromosomes at diakinesis; SKR-2::GFP is detected exclusively in the intestine.
43	T08D2.5	T08D2.5	n/a	chrX 178,809
44	C16C8.12	C16C8.12	n/a	chrII 3,453,161
45	T05H10.1	T05H10.1	n/a	chrII 8,044,949	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domains IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2), IPR011051 (Cupin, RmlC-type)
46	zim-2	T07G12.10	n/a	chrIV 10,556,907	zim-2 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1, ZIM-3, and C02F5.12; ZIM-2 is specifically required for homolog pairing, synapsis, and segregation of chromosome V during meiosis; zim-2(tm574) oocytes ending prophase have ~5 bivalents and ~2 univalents, the latter of which are consistently chromosome V; zim-2 oocytes fail to begin chromosome V pairing at the start of meiosis; ZIM-2 associates with the right end of chromosome V, which may indicate an association with its pairing center; while the C-terminal region of ZIM-2 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-2 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-2 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
47	C30F12.4	C30F12.4	n/a	chrI 6,972,971	contains similarity to Triticum aestivum Gamma-gliadin precursor.; SW:P08453
48	T05B9.1	T05B9.1	n/a	chrII 11,260,588	contains similarity to Saccharomyces cerevisiae Mlp proteins restrict telomere length by influencing the Rif1-Tel1 pathway of telomerase regulation; also involved in the translocation of macromolecules between the nucleoplasm and the NPC; SGD:YKR095W
49	W07E6.5	W07E6.5	n/a	chrII 477,174
50	ftr-1	Y113G7B.4	n/a	chrV 20,192,960	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.