UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C49C8.3	C49C8.3	9.999999999999999e-92	chrIV 8,644,987
2	fbxb-35	F07E5.2	n/a	chrII 2,052,208	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
3	EEED8.13	EEED8.13	n/a	chrII 5,411,874	contains similarity to Interpro domain IPR011038 (Calycin-like)
4	srp-2	C05E4.1	n/a	chrV 763,702	srp-2 encodes an ovalbumin-like serpin (ov-serpin) member of the serine protease inhibitor superfamily that is orthologous to human NEUROSERPIN (OMIM:602445, mutated in familial encephalopathy with neuroserpin inclusion bodies); SRP-2 is predicted to function as a suicide substrate that inhibits the proteolytic activity of serine proteases, and in vitro, recombinant SRP-2 is able to inhibit granzyme B activity; however, as loss of srp-2 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, the precise role of SRP-2 in C. elegans development and/or behavior is not yet known; srp-2 expression is detected in hypodermal cells, particularly in the lateral seam cells.
5	T13F2.6	T13F2.6	n/a	chrIV 9,779,719
6	F27C8.6	F27C8.6	n/a	chrIV 9,587,998	F27C8.6 encodes a putative arylacetamide deacetylase and microsomal lipase; F27C8.6 is required for sperm to normally migrate towards a PUFA-based signal exuded by oocytes; F27C8.6(RNAi) hermaphrodites are infertile, both through aberrant loss of their own sperm and through failure of males to effectively inseminate them.
7	M116.1	M116.1	n/a	chrIV 8,411,585
8	F28C6.2	F28C6.2	n/a	chrII 8,595,158	F28C6.2 encodes an AP-2-like transcription factor that is ~60% identical to that of F28C6.1, which lies adjacent to F28C6.1 on chromosome II; loss of F28C6.2 activity via large-scale RNAi results in some embryonic lethality and low levels of larval arrest, body morphology defects, and uncoordinated locomotion.
9	F57A10.4	F57A10.4	n/a	chrV 15,769,845	contains similarity to Oceanobacillus iheyensis Alkaliphily related protein.; TR:Q8EQ12
10	W06D11.1	W06D11.1	n/a	chrX 12,294,462
11	F53F4.4	F53F4.4	n/a	chrV 13,596,162	contains similarity to Candida albicans Chitinase 3 precursor (EC 3.2.1.14).; SW:CHI3_CANAL
12	C16C8.12	C16C8.12	n/a	chrII 3,453,161
13	ZC155.4	ZC155.4	n/a	chrIII 5,213,465	contains similarity to Pfam domain PF03009 Glycerophosphoryl diester phosphodiesterase family contains similarity to Interpro domain IPR004129 (Glycerophosphoryl diester phosphodiesterase)
14	hop-1	C18E3.8	n/a	chrI 4,209,468	hop-1 encodes one of three C. elegans presenilins (the other two presenilins are encoded by sel-12 and spe-4); originally identified on the basis of its sequence similarity to SEL-12 and the human PS1 and PS2 presenilins, HOP-1 has been shown to function redundantly with SEL-12 in embryonic, larval, and germline development and thus, to likely function by regulating LIN-12/GLP-1 signaling; in addition, hop-1 can functionally substitute for sel-12 by rescuing the egg-laying and vulval development defects of sel-12 mutants; hop-1 transcription appears to be regulated, at least in part, by the C. elegans spr genes, some of which encode orthologs of the mammalian CoREST repressor complex.
15	C31H1.8	C31H1.8	n/a	chrIV 5,812,882	contains similarity to Homo sapiens Protocadherin 15; ENSEMBL:ENSP00000378832
16	F54F7.6	F54F7.6	n/a	chrX 11,866,107	contains similarity to Homo sapiens Golgi autoantigen, golgin subfamily B member 1; ENSEMBL:ENSP00000315938
17	T19H5.4	T19H5.4	n/a	chrII 9,487,245	contains similarity to Gallus gallus Homeobox prospero-like protein PROX1 (PROX 1).; SW:PRX1_CHICK
18	lgg-3	B0336.8	n/a	chrIII 5,697,730	lgg-3 encodes a hydrophilic protein that is orthologous to Saccharomyces cerevisiae autophagy protein Apg12p; by homology, LGG-3 is predicted to function as a modifier protein required for a protein conjugation system essential for autophagy; in the context of this conjugation system, LGG-3 is predicted to interact with Apg7p and Apg5p homologs (encoded by M7.5 and Y71G12B.12a, respectively) to effect bulk degradation of cytoplasmic components under conditions of starvation or cellular remodeling; free LGG-3 is predicted to localize to the cytoplasm, while LGG-3 conjugated to the Apg5p homolog is predicted to associate with membrane compartments; loss of lgg-3 activity via large-scale RNAi screens results in no obvious developmental or behavioral abnormalities.
19	M02B7.1	M02B7.1	n/a	chrIV 3,806,054
20	R06C7.2	R06C7.2	n/a	chrI 7,234,078	contains similarity to Dictyostelium discoideum Hypothetical protein.; TR:Q86KG8
21	M01E11.3	M01E11.3	n/a	chrI 5,574,995	contains similarity to Pfam domain PF08585 Domain of unknown function (DUF1767) contains similarity to Interpro domain IPR013894 (Region of unknown function DUF1767)
22	rnh-1.2	ZK938.7	n/a	chrII 9,840,817	C. elegans RNH-1.2 protein; contains similarity to Pfam domains PF00339 (Arrestin (or S-antigen), N-terminal domain) , PF00075 (RNase H) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR011021 (Arrestin-like, N-terminal), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold), IPR002156 (Ribonuclease H)
23	mxl-1	T19B10.11	n/a	chrV 11,245,345	mxl-1 encodes a basic helix-loop-helix protein similar to the vertebrate MAX transcriptional regulators; in vitro, MXL-1 can heterodimerize, and bind an E-box DNA sequence, with MDL-1, a C. elegans MAD-like bHLH protein; mxl-1::gfp reporter fusions are expressed in the posterior intestine and in head and tail neurons.
24	C48B6.3	C48B6.3	n/a	chrI 6,915,508	contains similarity to Homo sapiens UPF0472 protein C16orf72; ENSEMBL:ENSP00000331720
25	F30F8.3	F30F8.3	n/a	chrI 7,836,374	contains similarity to Pfam domain PF00595 PDZ domain (Also known as DHR or GLGF) contains similarity to Interpro domain IPR001478 (PDZ/DHR/GLGF)
26	T25E12.5	T25E12.5	n/a	chrV 16,745,714	contains similarity to Pfam domain PF01501 Glycosyl transferase family 8 contains similarity to Interpro domain IPR002495 (Glycosyl transferase, family 8)
27	T01E8.4	T01E8.4	n/a	chrII 10,238,236	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains WD repeats.
28	W07A12.6	W07A12.6	n/a	chrII 9,158,925	contains similarity to Pfam domain PF01757 Acyltransferase family contains similarity to Interpro domain IPR002656 (Acyltransferase 3)
29	ttr-30	T08A9.2	n/a	chrX 7,331,455	C. elegans TTR-30 protein; contains similarity to Pfam domain PF01060 Transthyretin-like family contains similarity to Interpro domain IPR001534 (Transthyretin-like)
30	F32D1.6	F32D1.6	n/a	chrV 4,374,245
31	B0416.4	B0416.4	n/a	chrX 9,279,335	contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR000533 (Tropomyosin), IPR001841 (Zinc finger, RING-type), IPR000956 (Stathmin), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
32	bath-15	C08C3.2	n/a	chrIII 7,775,331	C. elegans BATH-15 protein; contains similarity to Pfam domains PF00917 (MATH domain) , PF00651 (BTB/POZ domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
33	F57C9.3	F57C9.3	n/a	chrI 4,838,180
34	F27B3.5	F27B3.5	n/a	chrIII 6,560,937	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
35	C42C1.8	C42C1.8	n/a	chrIV 12,292,136	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
36	tbx-36	ZK829.5	n/a	chrIV 11,951,305	C. elegans TBX-36 protein; contains similarity to Pfam domain PF00907 T-box contains similarity to Interpro domains IPR008967 (p53-like transcription factor, DNA-binding), IPR001699 (Transcription factor, T-box)
37	C41G6.13	C41G6.13	n/a	chrV 15,208,853	contains similarity to Homo sapiens Xylosyltransferase I; ENSEMBL:ENSP00000261381
38	C44B9.3	C44B9.3	n/a	chrIII 10,879,120	contains similarity to Trypanosoma cruzi Mucin-like protein.; TR:O61047
39	B0393.6	B0393.6	n/a	chrIII 4,781,174	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type)
40	C42C1.2	C42C1.2	n/a	chrIV 12,266,886	contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR000222 (), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
41	C16A3.2	C16A3.2	n/a	chrIII 6,390,183	contains similarity to Pfam domain PF00782 Dual specificity phosphatase, catalytic domain contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR016130 (Protein-tyrosine phosphatase, active site), IPR000387 (Protein-tyrosine phosphatase), IPR000340 (Protein-tyrosine phosphatase, dual specificity)
42	F52C6.3	F52C6.3	n/a	chrII 1,925,233	contains similarity to Interpro domain IPR000626 (Ubiquitin)
43	meg-2	K02B9.2	n/a	chrX 13,924,518	meg-2 encodes a novel protein that localizes exclusively to P granules; originally identified by microarray analyses of germline-enriched transcripts, loss of meg-2 activity by itself results in no obvious abnormalities, but loss of meg-2 activity in meg-1 mutant animals indicates that meg-1 and meg-2 likely have redundant functions in germline development; meg-2 may also function redundantly with mes-1; meg-2 expression in the proximal germline is positively regulated by MPK-1, the C. elegans MAP kinase ortholog; a GFP::MEG-2 fusion protein localizes exclusively to P granules in the embryonic germ cell lineage.
44	clec-127	W10G11.5	n/a	chrII 3,568,702	C. elegans CLEC-127 protein; contains similarity to Pfam domain PF00059 Lectin C-type domain contains similarity to Interpro domains IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
45	gna-2	T23G11.2	n/a	chrI 7,700,248	gna-2 encodes a glucosamine 6-phosphate N-acetyltransferase required for synthesis of UDP-N-acetylglucosamine (UDP-GlcNAc), N-acetylgalactosamine (UDP-GalNAc), alpha-GalNAc-modifications of mucin-like proteins, and chitin; GNA-2 is also required for eggshell synthesis and osmotic integrity, progression past meiosis metaphase I, error-free chromosomal segregation during meiosis, polar body extrusion, association of the sperm pronucleus/centrosome complex (SPCC) with the early embryonic cortex, localization of PAR-2 in early embryos, posterior localization of P granules or PIE-1, and pseudocleavage; gna-2 transcription is elevated during oogenesis; gna-2 mRNA is posttranslationally inhibited both by GLD-1 repression and by nonsense-mediated mRNA decay (NMD), with GLD-1 predominating in distal gonads and NMD (incompletely) predominating in proximal ones; gna-2 mRNA has two upstream open reading frames (uORFs) with premature stop codons, which normally cause NMD of this mRNA unless it is protected by GLD-1 binding to the gna-2 mRNA's 5' UTR; conversely, gna-2 mRNA is translationally repressed by bound GLD-1 during pachytene meiosis, and must be freed from this repression during diplotene meiosis for eggshell synthesis to proceed; gna-2(qa705) is suppressed by sup-46 mutations, but only in a gna-1(+) background.
46	EEED8.14	EEED8.14	n/a	chrII 5,413,091	contains similarity to Sulfolobus solfataricus DNA double-strand break repair rad50 ATPase.; SW:Q97WH0
47	C16C8.5	C16C8.5	n/a	chrII 3,445,041	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
48	C04F12.5	C04F12.5	n/a	chrI 9,690,333	contains similarity to Plasmodium yoelii nigeriensis Ookinete surface antigen-like protein Pfs28.; TR:Q9GTY7
49	Y106G6H.16	Y106G6H.16	n/a	chrI 10,475,167	contains similarity to Salmonella typhimurium Putative cytoplasmic protein (STMF1.42 protein).; TR:Q9L9K2
50	rev-1	ZK675.2	n/a	chrII 7,902,571	C. elegans REV-1 protein; contains similarity to Pfam domains PF00817 (impB/mucB/samB family) , PF00533 (BRCA1 C Terminus (BRCT) domain) contains similarity to Interpro domains IPR001126 (UMUC-like DNA-repair protein), IPR012112 (DNA repair protein, Rev1), IPR001357 (BRCT)