UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	ced-3	C48D1.2	0	chrIV 13,202,258	The ced-3 gene encodes a protease required for apoptosis.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	acr-3	K11G12.7	n/a	chrX 6,711,143	acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits.
4	ikb-1	C04F12.3	n/a	chrI 9,687,053	ikb-1 encodes an ortholog of human BCL3 (OMIM:109560) that physically interacts with the checkpoint protein MRT-2; ikb-1(nr2019) and ikb-1(nr2027) mutants display no obvious phenotype other than shortened lifespan; mutation of BCL3 is frequently associated with recurring translocations found in the neoplastic cells of patients with chronic lymphocytic leukemia, and has been implicated in cell cycle control (perhaps via apoptosis).
5	srw-59	H24D24.1	n/a	chrV 15,950,332	C. elegans SRW-59 protein; contains similarity to Pfam domain PF06976 Protein of unknown function (DUF1300) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR010726 (Protein of unknown function DUF1300), IPR000276 (GPCR, rhodopsin-like)
6	T05B4.4	T05B4.4	n/a	chrV 4,128,560
7	C26C6.8	C26C6.8	n/a	chrI 7,504,574	contains similarity to Pfam domains PF07653 (Variant SH3 domain) (3), PF00018 (SH3 domain) (2)contains similarity to Interpro domains IPR001452 (Src homology-3), IPR000108 (Neutrophil cytosol factor 2), IPR011511 (Variant SH3)
8	str-68	Y73C8C.6	n/a	chrV 3,106,888	C. elegans STR-68 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
9	nhr-83	F48G7.3	n/a	chrV 632,120	C. elegans NHR-83 protein; contains similarity to Pfam domains PF07914 (Protein of unknown function (DUF1679)) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR012877 (Protein of unknown function DUF1679, Caenorhabditis species), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core), IPR015897 (CHK kinase-like)
10	F25A2.1	F25A2.1	n/a	chrV 1,180,578	contains similarity to Rattus norvegicus C-X-C chemokine receptor type 7 (CXC-R7) (CXCR-7) (G-protein coupledsreceptor RDC1 homolog) (RDC-1) (Chemokine orphan receptor 1).; SW:O89039
11	F53B6.6	F53B6.6	n/a	chrI 8,956,012	contains similarity to Pfam domain PF00100 Zona pellucida-like domain contains similarity to Interpro domain IPR001507 (Endoglin/CD105 antigen)
12	Y69H2.1	Y69H2.1	n/a	chrV 18,621,264	contains similarity to Myxine glutinosa NADH-ubiquinone oxidoreductase chain 4 (EC 1.6.5.3).; SW:NU4M_MYXGL
13	Y56A3A.16	Y56A3A.16	n/a	chrIII 11,912,267	contains similarity to Homo sapiens Isoform 1 of Pleckstrin homology domain-containing family M member 3; ENSEMBL:ENSP00000373899
14	srz-15	C32H11.2	n/a	chrIV 12,916,637	C. elegans SRZ-15 protein ;
15	C08G5.1	C08G5.1	n/a	chrII 736,664	contains similarity to Pfam domain PF02206 Domain of unknown function contains similarity to Interpro domain IPR003125 (Protein of unknown function WSN)
16	moc-2	W01A11.6	n/a	chrV 6,503,257	C. elegans MOC-2 protein; contains similarity to Pfam domain PF00994 Probable molybdopterin binding domain contains similarity to Interpro domains IPR008284 (Molybdenum cofactor biosynthesis, conserved site), IPR001453 (Molybdopterin binding)
17	ZC487.3	ZC487.3	n/a	chrV 6,723,598
18	F43E2.1	F43E2.1	n/a	chrII 7,376,369
19	glb-9	C28F5.2	n/a	chrII 7,510,599	glb-9 encodes a globin with no obvious function in mass RNAi assays.
20	T23F4.1	T23F4.1	n/a	chrII 1,167,834	contains similarity to Pfam domain PF01738 Dienelactone hydrolase family contains similarity to Interpro domain IPR002925 (Dienelactone hydrolase)
21	F28H6.6	F28H6.6	n/a	chrX 14,121,403	contains similarity to Interpro domain IPR010993 (Sterile alpha motif homology)
22	T03E6.2	T03E6.2	n/a	chrV 16,582,078	contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
23	sre-45	F54F11.3	n/a	chrII 13,520,326	C. elegans SRE-45 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
24	atf-6	F45E6.2	n/a	chrX 12,482,840	atf-6 is an ortholog of mammalian ATF6alpha, a proximal sensor required for the unfolded protein response (UPR) in the endoplasmic reticulum (ER); ATF6alpha is a transmembrane protein, with a bZIP transcription factor domain in its cytosolic amino terminus that is released and activated by proteolytic cleavage upon ER stress; either ire-1 or xbp-1 deletions are synthetically lethal with atf-6 or pek-1 deletions, producing arrest in L2 larvae; RNAi of Y56A3A.2 (a S2P protease homolog) is synthetically lethal with ire-1(RNAi), consistent with the hypothesis that Y56A3A.2 cleaves ATF-6; atf-6 regulates few genes that are transcriptionally induced by UPR, but regulates roughly one-quarter of genes that require UPR constitutively; pdr-1 transcripts are strongly upregulated in a atf-6(ok551) mutant background, but atf-6(ok551);pdr-1(lg103) double mutants have a grossly normal phenotype ; atf-6 is dispensable for proper localization of GLR-1 glutamate receptors.
25	nhr-189	F47C10.8	n/a	chrV 3,859,413	C. elegans NHR-189 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
26	dpr-1	R10D12.2	n/a	chrV 13,941,139	dpr-1 encodes a putative nuclear hormone receptor that affects endoderm differentiation and may promote entry into the dauer state and maintenance of the dauer state; expressed in the endoderm lineage and localization appears dependent on growth conditions.
27	F49E12.8	F49E12.8	n/a	chrII 8,393,450	contains similarity to Homo sapiens Hypothetical protein KIAA0335; TR:O15044
28	Y66A7A.2	Y66A7A.2	n/a	chrIII 11,486,326	Y66A7A.2 encodes an ortholog of Pop5, a protein subunit shared by the endoribonucleases RNase MRP and RNAse P; RNAse MRP cleaves mitochondrial RNA in mitochondrial DNA synthesis, nucleolar pre-rRNA in ribosome synthesis, and at least one mRNA (CLB2) involved in cell-cycle regulation; RNAse P cleaves tRNA precursors to produce their mature 5' end; Y66A7A.2 is evolutionarily ubiquitous among eukaryotes.
29	npr-1	C39E6.6	n/a	chrX 4,768,551	npr-1 encodes a predicted G protein-coupled neuropeptide receptor that is homologous to the mammalian neuropeptide Y (NPY) receptor (OMIM:162641) required for regulating anxiety, food consumption, and pain sensation; in C. elegans, NPR-1 is involved in ethological variations of social behavior such as social versus solitary feeding; NPR-1 also affects some aspect of UNC-6/netrin-mediated branching of motor neurons, as strong npr-1 mutations can suppress abnormal migration of ventral nerve cord neurons induced by overexpression of UNC-6 lacking domain C; NPR-1 is expressed predominantly in the nervous system, and particularly in the AQR, PQR, and URX neurons that are exposed to the body fluid.
30	R05C11.2	R05C11.2	n/a	chrIV 2,058,493	contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
31	K04H4.5	K04H4.5	n/a	chrIII 9,360,700	contains similarity to Yaba monkey tumor virus Yb-L1L protein.; TR:Q9QBC3
32	C47E8.3	C47E8.3	n/a	chrV 14,681,957	contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
33	F47G6.3	F47G6.3	n/a	chrI 1,467,585	contains similarity to Homo sapiens Putative uncharacterized protein (Fragment); ENSEMBL:ENSP00000333119
34	nhr-32	K08H2.8	n/a	chrX 13,254,014	C. elegans NHR-32 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
35	clec-188	M199.3	n/a	chrIV 15,117,866	C. elegans CLEC-188 protein; contains similarity to Pfam domain PF08277 PAN-like domain contains similarity to Interpro domains IPR006583 (CW), IPR016187 (C-type lectin fold), IPR001304 (C-type lectin)
36	C49A9.1	C49A9.1	n/a	chrIV 6,229,082	contains similarity to Pfam domain PF03312 Protein of unknown function, DUF272 contains similarity to Interpro domain IPR004987 (Protein of unknown function DUF272)
37	str-211	C02E7.13	n/a	chrV 4,943,703	C. elegans STR-211 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
38	T08G3.6	T08G3.6	n/a	chrV 16,446,543	contains similarity to Interpro domain IPR008975 ()
39	ZK1240.5	ZK1240.5	n/a	chrII 2,317,121	contains similarity to Interpro domain IPR000315 (Zinc finger, B-box)
40	C46A5.1	C46A5.1	n/a	chrIV 7,765,495	contains similarity to Pfam domain PF00102 Protein-tyrosine phosphatase contains similarity to Interpro domains IPR003595 (Protein-tyrosine phosphatase, catalytic), IPR000242 (Protein-tyrosine phosphatase, receptor/non-receptor type), IPR000387 (Protein-tyrosine phosphatase)
41	W03D2.9	W03D2.9	n/a	chrIV 4,074,075	contains similarity to Interpro domain IPR009151 (Basigin)
42	C01A2.4	C01A2.4	n/a	chrI 13,393,035	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
43	ZK1307.4	ZK1307.4	n/a	chrII 9,651,306	contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein)
44	srab-8	C36C5.2	n/a	chrV 3,177,218	C. elegans SRAB-8 protein ;
45	ugt-37	F10D2.6	n/a	chrV 7,143,012	C. elegans UGT-37 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
46	aat-4	T13A10.10	n/a	chrIV 6,274,136	aat-4 encodes a predicted amino acid transporter catalytic subunit; unlike catalytic subunits in other organisms, however, AAT-4 does not contain the highly conserved cysteine residue known to facilitate covalent interaction with a glycoprotein subunit, suggesting that AAT-4 does not require this residue for heterodimer formation or, alternatively, does not require the glycoprotein subunit for function.
47	C33C12.9	C33C12.9	n/a	chrII 2,188,303	contains similarity to Pfam domain PF05175 Methyltransferase small domain contains similarity to Interpro domains IPR007848 (Methyltransferase small), IPR004557 (Putative methylase), IPR002296 (N6 adenine-specific DNA methyltransferase, N12 class), IPR002052 (N-6 adenine-specific DNA methylase, conserved site)
48	bbs-2	F20D12.3	n/a	chrIV 7,935,876	bbs-2 is orthologous to human BBS2 (OMIM:606151, mutated in Bardet-Biedl syndrome 2); while the function of BBS-2 is unknown, it shares conserved domains with its human paralogs BBS1 and BBS7, which also are mutated in other Bardet-Biedl syndromes.
49	srt-47	Y41E3.12	n/a	chrIV 15,051,352	C. elegans SRT-47 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR006121 (Heavy metal transport/detoxification protein)
50	C23H5.7	C23H5.7	n/a	chrIV 2,107,829	contains similarity to Pfam domains PF00027 (Cyclic nucleotide-binding domain) , PF00520 (Ion transport protein) contains similarity to Interpro domains IPR005821 (Ion transport), IPR000595 (Cyclic nucleotide-binding), IPR014710 (RmlC-like jelly roll fold)