UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C47D12.4	C47D12.4	2e-177	chrII 11,682,106	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
2	skr-9	C52D10.7	n/a	chrIV 17,163,837	skr-9 encodes a homolog of Skp1 in S. cerevisiae, a component of the SCF (Skp1, Cullin, F-box) ubiquitin-ligase complex that regulates ubiquitin-mediated protein degradation; SKR-9 is required for posterior body morphogenesis, embryonic and larval development, and postembryonic cell proliferation.
3	xbx-5	T24A11.2	n/a	chrIII 3,803,450	C. elegans XBX-5 protein ;
4	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
5	rpt-5	F56H1.4	n/a	chrI 5,742,805	rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
6	F54F2.9	F54F2.9	n/a	chrIII 8,826,142	contains similarity to Pfam domains PF00249 (Myb-like DNA-binding domain) , PF00226 (DnaJ domain) contains similarity to Interpro domains IPR015609 (Molecular chaperone, heat shock protein, Hsp40, DnaJ), IPR001005 (SANT, DNA-binding), IPR003095 (Heat shock protein DnaJ), IPR001623 (Heat shock protein DnaJ, N-terminal), IPR014778 (Myb, DNA-binding), IPR009057 (Homeodomain-like)
7	srh-68	T21B4.5	n/a	chrII 12,507,810	C. elegans SRH-68 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR002379 (ATPase, F0/V0 complex, subunit C)
8	W06D11.4	W06D11.4	n/a	chrX 12,302,364	contains similarity to Pfam domain PF08123 Histone methylation protein DOT1 contains similarity to Interpro domain IPR013110 (Histone methylation DOT1)
9	srsx-29	C51E3.4	n/a	chrV 10,155,688	C. elegans SRSX-29 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR001991 (Sodium:dicarboxylate symporter), IPR000276 (GPCR, rhodopsin-like)
10	ugt-32	F47C10.6	n/a	chrV 3,842,918	C. elegans UGT-32 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
11	C07E3.9	C07E3.9	n/a	chrII 10,351,043	contains similarity to Pfam domain PF00068 Phospholipase A2 contains similarity to Interpro domains IPR016090 (Phospholipase A2), IPR001211 (Phospholipase A2, eukaryotic), IPR013090 (Phospholipase A2, active site)
12	C07G1.2	C07G1.2	n/a	chrIV 8,208,755	contains similarity to Pfam domains PF00057 (Low-density lipoprotein receptor domain class A) , PF00051 (Kringle domain) , PF00024 (PAN domain) contains similarity to Interpro domains IPR001190 (Speract/scavenger receptor), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR003609 (Apple-like), IPR003014 (N/apple PAN), IPR000001 (), IPR013806 (Kringle-like fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin), IPR017448 (Speract/scavenger receptor related)
13	daf-8	R05D11.1	n/a	chrI 8,586,024	daf-8 encodes a Smad protein that represses dauer development, perhaps by antagonizing DAF-3 activity, and promotes a commitment to reproductive growth; genetic interactions suggest partial functional redundancy with daf-14 with respect to the TGF-beta signaling pathway that regulates dauer formation.
14	xpa-1	K07G5.2	n/a	chrI 7,160,236	xpa-1 encodes an ortholog of human XPA, the xeroderma pigmentosum complementation group A protein (OMIM:278700, mutations are associated with sensitivity to ultraviolet light and carcinomata at an early age); by homology, XPA-1 is predicted to function as a DNA-binding protein that is required for nucleotide excision repair of damaged DNA; in C. elegans, loss of xpa-1 activity via mutation or RNA-mediated interference (RNAi) results in increased sensitivity to UV irradiation at all stages of development; xpa-1 mRNA is detected in eggs and mixed stage populations.
15	polq-1	W03A3.2	n/a	chrIII 5,797,057	C. elegans POLQ-1 protein; contains similarity to Pfam domains PF00270 (DEAD/DEAH box helicase) , PF00476 (DNA polymerase family A) , PF00271 (Helicase conserved C-terminal domain) contains similarity to Interpro domains IPR011545 (DNA/RNA helicase, DEAD/DEAH box type, N-terminal), IPR001098 (DNA-directed DNA polymerase, family A), IPR014021 (Helicase, superfamily 1 and 2, ATP-binding), IPR002298 (DNA polymerase A), IPR003593 (AAA+ ATPase, core), IPR014001 (DEAD-like helicase, N-terminal), IPR001650 (DNA/RNA helicase, C-terminal)
16	M04D8.4	M04D8.4	n/a	chrIII 10,030,454	contains similarity to Clostridium perfringens Hypothetical protein CPE0262.; TR:Q8XNS0
17	lin-24	B0001.1	n/a	chrIV 12,132,269	lin-24 was identified in screens for mutations that result in altered vulval cell lineages; lin-24 is defined by two alleles, the first of which, a partially dominant mutation, generally results in vulvaless animals, while the second, a non-null amber mutation that is also partially dominant, results in wild-type animals when homozygous, but vulvaless animals when heterozygous with a wild-type allele; morphological examination of lin-24 animals indicates that some of the Pn.p cells that normally make up the vulva undergo inappropriate cell death that is dependent upon the ced-2, ced-5, and ced-10 engulfment genes, but not on the ced-3 and ced-4 killing genes; the precise molecular identity of lin-24 has not yet been reported.
18	mvb-12	C06A6.3	n/a	chrIV 7,831,453	C. elegans MVB-12 protein ; contains similarity to Homo sapiens Isoform 1 of Protein FAM125B; ENSEMBL:ENSP00000354772
19	F27C8.2	F27C8.2	n/a	chrIV 9,597,886	contains similarity to Interpro domain IPR016181 (Acyl-CoA N-acyltransferase)
20	T01G9.3	T01G9.3	n/a	chrI 8,283,218	contains similarity to Pfam domains PF00560 (Leucine Rich Repeat) (9), PF01463 (Leucine rich repeat C-terminal domain) contains similarity to Interpro domains IPR000483 (Cysteine-rich flanking region, C-terminal), IPR001611 (Leucine-rich repeat), IPR003591 (Leucine-rich repeat, typical subtype)
21	F39B2.7	F39B2.7	n/a	chrI 14,772,840	contains similarity to Pfam domain PF01926 GTPase of unknown function contains similarity to Interpro domains IPR005289 (GTP-binding), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR002917 (GTP-binding protein, HSR1-related), IPR003593 (AAA+ ATPase, core), IPR006073 (GTP1/OBG), IPR004520 (tRNA modification GTPase TrmE)
22	R11G1.2	R11G1.2	n/a	chrX 3,653,706
23	flp-22	F39H2.1	n/a	chrI 8,659,426	C. elegans FLP-22 protein; contains similarity to Pfam domain PF01581 FMRFamide related peptide family contains similarity to Interpro domain IPR001651 (Gastrin/cholecystokinin peptide hormone)
24	C47A4.1	C47A4.1	n/a	chrIV 13,716,255	contains similarity to Interpro domain IPR015609 (Molecular chaperone, heat shock protein, Hsp40, DnaJ)
25	F25H9.6	F25H9.6	n/a	chrV 13,467,638	contains similarity to Pfam domain PF02441 Flavoprotein contains similarity to Interpro domain IPR003382 (Flavoprotein)
26	lgc-14	T01H10.2	n/a	chrX 12,112,417	C. elegans LGC-14 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
27	M01E5.1	M01E5.1	n/a	chrI 13,275,251	contains similarity to Ichthyophthirius multifiliis Immobilization antigen isoform.; TR:Q9BMH3
28	T09E11.1	T09E11.1	n/a	chrI 12,338,593	contains similarity to Pfam domain PF03360 Glycosyltransferase family 43 contains similarity to Interpro domain IPR005027 (Glycosyl transferase, family 43)
29	W03G9.3	W03G9.3	n/a	chrI 4,960,459
30	eif-3.C	T23D8.4	n/a	chrI 9,978,188	eif-3.C encodes a putative c subunit of translation initiation factor 3 that is required for fertility and for embryonic osmotic integrity; eif-3.C is orthologous to human EIF3S8 (OMIM:603916) and budding yeast NIP1.
31	F33A8.6	F33A8.6	n/a	chrII 11,051,217	contains similarity to Pfam domain PF00481 Protein phosphatase 2C contains similarity to Interpro domains IPR001932 (Protein phosphatase 2C-related), IPR000222 (), IPR014045 (Protein phosphatase 2C, N-terminal), IPR015655 (Protein phosphatase 2C)
32	C41D7.1	C41D7.1	n/a	chrII 357,032
33	T10B11.4	T10B11.4	n/a	chrI 6,938,560
34	T20G5.9	T20G5.9	n/a	chrIII 10,210,308	contains similarity to Pfam domain PF09282 Mago binding contains similarity to Interpro domain IPR015362 (Exon junction complex, Pym)
35	F44A6.4	F44A6.4	n/a	chrX 10,214,952	contains similarity to Salmonella typhi Anaerobic sulfite reductase subunit A (EC 1.8.2.-).; TR:Q8Z4M7
36	B0280.10	B0280.10	n/a	chrIII 7,132,835
37	C08A9.9	C08A9.9	n/a	chrX 17,107,104	contains similarity to Pfam domain PF03353 DUF278 contains similarity to Interpro domain IPR005020 (Protein of unknown function DUF278)
38	ZK1307.7	ZK1307.7	n/a	chrII 9,638,262	contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
39	djr-1.1	B0432.2	n/a	chrII 291,212	djr-1.1 encodes an ortholog of DJ-1 (OMIM:602533, mutated in early-onset Parkinson disease); DJR-1.1 is required for resistance to rotenone, a mitochondrial complex I inhibitors that mimics Parkinson disease (PD); djr-1.1(RNAi) animals are partly rescued from PD-like sensitivity by D-beta-hydroxybutyrate or tauroursodeoxycholic acid, and fully rescued by both; by orthology with DJ-1, DJR-1.1 may promote stability of the transcription factors SKN-1 or SKNR-1 (homologs of mammalian NFE2L2).
40	F34H10.3	F34H10.3	n/a	chrX 9,634,393	contains similarity to Anabaena sp Hypothetical protein Asr1307.; TR:Q8YXA8
41	opt-1	C06G8.2	n/a	chrIV 10,792,535	opt-1 encodes a high-affinity, proton-coupled oligopeptide transporter; when expressed in Xenopus ooctyes, OPT-1 exhibits proton-coupled transport activity for a broad spectrum of peptide substrates; opt-1 mRNA is detected at all stages of development, but is expressed at highest levels in late larval and adult stages; additionally, an opt-1::GFP reporter exhibits expression primarily in vulval, pharyngeal, and anal muscles; as loss of opt-1 activity via large-scale RNAi screens does not result in any obvious abnormalities, the precise role of opt-1 in C. elegans development and/or behavior is not yet known.
42	F44C8.7	F44C8.7	n/a	chrV 2,216,907	contains similarity to Pfam domain PF04142 Nucleotide-sugar transporter contains similarity to Interpro domains IPR004689 (UDP-galactose transporter), IPR007271 (Nucleotide-sugar transporter)
43	F14H3.4	F14H3.4	n/a	chrV 16,054,667	contains similarity to Interpro domain IPR000215 (Protease inhibitor I4, serpin)
44	F02E9.7	F02E9.7	n/a	chrI 8,414,687	contains similarity to Pfam domain PF00149 Calcineurin-like phosphoesterase contains similarity to Interpro domain IPR004843 (Metallophosphoesterase)
45	fbxa-22	T12B5.5	n/a	chrIII 939,140	C. elegans FBXA-22 protein; contains similarity to Pfam domain PF01827 FTH domain contains similarity to Interpro domain IPR002900 (Protein of unknown function DUF38, Caenorhabditis species)
46	F41G4.5	F41G4.5	n/a	chrX 16,831,782
47	T14G10.7	T14G10.7	n/a	chrIV 10,148,080	contains similarity to Bos taurus GPI transamidase component PIG-S (Phosphatidylinositol-glycansbiosynthesis class S protein).; SW:Q3SZL5
48	fcd-2	Y41E3.9	n/a	chrIV 15,031,338	fcd-2 encodes an ortholog of the human gene FANCD2 (mutated in Fanconi anemia, OMIM:227646) that is strongly required for resistance to DNA interstrand crosslinking (ICL) agents, but not to ionizing radiation (IR); fcd-2 mutants are viable and dispensable for resistance to IR, meiotic recombination, and S-phase checkpoint activation, but are hypersensitive to ICL agents; like its human ortholog, FCD-2 is monoubiquitylated and recruited to chromosomal foci after ICL but not IR; transgenic expresssion of the FANCD2 gene in mutant FA-D2 cells rescues their abnormal sensitivity to mitomycin C, an agent that cross-links strands of DNA.
49	glr-7	C43H6.9	n/a	chrX 2,415,895	glr-7 encodes a protein containing a ligand-gated ion channel domain and is a predicted non-NMDA type ionotropic glutamate receptor; expressed in the pharyngeal nervous system.
50	ers-1	Y41E3.4	n/a	chrIV 15,010,805	ers-1 encodes a glutaminyl (Q) tRNA synthetase that affects growth and embryonic and larval viability in large-scale RNAi screens; it is predicted to be mitochondrial.