UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	pbs-2	C47B2.4	1.0000000000000001e-159	chrI 12,967,737	C. elegans PBS-2 protein; contains similarity to Pfam domain PF00227 Proteasome A-type and B-type contains similarity to Interpro domains IPR001353 (20S proteasome, A and B subunits), IPR016050 (Proteasome, beta-type subunit, conserved site), IPR000243 (Peptidase T1A, proteasome beta-subunit)
2	Y57G11C.15	Y57G11C.15	n/a	chrIV 14,823,817	contains similarity to Pfam domain PF00344 eubacterial secY protein contains similarity to Interpro domains IPR001991 (Sodium:dicarboxylate symporter), IPR002208 (SecY protein)
3	F55A11.1	F55A11.1	n/a	chrV 11,763,785	contains similarity to Pfam domain PF00036 EF hand contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand)
4	F47B10.1	F47B10.1	n/a	chrX 10,898,993	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR013815 (ATP-grasp fold, subdomain 1), IPR013816 (ATP-grasp fold, subdomain 2), IPR016102 (Succinyl-CoA synthetase-like)
5	dnj-2	B0035.2	n/a	chrIV 11,313,197	This gene encodes a protein containing a DnaJ ('J') domain.
6	F53A2.7	F53A2.7	n/a	chrIII 13,345,704	contains similarity to Pfam domains PF02803 (Thiolase, C-terminal domain) , PF00108 (Thiolase, N-terminal domain) contains similarity to Interpro domains IPR016038 (Thiolase-like, subgroup), IPR002155 (Thiolase), IPR016039 (Thiolase-like)
7	C56G2.7	C56G2.7	n/a	chrIII 6,340,161	contains similarity to Pfam domain PF04683 Adhesion regulating molecule conserved region contains similarity to Interpro domain IPR006773 (Adhesion regulating molecule)
8	cogc-6	K07C11.9	n/a	chrV 8,219,777	cogc-6 encodes an ortholog of mammalian COG-6, a subunit of lobe B of the conserved oligomeric Golgi complex (COGC); COGC-6 is weakly required for normal gonadal distal tip cell migration, a process that also requires seven other orthologs of COGC subunits; like other lobe B subunits in both C. elegans and S. cerevisiae, COGC-6 is only partially required for normal function, while lobe A subunits are strongly required in either worms or yeast.
9	srh-274	C32B5.2	n/a	chrII 983,859	C. elegans SRH-274 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
10	ZK1307.8	ZK1307.8	n/a	chrII 9,625,448	contains similarity to Pfam domains PF07915 (Glucosidase II beta subunit-like protein) , PF00036 (EF hand) contains similarity to Interpro domains IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR001907 (Peptidase S14, ClpP), IPR002172 (Low density lipoprotein-receptor, class A, cysteine-rich), IPR009011 (Mannose-6-phosphate receptor, binding), IPR000886 (Endoplasmic reticulum, targeting sequence), IPR012913 (Glucosidase II beta subunit-like)
11	B0272.3	B0272.3	n/a	chrX 9,432,002	contains similarity to Pfam domains PF00725 (3-hydroxyacyl-CoA dehydrogenase, C-terminal domain) , PF02737 (3-hydroxyacyl-CoA dehydrogenase, NAD binding domain) contains similarity to Interpro domains IPR013328 (Dehydrogenase, multihelical), IPR008927 (6-phosphogluconate dehydrogenase, C-terminal-like), IPR006176 (3-hydroxyacyl-CoA dehydrogenase, NAD binding), IPR006168 (NAD-dependent glycerol-3-phosphate dehydrogenase), IPR006108 (3-hydroxyacyl-CoA dehydrogenase, C-terminal), IPR006180 (3-hydroxyacyl-CoA dehydrogenase, conserved site), IPR016040 (NAD(P)-binding), IPR006036 (Potassium uptake protein TrkA)
12	K12C11.1	K12C11.1	n/a	chrI 1,343,024	The K12C11.1 gene encodes an ortholog of the human gene PEPTIDASE D (PEPD), which when mutated leads to prolidase deficiency (OMIM:170100).
13	ugt-22	C08F11.8	n/a	chrIV 13,641,793	C. elegans UGT-22 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
14	pfn-2	F35C8.6	n/a	chrX 5,353,590	C. elegans PFN-2 protein; contains similarity to Pfam domain PF00235 Profilin contains similarity to Interpro domains IPR002097 (Profilin/allergen), IPR005455 (Profilin, plant)
15	nhr-68	H12C20.3	n/a	chrV 11,574,552	C. elegans NHR-68 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
16	F23H11.3	F23H11.3	n/a	chrIII 900,827	contains similarity to Pfam domains PF00549 (CoA-ligase) , PF02629 (CoA binding domain) contains similarity to Interpro domains IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005810 (Succinyl-CoA ligase, alpha subunit), IPR016040 (NAD(P)-binding), IPR017440 (ATP-citrate lyase/succinyl-CoA ligase, active site), IPR003781 (CoA-binding), IPR016102 (Succinyl-CoA synthetase-like)
17	wrt-6	ZK377.1	n/a	chrX 3,481,938	wrt-6 encodes a hedgehog-like protein, with (from N- to C-terminus) a signal sequence, a Wart domain, an short region of low-complexity sequence, and a Hint/Hog domain; WRT-6 is expressed in sheath and socket cells of anterior sensilla, seam cells, and hypodermis; the Hint/Hog domain is predicted to cut WRT-6 into two halves and then covalently link cholesterol to the C-terminus of the Wart domain; the Wart domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; WRT-6 is weakly required for normal molting; WRT-6 is also required for normal growth to full size and locomotion; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
18	rpn-3	C30C11.2	n/a	chrIII 8,448,263	C. elegans RPN-3 protein; contains similarity to Pfam domains PF01399 (PCI domain) , PF08375 (Proteasome regulatory subunit C-terminal) contains similarity to Interpro domains IPR013586 (26S proteasome regulatory subunit, C-terminal), IPR013143 (PCI/PINT associated module), IPR000717 (Proteasome component region PCI), IPR015350 (Beta-trefoil)
19	pbs-7	F39H11.5	0.0000002	chrI 8,695,820	pbs-7 encodes a B-type subunit of the 26S proteasome's 20S protease core particle; by homology, PBS-7 is predicted to function in ATP/ubiquitin-dependent nonlysosomal protein degradation; loss of pbs-7 activity via large-scale RNAi screens indicates that, in C. elegans, PBS-7 is required for normal movement and for embryonic, germline, and larval development.
20	stc-1	F54C9.2	n/a	chrII 8,564,862	C. elegans STC-1 protein; contains similarity to Pfam domain PF00012 Hsp70 protein contains similarity to Interpro domains IPR001023 (Heat shock protein Hsp70), IPR013126 (Heat shock protein 70)
21	Y43F4B.2	Y43F4B.2	n/a	chrIII 13,294,800	contains similarity to Interpro domain IPR009079 (Four-helical cytokine-like, core)
22	F23C8.5	F23C8.5	n/a	chrI 2,419,472	The F23C8.5 gene encodes an ortholog of the human gene ELECTRON TRANSFER FLAVOPROTEIN BETA SUBUNIT (ETFB), which when mutated leads to glutaricaciduria type IIB (OMIM:130410).
23	cnx-1	ZK632.6	n/a	chrIII 9,815,658	cnx-1 encodes the C. elegans ortholog of calnexin, a type I Ca2+-binding integral membrane protein of the endoplasmic reticulum (ER); CNX-1 binds calcium and is predicted to function as a molecular chaperone required for glycoprotein folding and maturation as well as regulation of intracellular calcium homeostasis; in C. elegans, cnx-1 activity is required at 25 degrees C for wild-type levels of fertility and normal embryonic and larval development; cnx-1 activity is also required for maintaining viability in response to ER stress; in addition, cnx-1(RNAi) can suppress necrotic-like cell death induced by hyperactivated MEC-4 and DEG-1 ion channels, suggesting that CNX-1 also plays a role in regulating necrotic cell death; CNX-1 expression is first detected ubiquitously in the early embryo, with expression then becoming restricted to embryonic head and tail regions; post-embryonic expression is seen in the excretory cell, head and tail neurons, spermatheca, intestine, germ cells, and spicules in the male tail; antibody staining of early embryos indicates that CNX-1 localizes to the endoplasmic reticulum; in regulating reproduction at 25 degrees C, cnx-1 functions redundantly with crt-1, which encodes calreticulin, an additional Ca2+-binding ER chaperone protein.
24	col-68	C50D2.4	n/a	chrII 105,181	C. elegans COL-68 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR008160 (Collagen triple helix repeat)
25	C23H4.3	C23H4.3	n/a	chrX 12,227,955	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
26	sft-4	C54H2.5	n/a	chrX 5,779,970	sft-4 encodes a member of the SURF family highly conserved with the mouse Surf-4 gene, and conservation includes an encoded dilysine motif that is implicated in endoplasmic reticulum localization of the mouse protein.
27	M03F4.6	M03F4.6	n/a	chrX 4,966,692	contains similarity to Pfam domain PF01683 EB module contains similarity to Interpro domains IPR006150 (Cysteine-rich repeat), IPR009030 (Growth factor, receptor), IPR006149 (Nematode-specific EB region)
28	imp-2	T05E11.5	n/a	chrIV 11,117,784	C. elegans IMP-2 protein; contains similarity to Pfam domain PF04258 Signal peptide peptidase contains similarity to Interpro domains IPR006639 (Peptidase A22, presenilin signal peptide), IPR007369 (Peptidase A22B, signal peptide peptidase)
29	tag-257	F46G11.3	n/a	chrX 5,784,865	C. elegans TAG-257 protein; contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
30	ubh-4	C08B11.7	n/a	chrII 8,038,864	C. elegans UBH-4 protein; contains similarity to Pfam domain PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 contains similarity to Interpro domains IPR001578 (Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1), IPR017390 (Ubiquitinyl hydrolase, UCH37 type)
31	hke-4.2	H13N06.5	n/a	chrX 15,506,879	C. elegans HKE-4.2 protein; contains similarity to Pfam domain PF02535 ZIP Zinc transporter contains similarity to Interpro domains IPR002395 (HMW kininogen), IPR003689 (Zinc/iron permease)
32	gas-1	K09A9.5	n/a	chrX 15,588,527	The gas-1 gene encodes a 49 kDa subunit of mitochondrial complex I that is required for oxidative phosphorylation, resistance to volatile anesthetics, fecundity, and normal lifespan; gas-1 is expressed in the nematode neuromuscular system; its subcellular distribution appears to be mitochondrial; drug effects on mutants versus wild-type indicate that gas-1 functions at least partially through presynaptic effects; gas-1 mutants have strongly reduced Complex I-dependent metabolism in mitochondria, while Complex II-dependent metabolism is conversely increased in mutants; gas-1 mitochondria look structurally normal.
33	C13B9.3	C13B9.3	n/a	chrIII 6,623,764	C13B9.3 encodes a delta subunit of the coatomer (COPI) complex; in mass RNAi assays, C13B9.3 is required for fertility and general health.
34	W04G3.5	W04G3.5	n/a	chrX 11,074,823	contains similarity to Pfam domain PF00156 Phosphoribosyl transferase domain contains similarity to Interpro domains IPR005946 (Phosphoribosyl pyrophosphokinase), IPR000836 (Phosphoribosyltransferase)
35	tbb-2	C36E8.5	n/a	chrIII 4,016,820	tbb-2 encodes a homolog of mammalian beta-tubulin (TUBB) that is expressed at high levels in the germline; TBB-2 is redundant for embryonic viability, due to its paralog TBB-1; however, unlike its paralog TBB-1 it is preferred for normal microtubule severing by the katanin complex MEI-1/MEI-2; TBB-2 is required together with TBB-1, TBA-1, and tba-2 to make spindle structures in embryos and TBB-2 also affects the stability of the PO spindle; first divisions are normal in null mutants, but putative gain-of-function mutations affect centrosome rotations in the P0, P1, and EMS blastomeres of the early embryo, and affect pronuclear migration and meiosis.
36	F27D4.1	F27D4.1	n/a	chrI 7,703,501	The F27D4.1 gene encodes an ortholog of the human gene ELECTRON-TRANSFER-FLAVOPROTEIN, ALPHA POLYPEPTIDE (ETFA), which when mutated leads to glutaricaciduria type IIA (OMIM:231680).
37	srt-55	T16H12.8	n/a	chrIII 10,105,558	C. elegans SRT-55 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
38	mbf-1	H21P03.1	n/a	chrIV 11,479,744	C. elegans MBF-1 protein; contains similarity to Pfam domains PF01381 (Helix-turn-helix) , PF08523 (Multiprotein bridging factor 1) contains similarity to Interpro domains IPR010982 (Lambda repressor-like, DNA-binding), IPR013729 (Multiprotein bridging factor 1, N-terminal), IPR001387 (Helix-turn-helix type 3)
39	E02H9.5	E02H9.5	n/a	chrIII 2,447,417	E02H9.5 encodes a homolog of the human beta-glucosidase-like proteins KL (klotho; OMIM:604824), KLB (beta-klotho; OMIM:611135), GBA3 (cytosolic beta-glucosidase; OMIM:606619), LCT (lactase-phlorizin hydrolase; OMIM:603202, variant in adult lactose tolerance), and LCTL (lactase-like protein); E02H9.5 has 76% identity (364/478 residues) to its paralog C50F7.10; perhaps due to genetic redundancy, E02H9.5 has no obvious function in mass RNAi assays.
40	arl-1	F54C9.10	n/a	chrII 8,582,264	arl-1 encodes a member of the GTP-binding ADP-ribosylation factor family.
41	W03F9.10	W03F9.10	n/a	chrV 129,988	contains similarity to Pfam domains PF04046 (PSP) , PF04037 (Domain of unknown function (DUF382)) contains similarity to Interpro domains IPR006568 (PSP, proline-rich), IPR007180 (Protein of unknown function DUF382)
42	K08F11.5	K08F11.5	n/a	chrIV 4,714,405	contains similarity to Pfam domains PF08356 (EF hand associated) , PF08355 (EF hand associated) , PF00071 (Ras family) , PF00036 (EF hand) (2), PF08477 (Miro-like protein) (2)contains similarity to Interpro domains IPR013566 (EF hand associated, type-1), IPR011992 (EF-Hand type), IPR002048 (Calcium-binding EF-hand), IPR003577 (Ras small GTPase, Ras type), IPR013684 (Miro-like), IPR003578 (Ras small GTPase, Rho type), IPR005225 (Small GTP-binding protein), IPR001806 (Ras GTPase), IPR003579 (Ras small GTPase, Rab type), IPR013753 (Ras), IPR006689 (ARF/SAR superfamily), IPR013567 (EF hand associated, type-2)
43	K06A5.6	K06A5.6	n/a	chrI 6,465,004	contains similarity to Pfam domains PF08028 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02770 (Acyl-CoA dehydrogenase, middle domain) , PF00441 (Acyl-CoA dehydrogenase, C-terminal domain) , PF02771 (Acyl-CoA dehydrogenase, N-terminal domain) contains similarity to Interpro domains IPR013107 (Acyl-CoA dehydrogenase, type 2, C-terminal), IPR006090 (Acyl-CoA oxidase/dehydrogenase, type 1), IPR013786 (Acyl-CoA dehydrogenase/oxidase, N-terminal), IPR006091 (Acyl-CoA dehydrogenase/oxidase, central region), IPR006089 (Acyl-CoA dehydrogenase, conserved site), IPR013764 (Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal), IPR009100 (Acyl-CoA dehydrogenase/oxidase, middle and N-terminal), IPR006092 (Acyl-CoA dehydrogenase, N-terminal)
44	pyr-1	D2085.1	n/a	chrII 8,654,903	pyr-1 is orthologous to the human gene CARBAMYL PHOSPHATE SYNTHETASE I (CPS1, which when mutated leads to hyperammonemia (OMIM:237300); PYR-1 protein is predicted to be mitochondrial with 68% accuracy.
45	ZK686.3	ZK686.3	n/a	chrIII 7,768,245	ZK686.3 is orthologous to the putative tumor suppressor N33 (OMIM:601385, associated with homozygous deletion in metastatic prostate cancer and with loss of function in other tumors); ZK686.3 is also homologous to the S. cerevisiae dolichyl-diphosphooligosaccharide-protein glycotransferase gamma chain (34-kD) subunit, OST3.
46	F37C12.7	F37C12.7	n/a	chrIII 7,169,344	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
47	C23G10.8	C23G10.8	n/a	chrIII 6,204,357	contains similarity to Homo sapiens Conserved hypothetical protein; VG:OTTHUMP00000076919
48	ugt-12	T19H12.9	n/a	chrV 4,888,389	C. elegans UGT-12 protein; contains similarity to Pfam domains PF04101 (Glycosyltransferase family 28 C-terminal domain) , PF00201 (UDP-glucoronosyl and UDP-glucosyl transferase) contains similarity to Interpro domains IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase), IPR007235 (Glycosyl transferase, family 28, C-terminal)
49	C43H6.1	C43H6.1	n/a	chrX 2,411,333	contains similarity to Xenopus laevis MGC130942 protein.; TR:Q3KQ57
50	ZK6.8	ZK6.8	n/a	chrV 383,222	contains similarity to Pfam domain PF05978 Eukaryotic protein of unknown function (DUF895) contains similarity to Interpro domains IPR010291 (Protein of unknown function DUF895, eukaryotic), IPR016196 (MFS general substrate transporter)