UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	math-24	C46F9.3	0	chrII 1,901,084	The C46F9.3 gene encodes a protein with a meprin-associated Traf homology (MATH) domain that may be involved in apoptosis.
2	set-14	R06F6.4	n/a	chrII 10,794,856	set-14 encodes a divergent ortholog of human SMYD1 (OMIM:606846), SMYD2 (OMIM:610663), and SYMD3 (OMIM:608783); SET-14 is paralogous to SET-10, SET-18, and SET-30; SET-14 has no obvious function in individual RNAi assays of vulval development, or in mass RNAi assays.
3	F55A12.5	F55A12.5	n/a	chrI 5,347,791	contains similarity to Gallus gallus Nucleolin (Protein C23).; SW:P15771
4	K09F6.2	K09F6.2	n/a	chrII 2,268,709	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
5	cul-4	F45E12.3	n/a	chrII 7,303,864	cul-4 encodes one of six C. elegans cullin proteins; CUL-4 activity is essential for negative regulation of DNA-replication licensing and thus, for maintenance of genome stability; in regulating DNA replication, CUL-4 functions as part of a CUL-4/DDB-1 ubiquitin ligase complex that degrades the replication licensing factor CDT-1 and indirectly promotes nuclear export of the replication licensing factor CDC-6 by negatively regulating the levels of the CKI-1 CDK inhibitor; cul-4 mRNA is expressed throughout development with highest levels seen in embryos and lower levels seen in larvae and adults; maternal cul-4 mRNA is present in early embryos and larval and adult mRNA is most notably present in the intestine and germ line.
6	ZC373.3	ZC373.3	n/a	chrX 10,061,060	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR002290 (Serine/threonine protein kinase), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related)
7	ZC84.6	ZC84.6	n/a	chrIII 9,196,038	contains similarity to Pfam domains PF01683 (EB module) (3), PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain) (5)contains similarity to Interpro domains IPR002223 (Proteinase inhibitor I2, Kunitz metazoa), IPR006150 (Cysteine-rich repeat), IPR006149 (Nematode-specific EB region)
8	F16A11.1	F16A11.1	n/a	chrI 9,398,979	contains similarity to Pfam domain PF00622 SPRY domain contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR001870 (B302, (SPRY)-like), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR003877 (SPla/RYanodine receptor SPRY)
9	R52.2	R52.2	n/a	chrII 2,127,157	contains similarity to Pfam domains PF03564 (Protein of unknown function (DUF1759)) , PF05585 (Protein of unknown function (DUF1758)) contains similarity to Interpro domains IPR009007 (Peptidase aspartic, catalytic), IPR008737 (Protein of unknown function DUF1758), IPR005312 (Protein of unknown function DUF1759), IPR001878 (Zinc finger, CCHC-type)
10	str-25	F44G3.11	n/a	chrV 16,116,262	C. elegans STR-25 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
11	W06A11.2	W06A11.2	n/a	chrII 4,060,321
12	nspb-3	F38A5.5	n/a	chrIV 6,594,788	C. elegans NSPB-3 protein; contains similarity to Pfam domain PF07312 Protein of unknown function (DUF1459) contains similarity to Interpro domain IPR009924 (Protein of unknown function DUF1459)
13	mrp-2	F57C12.4	n/a	chrX 568,214	mrp-2 encodes a predicted multidomain transmembrane protein that is a member of the ATP-binding cassette (ABC) superfamily of transport proteins and is homologous to the human multidrug resistance-associated protein 1 (MRP1, OMIM:158343); by homology, MRP-2 is predicted to function as a membrane pump that couples the energy of ATP hydrolysis to membrane transport; as loss of MRP-2 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of MRP-2 in C. elegans development and/or behavior is not yet known; mrp-2 expression is, however, upregulated early in the exit from the alternative dauer stage and then remains induced, suggesting that MRP-2 activity is required for the transition to, and maintenance of, a more active metabolic state.
14	snx-3	W06D4.5	n/a	chrI 9,064,058	C. elegans SNX-3 protein; contains similarity to Pfam domain PF00787 PX domain contains similarity to Interpro domain IPR001683 (Phox-like)
15	nph-1	M28.7	n/a	chrII 10,650,519	nph-1 encodes a novel, SH3 domain-containing protein that is orthologous to mammalian nephrocystin-1.
16	M02D8.2	M02D8.2	n/a	chrX 8,739,895
17	B0495.2	B0495.2	n/a	chrII 7,700,550	contains similarity to Pfam domain PF00069 Protein kinase domain contains similarity to Interpro domains IPR008351 (JNK MAP kinase), IPR002290 (Serine/threonine protein kinase), IPR001245 (Tyrosine protein kinase), IPR017442 (Serine/threonine protein kinase-related), IPR011009 (Protein kinase-like), IPR008271 (Serine/threonine protein kinase, active site), IPR000719 (Protein kinase, core)
18	ZK328.4	ZK328.4	n/a	chrIII 6,007,663	contains similarity to Interpro domain IPR006640 (Protein of unknown function SprT)
19	Y102A5C.4	Y102A5C.4	n/a	chrV 16,923,224	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
20	rad-54	W06D4.6	n/a	chrI 9,067,667	rad-54 is orthologous to the human gene RAD54 (RAD54L; OMIM:603615), which when mutated leads to disease.
21	R144.5	R144.5	n/a	chrIII 5,000,320	contains similarity to Homo sapiens Isoform 1 of Smith-Magenis syndrome chromosomal region candidate gene 8 protein; ENSEMBL:ENSP00000379048
22	R05H11.1	R05H11.1	n/a	chrIII 6,796,617	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
23	F25G6.9	F25G6.9	n/a	chrV 8,567,613	contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
24	K09E3.4	K09E3.4	n/a	chrX 17,119,682
25	F19C7.3	F19C7.3	n/a	chrIV 4,598,308	contains similarity to Pfam domain PF07735 F-box associated contains similarity to Interpro domain IPR012885 (F-box associated type 2)
26	ptr-2	C32E8.8	n/a	chrI 3,791,060	ptr-2 encodes an ortholog of Drosophila and human PTCHD3, which defines one of seven paralogous families of sterol sensing domain (SSD) proteins; PTR-2 is required for cytokinesis in somatic cells, but not in the germline (the converse of PTC-1's function); PTR-2 is partially required for normal molting from L4 to adult stages; PTR-2 is also required for normal male tail development, growth to full size, locomotion, and viability.
27	trm-1	ZC376.5	n/a	chrV 14,184,351	C. elegans TRM-1 protein; contains similarity to Pfam domain PF02005 N2,N2-dimethylguanosine tRNA methyltransferase contains similarity to Interpro domain IPR002905 (N2,N2-dimethylguanosine tRNA methyltransferase)
28	nol-1	W07E6.1	n/a	chrII 473,591	C. elegans NOL-1 protein; contains similarity to Pfam domain PF01189 NOL1/NOP2/sun family contains similarity to Interpro domains IPR011023 (Nop2p), IPR006174 (rRNA subunit methyltransferase), IPR001678 (Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p)
29	R05D3.1	R05D3.1	n/a	chrIII 8,384,526	contains similarity to Pfam domains PF00521 (DNA gyrase/topoisomerase IV, subunit A) , PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) , PF00204 (DNA gyrase B) contains similarity to Interpro domains IPR002205 (DNA topoisomerase, type IIA, subunit A or C-terminal), IPR013506 (DNA topoisomerase, type IIA, subunit B, region 2), IPR001241 (DNA topoisomerase, type IIA, subunit B or N-terminal), IPR011558 (DNA topoisomerase, type IIA, subunit B, conserved region), IPR013758 (DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta), IPR013757 (DNA topoisomerase, type IIA, subunit A, alpha-helical), IPR003594 (ATP-binding region, ATPase-like), IPR013759 (DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta), IPR001154 (DNA topoisomerase II, eukaryotic-type), IPR014721 (Ribosomal protein S5 domain 2-type fold), IPR013760 (DNA topoisomerase, type IIA, central)
30	T24D1.2	T24D1.2	n/a	chrI 9,954,687	contains similarity to Interpro domain IPR001841 (Zinc finger, RING-type)
31	let-711	F57B9.2	n/a	chrIII 6,952,757	let-711 encodes the C. elegans ortholog of NOT1, the conserved core component of the multisubunit CCR4/NOT complex that plays a role in regulation of gene expression via various processes including transcriptional control, mRNA deadenylation, and protein ubiquitination; in C. elegans, let-711 activity is essential for embryonic and larval development and in particular, for proper spindle positioning, microtubule length, and centrosome morphology in early embryos; in addition, let-711 is essential for normal germline development and levels of fertility; in embryos, let-711 mutations can suppress the short microtubule phenotype produced by mutations in zyg-9, which encodes the C. elegans XMAP125 homolog, and centrosomoal ZYG-9 levels are increased in let-711 mutants, suggesting that let-711 functions, in part, by negatively regulating ZYG-9 levels or localization; in situ hybridization studies indicate that let-711 mRNA is broadly expressed in the gonad and that its gonadal expression is negatively regulated by lin-35/Rb.
32	F35H12.4	F35H12.4	n/a	chrX 922,380	contains similarity to Pfam domain PF00454 Phosphatidylinositol 3- and 4-kinase contains similarity to Interpro domains IPR011009 (Protein kinase-like), IPR000403 (Phosphatidylinositol 3- and 4-kinase, catalytic), IPR015433 (Phosphatidylinositol Kinase)
33	C09G9.2	C09G9.2	n/a	chrIV 8,868,853	contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
34	mab-21	F35G12.6	n/a	chrIII 4,601,861	mab-21 encodes a novel protein that is a member of a highly conserved family of proteins with Drosophila and vertebrate orthologs; MAB-21 is cell-autonomously required for specifying the identity of sensory ray 6 in the male tail, and also for backward locomotion, normal body morphology, fecundity, and embryonic morphogenesis; MAB-21 expression begins in embryonic hypodermal cells and continues in larval and adult animals in hypodermis, anterior and ventral cord neurons, some body wall muscles, and ray cells.
35	fbxa-167	C31C9.3	n/a	chrII 13,642,551	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
36	msh-2	H26D21.2	n/a	chrI 3,695,931	The msh-2 gene encodes a DNA mismatch repair protein homolog that is orthologous to human MSH2 (OMIM:120435); mutation of the human MSH2 gene leads to hereditary non-polyposis colon cancer (OMIM:120436).
37	C05C8.8	C05C8.8	n/a	chrV 7,253,723	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
38	zim-3	T07G12.11	n/a	chrIV 10,559,796	zmp-3 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1/-2, and C02F5.12; ZIM-3 is specifically required for homolog pairing, synapsis, and segregation of chromosomes I and IV during meiosis; zim-3(tm2303) oocytes ending prophase have ~4 bivalents and ~4 univalents, the latter of which are consistently chromosomes I and IV; ZIM-3 associates with the right end of chromosome I and the left end of chromosome IV, which may indicate an association with their pairing centers; while the C-terminal region of ZIM-3 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-3 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-3 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
39	R11A8.2	R11A8.2	n/a	chrIV 10,359,115	contains similarity to Interpro domains IPR008991 (Translation protein SH3-like), IPR005824 (KOW), IPR000467 (D111/G-patch)
40	ZK1248.15	ZK1248.15	n/a	chrII 5,837,633	contains similarity to Pfam domain PF00397 WW domain contains similarity to Interpro domains IPR006596 (Nucleotide binding protein, PINc), IPR001202 (WW/Rsp5/WWP)
41	C50F7.4	C50F7.4	n/a	chrIV 7,729,765	contains similarity to Pfam domains PF08442 (ATP-grasp domain) , PF00549 (CoA-ligase) contains similarity to Interpro domains IPR013650 (ATP-grasp fold, succinyl-CoA synthetase-type), IPR005811 (ATP-citrate lyase/succinyl-CoA ligase), IPR005809 (Succinyl-CoA synthetase, beta subunit), IPR013815 (ATP-grasp fold, subdomain 1), IPR002347 (Glucose/ribitol dehydrogenase), IPR002198 (Short-chain dehydrogenase/reductase SDR), IPR013816 (ATP-grasp fold, subdomain 2), IPR016102 (Succinyl-CoA synthetase-like)
42	rpt-5	F56H1.4	n/a	chrI 5,742,805	rpt-5 encodes a triple A ATPase subunit of the 26S proteasome's 19S regulatory particle (RP) base subcomplex; RPT-5 is required for embryonic, larval, and germline development and by homology, is predicted to function in unfolding protein substrates and translocating them into the core proteolytic particle (CP) of the proteasome.
43	F52G3.3	F52G3.3	n/a	chrX 16,946,368	contains similarity to Medicago truncatula Putative uncharacterized protein.; TR:A2Q378
44	C02G6.2	C02G6.2	n/a	chrV 5,873,482	contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) (2)contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
45	T02E1.2	T02E1.2	n/a	chrI 8,221,514	contains similarity to Plasmodium falciparum Hypothetical protein.; TR:Q8IJZ2
46	K02C4.3	K02C4.3	n/a	chrII 8,083,916	contains similarity to Pfam domain PF00443 Ubiquitin carboxyl-terminal hydrolase contains similarity to Interpro domain IPR001394 (Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)
47	C05D12.2	C05D12.2	n/a	chrII 11,420,763	contains similarity to Interpro domains IPR000742 (EGF-like, type 3), IPR006210 (EGF), IPR002049 (EGF-like, laminin), IPR013032 (EGF-like region, conserved site), IPR006582 (Region of unknown fuction MD, Caenorhabditis elegans)
48	sre-55	C50E10.7	n/a	chrII 12,330,123	C. elegans SRE-55 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
49	lgc-45	W10G11.16	n/a	chrII 3,566,681	C. elegans LGC-45 protein; contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) , PF02932 (Neurotransmitter-gated ion-channel transmembrane region) contains similarity to Interpro domains IPR006028 (Gamma-aminobutyric acid A receptor), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding), IPR006029 (Neurotransmitter-gated ion-channel transmembrane region)
50	nhl-1	F54G8.4	n/a	chrIII 9,150,557	The nhl-1 gene encodes an RBCC protein, orthologous to the mammalian protein BERP; its C. elegans paralogs include ncl-1 and lin-41.