UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C44B12.6	C44B12.6	4.0000000000000004e-82	chrIV 1,131,250	contains similarity to Interpro domain IPR010345 (Interleukin-17)
2	ZK353.2	ZK353.2	n/a	chrIII 8,398,849	contains similarity to Interpro domain IPR002952 (Eggshell protein)
3	nhr-273	T12C9.1	n/a	chrII 4,436,140	C. elegans NHR-273 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	lin-11	ZC247.3	n/a	chrI 10,251,797	lin-11 encodes a predicted LIM homeodomain transcription factor that affects vulval development, neuronal development and fate specification, utse cell differentiation, and fertility; it is expressed in some neurons, the vulva, pi cells and their progeny, and the spermatheca.
5	Y65A5A.1	Y65A5A.1	n/a	chrIV 16,399,303	contains similarity to Interpro domain IPR001092 (Basic helix-loop-helix dimerization domain bHLH)
6	uev-3	F26H9.7	n/a	chrI 9,311,457	uev-3 encodes a ubiquitin-conjugating enzyme (UBC or E2) variant that contains the UBC motif, but lacks the critical active-site cysteine residue necessary for catalytic activity; as loss of UEV-3 function via RNA-mediated interference (RNAi) does not result in any abnormalities, the precise role of UEV-3 in C. elegans development and/or behavior is not yet known; based on similarity to Saccharomyces cerevisiae and human proteins, however, UEV-3 may play a role in cell cycle control or response to stress or DNA damage.
7	R09H3.1	R09H3.1	n/a	chrX 1,660,650	contains similarity to Sulfolobus solfataricus DNA double-strand break repair rad50 ATPase.; SW:Q97WH0
8	str-136	F21F8.9	n/a	chrV 8,278,202	C. elegans STR-136 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR003002 (7TM chemoreceptor, subfamily 1)
9	K05F6.8	K05F6.8	n/a	chrII 1,567,541	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
10	C50H11.1	C50H11.1	n/a	chrV 3,090,166	contains similarity to Pfam domain PF00501 AMP-binding enzyme contains similarity to Interpro domain IPR000873 (AMP-dependent synthetase and ligase)
11	str-256	T01G6.9	n/a	chrV 500,551	C. elegans STR-256 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	F22E12.3	F22E12.3	n/a	chrV 10,461,278	contains similarity to Petroselinum crispum Reverse transcriptase (Fragment).; TR:Q9ZRL1
13	C50F7.6	C50F7.6	n/a	chrIV 7,721,871	contains similarity to Homo sapiens Isoform 4 of PDZ domain-containing RING finger protein 4; ENSEMBL:ENSP00000370169
14	srd-25	F07C4.4	n/a	chrV 7,632,583	C. elegans SRD-25 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
15	B0238.7	B0238.7	n/a	chrV 5,261,699	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
16	K07G6.1	K07G6.1	n/a	chrII 1,741,871
17	F21C10.6	F21C10.6	n/a	chrV 9,124,712	contains similarity to Pfam domain PF01705 CX module contains similarity to Interpro domain IPR002619 (Protein of unknown function CX)
18	dop-4	C52B11.3	n/a	chrX 1,296,964	C. elegans DOP-4 protein; contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000929 (Dopamine receptor), IPR002233 (Adrenergic receptor), IPR001671 (Melanocortin/ACTH receptor), IPR000995 (Muscarinic acetylcholine receptor), IPR000276 (GPCR, rhodopsin-like)
19	wrn-1	F18C5.2	n/a	chrII 6,557,068	wrn-1 encodes an ortholog of human WRN, which when mutated leads to Werner syndrome (OMIM:277700), and one of four C. elegans homologs of the RecQ DNA helicase family that includes E. coli RecQ; by homology, WRN-1 is predicted to function as a helicase, DNA-dependent ATPase, and exonuclease that plays a key role in DNA replication, recombination, and repair; RNA interference studies in C. elegans and the enhancement of many of the resulting phenotypes by ionizing radiation indicate that wrn-1 affects life span and aging and acts at a DNA damage checkpoint; the wrn-1 phenotypes such as premature aging are similar to those of Werner syndrome; immunolocalization studies indicate that WRN-1 expression is nuclear in cells at the embryonic, larval and adult stages.
20	F29D10.2	F29D10.2	n/a	chrI 8,842,038	contains similarity to Interpro domains IPR000853 (Nematoda metallothionein, family 6), IPR000006 (Metallothionein, vertebrate), IPR002952 (Eggshell protein), IPR004035 (Endonuclease III, iron-sulphur binding, conserved site-1), IPR001396 (Echinodermata metallothionein, family 4), IPR001008 (Mollusc metallothionein, family 2)
21	F59H6.6	F59H6.6	n/a	chrII 2,011,980	contains similarity to Interpro domain IPR009057 (Homeodomain-like)
22	srt-16	C50H11.11	n/a	chrV 3,064,037	C. elegans SRT-16 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domain IPR002651 (Protein of unknown function DUF32)
23	srsx-1	F40D4.5	n/a	chrV 17,177,360	C. elegans SRSX-1 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
24	tat-6	F02C9.3	n/a	chrV 3,131,186	C. elegans TAT-6 protein; contains similarity to Pfam domain PF00702 haloacid dehalogenase-like hydrolase contains similarity to Interpro domains IPR006069 (ATPase, P-type cation exchange, alpha subunit), IPR006539 (Phospholipid-translocating P-type ATPase, flippase), IPR001757 (ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter), IPR005834 (Haloacid dehalogenase-like hydrolase)
25	twk-10	K04A8.4	n/a	chrV 6,553,200	C. elegans TWK-10 protein; contains similarity to Pfam domain PF07885 Ion channel contains similarity to Interpro domains IPR003280 (Potassium channel, two pore-domain), IPR013099 (Ion transport 2)
26	sdz-34	Y73C8C.7	n/a	chrV 3,108,727	C. elegans SDZ-34 protein; contains similarity to Pfam domain PF00097 Zinc finger, C3HC4 type (RING finger) contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR001965 (Zinc finger, PHD-type), IPR013083 (Zinc finger, RING/FYVE/PHD-type), IPR000533 (Tropomyosin), IPR011016 (Zinc finger, variant RING-type)
27	F31B9.1	F31B9.1	n/a	chrX 15,912,318	contains similarity to Pfam domain PF00001 7 transmembrane receptor (rhodopsin family) contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR002286 (P2 purinoceptor), IPR006121 (Heavy metal transport/detoxification protein), IPR000276 (GPCR, rhodopsin-like)
28	C54G10.1	C54G10.1	n/a	chrV 14,641,219	contains similarity to Homo sapiens similar to secreted gel-forming mucin; ENSEMBL:ENSP00000328427
29	F33C8.2	F33C8.2	n/a	chrX 14,722,337	contains similarity to Interpro domain IPR003382 (Flavoprotein)
30	W09B6.5	W09B6.5	n/a	chrII 1,140,824
31	F01F1.14	F01F1.14	n/a	chrIII 5,882,603
32	gcy-4	ZK970.5	n/a	chrII 10,306,418	gcy-4 encodes a predicted transmembrane guanylyl cyclase; by homology, GCY-4 may function as a chemosensory receptor; however, as loss of gcy-4 activity via mutation or large-scale RNAi screens results in no obvious abnormalities, the precise role of gcy-4 in C. elegans development and/or behavior is not yet known; the sole gcy-4 ::GFP reporter construct reported to date did not produce any specific GFP signals.
33	ZC190.9	ZC190.9	n/a	chrV 8,692,862
34	Y38H8A.5	Y38H8A.5	n/a	chrIV 13,467,731	The Y38H8A.5 gene encodes a homolog of the human gene ZNF195 (or p57KIP2), which when mutated leads to Beckwith-Wiedemann syndrome (OMIM:130650).
35	C07A9.12	C07A9.12	n/a	chrIII 9,726,313	contains similarity to Pfam domain PF01705 CX module contains similarity to Interpro domain IPR002619 (Protein of unknown function CX)
36	bath-45	F29C12.5	n/a	chrII 13,123,821	C. elegans BATH-45 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) (2), PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
37	dsl-4	F16B12.2	n/a	chrX 14,091,441	dsl-4 encodes a putative secreted protein with a single DSL domain and three EGF domains in series, somewhat like Delta/LAG-2; unlike the nematode-specific family of Delta/LAG-2-like proteins (including DSL-1, -2, -3, -5, -6, and -7), DSL-4 is evolutionarily divergent, with perhaps a distant affinity to APX-1, ARG-1, and LAG-2.
38	F48E8.6	F48E8.6	n/a	chrIII 5,444,858	contains similarity to Pfam domain PF00773 RNB domain contains similarity to Interpro domain IPR001900 (Ribonuclease II and R)
39	K10H10.5	K10H10.5	n/a	chrII 14,502,114	contains similarity to Interpro domain IPR001030 (Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha)
40	sre-33	W05H5.6	n/a	chrII 12,453,974	C. elegans SRE-33 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
41	K09H9.4	K09H9.4	n/a	chrI 3,134,515	contains similarity to Interpro domains IPR015706 (RNA-directed DNA polymerase (reverse transcriptase), related), IPR003286 (Nematode reverse transcriptase-like)
42	B0302.4	B0302.4	n/a	chrX 17,176,549
43	F45G2.7	F45G2.7	n/a	chrIII 13,433,876	contains similarity to Oceanobacillus iheyensis Two-component response regulator involved in modulation ofsflagellar.; TR:Q8EQW9
44	F07H5.7	F07H5.7	n/a	chrII 8,793,642
45	F21C10.5	F21C10.5	n/a	chrV 9,125,800	contains similarity to Xenopus tropicalis H/ACA ribonucleoprotein complex subunit 1-like protein.; SW:Q5RJV1
46	ZK262.9	ZK262.9	n/a	chrV 18,440,924	contains similarity to Brachydanio rerio Similar to formin binding protein 3.; TR:Q7ZUE4
47	ZK688.1	ZK688.1	n/a	chrIII 7,910,130
48	dos-1	ZK507.4	n/a	chrIII 9,105,304	C. elegans DOS-1 protein ;
49	sre-7	K02E11.2	n/a	chrV 14,245,132	C. elegans SRE-7 protein; contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
50	mcd-1	Y51H1A.6	n/a	chrII 13,891,577	mcd-1 encodes a highly acidic C2H2-type zinc-finger protein that, in conjunction with LIN-35/Rb, DPL-1/DP, EFL-1/E2F, LIN-37/Mip40, and LIN-52, promotes the developmentally programmed progression of cells through full apoptosis; MCD-1 can promote ectopic apoptosis in cells normally fated to live, and is thus active in such cells; MCD-1 is not required for CED-3-independent cell death, does not regulate CED-9, and probably does not transcriptionally regulate egl-1; MCD-1 and its partners do not act together with CED-1 or CED-8, and their function in cell death is distinct from the LET-60/RAS or SynMuv pathways; however, MCD-1 is redundantly required with some class B/C synMuv proteins for viability (LIN-9, LIN-35/Rb, or LIN-37/Mip40) and normally rapid growth (DPL-1/DP, LIN-13, LIN-53, LIN-54, or MYS-1); in mcd-1(n4005) animals, cells that would normally undergo apoptosis can instead pass through an episode of pre-apoptotic condensation, after which they sometimes revert to normal shape, survive, and differentiate; MCD-1 contains an N-terminal low-complexity region and a single central zinc-finger, but no other recognizable protein domains; MCD-1 is paralogous to Y48E1B.7, but has no obvious non-nematode orthologs.