UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C41G7.3	C41G7.3	0	chrI 9,516,858	contains similarity to Pfam domains PF00013 (KH domain) , PF03073 (TspO/MBR family) contains similarity to Interpro domains IPR004307 (TspO/MBR-related protein), IPR004087 (K Homology), IPR004088 (K Homology, type 1)
2	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
3	F08G5.1	F08G5.1	n/a	chrIV 12,409,650	contains similarity to Homo sapiens Putative protein TPRXL; ENSEMBL:ENSP00000322097
4	btb-20	F57C2.1	n/a	chrII 14,522,887	C. elegans BTB-20 protein; contains similarity to Pfam domain PF00651 BTB/POZ domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
5	bir-2	C50B8.2	n/a	chrV 13,569,366	The bir-2 gene encodes a protein with two BIR domains that may be involved in apoptosis.
6	F49E8.2	F49E8.2	n/a	chrIV 7,549,959	contains similarity to Interpro domains IPR011767 (Glutaredoxin active site), IPR007087 (Zinc finger, C2H2-type)
7	syp-3	F39H2.4	n/a	chrI 8,663,589	syp-3 encodes a coiled-coil protein; SYP-3 activity is required during meiosis for chromosome synapsis and chiasma formation, specifically for proper assembly of the central region of the synaptonemal complex; thus, SYP-3 is essential activity is essential for normal embryonic development; immunolocalization studies indicate that SYP-3 is likely a structural component of the central element of the synaptonemal complex.
8	spo-11	T05E11.4	n/a	chrIV 11,123,963	spo-11 encodes an ortholog of Spo11p in S. cerevisiae that is required for meiotic DNA recombination, and (in conjunction with CHK-2 and MRE-11) for the localization of RAD-51 to foci in late zygotene/early pachytene nuclei; like its yeast ortholog, SPO-11 is related to a subunit of archaebacterial topoisomerase VI, and probably causes double-stranded DNA breaks through a topoisomerase-like transesterase mechanism; however, unlike Spo11p, SPO-11 is dispensable for homologous synapsis and formation of the synaptonemal complex; SPO-11 is active even in syp-1 mutants where its double-stranded breaks cannot be correctly processed; spo-11 is transcribed in the germline.
9	M01A10.1	M01A10.1	n/a	chrI 5,565,037	M01A10.1 encodes a protein, belonging to an ancient family of single-stranded nucleic acid-binding proteins, that is predicted to regulate gene expression through binding either mRNA or (locally) single-stranded DNA; it is most likely to specifically bind one or more discrete mRNAs and regulate their spatial localization or alternative splicing.
10	C16C8.16	C16C8.16	n/a	chrII 3,447,247	contains similarity to Pfam domain PF00240 Ubiquitin family contains similarity to Interpro domain IPR000626 (Ubiquitin)
11	klc-1	M7.2	n/a	chrIV 11,085,048	klc-1 encodes one of two C. elegans kinesin light chains; by homology, KLC-1 is predicted to function, along with kinesin-like heavy chains, as part of a multimeric kinesin complex involved in intracellular transport; consistent with this, KLC-1 has been shown to interact with UNC-116/kinesin, KCA-1/kinesin cargo adaptor, and the ARX-2/Arp2/3 complex component in yeast two-hybrid assays; RNAi experiments indicate that klc-1 activity is required for normal embryonic development.
12	F26H11.4	F26H11.4	n/a	chrII 14,410,374	contains similarity to Saccharomyces cerevisiae Mitochondrial ATPase (similar to E. coli FtsH protein) that resides in the innner mitochondrial membrane; SGD:YMR089C
13	bra-2	F23H11.1	n/a	chrIII 911,744	The bra-2 gene encodes a homolog of the human BMP receptor-associated molecule (BRAM1), paralogous to bra-1, that may act upon the SMA-6 TGF-beta signalling pathway
14	lsl-1	F52F12.4	n/a	chrI 9,902,069	C. elegans LSL-1 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
15	D2030.7	D2030.7	n/a	chrI 7,589,605	contains similarity to Interpro domains IPR001841 (Zinc finger, RING-type), IPR015880 (Zinc finger, C2H2-like), IPR007087 (Zinc finger, C2H2-type)
16	bath-2	F52C6.11	n/a	chrII 1,922,182	C. elegans BATH-2 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
17	F21F3.4	F21F3.4	n/a	chrI 4,896,773	contains similarity to Homo sapiens Uncharacterized protein ENSP00000372122; ENSEMBL:ENSP00000372122
18	glh-2	C55B7.1	n/a	chrI 6,515,665	glh-2 encodes a putative DEAD-box RNA helicase that contains six CCHC zinc fingers and is homologous to Drosophila VASA, a germ-line-specific, ATP-dependent, RNA helicase; at non-permissive temperatures, GLH-2 plays a role in germ-line development and fertility, specifically in regulating the normal extent of germ-line proliferation, oogenesis, and the production of functional sperm; GLH-2 activity may also be required for the wild-type morphology of P granules and for localization of several protein components, but not accumulation of P granule mRNA components; GLH-2 interacts in vitro with itself and with KGB-1, a JNK-like MAP kinase; GLH-2 is a constitutive P granule component and thus, with the exception of mature sperm, is expressed in germ cells at all stages of development; GLH-2 is cytoplasmic in oocytes and the early embryo, while perinuclear in all later developmental stages as well as in the distal and medial regions of the hermaphrodite gonad; GLH-2 is expressed at barely detectable levels in males.
19	C36A4.4	C36A4.4	n/a	chrIII 3,842,530	C36A4.4 encodes a putative UDP-N-acetylglucosamine pyrophosphorylase, paralogous to K06B9.2 and orthologous to human UAP1 (OMIM:602862) and UAP1L1; C36A4.4 is thought to catalyse the fourth step of the hexosamine pathway to UDP-N-acetylglucosamine or UDP-N-acetylgalactosamine; C36A4.4 transcripts are enriched during oogenesis; C36A4.4(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis.
20	T04A8.8	T04A8.8	n/a	chrIII 4,694,596	contains similarity to Homo sapiens;Mus musculus;Rattus norvegicus;Bos taurus;Sus scrofa Ubiquitin-like protein SMT3B (Sentrin 2) (HSMT3).; SW:SM32_HUMAN
21	T23D8.7	T23D8.7	n/a	chrI 9,991,647	contains similarity to Pfam domains PF02170 (PAZ domain) , PF08699 (Domain of unknown function (DUF1785)) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR014811 (Region of unknown function DUF1785), IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
22	C55B7.11	C55B7.11	n/a	chrI 6,512,726
23	bath-5	F59H6.11	n/a	chrII 2,031,389	C. elegans BATH-5 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) , PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
24	F33E11.2	F33E11.2	n/a	chrV 298,304	contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR003980 (Histamine H3 receptor)
25	C14B1.9	C14B1.9	n/a	chrIII 3,725,339	contains similarity to Homo sapiens Hypothetical protein; ENSEMBL:ENSP00000307805
26	dhs-5	F56D1.5	n/a	chrII 5,454,878	dhs-5 encodes a possible steroid dehydrogenase; DHS-5 generally resembles short chain-type alcohol/other dehydrogenases, but has two predicted N-terminal transmembrane sequences, and its closest relatives in vertebrates are known or putative steroid dehydrogenases such as hydroxysteroid (17-beta) dehydrogenase 12 from mouse (also known as KIK-I or DHBK_MOUSE).
27	F56C9.3	F56C9.3	n/a	chrIII 7,312,130	contains similarity to Pfam domain PF01545 Cation efflux family contains similarity to Interpro domain IPR002524 (Cation efflux protein)
28	rnp-8	R119.7	n/a	chrI 366,516	C. elegans RNP-8 protein; contains similarity to Pfam domain PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) contains similarity to Interpro domains IPR012677 (Nucleotide-binding, alpha-beta plait), IPR000504 (RNA recognition motif, RNP-1)
29	ZK1128.4	ZK1128.4	n/a	chrIII 10,119,727	contains similarity to Pfam domain PF03850 Transcription factor Tfb4 contains similarity to Interpro domain IPR004600 (Transcription factor Tfb4)
30	syp-2	C24G6.1	n/a	chrV 5,537,191	C. elegans SYP-2 protein ;
31	C16C10.3	C16C10.3	n/a	chrIII 4,174,219	contains similarity to Pfam domains PF02170 (PAZ domain) , PF02171 (Piwi domain) contains similarity to Interpro domains IPR003165 (Stem cell self-renewal protein Piwi), IPR003100 (Argonaute and Dicer protein, PAZ), IPR012337 (Polynucleotidyl transferase, Ribonuclease H fold)
32	zim-2	T07G12.10	n/a	chrIV 10,556,907	zim-2 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include HIM-8, ZIM-1, ZIM-3, and C02F5.12; ZIM-2 is specifically required for homolog pairing, synapsis, and segregation of chromosome V during meiosis; zim-2(tm574) oocytes ending prophase have ~5 bivalents and ~2 univalents, the latter of which are consistently chromosome V; zim-2 oocytes fail to begin chromosome V pairing at the start of meiosis; ZIM-2 associates with the right end of chromosome V, which may indicate an association with its pairing center; while the C-terminal region of ZIM-2 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region instead most closely resembles those of its paralogs in C. elegans, indicating coevolving, species-specific functions; ZIM-2 foci, like HIM-8 foci, associate with the nuclear envelope during meiotic prophase; zim-2 mutants also have some defective segregation of the X chromosome (yielding a Him phenotype), but this may be an indirect effect of autosomal asynapsis.
33	T08D2.5	T08D2.5	n/a	chrX 178,809
34	C48B4.6	C48B4.6	n/a	chrIII 9,557,903	contains similarity to Plateumaris constricticollis toyamensis Cytochrome oxidase subunit I (Fragment).; TR:Q85QH2
35	ugt-58	F35H8.6	n/a	chrII 9,585,502	C. elegans UGT-58 protein; contains similarity to Pfam domain PF00201 UDP-glucoronosyl and UDP-glucosyl transferase contains similarity to Interpro domain IPR002213 (UDP-glucuronosyl/UDP-glucosyltransferase)
36	W05F2.6	W05F2.6	n/a	chrI 3,370,130	contains similarity to Interpro domains IPR000504 (RNA recognition motif, RNP-1), IPR001620 (Dopamine D3 receptor)
37	C36B1.11	C36B1.11	n/a	chrI 8,756,734	contains similarity to Interpro domain IPR001576 (Phosphoglycerate kinase)
38	cgh-1	C07H6.5	n/a	chrIII 7,496,952	cgh-1 encodes a putative DEAD-box RNA helicase, orthologous to budding yeast Dhh1p, fission yeast Ste13p, Drosophila ME31B, and human DDX6 (OMIM:600326); CGH-1 inhibits physiological apoptosis in oocytes, keeping it down to a normal level of ~50% in hermaphrodite gonads; independently of apoptosis, CGH-1 is also required for sperm function, oocyte fertilization, and early embryonic cytokinesis; by orthology with budding yeast, CGH-1 is expected to enable decapping-dependent mRNA degradation; CGH-1 is expressed in meiotic germ cells, oocytes, sperm, early embryonic P granules, other unidentified cytoplasmic foci of the gonad core and early embryos, and the germline precursors Z2 and Z3; cgh-1(RNAi) hermaphrodites lose ~100% of their oocytes to physiological apoptosis; gonadal CGH-1 accumulation is suppressed by either glh-1/4 RNAi or gld-1(q485);gld-2(q497) mutations, yet physiological apoptosis (which would normally be elevated by loss of CGH-1) is also abnormally low in these genotypes; cgh-1(RNAi) males have sterile sperm with abnormally short pseudopods; CGH-1 associates with CAR-1, DCAP-2, and CEY-2/3/4 in P granules and cytoplasmic particles of the early embryo; CGH-1 is required for normal CAR-1 localization in early embyros, and binds CAR-1 in an RNA-dependent manner.
39	F54D5.9	F54D5.9	n/a	chrII 11,543,652	F54D5.9 encodes an F-box protein orthologous to to human FBXO47 (OMIM:609498, deleted in renal cell carcinoma) and paralogous to PROM-1, that suppresses excess embryonic cell division; F54D5.9(RNAi) animals show hyperproliferating embryonic tissues, while having no obvious meiotic defects.
40	zif-1	F59B2.6	n/a	chrIII 9,003,725	zif-1 encodes a SOCS-box protein that promotes establishment of the germ line by targetting germline proteins for cullin-dependent degradation in non-germline (somatic) cells; ZIF-1 binds germline CCCH-(zinc)-finger proteins and the E3 ubiquitin ligase subunit elongin C (ELC-1); while ZIF-1 has no obvious homologs, it may be analogous to the Drosophila SOCS-box protein GUSTAVUS, which is required for VASA localization to the germline and which does have mammalian homologs.
41	skr-17	C06A8.4	n/a	chrII 7,784,177	skr-17 encodes a homolog of Skp1 in S. cerevisiae, a core component of the SCF (Skp1p, Cullin, F-box) ubiquitin-ligase complex that facilitates ubiquitin-mediated protein degradation; SKR-17 has no known function in vivo, since skr-17(RNAi) animals are at least superficially normal, and SKR-17 does not appear to interact in vitro with any of the C. elegans cullin homologs.
42	Y53C12A.6	Y53C12A.6	n/a	chrII 9,717,654	contains similarity to Bacteriophage RB69 Hypothetical protein RB69ORF024c.; TR:Q7Y5B4
43	K06B9.2	K06B9.2	n/a	chrIV 4,192,443	K06B9.2 encodes a putative UDP-N-acetylglucosamine pyrophosphorylase, paralogous to C36A4.4 and orthologous to human UAP1 (OMIM:602862) and UAP1L1; K06B9.2 is thought to catalyse the fourth step of the hexosamine pathway to UDP-N-acetylglucosamine or UDP-N-acetylgalactosamine; K06B9.2 transcripts are enriched during oogenesis; K06B9.2(RNAi) animals have an osmotically-sensitive embryonic lethal phenotype, presumably because of defects in chitin and eggshell synthesis.
44	srsx-26	C51E3.1	n/a	chrV 10,149,791	C. elegans SRSX-26 protein; contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR000276 (GPCR, rhodopsin-like)
45	C38D4.4	C38D4.4	n/a	chrIII 4,794,206	contains similarity to Saccharomyces cerevisiae Delayed Anaerobic Gene; SGD:YJR151C
46	F35G12.5	F35G12.5	n/a	chrIII 4,585,670	contains similarity to Wigglesworthia glossinidia brevipalpis RpoD protein.; TR:Q8D286
47	glp-1	F02A9.6	n/a	chrIII 9,095,873	glp-1 encodes an N-glycosylated transmembrane protein that, along with LIN-12, comprises one of two C. elegans members of the LIN-12/Notch family of receptors; from the N- to the C-terminus, GLP-1 is characterized by ten extracellular EGF-like repeats, three LIN-12/Notch repeats, a CC-linker, a transmembrane domain, a RAM domain, six intracellular ankyrin repeats, and a PEST sequence; in C. elegans, GLP-1 activity is required for cell fate specification in germline and somatic tissues; in the germline, GLP-1, acting as a receptor for the DSL family ligand LAG-2, is essential for mitotic proliferation of germ cells and maintenance of germline stem cells; in somatic tissues, maternally provided GLP-1, acting as a receptor for the DSL family ligand APX-1, is required for inductive interactions that specify the fates of certain embryonic blastomeres; GLP-1 is also required for some later embryonic cell fate decisions, and in these decisions its activity is functionally redundant with that of LIN-12; GLP-1 expression is regulated temporally and spatially via translational control, as GLP-1 mRNA, present ubiquitously in the germline and embryo, yields detectable protein solely in lateral, interior, and endomembranes of distal, mitotic germ cells, and then predominantly in the AB blastomere and its descendants in the early embryo; proper spatial translation of glp-1 mRNA in the embryo is dependent upon genes such as the par genes, that are required for normal anterior-posterior asymmetry in the early embryo; signaling through GLP-1 controls the activity of the downstream Notch pathway components LAG-3 and LAG-1, the latter being predicted to function as part of a transcriptional feedback mechanism that positively regulates GLP-1 expression; signaling through the DNA-binding protein LAG-1 is believed to involve a direct interaction between LAG-1 and the GLP-1 RAM and ankyrin domains
48	ZK792.5	ZK792.5	n/a	chrIV 11,686,516	contains similarity to Pfam domain PF00806 Pumilio-family RNA binding repeat contains similarity to Interpro domains IPR011989 (Armadillo-like helical), IPR002952 (Eggshell protein), IPR001313 (Pumilio RNA-binding region), IPR016024 (Armadillo-type fold)
49	T01H3.2	T01H3.2	n/a	chrII 7,876,054	T01H3.2 encodes a large (980-residue) uncharacterized protein, with multiple dysferlin and beta-propeller domains, that is conserved among metazoa; T01H3.2 shares an operon with vha-4, and thus might be a previously undescribed V-ATPase component or ancillary protein.
50	ZC410.3	ZC410.3	n/a	chrIV 9,077,529	contains similarity to Pfam domain PF01532 Glycosyl hydrolase family 47 contains similarity to Interpro domain IPR001382 (Glycoside hydrolase, family 47)