UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	lon-2	C39E6.1	0	chrX 4,743,993	lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface.
2	Y56A3A.5	Y56A3A.5	n/a	chrIII 11,889,625	contains similarity to Pfam domain PF01425 Amidase contains similarity to Interpro domains IPR000120 (Amidase signature enzyme), IPR000504 (RNA recognition motif, RNP-1)
3	mls-2	C39E6.4	n/a	chrX 4,760,178	mls-2 encodes a homeodomain protein of the HMX family; during postembryonic development, MLS-2 is required for cell proliferation, cleavage orientation, and fate specification in the mesodermal M lineage; in regulating M lineage proliferation and fate specification, MLS-2 appears to act upstream of CYE-1/cyclin E and HLH-1/CeMyoD, respectively, the latter of which is not expressed in the M lineage in mls-2 mutant animals; MLS-2 is expressed in the nuclei of early proliferating undifferentiated M lineage cells (up to the 8-M stage), in a subset of head neurons, and in cells near the vulva during the L2 and L3 larval stages.
4	str-129	F58G4.5	n/a	chrV 8,091,709	C. elegans STR-129 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
5	K01A11.2	K01A11.2	n/a	chrIII 3,426,861	contains similarity to Xenopus laevis LOC495955 protein.; TR:Q5PQ79
6	F56C9.8	F56C9.8	n/a	chrIII 7,317,655
7	qui-1	Y45F10B.10	n/a	chrIV 13,568,114	The qui-1 gene encodes a protein of unknown function that contains several WD-40 domains.
8	clec-92	Y52B11A.5	n/a	chrI 11,016,484	C. elegans CLEC-92 protein; contains similarity to Interpro domains IPR000694 (Proline-rich region), IPR016187 (C-type lectin fold), IPR016186 (C-type lectin-like), IPR001304 (C-type lectin)
9	ZK1053.3	ZK1053.3	n/a	chrI 13,248,255	contains similarity to Interpro domain IPR011008 (Dimeric alpha-beta barrel)
10	Y54E2A.2	Y54E2A.2	n/a	chrII 14,750,101	contains similarity to Interpro domain IPR003593 (AAA+ ATPase, core)
11	T05C12.8	T05C12.8	n/a	chrII 8,189,001	contains similarity to Interpro domain IPR002110 (Ankyrin)
12	T04F8.3	T04F8.3	n/a	chrX 11,658,991	contains similarity to Staphylococcus phage 44AHJD Hypothetical protein.; TR:Q859L9
13	srh-7	K09D9.7	n/a	chrV 4,009,007	C. elegans SRH-7 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
14	F22E5.12	F22E5.12	n/a	chrII 2,646,586	contains similarity to Pfam domain PF02214 K+ channel tetramerisation domain contains similarity to Interpro domains IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR003131 (Potassium channel, voltage dependent, Kv, tetramerisation)
15	Y69H2.9	Y69H2.9	n/a	chrV 18,703,400	contains similarity to Grapevine leafroll-associated virus 3 Polymerase (Fragment).; TR:Q8V2G8
16	col-9	F54B11.1	n/a	chrX 13,590,542	col-9 encodes a collagen protein.
17	lgc-1	T05B4.1	n/a	chrV 4,136,911	C. elegans LGC-1 protein; contains similarity to Pfam domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain contains similarity to Interpro domains IPR002394 (Nicotinic acetylcholine receptor, N-terminal), IPR006201 (Neurotransmitter-gated ion-channel), IPR006202 (Neurotransmitter-gated ion-channel ligand-binding)
18	srh-298	Y94A7B.5	n/a	chrV 17,819,902	C. elegans SRH-298 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
19	math-5	C16C4.10	n/a	chrII 1,882,210	C. elegans MATH-5 protein; contains similarity to Pfam domain PF00917 MATH domain contains similarity to Interpro domains IPR008974 (TRAF-like), IPR002083 (MATH)
20	snt-6	C08G5.4	n/a	chrII 747,906	C. elegans SNT-6 protein; contains similarity to Pfam domain PF00168 C2 domain contains similarity to Interpro domains IPR001565 (Synaptotagmin), IPR008973 (C2 calcium/lipid-binding region, CaLB), IPR000008 (C2 calcium-dependent membrane targeting)
21	cof-2	C48E7.5	n/a	chrI 6,251,698	cof-2 encodes a homolog of human GLC1A, which when mutated leads to glaucome primary open angle (OMIM:137750)
22	sri-47	F22E5.4	n/a	chrII 2,657,583	C. elegans SRI-47 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
23	T28F12.1	T28F12.1	n/a	chrV 4,514,448
24	C24A8.1	C24A8.1	n/a	chrX 4,323,582	C24A8.1 encodes an homolog of mammalian D2 or D3 dopamine receptors, and a paralog of DOP-2/-3; C24A8.1 is expressed in the nervous system; because of its paralogy, C24A8.1 might act redundantly with DOP-2 to promote the basal slowing response to bacterial feeding, or it might account for the residual response to excess dopamine seen in triple dop-1/-2/-3 mutants; but C24A8.1 otherwise has no obvious function in RNAi assays of brood size, egg laying, pharyngeal pumping, locomotion, or male mating.
25	T13A10.1	T13A10.1	n/a	chrIV 6,276,666	contains similarity to Danio rerio Synaptic vesicle membrane protein VAT-1 homolog (EC 1.-.-.-).; SW:Q8JFV8
26	F08D12.12	F08D12.12	n/a	chrII 2,784,540	contains similarity to Homo sapiens hypothetical protein; VG:OTTHUMP00000024537
27	F13A2.3	F13A2.3	n/a	chrV 4,394,967
28	flp-4	C18D1.3	n/a	chrII 10,054,913	C. elegans FLP-4 protein ;
29	tsp-17	C02F12.1	n/a	chrX 3,682,658	C. elegans TSP-17 protein; contains similarity to Pfam domain PF00335 Tetraspanin family contains similarity to Interpro domains IPR000301 (CD9/CD37/CD63 antigen), IPR008952 (Tetraspanin)
30	Y43F8C.13	Y43F8C.13	n/a	chrV 19,691,051	contains similarity to Pfam domain PF01156 Inosine-uridine preferring nucleoside hydrolase contains similarity to Interpro domain IPR001910 (Inosine/uridine-preferring nucleoside hydrolase)
31	Y7A5A.2	Y7A5A.2	n/a	chrX 15,772,148	contains similarity to Aquifex aeolicus Hypothetical protein AQ_372.; SW:Y372_AQUAE
32	T02H6.8	T02H6.8	n/a	chrII 681,180
33	glb-11	C36E8.2	n/a	chrIII 3,990,752	glb-11 encodes a globin; glb-11 transcription is higher in L3 and dauers than in young adults; glb-11 has no obvious function in mass RNAi assays; glb-11 expression is induced by anoxia in a HIF-1 dependent manner, although it is also paradoxically upregulated in a hif-1 mutant background.
34	zig-8	Y39E4B.8	n/a	chrIII 13,126,726	zig-8 encodes a predicted secreted protein that is a member of the immunoglobulin superfamily of proteins; a zig-8::gfp reporter fusion is expressed in the PVT neuron and in pharyngeal muscle.
35	bbs-9	C48B6.8	n/a	chrI 6,920,270	C. elegans BBS-9 protein ; contains similarity to Homo sapiens 95 kDa protein; ENSEMBL:ENSP00000346214
36	C18D11.1	C18D11.1	n/a	chrIII 11,818,072	contains similarity to Sporobolus stapfianus Hypothetical protein.; TR:O04820
37	T13C2.2	T13C2.2	n/a	chrII 6,795,686
38	F21H7.3	F21H7.3	n/a	chrV 16,232,966	contains similarity to Rickettsia conorii Hypothetical protein RC0540.; TR:Q92I80
39	fax-1	F56E3.4	n/a	chrX 3,198,294	fax-1 encodes a conserved nuclear receptor that contains two C4-type zinc fingers and is orthologous to the vertebrate photoreceptor-specific nuclear receptor PNR (OMIM:604485, mutated in enhanced S-cone syndrome and retinitis pigmentosa); fax-1 is required for normal locomotion and neuron fate specification, including specification of the AVA, AVE, and AVK interneurons and proper axon pathfinding of the AVK, HSNL, and PVQL axons; expression of reporter gene fusions in fax-1 mutants suggests that fax-1 functions by regulating expression of a number of downstream targets, including nmr-1 and nmr-2, opt-3, flp-1, and ncs-1; in some neurons, fax-1 regulates expression combinatorially with unc-42, which encodes a paired-like homeodomain protein that additionally, regulates fax-1 expression in AVK neurons; FAX-1 is expressed in the nuclei of 18 neurons, including the AVK, AVA, AVB, and AVE interneurons, beginning at mid-embryogenesis and continuing through larval and adult stages; FAX-1 is also seen in two non-neuronal cell types: the distal tip cells (DTCs), from L2 to L4 larval stages, and two pairs of vulval cells in L4 animals.
40	T27A8.5	T27A8.5	n/a	chrX 16,065,286	contains similarity to Pfam domain PF06869 Protein of unknown function (DUF1258) contains similarity to Interpro domain IPR009667 (Protein of unknown function DUF1258)
41	W03F11.5	W03F11.5	n/a	chrI 2,217,759	n/a
42	srx-23	F31F4.2	n/a	chrV 683,114	C. elegans SRX-23 protein ;
43	F58F6.5	F58F6.5	n/a	chrIV 1,343,974	contains similarity to Pfam domain PF04789 Protein of unknown function (DUF621) contains similarity to Interpro domain IPR006874 (Protein of unknown function DUF621)
44	W04G5.8	W04G5.8	n/a	chrI 11,650,893	contains similarity to Pfam domain PF05075 Protein of unknown function (DUF684) contains similarity to Interpro domain IPR007767 (Protein of unknown function DUF684)
45	sph-1	F42G8.11	n/a	chrIV 8,132,914	sph-1 encodes a member of the synaptophysin/synaptoporin family that contains a MARVEL domain, a membrane-associating domain found in lipid-associating proteins, and contains a transmembrane domain.
46	C36C5.15	C36C5.15	n/a	chrV 3,168,358	contains similarity to Pfam domain PF01579 Domain of unknown function DUF19 contains similarity to Interpro domains IPR016638 (Uncharacterised conserved protein UPF0376), IPR002542 (Protein of unknown function DUF19)
47	che-12	B0024.8	n/a	chrV 10,303,399	che-12 encodes a conserved protein that contains at least seven predicted HEAT repeats; CHE-12 activity is required continuously in sensory neurons for formation of distal ciliary segments and thus, for normal sensory cilium morphology and function and chemotaxis to a subset of attractants, including sodium chloride; a che-12::gfp promoter fusion is expressed in the two phasmid neurons and the subset of amphid neurons that contain relatively simple cilia; a CHE-12::GFP protein localizes to cilia in a manner suggesting that it requires intraflagellar transport for proper localization, but is unlikely to be a core IFT particle component; che-12 expression in ciliated neurons is dependent upon the presence of the DAF-19 RFX transcription factor.
48	srxa-15	Y44A6B.2	n/a	chrV 20,638,710	C. elegans SRXA-15 protein; contains similarity to Pfam domain PF03383 Caenorhabditis serpentine receptor-like protein, class xa contains similarity to Interpro domains IPR017452 (GPCR, rhodopsin-like superfamily), IPR005047 (Protein of unknown function DUF286, G protein-coupled receptor-like putative Caenorhabditis species)
49	srd-5	T19E7.5	n/a	chrIV 5,673,565	C. elegans SRD-5 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domains IPR003002 (7TM chemoreceptor, subfamily 1), IPR004268 (Virulence factor MVIN-like)
50	T05C1.1	T05C1.1	n/a	chrII 4,479,688