UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C36A4.10	C36A4.10	4e-17	chrIII 3,830,011
2	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
3	gon-1	F25H8.3	n/a	chrIV 9,940,393	gon-1 encodes a functional metalloprotease that defines a new sub-family of secreted proteases known as MPT (metalloprotease with thrombospondin type 1 repeats); the other two members of this family are the bovine procollagen I N-protease ( PINP ) and the murine enzyme ADAMTS-1; gon-1 is essential for hermaphrodite gonadal morphogenesis; sequence homology with other metalloproteases suggests that it functions by remodelling the extracellular matrix; GON-1 is expressed at high levels within the gonadal distal tip cell during migration.
4	tag-304	F53E2.1	n/a	chrV 1,469,424	C. elegans TAG-304 protein; contains similarity to Pfam domain PF08513 LisH contains similarity to Interpro domains IPR006594 (LisH dimerisation motif), IPR013144 (CT11-RanBPM), IPR013720 (LisH dimerisation motif, subgroup), IPR006595 (CTLH, C-terminal to LisH motif)
5	sel-7	K04G11.2	n/a	chrX 14,336,558	sel-7 encodes a novel protein with two predicted PEST sequences that is conserved in the related nematode C. briggsae and several parasitic nematodes, but has no known homologs in other organisms; sel-7 was identified in screens for suppressors of dominant lin-12 mutations that result in vulvaless and egg-laying defective animals; although loss of SEL-7 function via mutation or RNAi results in no obvious defects in a wild-type background, genetic studies suggests that SEL-7 acts downstream of LIN-12/Notch to positively regulate LIN-12 signaling, perhaps by regulating the activity or formation of the LAG-1, LIN-12(intra), SEL-8 nuclear complex; in vitro, SEL-7 self-associates and also interacts with TIR-1 (F13B10.1B), a protein that contains sterile alpha and Toll interleukin receptor motifs, and MDT-29 (K08E3.8), a glutamine-rich protein similar to mediator complex subunits, however the functional significance of these interactions is not yet known; a SEL-7::GFP translational fusion reveals expression in the nuclei of several cell types, including vulval precursor cells and those of the developing gonad.
6	F26A10.2	F26A10.2	n/a	chrX 7,634,533	F26A10.2 encodes a protein with four zinc-finger domains and a glutamine/asparagine-rich domain, that is required for maintenance of the germline and for locomotion; F26A10.2(RNAi) animals are uncoordinated and have sterile progeny.
7	F14B8.6	F14B8.6	n/a	chrX 6,930,764
8	T19B10.3	T19B10.3	n/a	chrV 11,224,368	The T19B10.3 gene encodes an ortholog of the human gene GALACTOSIDASE, BETA 1 (GLB1), which when mutated leads to gangliosidosis type I (OMIM:230500).
9	T05B11.1	T05B11.1	n/a	chrV 7,750,009	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
10	R07B1.5	R07B1.5	n/a	chrX 9,865,660	contains similarity to Pfam domain PF01681 C6 domain contains similarity to Interpro domain IPR002601 (Protein of unknown function C6)
11	srg-67	ZC317.4	n/a	chrV 5,462,245	C. elegans SRG-67 protein; contains similarity to Interpro domain IPR000609 (Serpentine gamma receptor, Caenorhabditis species)
12	F57G12.2	F57G12.2	n/a	chrX 12,158,178	contains similarity to Mus musculus Nuclear protein ZAP3.; SW:ZAP3_MOUSE
13	dao-3	K07E3.3	n/a	chrX 8,085,329	dao-3 encodes a protein containing tetrahydrofolate dehydrogenase/cyclohydrolase catalytic and NAD(P)-binding domains; by similarity to mammalian enzymes, DAO-3 is predicted to function in one-carbon unit metabolism and thus, in amino acid and nucleotide biosynthesis; dao-3 expression appears to be regulated by daf-2-mediated insulin signaling: microarray experiments suggest that it is upregulated in daf-2 mutant adults, while differential display and Northern analyses suggest that it is down-regulated; a dao-3 promoter gfp fusion is expressed in larvae in the hypodermis and in the nervous system, including tail neurons and phasmids.
14	C34E7.4	C34E7.4	n/a	chrX 12,933,527	contains similarity to Interpro domain IPR000345 (Cytochrome c heme-binding site)
15	C33D9.8	C33D9.8	n/a	chrIV 8,784,995	contains similarity to Interpro domains IPR000533 (Tropomyosin), IPR009053 (Prefoldin)
16	lrx-1	T04H1.6	n/a	chrV 12,253,997	lrx-1 encodes a protein that contains four class A low-density lipoprotein receptor domains.
17	F13B6.1	F13B6.1	n/a	chrIV 7,457,398
18	Y45F3A.8	Y45F3A.8	n/a	chrIII 10,591,217	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domain IPR003582 (Metridin-like ShK toxin)
19	Y38H6C.16	Y38H6C.16	n/a	chrV 20,532,568	contains similarity to Pfam domain PF03125 C. elegans Sre G protein-coupled chemoreceptor contains similarity to Interpro domain IPR004151 (C. elegans Sre G protein-coupled chemoreceptor)
20	let-19	K08F8.6	n/a	chrII 8,776,425	The let-19 gene encodes a protein related to human TRAP240 (thyroid hormone receptor-associated protein 240, OMIM:300182), a transcriptional co-activation complex subunit conserved in yeast, Drosophila, and humans; LET-19 is required for proper asymmetric cell divisions and cell fusions regulated by LIN-44/Wnt and LIN-17/frizzled, as well as for proper development of secondary vulval cell fates as regulated by Notch signaling.
21	C50F7.9	C50F7.9	n/a	chrIV 7,731,347
22	T01B6.1	T01B6.1	n/a	chrX 2,342,147	n/a
23	Y57G11C.21	Y57G11C.21	n/a	chrIV 14,846,701	contains similarity to Interpro domain IPR000358 (Ribonucleotide reductase)
24	F35D2.1	F35D2.1	n/a	chrII 7,577,252
25	tbb-4	B0272.1	n/a	chrX 9,435,612	C. elegans TBB-4 protein; contains similarity to Pfam domains PF00091 (Tubulin/FtsZ family, GTPase domain) , PF03953 (Tubulin/FtsZ family, C-terminal domain) contains similarity to Interpro domains IPR002454 (Gamma tubulin), IPR002452 (Alpha tubulin), IPR002453 (Beta tubulin), IPR000158 (Cell division protein FtsZ, N-terminal), IPR000217 (Tubulin), IPR003008 (Tubulin/FtsZ, GTPase), IPR008280 (Tubulin/FtsZ, C-terminal), IPR013838 (Beta tubulin, autoregulation binding site), IPR004057 (Epsilon tubulin), IPR002967 (Delta tubulin)
26	nmgp-1	F13H8.4	n/a	chrII 6,261,707	F13H8.4 encodes a homolog of the human neuronal membrane glycoproteins PLP1 (OMIM:300401, mutated in Pelizaeus-Merzbacher disease and spastic paraplegia), M6A (OMIM:601275), and M6B (300051); the presence of a myelin-related protein in C. elegans is currently unexplained, but suggests that some evolutionary precursor of myelin may exist in invertebrates, perhaps involving septate junctions between cells.
27	sec-24.2	ZC518.2	n/a	chrIV 12,358,176	C. elegans SEC-24.2 protein; contains similarity to Pfam domains PF04811 (Sec23/Sec24 trunk domain) , PF04815 (Sec23/Sec24 helical domain) , PF04810 (Sec23/Sec24 zinc finger) , PF00626 (Gelsolin repeat) , PF08033 (Sec23/Sec24 beta-sandwich domain) contains similarity to Interpro domains IPR006900 (Sec23/Sec24 helical region), IPR012990 (Sec23/Sec24 beta-sandwich), IPR000694 (Proline-rich region), IPR006896 (Sec23/Sec24 trunk region), IPR006895 (Zinc finger, Sec23/Sec24-type), IPR007123 (Gelsolin region)
28	T19B10.5	T19B10.5	n/a	chrV 11,235,863	T19B10.5 encodes a protein with partial similarity to human PERIAXIN (PRX; OMIM:605725), which when mutated leads to Dejerine-Sottas neuropathy.
29	fbxb-85	R17.1	n/a	chrIII 10,848,088	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; its encoded protein also contains a Pfam-B45 motif of presently unknown function.
30	sru-6	C33A12.8	n/a	chrIV 9,491,282	C. elegans SRU-6 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
31	K07E8.6	K07E8.6	n/a	chrII 638,824	contains similarity to Pfam domain PF08565 Cdc37 Hsp90 binding domain contains similarity to Interpro domains IPR004918 (Cdc37), IPR013874 (Cdc37, Hsp90 binding)
32	tba-9	F40F4.5	n/a	chrX 3,254,559	tba-9 encodes one of nine C. elegans alpha tubulins; by homology, TBA-9 is predicted to be a component of microtubules; as loss of tba-9 function via RNA-mediated interference (RNAi) does not result in any obvious abnormalities, TBA-9 likely functions redundantly with other alpha tubulins as a basic component of cellular architecture that may play additional roles in processes such as cell division, cell movement, and intracellular transport.
33	C07B5.2	C07B5.2	n/a	chrX 9,516,733	contains similarity to Listeria monocytogenes Probable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferases(EC 2.1.1.61).; SW:TRMU_LISMO
34	K10B4.3	K10B4.3	n/a	chrII 117,838	contains similarity to Pfam domain PF00169 PH domain contains similarity to Interpro domains IPR001849 (Pleckstrin-like), IPR011993 (Pleckstrin homology-type), IPR016024 (Armadillo-type fold)
35	nsy-1	F59A6.1	n/a	chrII 5,026,357	nsy-1 encodes a MAP kinase kinase kinase homolog that affects chemotaxis, egg laying, and pathogen response; NSY-1 activity is activated by the calmodulin kinase UNC-43, and is required for lateral signalling that leads to asymmetric olfactory neuron fates; interacts with SEK-1, and is expressed in the intestine, hypodermis, rectal gland cells, and neurons.
36	nas-29	F58A6.4	n/a	chrII 5,140,235	C. elegans NAS-29 protein; contains similarity to Pfam domains PF00431 (CUB domain) , PF01400 (Astacin (Peptidase family M12A)) contains similarity to Interpro domains IPR017050 (Peptidase M12A, astacin, nematode), IPR006025 (Peptidase M, neutral zinc metallopeptidases, zinc-binding site), IPR001506 (Peptidase M12A, astacin), IPR006026 (Peptidase, metallopeptidases), IPR000859 (CUB), IPR013032 (EGF-like region, conserved site)
37	R173.3	R173.3	n/a	chrX 7,033,107	contains similarity to Pfam domain PF00135 Carboxylesterase contains similarity to Interpro domain IPR002018 (Carboxylesterase, type B)
38	plx-2	K04B12.1	n/a	chrII 14,421,292	C. elegans PLX-2 protein; contains similarity to Pfam domains PF01833 (IPT/TIG domain) (3), PF01437 (Plexin repeat) (3), PF08337 (Plexin cytoplasmic region) contains similarity to Interpro domains IPR014756 (Immunoglobulin E-set), IPR002165 (Plexin), IPR008936 (Rho GTPase activation protein), IPR002909 (Cell surface receptor IPT/TIG), IPR001627 (Semaphorin/CD100 antigen), IPR003659 (Plexin/semaphorin/integrin), IPR016201 (Plexin-like fold), IPR013548 (Plexin cytoplasmic region), IPR015943 (WD40/YVTN repeat-like)
39	T04C9.3	T04C9.3	n/a	chrIII 5,985,695
40	F23C8.6	F23C8.6	n/a	chrI 2,421,287	contains similarity to Pfam domain PF03357 Snf7 contains similarity to Interpro domain IPR005024 (Snf7)
41	F45B8.3	F45B8.3	n/a	chrX 14,960,981	contains similarity to Interpro domains IPR003267 (Small proline-rich), IPR000694 (Proline-rich region)
42	nmr-2	T01C3.10	n/a	chrV 15,009,000	C. elegans NMR-2 protein ;
43	F47B7.1	F47B7.1	n/a	chrX 3,788,259	contains similarity to Pfam domain PF01679 Uncharacterized protein family UPF0057 contains similarity to Interpro domain IPR000612 (Protein of unknown function UPF0057)
44	W04E12.7	W04E12.7	n/a	chrV 19,731,742	contains similarity to Pfam domain PF06162 Caenorhabditis elegans protein of unknown function (DUF976) contains similarity to Interpro domains IPR010381 (Protein of unknown function DUF976, Caenorhabditis species), IPR016125 (Peptidase C15, pyroglutamyl peptidase I-like)
45	dpy-19	F22B7.10	n/a	chrIII 8,663,628	The dpy-19 gene encodes a novel transmembrane protein whose human homolog is expressed in brain, and that is required for correct polarization and migration of the neuroblasts QL and QR.
46	aat-1	F27C8.1	n/a	chrIV 9,600,317	aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly.
47	blmp-1	F25D7.3	n/a	chrI 10,411,592	C. elegans BLMP-1 protein; contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR001214 (SET), IPR015880 (Zinc finger, C2H2-like), IPR007086 (Zinc finger, C2H2-subtype), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR003656 (Zinc finger, BED-type predicted), IPR007087 (Zinc finger, C2H2-type)
48	ltd-1	K02C4.4	n/a	chrII 8,090,520	ltd-1 encodes a protein with LIM and transglutaminase domains; LTD-1 is homologous to the mouse KY protein (MGI:96709, mutated in kyphoscoliosis), and to the HILLARIN protein of Hirudo medicinalis, found at axon hillocks; ltd-1 is expressed in hypodermal cells from the twofold stage embryo to adulthood, but has no obvious function in mass RNAi assays.
49	ptd-2	F07C3.1	n/a	chrV 9,252,223	C. elegans PTD-2 protein; contains similarity to Interpro domains IPR000731 (Sterol-sensing 5TM box), IPR006069 (ATPase, P-type cation exchange, alpha subunit)
50	H22K11.2	H22K11.2	n/a	chrX 6,785,820	contains similarity to Pfam domain PF01301 Glycosyl hydrolases family 35 contains similarity to Interpro domains IPR000583 (Glutamine amidotransferase, class-II), IPR017853 (Glycoside hydrolase, catalytic core), IPR013781 (Glycoside hydrolase, subgroup, catalytic core), IPR001944 (Glycoside hydrolase, family 35)