UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C34H4.2	C34H4.2	0	chrIV 1,554,675	contains similarity to Pfam domain PF03409 Protein of unknown function (DUF274) contains similarity to Interpro domain IPR005071 (Protein of unknown function DUF274)
2	lips-14	H17B01.3	n/a	chrII 1,485,043	C. elegans LIPS-14 protein; contains similarity to Pfam domain PF01674 Lipase (class 2) contains similarity to Interpro domain IPR002918 (Lipase, class 2)
3	nhr-79	T26H2.9	n/a	chrV 19,209,750	C. elegans NHR-79 protein; contains similarity to Pfam domains PF00104 (Ligand-binding domain of nuclear hormone receptor) , PF00105 (Zinc finger, C4 type (two domains)) contains similarity to Interpro domains IPR008946 (Nuclear hormone receptor, ligand-binding), IPR001723 (Steroid hormone receptor), IPR000324 (Vitamin D receptor), IPR013088 (Zinc finger, NHR/GATA-type), IPR001628 (Zinc finger, nuclear hormone receptor-type), IPR000536 (Nuclear hormone receptor, ligand-binding, core)
4	F02C12.1	F02C12.1	n/a	chrX 13,404,175	contains similarity to Interpro domain IPR000433 (Zinc finger, ZZ-type)
5	F49F1.8	F49F1.8	n/a	chrIV 4,132,560	contains similarity to Pfam domain PF00098 Zinc knuckle contains similarity to Interpro domains IPR013084 (Zinc finger, CCHC retroviral-type), IPR001878 (Zinc finger, CCHC-type)
6	E01G4.6	E01G4.6	n/a	chrII 13,483,996	contains similarity to Caenorhabditis remanei P17 (Fragment).; TR:A0MIX2
7	T08B2.11	T08B2.11	n/a	chrI 6,222,182	contains similarity to Homo sapiens Transcription initiation factor TFIID subunit 3; ENSEMBL:ENSP00000340271
8	lbp-8	T22G5.6	n/a	chrV 13,891,011	lpb-8 belongs to a family of small intracellular fatty acid binding proteins (FABPs) that includes As-p18, found in the parasitic nematode Ascaris suum; lpb-8 shares 55% identity with bovine heart FABP but only 25% identity with As-p18 and lacks a secretory signal
9	D2092.6	D2092.6	n/a	chrI 6,597,924	contains similarity to Homo sapiens Ubiquitin carboxyl-terminal hydrolase 8; ENSEMBL:ENSP00000302239
10	F49H6.3	F49H6.3	n/a	chrV 17,015,023	contains similarity to Pfam domain PF06653 Protein of unknown function (DUF1164) contains similarity to Interpro domain IPR009545 (Protein of unknown function DUF1164)
11	dbr-1	C55B7.8	n/a	chrI 6,491,723	dbr-1 encodes a homolog of the RNA lariat-debranching enzyme; DBR-1 is predicted to function in RNA processing by hydrolyzing the 2'-5' phosphodiester bond at the branchpoint of excised lariat intron RNA, thus converting the introns into linear molecules that can subsequently be degraded by exonucleases; in C. elegans, DBR-1 activity is required for embryonic and germline development, as well as for normal rates of postembryonic growth; overexpression of C. elegans DBR-1 in Saccharomyces cerevisiae can complement the RNA processing defects of a dbr1 null mutant strain, restoring debranching activity and intron degradation to near wild-type levels.
12	F54D5.14	F54D5.14	n/a	chrII 11,580,652	contains similarity to Pfam domain PF02463 RecF/RecN/SMC N terminal domain contains similarity to Interpro domain IPR003395 (RecF/RecN/SMC protein, N-terminal)
13	F15E11.2	F15E11.2	n/a	chrV 2,335,582	contains similarity to Pfam domain PF01030 Receptor L domain contains similarity to Interpro domain IPR000494 (EGF receptor, L domain)
14	F53C11.1	F53C11.1	n/a	chrV 13,776,738	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domain IPR003366 (CUB-like region)
15	ptr-23	ZK270.1	n/a	chrI 14,911,168	ptr-23 encodes a nematode-specific member of the sterol sensing domain (SSD) proteins, distantly paralogous to Drosophila PATCHED (PTC) and human PTCH (OMIM:601309, mutated in basal cell nevus syndrome); PTR-23 is strongly required for normal molting from L4 to adult stages (a role conserved in C. briggsae); PTR-23 is also required for normal male tail development, vulval morphogenesis, adult alae formation, and (partly) for endocytosis of yolk by oocytes.
16	F09A5.1	F09A5.1	n/a	chrX 13,132,007	contains similarity to Pfam domain PF07690 Major Facilitator Superfamily contains similarity to Interpro domains IPR007114 (Major facilitator superfamily), IPR011701 (Major facilitator superfamily MFS-1), IPR016196 (MFS general substrate transporter)
17	F08F8.2	F08F8.2	n/a	chrIII 7,360,724	contains similarity to Pfam domain PF00368 Hydroxymethylglutaryl-coenzyme A reductase contains similarity to Interpro domains IPR004554 (Hydroxymethylglutaryl-CoA reductase, class I, catalytic), IPR009029 (Hydroxymethylglutaryl-CoA reductase, class I/II, substrate-binding), IPR002202 (Hydroxymethylglutaryl-CoA reductase, class I/II, catalytic)
18	C02G6.1	C02G6.1	n/a	chrV 5,878,092	contains similarity to Pfam domains PF00675 (Insulinase (Peptidase family M16)) , PF05193 (Peptidase M16 inactive domain) (2)contains similarity to Interpro domains IPR001431 (Peptidase M16, zinc-binding site), IPR011765 (Peptidase M16, N-terminal), IPR011237 (Peptidase M16, core), IPR007863 (Peptidase M16, C-terminal), IPR011249 (Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)
19	col-103	F56B3.1	n/a	chrIV 763,047	C. elegans COL-103 protein; contains similarity to Pfam domains PF01484 (Nematode cuticle collagen N-terminal domain) , PF01391 (Collagen triple helix repeat (20 copies)) (3)contains similarity to Interpro domains IPR002952 (Eggshell protein), IPR002486 (Nematode cuticle collagen, N-terminal), IPR000694 (Proline-rich region), IPR000817 (Prion protein), IPR008160 (Collagen triple helix repeat), IPR013286 (Annexin, type VII)
20	F55A12.6	F55A12.6	n/a	chrI 5,340,452	contains similarity to Interpro domain IPR002952 (Eggshell protein)
21	T22B2.6	T22B2.6	n/a	chrX 3,915,288
22	ZK1058.9	ZK1058.9	n/a	chrIII 3,924,612	contains similarity to Borrelia burgdorferi Probable O-sialoglycoprotein endopeptidase (EC 3.4.24.57)s(Glycoprotease).; SW:GCP_BORBU
23	F01D5.2	F01D5.2	n/a	chrII 13,998,627	contains similarity to Pfam domain PF01549 ShK domain-like contains similarity to Interpro domains IPR001368 (TNFR/CD27/30/40/95 cysteine-rich region), IPR000480 (Glutelin), IPR003582 (Metridin-like ShK toxin)
24	nduf-2.2	T26A5.3	n/a	chrIII 6,466,129	T26A5.3 encodes a predicted mitochondrial protein whose mature sequence has near-identity (95%) to GAS-1; T26A5.3 transcription is detectable by RT-PCR, but not visible by promoter-GFP fusion; however, a transgene containing a fusion of the gas-1 promoter to the T26A5.3 protein-coding sequence is able to fully rescue gas-1 mutants, indicating that T26A5.3 encodes a fully functional mitochondrial 49 kDa subunit that may rescue gas-1(fc21) mutants from lethality; mutants homozygous for a T26A5.3 deletion have normal anesthetic sensitivity and normal sensitivity to oxygen (unlike gas-1 mutants) but a shortened lifespan at normal laboratory oxygen levels (20%); animals doubly mutant for gas-1 and T26A5.3 have maternal-effect lethality, but sterile surviving parents are abnormally long-lived (2.7 times longer than wild-type and 4.2 times longer than gas-1 mutants); double mutants remain hypersensitive to oxygen.
25	srab-22	T20D4.2	n/a	chrV 3,427,052	C. elegans SRAB-22 protein ;
26	ech-1	C29F3.1	n/a	chrV 15,359,193	ech-1 encodes an enoyl-CoA hydratase; loss of ech-1 activity via RNAi results in reduced body fat, consistent with ECH-1's predicted role in fatty acid metabolism; expression of ech-1 mRNA is positively regulated by the NHR-49 nuclear receptor.
27	vpr-1	F33D11.11	n/a	chrI 5,869,119	C. elegans VPR-1 protein; contains similarity to Pfam domain PF00635 MSP (Major sperm protein) domain contains similarity to Interpro domains IPR008962 (PapD-like), IPR000535 (Major sperm protein), IPR016763 (Vesicle-associated membrane protein)
28	C49C8.5	C49C8.5	n/a	chrIV 8,651,156	contains similarity to Pfam domain PF00147 Fibrinogen beta and gamma chains, C-terminal globular domain contains similarity to Interpro domains IPR014716 (Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1), IPR002181 (Fibrinogen, alpha/beta/gamma chain, C-terminal globular)
29	F41E6.11	F41E6.11	n/a	chrV 8,620,645	contains similarity to Interpro domains IPR003267 (Small proline-rich), IPR000694 (Proline-rich region), IPR000480 (Glutelin)
30	Y49G5A.1	Y49G5A.1	n/a	chrV 5,286,867	contains similarity to Pfam domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain contains similarity to Interpro domain IPR002223 (Proteinase inhibitor I2, Kunitz metazoa)
31	fbxa-59	T12B5.8	n/a	chrIII 942,155	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
32	mrp-3	E03G2.2	n/a	chrX 15,934,560	C. elegans MRP-3 protein; contains similarity to Pfam domains PF00664 (ABC transporter transmembrane region) (2), PF00005 (ABC transporter) (2)contains similarity to Interpro domains IPR003439 (ABC transporter-like), IPR011527 (ABC transporter, transmembrane region, type 1), IPR001140 (ABC transporter, transmembrane region), IPR003593 (AAA+ ATPase, core)
33	F42E8.1	F42E8.1	n/a	chrV 13,063,254	contains similarity to Campylobacter jejuni DNA polymerase III alpha subunit (EC 2.7.7.7).; SW:DP3A_CAMJE
34	T05C12.4	T05C12.4	n/a	chrII 8,178,909	contains similarity to Interpro domain IPR003566 (T-cell surface glycoprotein CD5)
35	F44E7.3	F44E7.3	n/a	chrV 5,772,314
36	F57G4.9	F57G4.9	n/a	chrV 17,644,291	contains similarity to Xenopus laevis Putative uncharacterized protein.; TR:Q08AY0
37	T26E3.7	T26E3.7	n/a	chrI 12,655,698	contains similarity to Pfam domain PF00006 ATP synthase alpha/beta family, nucleotide-binding domain contains similarity to Interpro domain IPR000194 (ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)
38	cyp-25A1	C36A4.1	n/a	chrIII 3,833,539	C. elegans CYP-25A1 protein; contains similarity to Pfam domain PF00067 Cytochrome P450 contains similarity to Interpro domains IPR001128 (Cytochrome P450), IPR002401 (Cytochrome P450, E-class, group I), IPR002402 (Cytochrome P450, E-class, group II), IPR002403 (Cytochrome P450, E-class, group IV), IPR002397 (Cytochrome P450, B-class)
39	abu-1	AC3.3	n/a	chrV 10,381,053	abu-1 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-1 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-1 may help protect the organism from damage by improperly folded nascent protein.
40	ZK1037.6	ZK1037.6	n/a	chrV 15,326,789	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR003366 (CUB-like region)
41	F07A11.5	F07A11.5	n/a	chrII 11,613,153	contains similarity to Pfam domain PF00294 pfkB family carbohydrate kinase contains similarity to Interpro domains IPR011611 (Carbohydrate/purine kinase), IPR011877 (Ribokinase, bacterial), IPR002139 (Ribokinase)
42	B0303.11	B0303.11	n/a	chrIII 8,706,616	contains similarity to Pfam domain PF00324 Amino acid permease contains similarity to Interpro domain IPR004841 (Amino acid permease-associated region)
43	F38B2.4	F38B2.4	n/a	chrX 11,287,008	F38B2.4 is orthologous to the human gene ADENYLATE KINASE 1 (AK1; OMIM:103000), which when mutated leads to hemolytic anemia.
44	abu-7	C03A7.8	n/a	chrV 5,164,061	abu-7 encodes a transmembrane protein with a predicted signal sequence, a glutamine/asparagine-rich domain and multiple cysteine-rich repeats (DUF139); abu-7 expression is induced by blockage of the unfolded-protein response in the endoplasmic reticulum, and ABU-7 may help protect the organism from damage by improperly folded nascent protein.
45	C34C6.4	C34C6.4	n/a	chrII 8,697,694	contains similarity to Pfam domains PF00732 (GMC oxidoreductase) , PF05199 (GMC oxidoreductase) contains similarity to Interpro domains IPR013027 (FAD-dependent pyridine nucleotide-disulphide oxidoreductase), IPR012132 (Glucose-methanol-choline oxidoreductase), IPR007867 (Glucose-methanol-choline oxidoreductase, C-terminal), IPR000172 (Glucose-methanol-choline oxidoreductase, N-terminal), IPR001100 (Pyridine nucleotide-disulphide oxidoreductase, class I)
46	K10C2.4	K10C2.4	n/a	chrX 6,447,827	K10C2.4 encodes a putative fumarylacetoacetate hydrolase, orthologous to human FAH (OMIM:276700, mutated in type I tyrosinemia), that is required for tyrosine metabolism, resistance to oxidative and protein-folding stresses, and more generally for normally rapid growth, normal locomotion, fertility, and viability; K10C2.4 is expressed in hypodermis and intestine; the intestines of K10C2.4(RNAi) animals atrophy rapidly, and show an abnormally active oxidative stress response (seen via gst-4::GFP) and ER stress response (seen via hsp-4::GFP); while RNAi against enzymes upstream of K10C2.4 suppresses the K10C2.4(RNAi) phenotype, excess dietary tyrosine or homogentisic acid enhances it, and exogenous succinylacetone (SA) mimics it, consistent with the hypothesis that blocked SA metabolism is toxic in K10C2.4(RNAi) animals.
47	M01G12.9	M01G12.9	n/a	chrI 12,111,806	contains similarity to Lactococcus lactis ORF (Fragment).; TR:Q48730
48	grd-14	T01B10.2	n/a	chrX 8,500,290	grd-14 encodes a hedgehog-like protein, with an N-terminal signal sequence and a C-terminal Ground domain; the Ground domain is predicted to form a cysteine-crosslinked protein involved in intercellular signalling, and it has subtle similarity to the N-terminal Hedge domain of HEDGEHOG proteins; GRD-14 is required for normal growth to full size, locomotion, and vulval morphogenesis; all of these requirements may reflect common defects in cholesterol-dependent hedgehog-like signalling or in vesicle trafficking.
49	ZC116.3	ZC116.3	n/a	chrV 12,620,623	ZC116.3 is orthologous to the human gene CUBILIN (CUBN; OMIM:602997), which when mutated leads to hereditary megaloblastic anaemia 1 (OMIM:261100).
50	H25K10.1	H25K10.1	n/a	chrIV 16,204,661	contains similarity to Pfam domain PF00149 Calcineurin-like phosphoesterase contains similarity to Interpro domains IPR015914 (Purple acid phosphatase, N-terminal), IPR004843 (Metallophosphoesterase)