UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	cyn-12	C34D4.12	4e-88	chrIV 7,132,656	cyn-12 encodes a member of the cyclophilin family that is related to human PPIL1 (CGI-124); based upon its sequence similarity, CYN-12 is predicted to be a cytoplasmic protein potentially involved in a wide range of signal transduction pathways.
2	sdz-36	ZK1251.7	n/a	chrIV 9,691,129	C. elegans SDZ-36 protein
3	R107.2	R107.2	n/a	chrIII 9,044,850	contains similarity to Pfam domain PF01256 Carbohydrate kinase contains similarity to Interpro domain IPR000631 (Carbohydrate kinase)
4	R07E4.5	R07E4.5	n/a	chrX 5,951,318	contains similarity to Plasmodium lophurae Histidine-rich glycoprotein precursor.; SW:P04929
5	R10E4.6	R10E4.6	n/a	chrIII 4,294,138
6	him-8	T07G12.12	n/a	chrIV 10,562,902	him-8 encodes a protein with two C-terminal noncanonical C2H2 zinc-fingers whose paralogs include ZIM-1/-3 and C02F5.12; HIM-8 is required by X chromosomes for normal homolog pairing, synapsis, recombination, and segregation during meiosis; him-8 mutants have an increased frequency of genotypically XO males in self-fertile hermaphrodite populations; HIM-8 is expressed during meiosis, and is associated with the X chromosome's meiotic pairing center (PC), which associates with the nuclear envelope during meiotic prophase; him-8 mutations are enhanced by rearrangements that inactivate the X-chromosomal PC; HIM-8 functions are genetically separable, since the him-8(me4) point mutation (which alters a domain N-terminal to HIM-8's zinc fingers) permits normal chromosome binding and nuclear localization, but causes abnormal pairing and synapsis; while the C-terminal region of HIM-8 most closely resembles those of its orthologs in other Caenorhabditis species, its N-terminal region is highly divergent, suggesting species-specific functions; unlike other him mutations, him-8 solely affects X chromosomes, and does not produce embryonic lethality via autosomal nondisjunction or aneuploidy; however, failure of X-chromosomal synapsis in him-8 mutants blocks the pachytene transistion from polarized to nonpolarized meiotic nuclei, by blocking the resolution of recombination intermediates on other chromosomes; him-8-blocked meiotic autosomes show persistent RAD-51 foci and have excess crossovers, both of which may be symptoms of a HUS-1-independent checkpoint induced by X-chromosomal nonsynapsis rather than DNA damage; HIM-8 also acts outside of meiosis, by inhibiting EGL-13 expression or activity; mutations of the HIM-8 zinc-finger domain semidominantly suppress missense (but not null) egl-13 mutations, due to him-8 haploinsufficiency; mutant HIM-8 fails to suppress mutant egl-13 on a free transgenic array, and also fails to suppress native mutant egl-13 if transgenic excess copies of the egl-13 promoter are present.
7	Y18D10A.16	Y18D10A.16	n/a	chrI 12,903,539	contains similarity to Homo sapiens Uncharacterized protein C2orf64; ENSEMBL:ENSP00000330730
8	his-46	B0035.9	n/a	chrIV 11,326,144	his-46 encodes an H4 histone.
9	D1007.4	D1007.4	n/a	chrI 4,580,304	contains similarity to Homo sapiens Gem-associated protein 6; ENSEMBL:ENSP00000281950
10	lsm-7	ZK593.7	n/a	chrIV 10,933,821	C. elegans LSM-7 protein; contains similarity to Pfam domain PF01423 LSM domain contains similarity to Interpro domains IPR001163 (Like-Sm ribonucleoprotein, core), IPR006649 (Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core), IPR010920 (Like-Sm ribonucleoprotein-related, core), IPR017132 (U6 snRNA-associated Sm-like protein LSm7)
11	R144.3	R144.3	n/a	chrIII 5,022,586	contains similarity to Interpro domain IPR007087 (Zinc finger, C2H2-type)
12	Y5F2A.4	Y5F2A.4	n/a	chrIV 11,077,311	contains similarity to Pfam domain PF00096 Zinc finger, C2H2 type contains similarity to Interpro domains IPR015880 (Zinc finger, C2H2-like), IPR013087 (Zinc finger, C2H2-type/integrase, DNA-binding), IPR007087 (Zinc finger, C2H2-type)
13	sra-25	T26E3.9	n/a	chrI 12,687,150	C. elegans SRA-25 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR003945 (NADH-plastoquinone oxidoreductase, chain 5), IPR000344 (Nematode chemoreceptor, Sra)
14	cks-1	C09G4.3	n/a	chrIV 8,514,308	A homolog of Cks/Suc1, a highly conserved member of the eukaryotic cell cycle machinery that affects both meiosis and mitosis and has a role in the inactivation of the M-phase promoting factor (MPF) during early embryogenesis.
15	C05E7.2	C05E7.2	n/a	chrX 12,939,625
16	syn-4	T01B11.3	n/a	chrIV 8,458,062	syn-4 encodes a Type-I transmembrane protein that is orthologous to mammalian Syntaxin 1, a t-SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor); by homology, SYN-4 is predicted to function as a receptor for intracellular transport vesicles during membrane fusion reactions; in C. elegans, SYN-4 activity is essential for three aspects of early embryogenesis: polar body extrusion, cytokinesis, and nuclear envelope reassembly following mitosis; in addition, SYN-4 may also play a role in formation of the vitelline membrane and/or eggshell; SYN-4 is expressed in the outer membrane of the early embryo, in a punctate pattern around reforming nuclear envelopes, and at the cleavage furrow during ingression; in L1 larvae, SYN-4 is expressed at high levels in lateral seam cells, and in adult hermaphrodites SYN-4 localizes to the incomplete membranes that separate germline nuclei in the gonad.
17	C36C9.1	C36C9.1	n/a	chrX 1,684,665	contains similarity to Dictyostelium discoideum Similar to Homo sapiens (Human). Dentin sialophosphoprotein [Contains:sDentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentinssialoprotein (DSP)].; TR:Q869X8
18	C43F9.7	C43F9.7	n/a	chrIV 10,593,293	contains similarity to Xanthomonas campestris Hypothetical protein XCC1495.; TR:Q8PAI8
19	R11H6.5	R11H6.5	n/a	chrV 14,611,457	contains similarity to Pfam domain PF07528 DZF contains similarity to Interpro domains IPR006561 (DZF), IPR006116 (2-5-oligoadenylate synthetase, ubiquitin-like region)
20	Y39A1A.16	Y39A1A.16	n/a	chrIII 10,680,725	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
21	ekl-5	Y26E6A.1	n/a	chrX 13,915,941	C. elegans EKL-5 protein; contains similarity to Interpro domains IPR001579 (Glycoside hydrolase, chitinase active site), IPR006642 (Zinc finger, Rad18-type putative)
22	Y57G11C.25	Y57G11C.25	n/a	chrIV 14,919,983	Y57G11C.25 encodes a CCCH tandem zinc finger (TZF) protein; based upon its sequence similarity to C. elegans POS-1, the product of Y57G11C.25 is predicted to function as an RNA-binding protein.
23	gut-2	T10G3.6	n/a	chrV 13,498,242	gut-2 encodes a member of the Sm protein family with highest similarity to human U6 snRNA-associated Sm-like protein, LSm2, that affects embryonic viability.
24	pcbd-1	T10B11.1	n/a	chrI 6,951,540	T10B11.1 is orthologous to the human gene PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE (PCBD or TCF1; OMIM:126090), which when mutated leads to hyperphenylalaninemia with primapterinuria.
25	F01F1.11	F01F1.11	n/a	chrIII 5,870,989
26	F28F8.5	F28F8.5	n/a	chrV 15,574,751	contains similarity to Methanosarcina mazei Glutamyl-tRNA(Gln) amidotransferase subunit E (EC 6.3.5.-) (Glu-ADTssubunit E).; SW:GATE_METMA
27	C29G2.1	C29G2.1	n/a	chrV 2,591,466
28	F36A2.8	F36A2.8	n/a	chrI 8,811,005	contains similarity to Pfam domain PF05005 Janus/Ocnus family (Ocnus) contains similarity to Interpro domain IPR007702 (Janus/Ocnus)
29	ZK380.2	ZK380.2	n/a	chrX 1,633,167	contains similarity to Interpro domain IPR011072 (HR1 rho-binding repeat)
30	ZK632.12	ZK632.12	n/a	chrIII 9,831,513	ZK632.12 encodes one of 12 C. elegans FYVE-domain containing proteins and is orthologous to mammalian Phafin2; as loss of ZK632.12 activity via RNAi screens results in no obvious defects, the precise role of ZK632.12 in C. elegans development and/or behavior is not yet known.
31	pfd-6	F21C3.5	n/a	chrI 7,283,387	pfd-6 encodes a putative prefoldin 6 subunit, orthologous to human PFDN6 (OMIM:605660), required for normal microtubule growth and distal tip cell migration; PFD-6 is expressed cytoplasmically in most, if not all, tissues, including the germline; in mass RNAi assays, PFD-6 is required for normal mitotic spindle position, embryonic and larval viability, fertility, body shape, vulval development, and locomotion, and for normally rapid growth; pfd-6(RNAi) embryos show a reduced microtubule growth rate.
32	mec-14	F37C12.12	n/a	chrIII 7,191,528	mec-14 encodes a protein with similarity to the beta-subunits of Shaker-type potassium channels, which are members of the aldo-keto reductase superfamily; MEC-14 is required for response to gentle touch by the six touch receptor neurons, and likely functions to regulate activity of the MEC-4 and MEC-10 degenerin channels; mec-14 expression is detected solely in the touch receptor neurons and is dependent on the MEC-3 LIM domain transcription factor; proper MEC-14 localization in the touch receptor neurons is dependent on MEC-12/alpha-tubulin.
33	F38H4.10	F38H4.10	n/a	chrIV 11,861,497	contains similarity to Pfam domain PF03637 Mob1/phocein family contains similarity to Interpro domain IPR005301 (Mob1/phocein)
34	C06G3.8	C06G3.8	n/a	chrIV 7,032,043	contains similarity to Pfam domain PF01336 OB-fold nucleic acid binding domain contains similarity to Interpro domains IPR016027 (Nucleic acid-binding, OB-fold-like), IPR012340 (Nucleic acid-binding, OB-fold)
35	F55C5.4	F55C5.4	n/a	chrV 12,273,750	contains similarity to Pfam domain PF02985 HEAT repeat contains similarity to Interpro domain IPR016024 (Armadillo-type fold)
36	glb-7	C23H5.2	n/a	chrIV 2,124,416	glb-7 encodes a globin with no obvious function in mass RNAi assays.
37	rnf-5	C16C10.7	n/a	chrIII 4,165,557	This gene encodes a homolog of mammalian RNF5, a C3HC4 (RING-finger) zinc-finger protein.
38	rfc-3	C39E9.13	n/a	chrIV 13,096,350	C. elegans RFC-3 protein; contains similarity to Interpro domains IPR008921 (DNA polymerase III clamp loader subunit, C-terminal), IPR003593 (AAA+ ATPase, core)
39	T09B4.1	T09B4.1	n/a	chrI 6,186,762	contains similarity to Pfam domain PF04188 Mannosyltransferase (PIG-V)) contains similarity to Interpro domain IPR007315 (Mannosyltransferase, PIG-V)
40	D1005.4	D1005.4	n/a	chrX 1,485,247
41	F26F12.2	F26F12.2	n/a	chrV 5,838,075
42	K09E3.7	K09E3.7	n/a	chrX 17,132,904	contains similarity to Homo sapiens Conserved hypothetical protein; HI:HIT000048720
43	F02D10.6	F02D10.6	n/a	chrX 13,450,586	contains similarity to Cryptophlebia leucotreta granulosis virus Hypothetical protein.; TR:Q7T5R9
44	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
45	C02B10.2	C02B10.2	n/a	chrIV 5,090,651	contains similarity to Homo sapiens SNARE-associated protein Snapin; ENSEMBL:ENSP00000357674
46	M02B7.4	M02B7.4	n/a	chrIV 3,802,482	contains similarity to Pfam domain PF08660 Oligosaccharide biosynthesis protein Alg14 like contains similarity to Interpro domain IPR013969 (Oligosaccharide biosynthesis protein Alg14 like)
47	F31B9.3	F31B9.3	n/a	chrX 15,924,034	contains similarity to Homo sapiens Similar to polymerase (RNA) III; ENSEMBL:ENSP00000334758
48	srw-22	T10H4.3	n/a	chrV 15,269,194	C. elegans SRW-22 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
49	bath-19	F59H6.1	n/a	chrII 2,037,587	C. elegans BATH-19 protein; contains similarity to Pfam domains PF00651 (BTB/POZ domain) (3), PF00917 (MATH domain) contains similarity to Interpro domains IPR002083 (MATH), IPR000210 (BTB/POZ-like), IPR011333 (BTB/POZ fold), IPR013069 (BTB/POZ)
50	C49F5.6	C49F5.6	n/a	chrX 11,989,713	contains similarity to Homo sapiens Ankyrin 3; ENSEMBL:ENSP00000280772