UCSC C. elegans Gene Sorter

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UCSC C. elegans Gene Sorter

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#	Name	WormBase	BLASTP E-Value	Genome Position	Description
1	C33H5.1	C33H5.1	3e-167	chrIV 7,809,904	contains similarity to Pfam domain PF01482 Domain of unknown function DUF13 contains similarity to Interpro domain IPR002485 (Protein of unknown function DUF13)
2	F46F5.14	F46F5.14	n/a	chrII 800,774	contains similarity to Pfam domain PF03314 Protein of unknown function, DUF273 contains similarity to Interpro domain IPR004988 (Protein of unknown function DUF273)
3	fbxa-157	C06H5.2	n/a	chrV 17,900,819	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
4	Y40H7A.3	Y40H7A.3	n/a	chrIV 15,162,987	contains similarity to Pfam domain PF05050 Protein of unknown function (DUF672) contains similarity to Interpro domain IPR007744 (Protein of unknown function DUF672)
5	srh-72	ZC204.5	n/a	chrII 1,639,907	C. elegans SRH-72 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
6	H20E11.2	H20E11.2	n/a	chrIV 6,828,617	contains similarity to Pfam domain PF02408 CUB-like domain contains similarity to Interpro domains IPR000859 (CUB), IPR001778 (Pollen allergen Poa pIX/Phl pVI, C-terminal), IPR003366 (CUB-like region)
7	D1065.1	D1065.1	n/a	chrV 4,075,636	contains similarity to Pfam domain PF03189 Protein of unknown function, DUF270 contains similarity to Interpro domain IPR004878 (Protein of unknown function DUF270)
8	F46B6.2	F46B6.2	n/a	chrV 9,773,402	contains similarity to Trypanosoma brucei Hypothetical protein.; TR:Q7YVJ9
9	T16G12.4	T16G12.4	n/a	chrIII 10,058,154	contains similarity to Treponema denticola FlhB.; TR:Q9APY7
10	srz-32	W05E7.2	n/a	chrIV 3,437,096	C. elegans SRZ-32 protein; contains similarity to Interpro domain IPR002184 (Serpentine beta receptor)
11	srh-247	C31B8.13	n/a	chrV 2,933,658	C. elegans SRH-247 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
12	B0379.2	B0379.2	n/a	chrI 10,071,342	contains similarity to Saccharomyces cerevisiae Possible role for UBP3 in controlling the activity or assembly of the SIR protein complex.; SGD:YER151C
13	W04G5.5	W04G5.5	n/a	chrI 11,635,717	contains similarity to Pfam domain PF04721 Domain of unknown function (DUF750) contains similarity to Interpro domain IPR006588 (Protein of unknown function PAW)
14	F55G1.1	F55G1.1	n/a	chrIV 7,492,779
15	R07E5.15	R07E5.15	n/a	chrIII 4,401,952
16	Y47D3B.4	Y47D3B.4	n/a	chrIII 11,407,290	contains similarity to Pfam domain PF01697 Domain of unknown function contains similarity to Interpro domain IPR008166 (Protein of unknown function DUF23)
17	ces-1	F43G9.11	n/a	chrI 8,634,989	ces-1 encodes a C2H2-type zinc finger transcription factor that is a member of the Snail family of proteins that includes Drosophila Scratch, Snail, and Slug, and human SNAIL and SLUG; although the normal function of CES-1 is not fully understood, gain-of-function mutations indicate that CES-1 can function as a transcriptional repressor that blocks programmed cell death in specific neurons by inhibiting expression of the cell-death activator EGL-1; in regulating EGL-1 expression, CES-1 appears to antagonize the transcriptional activity of the bHLH proteins, HLH-2 and HLH-3; despite its cell-type specific role in apoptosis, CES-1 expression is reportedly detected in many embryonic nuclei from the 100-cell stage of embryogenesis through the beginning of morphogenesis, with some CES-1 expression remaining at later embryonic stages; genetic studies indicate that CES-1 is negatively regulated by the bZIP transcription factor CES-2, which can bind CES-1 upstream sequences in vitro and thus may directly regulate CES-1 transcription in vivo
18	srh-67	T21B4.6	n/a	chrII 12,509,457	C. elegans SRH-67 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
19	unc-8	R13A1.4	n/a	chrIV 7,200,978	unc-8 encodes an amiloride-sensitive DEG/ENaC cation-selective channel subunit orthologous to human ENaCB (OMIM:600760, associated with Liddle syndrome, an autosomal dominant form of hypertension); UNC-8 is predicted to function as part of a mechanically gated channel that responds to stretch, and is required for modulating the sinusoidal body wave that is characteristic of C. elegans locomotion; unc-8 interacts genetically with unc-1 and unc-24, which encode stomatin-like proteins, and with mec-6, which encodes a paraoxonase; UNC-8 is expressed in motor neurons, sensory neurons, and interneurons in the nerve ring; UNC-8 may form a channel with the degenerin DEL-1, with which it is coexpressed in ventral cord motor neurons.
20	H14E04.4	H14E04.4	n/a	chrIII 2,391,147
21	fbxa-149	Y38H6C.10	n/a	chrV 20,512,556	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins.
22	C14E2.5	C14E2.5	n/a	chrX 1,824,473
23	srb-18	C54F6.7	n/a	chrV 7,516,266	C. elegans SRB-18 protein; contains similarity to Pfam domain PF02117 C.elegans Sra family integral membrane protein contains similarity to Interpro domains IPR002184 (Serpentine beta receptor), IPR000344 (Nematode chemoreceptor, Sra)
24	W03H9.3	W03H9.3	n/a	chrII 14,143,131	contains similarity to Streptomyces avermitilis Putative oxidoreductase.; TR:Q82DU1
25	pop-1	W10C8.2	n/a	chrI 2,826,881	pop-1 encodes an HMG box-containing protein that is the sole C. elegans member of the TCF/LEF family of transcription factors; in C. elegans, POP-1 functions as a component of the canonical and noncanonical Wnt signaling pathways that are required for cell migrations and binary cell fate decisions associated with asymmetric cell division, respectively; in yeast two-hybrid assays, the POP-1 N-terminal beta-catenin binding domain interacts with BAR-1/beta-catenin as well as with the more divergent beta-catenin, SYS-1; when coexpressed with SYS-1, POP-1 is able to activate transcription from a promoter with TCF binding sites; during development, maternally provided POP-1 is first detected in the nuclei of maturing oocytes and then in nearly all cells of the early embryo; in sister blastomeres in the early embryo, POP-1 is detected at lower levels in posterior blastomeres, such as E and P3, than in corresponding anterior blastomeres, MS and C; in later developmental stages, POP-1 is detected in a subset of tissues including hypodermal seam cells, gonadal precursors, and the developing vulva; in the vulva, POP-1 also exhibits an asymmetric staining pattern, with sister cells showing high or low levels of POP-1 depending upon their orientation along the anterior/posterior axis of the vulva.
26	srab-13	F59A7.3	n/a	chrV 2,026,295	C. elegans SRAB-13 protein ;
27	set-10	F33H2.7	n/a	chrI 15,029,120	set-10 encodes a divergent ortholog of human SMYD1 (OMIM:606846), SMYD2 (OMIM:610663), and SYMD3 (OMIM:608783); SET-10 is paralogous to SET-14, SET-18, and SET-30; SET-10 has no obvious function in individual RNAi assays of vulval development, or in mass RNAi assays.
28	T18D3.6	T18D3.6	n/a	chrX 12,450,290	contains similarity to Streptomyces coelicolor Chromosomal replication initiator protein dnaA.; SW:DNAA_STRCO
29	acr-9	C40C9.2	n/a	chrX 13,644,544	acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors.
30	srx-16	T07H8.1	n/a	chrV 6,976,849	C. elegans SRX-16 protein; contains similarity to Interpro domain IPR017452 (GPCR, rhodopsin-like superfamily)
31	Y43F4A.3	Y43F4A.3	n/a	chrIII 13,240,329	contains similarity to Interpro domain IPR001878 (Zinc finger, CCHC-type)
32	unc-40	T19B4.7	n/a	chrI 5,685,676	The unc-40 gene encodes a netrin receptor that is required to guide dorsal-ventral cell and axon migrations, and is required for correct polarization and migration of the neuroblasts QL and QR.
33	C32A9.1	C32A9.1	n/a	chrX 10,259,366	contains similarity to Plasmodium falciparum Hypothetical protein, conserved.; TR:Q8IEA2
34	T15B7.17	T15B7.17	n/a	chrV 6,814,434	contains similarity to Pfam domain PF03385 Protein of unknown function, DUF288 contains similarity to Interpro domain IPR005049 (Protein of unknown function DUF288)
35	F20C5.4	F20C5.4	n/a	chrIV 8,766,075	contains similarity to Pfam domain PF03381 LEM3 (ligand-effect modulator 3) family / CDC50 family contains similarity to Interpro domain IPR005045 (Protein of unknown function DUF284, transmembrane eukaryotic)
36	C15C6.3	C15C6.3	n/a	chrI 12,209,642	contains similarity to Interpro domains IPR006077 (Vinculin/alpha-catenin), IPR000694 (Proline-rich region)
37	C34D4.10	C34D4.10	n/a	chrIV 7,120,692
38	F15D3.7	F15D3.7	n/a	chrI 11,579,107	contains similarity to Pfam domain PF02466 Tim17/Tim22/Tim23 family contains similarity to Interpro domain IPR003397 (Mitochondrial import inner membrane translocase, subunit Tim17/22)
39	sel-12	F35H12.3	n/a	chrX 917,054	sel-12 encodes a transmembrane domain protein orthologous to presenilins; during gonadal, germline, and vulval development, sel-12 functions, within receiving cells, to positively regulate lin-12 and glp-1 Notch-like signaling pathways; sel-12 presenilin activity and/or levels are likely regulated by the SET/NAP protein sub-family member encoded by spr-2, as mutations in sel-12 are suppressed by mutations in spr-2; spr-2 regulation of sel-12 occurs in a hop-1 presenilin dependent manner.
40	sru-16	Y45F10B.4	n/a	chrIV 13,581,181	C. elegans SRU-16 protein; contains similarity to Pfam domain PF02688 Domain of unknown function DUF215 contains similarity to Interpro domain IPR003839 (Protein of unknown function DUF215)
41	F29A7.5	F29A7.5	n/a	chrII 2,747,560
42	fbxa-190	F56C3.2	n/a	chrX 1,373,317	This gene encodes a protein containing an F-box, a motif predicted to mediate protein-protein interactions either with homologs of yeast Skp-1p or with other proteins; this gene's encoded protein also contains an FTH/DUF38 motif, which may also mediate protein-protein interaction.
43	AH10.4	AH10.4	n/a	chrV 14,137,472	contains similarity to Methanosarcina acetivorans Hypothetical protein MA1935.; TR:Q8TPH7
44	str-205	C02E7.9	n/a	chrV 4,929,096	C. elegans STR-205 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
45	F38A1.13	F38A1.13	n/a	chrIV 1,265,538
46	sel-2	F10F2.1	n/a	chrIII 4,604,205	sel-2 encodes a PH, BEACH and WD40 domain-containing protein that is homologous to mammalian neurobeachin/BCL8B and LRBA (LPS-responsive, beige-like anchor protein); during development, SEL-2 functions to regulate endosomal traffic in polarized epithelial cells such as the vulval precursor cells (VPCs) and intestinal cells; specifically, in a subset of the VPCs, SEL-2 activity is required for proper levels and apical localization of LIN-12/Notch and for LET-23/EGFR downregulation; sel-2::yfp reporters are expressed in a number of cell types, including the VPCs and intestinal cells; a rescuing SEL-2::GFP reporter is expressed most strongly in the rectal epithelial cells and hypodermal seam cells where it localizes to the cytoplasm and the perinuclear region.
47	F39H12.2	F39H12.2	n/a	chrX 832,122	contains similarity to Pfam domain PF00400 WD domain, G-beta repeat contains similarity to Interpro domains IPR011046 (WD40 repeat-like), IPR001680 (WD40 repeat), IPR015943 (WD40/YVTN repeat-like)
48	srh-165	C41G6.9	n/a	chrV 15,220,637	C. elegans SRH-165 protein; contains similarity to Pfam domain PF01461 7TM chemoreceptor contains similarity to Interpro domain IPR003002 (7TM chemoreceptor, subfamily 1)
49	srt-13	ZC142.1	n/a	chrV 4,249,044	C. elegans SRT-13 protein; contains similarity to Pfam domain PF01748 Caenorhabditis serpentine receptor-like protein contains similarity to Interpro domains IPR002651 (Protein of unknown function DUF32), IPR000539 (Frizzled protein)
50	tmbi-4	B0563.4	n/a	chrX 9,155,606	C. elegans TMBI-4 protein; contains similarity to Pfam domain PF01027 Uncharacterised protein family UPF0005 contains similarity to Interpro domain IPR006214 (Protein of unknown function UPF0005)